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1. 发明授权

US06662039B2 Optical probing of neuronal connections with fluorescent indicators 失效
标题翻译：用荧光指示器进行神经元连接的光学探测
公开(公告)号：US06662039B2
公开(公告)日：2003-12-09
申请号：US09336026
申请日：1999-06-18
申请人： Rafael Yuste , Zita Peterlin
发明人： Rafael Yuste , Zita Peterlin
IPC分类号： A61B600
CPC分类号： A61B5/0059 , A61B5/4064
摘要： This invention provides methods of identifying a connection between a first neuron and a second neuron or plurality of neurons in a neural tissue slice with a fluorescent indicator. This invention also provides a method of detecting the effect of a neuromodulator on a connection between a first neuron and a second neuron or a plurality of neurons forming a circuit; methods of identifying an inhibitory connection between a first neuron and a second neuron or plurality of neurons; and a method of identifying a connection between a first neuron and a second neuron or plurality of neurons in vivo or in vitro.
摘要翻译：本发明提供了用荧光指示器识别神经组织切片中的第一神经元和第二神经元或多个神经元之间的连接的方法。本发明还提供一种检测神经调节剂对形成电路的第一神经元和第二神经元或多个神经元之间的连接的影响的方法; 识别第一神经元和第二神经元或多个神经元之间的抑制性连接的方法; 以及在体内或体外鉴定第一神经元和第二神经元或多个神经元之间的连接的方法。

2. 发明授权

US09273032B2 Photolabile compounds 有权
标题翻译：光不稳定化合物
公开(公告)号：US09273032B2
公开(公告)日：2016-03-01
申请号：US13279876
申请日：2011-10-24
申请人： Roberto Etchenique , Rafael Yuste , Luis Baraldo
发明人： Roberto Etchenique , Rafael Yuste , Luis Baraldo
IPC分类号： C07F15/00 , C07D213/73 , A61K31/555 , C07D401/14
CPC分类号： C07F15/0046 , C07D401/14 , C07F15/06 , G01N33/5008
摘要： The present invention describes photolabile compounds and methods for use of the compounds. The photolabile compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect.
摘要翻译：本发明描述了光不稳定化合物和使用该化合物的方法。光不稳定化合物具有光可释放配体，其可以是生物活性的，并且其在暴露于光时从化合物中光分解。在一个实施方案中，光是可见光，其对生物样品（例如细胞和组织）的活力无害，其中释放的有机分子是生物活性的并且可以具有治疗效果。

3. 发明授权

US08063216B2 Photolabile compounds 有权
标题翻译：光不稳定化合物
公开(公告)号：US08063216B2
公开(公告)日：2011-11-22
申请号：US10585013
申请日：2004-12-14
申请人： Roberto Etchenique , Rafael Yuste , Luis Baraldo
发明人： Roberto Etchenique , Rafael Yuste , Luis Baraldo
IPC分类号： C07F15/00 , A61K31/555
CPC分类号： C07F15/0046 , C07D401/14 , C07F15/06 , G01N33/5008
摘要： The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect.
摘要翻译：本发明描述了使用该化合物的光不稳定化合物方法。光不稳定化合物具有光可释放的配体，其可以是生物活性的，并且其在暴露于光时从化合物中光分解。在一个实施方案中，光是可见光，其对生物样品（例如细胞和组织）的活力无害，其中释放的有机分子是生物活性的并且可以具有治疗效果。

