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1. 发明授权

US07806853B2 Array and method for dosing a hormone regulating blood sugar in a patient 有权
标题翻译：用于给予调节患者血糖的激素的阵列和方法
公开(公告)号：US07806853B2
公开(公告)日：2010-10-05
申请号：US12471150
申请日：2009-05-22
申请人： Uwe Wittmann , Helmut Rinne , Ralf Gessler , Hans-Joerg Pfleiderer
发明人： Uwe Wittmann , Helmut Rinne , Ralf Gessler , Hans-Joerg Pfleiderer
IPC分类号： A61M31/00
CPC分类号： A61M5/1723 , A61B5/14532 , A61M5/14244 , A61M2230/201 , A61M2230/62 , G06F19/00
摘要： The invention concerns an array and a method for dosing a hormone regulating the blood glucose, especially insulin, of a diabetic patient. In order to improve the administration of the hormone, the invention provides the following characteristic combination: a first sensor for measuring tissue glucose level; a controller having as an input the measured tissue glucose level from the first sensor, the controller having a control algorithm to determine an amount of hormone to be dosed based upon the measured tissue glucose level; a hormone dosing unit connected to the controller and automatically administering a hormone dose based upon a signal received from the controller; a second sensor for measuring an influencing patient variable; a pilot control device connected to the second sensor, the pilot control device connected to and forming a circuit with the controller, the pilot control device acting on the controller in accordance with the influencing patient variable that is measured by the second sensor, whereby the pilot control device reduces dead time of the controller.
摘要翻译：本发明涉及用于给予调节糖尿病患者的血糖，特别是胰岛素的激素的阵列和方法。为了改善激素的施用，本发明提供以下特征组合：用于测量组织葡萄糖水平的第一传感器; 控制器具有来自第一传感器的测量的组织葡萄糖水平作为输入，控制器具有控制算法，用于基于所测量的组织葡萄糖水平来确定要给药的激素的量; 激素计量单元，其连接到所述控制器并基于从所述控制器接收的信号自动施用激素剂量; 用于测量影响患者变量的第二传感器; 连接到所述第二传感器的先导控制装置，所述先导控制装置与所述控制器连接并与所述控制器形成电路，所述先导控制装置根据由所述第二传感器测量的影响的患者变量作用在所述控制器上，控制装置减少控制器的死区时间。

2. 发明申请

US20090254024A1 ARRAY AND METHOD FOR DOSING A HORMONE REGULATING BLOOD SUGAR IN A PATIENT 有权
标题翻译：用于在患者体内调节血糖的调节剂的阵列和方法
公开(公告)号：US20090254024A1
公开(公告)日：2009-10-08
申请号：US12471150
申请日：2009-05-22
申请人： Uwe Wittmann , Helmut Rinne , Ralf Gessler , Hans-Joerg Pfleiderer
发明人： Uwe Wittmann , Helmut Rinne , Ralf Gessler , Hans-Joerg Pfleiderer
IPC分类号： A61M37/00
CPC分类号： A61M5/1723 , A61B5/14532 , A61M5/14244 , A61M2230/201 , A61M2230/62 , G06F19/00
摘要： The invention concerns an array and a method for dosing a hormone regulating the blood glucose, especially insulin, of a diabetic patient (10). In order to improve the administration of the hormone, the invention provides the following characteristic combination: a) a measuring device (16) to detect measured values correlatable with blood sugar; b) a controlling means (12) comprising a controller (44) and a hormone dosing device (46) for supplying a hormone dosage; c) a pilot control device (14) acting on the hormone fine dosage controlling means (12) for performing a coarse pre-control in accordance with at least one influence variable that influences blood glucose.
摘要翻译：本发明涉及用于给予调节糖尿病患者的血糖特别是胰岛素的激素的阵列和方法（10）。为了改善激素的施用，本发明提供以下特征组合：a）检测与血糖相关的测量值的测量装置（16）; b）包括用于提供激素剂量的控制器（44）和激素计量装置（46）的控制装置（12） c）作用于激素精细剂量控制装置（12）的先导控制装置（14），用于根据影响血糖的至少一个影响变量执行粗略预控制。

