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1. 发明申请

US20120016102A1 NON-TOXIC BIOFILM INHIBITOR 有权
标题翻译：非毒性生物膜抑制剂
公开(公告)号：US20120016102A1
公开(公告)日：2012-01-19
申请号：US13179058
申请日：2011-07-08
申请人： Robert S. Hodges , Randall T. Irvin , Carmen Giltner , Erin Van Schaik
发明人： Robert S. Hodges , Randall T. Irvin , Carmen Giltner , Erin Van Schaik
IPC分类号： C07K7/08 , C07K14/00
CPC分类号： A61K38/164 , A61L12/14 , A61L27/227 , A61L27/54 , A61L29/048 , A61L29/16
摘要： The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.
摘要翻译：本发明涉及在生物或非生物表面上预防或抑制生物膜形成的组合物，装置和方法。组合物包含基于铜绿假单胞菌IV型皮林的C-末端受体结合结构域的肽，其以高亲和力结合非生物表面（例如，钢，塑料），并防止多种铜绿假单胞菌菌株与表面。本发明的组合物代表用于生物膜形成的无毒性抑制剂，特别是在非生物表面上，其负责大量有问题的疾病和巨大的经济损失。本发明的方法可用作改变各种生物医学，纳米技术和生物技术装置或制品的表面的安全和环境友好的手段。

2. 发明申请

US20080287367A1 Non-Toxic Biofilm Inhibitor 有权
标题翻译：无毒生物膜抑制剂
公开(公告)号：US20080287367A1
公开(公告)日：2008-11-20
申请号：US11996379
申请日：2006-07-21
申请人： Robert S. Hodges , Randall T. Irvin , Carmen Giltner , Erin Van Schaik
发明人： Robert S. Hodges , Randall T. Irvin , Carmen Giltner , Erin Van Schaik
IPC分类号： A01N37/18 , C07K7/00 , A01P1/00
CPC分类号： A61K38/164 , A61L12/14 , A61L27/227 , A61L27/54 , A61L29/048 , A61L29/16
摘要： The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.
摘要翻译：本发明涉及在生物或非生物表面上预防或抑制生物膜形成的组合物和方法。组合物包含基于铜绿假单胞菌IV型皮林的C-末端受体结合结构域的肽，其以高亲和力结合非生物表面（例如，钢，塑料），并防止多种铜绿假单胞菌菌株与表面。本发明的组合物代表用于生物膜形成的无毒性抑制剂，特别是在非生物表面上，其负责大量有问题的疾病和巨大的经济损失。本发明的方法可用作改变各种生物医学，纳米技术和生物技术装置或制品的表面的安全和环境友好的手段。

3. 发明授权

US06767545B2 Pseudomonas treatment composition and method 失效
标题翻译：假单胞菌治疗组合物及方法
公开(公告)号：US06767545B2
公开(公告)日：2004-07-27
申请号：US09865159
申请日：2001-05-24
申请人： Randall T. Irvin , Randy J. Read , Bart Hazes , Wah Y. Wong , Sastry A. Parimi , Linda M. G. Glasier
发明人： Randall T. Irvin , Randy J. Read , Bart Hazes , Wah Y. Wong , Sastry A. Parimi , Linda M. G. Glasier
IPC分类号： A61K3902
CPC分类号： A61K38/164 , C07K14/21 , C07K2319/00
摘要： A composition and method for treating or preventing infection by Pseudomonas aeruginosa is disclosed. The composition includes a P. aeruginosa pilin peptide modified to prevent oligomerization of the pilin. The method involves administered the composition to a person infected with Pseudomonas are at risk of such infection.
摘要翻译：公开了一种用于治疗或预防铜绿假单胞菌感染的组合物和方法。该组合物包括经改良的铜绿假单胞菌肽蛋白肽，以防止皮林的低聚。该方法包括将组合物给予感染了假单胞菌的人患有这种感染的风险。

4. 发明授权

US5468484A Method of prevention of pseudomonas infection 失效
标题翻译：预防假单胞菌感染的方法
公开(公告)号：US5468484A
公开(公告)日：1995-11-21
申请号：US84739
申请日：1993-06-28
申请人： Robert S. Hodges , Randall T. Irvin , William Paranchych , Pamela A. Sokol , Donald E. Woods
发明人： Robert S. Hodges , Randall T. Irvin , William Paranchych , Pamela A. Sokol , Donald E. Woods
IPC分类号： A61K39/00 , C07K14/21 , C12N9/10 , A61K39/395 , A61K39/40 , C12P21/08 , C07K15/28
CPC分类号： C07K14/21 , C12N9/1077 , A61K39/00
摘要： The invention described includes methods and compositions useful in preventing infection by Pseudomonas aeruginosa and related organisms. Diclosed is a peptide having the sequence corresponding to an antigenic site in the protein exoenzyme S which is antigenically similar to a C-terminal portion of the Pseudomonas aeruginosa pilin protein. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against Pseudomonas aeruginosa as well as against such cross-reactive microorganisms.
摘要翻译：所描述的发明包括可用于预防铜绿假单胞菌和相关生物体感染的方法和组合物。被分离的是具有与蛋白质外切酶S中的抗原位点相对应的序列的肽，其与铜绿假单胞菌皮林蛋白质的C末端部分具有抗原性。该肽与某些细菌和真菌微生物中存在的表面肽具有交叉反应性，并且有效抑制这些生物体与目标上皮细胞的结合。肽也可以用于疫苗组合物中，用于产生针对铜绿假单胞菌的免疫以及针对这种交叉反应性微生物。