4. 发明授权

US09744236B2 Photolabile compounds 有权
公开(公告)号：US09744236B2
公开(公告)日：2017-08-29
申请号：US13336643
申请日：2011-12-23
申请人： Rafael Yuste , Roberto Etchenique , Luis Baraldo
发明人： Rafael Yuste , Roberto Etchenique , Luis Baraldo
IPC分类号： C07F15/00 , A61K31/555 , A61K41/00 , A61K31/4045 , A61K31/41 , A61K31/4409 , A61K31/465 , A61K31/198 , A61K31/675 , A61K47/48 , A61N5/06 , B01J19/12 , A61N5/067
CPC分类号： A61K41/0042 , A61K31/198 , A61K31/4045 , A61K31/41 , A61K31/4409 , A61K31/465 , A61K31/675 , A61K47/547 , A61N5/062 , A61N2005/0657 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/067 , B01J19/12 , B01J2219/12 , C07F15/0053
摘要： The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In some embodiments, the Photolabile Compounds comprise a light antenna, such as a labeling molecule or an active derivative thereof. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect. In another embodiment, the photoreleasable ligand can be a labeling molecule, such as a fluorescent molecule.

5. 发明申请

US20120116287A1 PHOTOLABILE COMPOUNDS 有权
标题翻译：可溶性化合物
公开(公告)号：US20120116287A1
公开(公告)日：2012-05-10
申请号：US13279876
申请日：2011-10-24
申请人： Roberto ETCHENIQUE , Rafael Yuste , Luis Baraldo
发明人： Roberto ETCHENIQUE , Rafael Yuste , Luis Baraldo
IPC分类号： A61M37/00 , C07F19/00 , B01J19/12 , A61K31/675 , A61P35/00 , C12Q1/02 , C07F15/00 , A61K31/555
CPC分类号： C07F15/0046 , C07D401/14 , C07F15/06 , G01N33/5008
摘要： The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect.
摘要翻译：本发明描述了使用该化合物的光不稳定化合物方法。光不稳定化合物具有光可释放的配体，其可以是生物活性的，并且其在暴露于光时从化合物中光分解。在一个实施方案中，光是可见光，其对生物样品（例如细胞和组织）的活力无害，其中释放的有机分子是生物活性的并且可以具有治疗效果。

6. 发明申请

US20080176940A1 Photolabile Compounds 有权
标题翻译：光不稳定化合物
公开(公告)号：US20080176940A1
公开(公告)日：2008-07-24
申请号：US10585013
申请日：2004-12-14
申请人： Roberto Etchenique , Rafael Yuste , Luis Baraldo
发明人： Roberto Etchenique , Rafael Yuste , Luis Baraldo
IPC分类号： A61K31/28 , C07F15/00 , A61K31/295 , C12Q1/00
CPC分类号： C07F15/0046 , C07D401/14 , C07F15/06 , G01N33/5008
摘要： The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect.
摘要翻译：本发明描述了使用该化合物的光不稳定化合物方法。光不稳定化合物具有光可释放的配体，其可以是生物活性的，并且其在暴露于光时从化合物中光分解。在一个实施方案中，光是可见光，其对生物样品（例如细胞和组织）的活力无害，其中释放的有机分子是生物活性的并且可以具有治疗效果。

7. 发明授权

US06823286B2 Method and system for analyzing multi-dimensional data 失效
公开(公告)号：US06823286B2
公开(公告)日：2004-11-23
申请号：US10297160
申请日：2003-06-26
申请人： Rafael Yuste , Vikram S. Kumar , Robert C. Froemke
发明人： Rafael Yuste , Vikram S. Kumar , Robert C. Froemke
IPC分类号： G06F1900
CPC分类号： G06T7/0012 , G06F19/20 , G06F19/24 , G06K9/6297 , G06T2207/30072
摘要： Disclosed is a method for analyzing a sequence of data arrays. A selection of at least one type of region of interest and at least one region of interest from said data arrays is made. The sequence of data arrays are then transformed into a simplified data array. Events of interest in the selected regions of interest are then detected and stored in a second simplified data array. The data is then analyzed to determine relationships between the detected events of interest