3. 发明授权

US07556613B2 Array and method for dosing a hormone regulating blood sugar in a patient 有权
标题翻译：用于给予调节患者血糖的激素的阵列和方法
公开(公告)号：US07556613B2
公开(公告)日：2009-07-07
申请号：US10203673
申请日：2001-01-20
申请人： Uwe Wittmann , Helmut Rinne , Ralf Gessler , Hans-Joerg Pfleiderer
发明人： Uwe Wittmann , Helmut Rinne , Ralf Gessler , Hans-Joerg Pfleiderer
IPC分类号： A61M31/00 , A61K9/22
CPC分类号： A61M5/1723 , A61B5/14532 , A61M5/14244 , A61M2230/201 , A61M2230/62 , G06F19/00
摘要： The invention concerns an array and a method for dosing a hormone regulating the blood glucose, especially insulin of a diabetic patient (10). In order to improve the administration of the hormone, the invention provides the following characteristic combination: a) a measuring device (16) to detect measured values correlatable with blood sugar; b) a controlling means (12) comprising a controller (44) and a hormone dosing device (46) for supplying a hormone dosage; c) a pilot control device (14) acting on the hormone fine dosage controlling means (12) for performing a coarse pre-control in accordance with at least one influence variable that influences blood glucose.
摘要翻译：本发明涉及用于给予调节血糖的激素，特别是糖尿病患者的胰岛素的激素的阵列和方法（10）。为了改善激素的施用，本发明提供以下特征组合：a）检测与血糖相关的测量值的测量装置（16）; b）包括用于提供激素剂量的控制器（44）和激素计量装置（46）的控制装置（12） c）作用于激素精细剂量控制装置（12）的先导控制装置（14），用于根据影响血糖的至少一个影响变量执行粗略预控制。

4. 发明授权

US07169600B2 Device for determining a glucose concentration in a tissue fluid 失效
标题翻译：用于测定组织液中葡萄糖浓度的装置
公开(公告)号：US07169600B2
公开(公告)日：2007-01-30
申请号：US10782290
申请日：2004-02-19
申请人： Udo Hoss , Hans-Joerg Pfleiderer , Ralf Gessler , Hans-Ulrich Zieten , Rolf Fussgaenger
发明人： Udo Hoss , Hans-Joerg Pfleiderer , Ralf Gessler , Hans-Ulrich Zieten , Rolf Fussgaenger
IPC分类号： C12M1/34
CPC分类号： A61B5/14865 , A61B5/14528 , A61B5/14532
摘要： The invention concerns an arrangement for determining the concentration of glucose in a tissue fluid. In the microdialysis technology used for this purpose, perfusate-containing glucose is transported in intermittent delivery pulses through a microdialysis probe inserted into the tissue fluid and dialysate obtained in this process is passed to a measuring cell to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the tissue fluid by means of a control device in accordance with a command variable derived from the measurement signals of the measuring cell. When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the tissue fluid.
摘要翻译：本发明涉及一种用于确定组织液中葡萄糖浓度的装置。在用于此目的的微透析技术中，含有灌注液的葡萄糖通过插入组织液中的微量透析探针在间歇递送脉冲中运输，并将在该过程中获得的透析液送至测量池以记录葡萄糖含量。为了即使在透析时间缩短的情况下也可以精确测定葡萄糖，建议根据命令变量，通过控制装置使灌注液中的葡萄糖的起始含量适应于组织液的葡萄糖含量源自测量单元的测量信号。当控制偏差可忽略时，灌注液中葡萄糖的瞬时起始含量可以被确定为组织液的葡萄糖含量的量度。

5. 发明授权

US06852500B1 Method for determining the concentration of glucose in a body fluid with glucose-containing perfusate 失效
标题翻译：用含葡萄糖的灌注液测定体液中葡萄糖浓度的方法
公开(公告)号：US06852500B1
公开(公告)日：2005-02-08
申请号：US09620038
申请日：2000-07-20
申请人： Udo Hoss , Hans-Joerg Pfleiderer , Ralf Gessler , Hans-Ulrich Zieten , Rolf Fussgaenger
发明人： Udo Hoss , Hans-Joerg Pfleiderer , Ralf Gessler , Hans-Ulrich Zieten , Rolf Fussgaenger
IPC分类号： G01N33/66 , A61B5/00 , G01N33/487 , C12Q1/54
CPC分类号： A61B5/14865 , A61B5/14528 , A61B5/14532
摘要： The invention concerns a method and an arrangement for determining the concentration of glucose in a body fluid. In the microdialysis technology used for this purpose, perfusate containing glucose is transported in intermittent delivery pulses through a microdialysis probe (10) inserted into the body fluid and dialysate obtained in this process is passed to a measuring cell (16) to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the body fluid by means of a control device (18, 20) in accordance with a command variable derived from the measurement signals of the measuring cell (16). When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the body fluid.
摘要翻译：本发明涉及一种用于确定体液中葡萄糖浓度的方法和装置。在用于此目的的微透析技术中，含有葡萄糖的灌注液通过插入到体液中的微量透析探针（10）以间歇递送脉冲的形式输送，并将在该过程中获得的透析液送至测量池（16）以记录葡萄糖含量。为了即使在透析时间缩短的情况下也能够精确地确定葡萄糖，建议通过控制装置（18,20）将灌注液中葡萄糖的起始含量与体液的葡萄糖含量相适应根据从测量单元（16）的测量信号导出的命令变量。当控制偏差可忽略时，可以将灌注液中葡萄糖的瞬时起始含量确定为体液葡萄糖含量的量度。

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