5. 发明授权

US09096775B2 Surface-coated structures and methods 有权
标题翻译：表面涂层结构和方法
公开(公告)号：US09096775B2
公开(公告)日：2015-08-04
申请号：US13087257
申请日：2011-04-14
申请人： Randall T. Irvin , Elisabeth M. Davis , DongYang Li , Daniel Abraham Muruve
发明人： Randall T. Irvin , Elisabeth M. Davis , DongYang Li , Daniel Abraham Muruve
IPC分类号： A61K39/00 , A61K39/108 , A61K39/02 , C09D179/00 , A01N37/46 , A01N63/02 , A61B5/145 , A61L27/04 , A61L27/22 , A61L27/34 , A61L27/54 , C07K14/21
CPC分类号： C09D179/00 , A01N37/46 , A01N63/02 , A61B5/14532 , A61B5/14546 , A61L27/04 , A61L27/227 , A61L27/34 , A61L27/54 , A61L2300/25 , A61L2400/18 , C07K14/21 , Y10T428/31725
摘要： The present invention relates to a methods and composition in which a D-form or retro-inverso Pseudomonas pilin peptide is bound to a substrate. The disclosed methods and composition are useful for inhibiting biofilm formation by non-Pseudomonas bacteria, for reducing the inflammatory response to a material, for reducing corrosion of metals, and in biosensor applications.
摘要翻译：本发明涉及一种方法和组合物，其中D型或逆反式假单胞菌肽素结合到底物上。所公开的方法和组合物可用于抑制非假单胞菌的生物膜形成，用于降低对材料的炎症反应，用于减少金属的腐蚀和生物传感器应用。

6. 发明授权

US08454977B2 Non-toxic biofilm inhibitor 有权
标题翻译：无毒生物膜抑制剂
公开(公告)号：US08454977B2
公开(公告)日：2013-06-04
申请号：US13179058
申请日：2011-07-08
申请人： Robert S. Hodges , Randall T. Irvin , Carmen Giltner , Erin Van Schaik
发明人： Robert S. Hodges , Randall T. Irvin , Carmen Giltner , Erin Van Schaik
IPC分类号： A61K39/108 , A61K39/00 , A61K39/02
CPC分类号： A61K38/164 , A61L12/14 , A61L27/227 , A61L27/54 , A61L29/048 , A61L29/16
摘要： The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.
摘要翻译：本发明涉及在生物或非生物表面上预防或抑制生物膜形成的组合物，装置和方法。组合物包含基于铜绿假单胞菌IV型皮林的C-末端受体结合结构域的肽，其以高亲和力结合非生物表面（例如，钢，塑料），并防止多种铜绿假单胞菌菌株与表面。本发明的组合物代表用于生物膜形成的无毒性抑制剂，特别是在非生物表面上，其负责大量有问题的疾病和巨大的经济损失。本发明的方法可用作改变各种生物医学，纳米技术和生物技术装置或制品的表面的安全和环境友好的手段。

7. 发明申请

US20110293684A1 SURFACE-COATED STRUCTURES AND METHODS 有权
标题翻译：表面涂层结构和方法
公开(公告)号：US20110293684A1
公开(公告)日：2011-12-01
申请号：US13087257
申请日：2011-04-14
申请人： Randall T. Irvin , Elisabeth M. Davis , DongYang Li , Daniel Abraham Muruve
发明人： Randall T. Irvin , Elisabeth M. Davis , DongYang Li , Daniel Abraham Muruve
IPC分类号： A61K9/00 , B01J19/00 , C07K7/08 , C07K14/195 , A01N37/18 , A01P1/00
CPC分类号： C09D179/00 , A01N37/46 , A01N63/02 , A61B5/14532 , A61B5/14546 , A61L27/04 , A61L27/227 , A61L27/34 , A61L27/54 , A61L2300/25 , A61L2400/18 , C07K14/21 , Y10T428/31725
摘要： The present invention relates to a methods and composition in which a D-form or retro-inverso Pseudomonas pilin peptide is bound to a substrate. The disclosed methods and composition are useful for inhibiting biofilm formation by non-Pseudomonas bacteria, for reducing the inflammatory response to a material, for reducing corrosion of metals, and in biosensor applications.
摘要翻译：本发明涉及一种方法和组合物，其中D型或逆反式假单胞菌肽素结合到底物上。所公开的方法和组合物可用于抑制非假单胞菌的生物膜形成，用于降低对材料的炎症反应，用于减少金属的腐蚀和生物传感器应用。