8. 发明申请

US20210033836A1 SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR MULTI-PLANE IMAGING OF NEURAL CIRCUITS 有权
公开(公告)号：US20210033836A1
公开(公告)日：2021-02-04
申请号：US16730344
申请日：2019-12-30
申请人： Rafael Yuste , Darcy S. Peterka , Weijian Yang
发明人： Rafael Yuste , Darcy S. Peterka , Weijian Yang
IPC分类号： G02B21/00 , G02B21/06 , G02B21/08 , G02B21/16 , G02B21/36 , G02B26/10
摘要： An exemplary device can be provided which can include, for example, a radiation source(s) configured to generate a first radiation(s), a spatial light modulator (SLM) arrangement(s) configured to receive the first radiation(s) and generate a second radiation(s) based on the first radiation(s), and a galvanometer(s) configured to receive the second radiation(s), generate a third radiation(s) based on the second radiation(s), and provide the third radiation(s) to a sample(s).

9. 发明授权

US09846313B2 Devices, apparatus and method for providing photostimulation and imaging of structures 有权
公开(公告)号：US09846313B2
公开(公告)日：2017-12-19
申请号：US13121084
申请日：2009-09-25
申请人： Volodymyr Nikolenko , Rafael Yuste , Brendon O. Watson , Darcy Peterka
发明人： Volodymyr Nikolenko , Rafael Yuste , Brendon O. Watson , Darcy Peterka
IPC分类号： G02B27/46 , G01N21/64 , A61N5/06 , G01N21/65 , G02B21/00
CPC分类号： G02B27/46 , A61N5/0622 , G01N21/6458 , G01N2021/653 , G01N2201/0221 , G02B21/0004
摘要： According to exemplary embodiments of the present disclosure, it is possible to provide method, system, arrangement, computer-accessible medium and device to stimulate individual neurons in brain slices in any arbitrary spatio-temporal pattern, using two-photon uncaging of photo-sensitive compounds such as MNI-glutamate and/or RuBi-Glutamate with beam multiplexing. Such exemplary method and device can have single-cell and three-dimensional precision. For example, by sequentially stimulating up to a thousand potential presynaptic neurons, it is possible to generate detailed functional maps of inputs to a cell. In addition, it is possible to combine this exemplary approach with two-photon calcium imaging in an all-optical method to image and manipulate circuit activity. Further exemplary embodiments of the present disclosure can include a light-weight, compact portable device providing for uses in a wide variety of applications.

10. 发明申请

US20120220922A1 PHOTOLABILE COMPOUNDS 有权
标题翻译：可溶性化合物
公开(公告)号：US20120220922A1
公开(公告)日：2012-08-30
申请号：US13336643
申请日：2011-12-23
申请人： Rafael YUSTE , Roberto Etchenique , Luis Baraldo
发明人： Rafael YUSTE , Roberto Etchenique , Luis Baraldo
IPC分类号： A61M37/00 , C07F19/00 , C07H23/00 , A61K31/555 , A61K31/675 , B01J19/12 , A61P25/00 , A61P21/00 , A61P25/08 , A61P35/00 , A61P17/00 , B01L3/00 , C07F15/00 , A61K31/7135
CPC分类号： A61K41/0042 , A61K31/198 , A61K31/4045 , A61K31/41 , A61K31/4409 , A61K31/465 , A61K31/675 , A61K47/547 , A61N5/062 , A61N2005/0657 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/067 , B01J19/12 , B01J2219/12 , C07F15/0053
摘要： The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In some embodiments, the Photolabile Compounds comprise a light antenna, such as a labeling molecule or an active derivative thereof. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect. In another embodiment, the photoreleasable ligand can be a labeling molecule, such as a fluorescent molecule.
摘要翻译：本发明描述了使用该化合物的光不稳定化合物方法。光不稳定化合物具有光可释放的配体，其可以是生物活性的，并且其在暴露于光时从化合物中光分解。在一些实施方案中，光不稳定化合物包含光天线，例如标记分子或其活性衍生物。在一个实施方案中，光是可见光，其对生物样品（例如细胞和组织）的活力无害，其中释放的有机分子是生物活性的并且可以具有治疗效果。在另一个实施方案中，光可释放配体可以是标记分子，例如荧光分子。

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