8. 发明授权

US06461490B1 Biosensor device and method 失效
标题翻译：生物传感器装置及方法
公开(公告)号：US06461490B1
公开(公告)日：2002-10-08
申请号：US09626775
申请日：2000-07-27
申请人： R. Bruce Lennox , Robert S. Hodges , Randall T. Irvin
发明人： R. Bruce Lennox , Robert S. Hodges , Randall T. Irvin
IPC分类号： G02N2726
CPC分类号： G01N33/5438 , B01J2219/00653 , B01J2219/00659 , B01J2219/00704 , B01J2219/00725 , C12Q1/003 , C12Q1/6825 , C40B40/10 , G01N33/54373 , Y10S436/908 , C12Q2565/607
摘要： A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes a biosensor surface and surface-bound two-subunit heterodimer complexes composed of first and second, preferably oppositely charged peptides that together form an &agr;-helical coiled-coil heterodimer. The-first peptide is attached to the biosensor surface, and the second peptide carries the ligand, accessible for binding by a ligand-binding agent. Binding of anti-ligand binding agent to the surface-bound ligand is detected by a suitable detector. A ligand-specific biosensor surface can be readily prepared from a universal template containing the first charged peptide, by addition of a selected ligand attached to the second peptide.
摘要翻译：一种用于检测配体和受体之间的结合事件的生物传感器装置。该装置包括由第一和第二，优选相反电荷的肽组成的生物传感器表面和表面结合的双亚基异二聚体复合物，其一起形成α-螺旋卷曲螺旋二聚体。第一个肽连接到生物传感器表面，第二个肽携带配体，可以通过配体结合剂结合。通过合适的检测器检测抗配体结合剂与表面结合配体的结合。配体特异性生物传感器表面可以容易地由含有第一带电荷肽的通用模板制备，通过加入附着于第二肽的选定配体。

9. 发明授权

US6130037A Biosensor device and method 失效
公开(公告)号：US6130037A
公开(公告)日：2000-10-10
申请号：US845505
申请日：1997-04-24
申请人： R. Bruce Lennox , Robert S. Hodges , Randall T. Irvin
发明人： R. Bruce Lennox , Robert S. Hodges , Randall T. Irvin
IPC分类号： C12Q1/00 , C40B40/10 , G01N33/543 , G01N27/00 , C12Q1/68 , G01N33/557 , A61L3/00
CPC分类号： C12Q1/003 , G01N33/54373 , G01N33/5438 , B01J2219/00653 , B01J2219/00659 , B01J2219/00704 , B01J2219/00725 , C40B40/10 , Y10S436/807
摘要： A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes an electrode substrate coated with a high-dielectric hydrocarbon-chain monolayer, and having ligands attached to the exposed monolayer surface. Binding of a receptor to the monolayer-bound ligand, and the resultant perturbation of the monolayer structure, causes ion-mediated electron flow across the monolayer. In one embodiment, the monolayers have a coil-coil heterodimer embedded therein, one subunit of which is attached to the substrate, and the second of which carries the ligand at the monolayer surface.

10. 发明授权

US5738996A Combinational library composition and method 失效
标题翻译：组合图书馆的组成和方法
公开(公告)号：US5738996A
公开(公告)日：1998-04-14
申请号：US260199
申请日：1994-06-15
申请人： Robert S. Hodges , Randall T. Irvin , Arne Holm , Wah Y. Wong , Hasmukh B. Sheth , Devon L. Husband
发明人： Robert S. Hodges , Randall T. Irvin , Arne Holm , Wah Y. Wong , Hasmukh B. Sheth , Devon L. Husband
IPC分类号： B01J19/00 , C07K1/04 , C40B40/10 , C40B60/14 , G01N33/53
CPC分类号： C40B80/00 , B01J19/0046 , C07K1/047 , G01N33/53 , B01J2219/00315 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00659 , B01J2219/00725 , C40B40/10 , C40B60/14
摘要： A combinatorial library composition and method for using the library to construct oligomers effective to bind to a selected ligand is disclosed. The library composition includes at least two sets of ar oligomer libraries, each library set having selected oligomer subunit positions filled by known subunits, and other subunit positions containing permutations of subunits. In the selection method, oligomers from each library set are identified, and a new permutation library formed of subunits corresponding to the highest binding affinity oligomers in each library is screened for binding affinity to the selected ligand.
摘要翻译：公开了组合文库组合物和使用文库构建有效结合选定配体的低聚物的方法。文库组合物包括至少两组ar寡聚体文库，每个文库集合具有由已知亚基填充的选定的寡聚体亚单位，以及含有亚基排列的其它亚基位置。在选择方法中，鉴定了来自每个文库的寡聚体，并筛选了与每个文库中最高结合亲和性寡聚体相应的亚基形成的新的置换文库，以对所选择的配体进行结合亲和力。

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