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1. 发明申请

US20120069331A1 PLASMONIC ENHANCEMENT OF WHISPERING GALLERY MODE BIOSENSORS 有权
标题翻译：通过画廊模式生物传感器的等离子体增强
公开(公告)号：US20120069331A1
公开(公告)日：2012-03-22
申请号：US13205756
申请日：2011-08-09
申请人： Siyka SHOPOVA , Stephen Arnold , Raaj Haresh Rajmangal
发明人： Siyka SHOPOVA , Stephen Arnold , Raaj Haresh Rajmangal
IPC分类号： G01J3/44 , G01N21/55
CPC分类号： G01N21/554 , G01N21/7746
摘要： A sensor for determining the presence or concentration of a target entity in a medium is described, and includes (a) an optical waveguide; (b) a microresonator optically coupled with the optical waveguide such that light within the optical waveguide induces a resonant mode within the microresonator at an equator region (or a mode volume); and (c) at least one plasmonic nanoparticle adsorbed onto a surface area of the microresonator within the equator region (or the mode volume) such that light inducing a resonant mode within the microresonator also causes a plasmonic resonance in the at least one plasmonic nanoparticle. Detection methods for using such sensors are also described. Finally, methods, involving the use of carousel forces, for fabricating such sensors are also described.
摘要翻译：描述了用于确定介质中目标实体的存在或集中的传感器，并且包括（a）光波导; （b）与所述光波导光学耦合的微谐振器，使得所述光波导内的光在赤道区域（或模式体积）下在微谐振器内引起谐振模式; 和（c）至少一种等离子体激元纳米粒子吸附在赤道区域内的微谐振器的表面区域（或模式体积）上，使得在微谐振器内产生共振模式的光也导致至少一种等离子体激元纳米粒子中的等离子体共振。还描述了使用这种传感器的检测方法。最后，还描述了涉及使用转盘力的方法来制造这种传感器。

2. 发明授权

US08886270B2 Syringe-based whispering gallery mode microresonator microfluidic biochem sensor 有权
标题翻译：基于注射器的耳语画廊模式微谐振微流体生物传感器
公开(公告)号：US08886270B2
公开(公告)日：2014-11-11
申请号：US13090836
申请日：2011-04-20
申请人： Stephen Arnold , Siyka Shopova , Ying Chen , William Chin , Guyu Liu , Raaj Haresh Rajmangal
发明人： Stephen Arnold , Siyka Shopova , Ying Chen , William Chin , Guyu Liu , Raaj Haresh Rajmangal
IPC分类号： A61B5/1455 , G02B6/26 , A61M5/178 , G02B6/293 , G01N33/543 , A61B5/1473 , A61B5/1459 , A61B5/00 , G01N21/77
CPC分类号： G01N21/77 , A61B5/1459 , A61B5/1473 , A61B5/6848 , A61M5/178 , G01N33/54366 , G01N2021/7789 , G02B6/29341 , G02B6/29356
摘要： A syringe-based whispering gallery mode sensor includes a syringe including an assembly provided its needle, the assembly including (1) an optical carrier having a reflective distal end, and (2) at least one resonator coupled with the optical carrier. This sensor may be provided in a system including a light source, a light detector, and a data analysis component. A method for determining the presence or concentration of a target substance in body fluid may be performed using such a system.
摘要翻译：基于注射器的耳语画廊模式传感器包括一个注射器，其包括提供其针的组件，该组件包括（1）具有反射远端的光学载体，和（2）至少一个与光学载体耦合的谐振器。该传感器可以设置在包括光源，光检测器和数据分析部件的系统中。可以使用这样的系统来执行用于确定体液中目标物质的存在或浓度的方法。

3. 发明授权

US08493560B2 Plasmonic enhancement of whispering gallery mode biosensors 有权
标题翻译：等离子体增强的耳语画廊模式生物传感器
公开(公告)号：US08493560B2
公开(公告)日：2013-07-23
申请号：US13205756
申请日：2011-08-09
申请人： Siyka Shopova , Stephen Arnold , Raaj Haresh Rajmangal
发明人： Siyka Shopova , Stephen Arnold , Raaj Haresh Rajmangal
IPC分类号： G01J3/44
CPC分类号： G01N21/554 , G01N21/7746
摘要： A sensor for determining the presence or concentration of a target entity in a medium is described, and includes (a) an optical waveguide; (b) a microresonator optically coupled with the optical waveguide such that light within the optical waveguide induces a resonant mode within the microresonator at an equator region (or a mode volume); and (c) at least one plasmonic nanoparticle adsorbed onto a surface area of the microresonator within the equator region (or the mode volume) such that light inducing a resonant mode within the microresonator also causes a plasmonic resonance in the at least one plasmonic nanoparticle. Detection methods for using such sensors are also described. Finally, methods, involving the use of carousel forces, for fabricating such sensors are also described.
摘要翻译：描述了用于确定介质中目标实体的存在或集中的传感器，并且包括（a）光波导; （b）与所述光波导光学耦合的微谐振器，使得所述光波导内的光在赤道区域（或模式体积）下在微谐振器内引起谐振模式; 和（c）至少一种等离子体激元纳米粒子吸附在赤道区域内的微谐振器的表面区域（或模式体积）上，使得在微谐振器内产生共振模式的光也导致至少一种等离子体激元纳米粒子中的等离子体共振。还描述了使用这种传感器的检测方法。最后，还描述了涉及使用转盘力的方法来制造这种传感器。

4. 发明申请

US20110306854A1 SYRINGE-BASED WHISPERING GALLERY MODE MICRORESONATOR MICROFLUIDIC BIOCHEM SENSOR 有权
标题翻译：以SYRINGE为基础的画廊模式微型微型流感传感器
公开(公告)号：US20110306854A1
公开(公告)日：2011-12-15
申请号：US13090836
申请日：2011-04-20
申请人： Stephen Arnold , Slyka Shopova , Ying Chen , William Chin , Guyu Liu , Raaj Haresh Rajmangal
发明人： Stephen Arnold , Slyka Shopova , Ying Chen , William Chin , Guyu Liu , Raaj Haresh Rajmangal
IPC分类号： A61B5/1468 , G01N21/55
CPC分类号： G01N21/77 , A61B5/1459 , A61B5/1473 , A61B5/6848 , A61M5/178 , G01N33/54366 , G01N2021/7789 , G02B6/29341 , G02B6/29356
摘要： A syringe-based whispering gallery mode sensor includes a syringe including an assembly provided its needle, the assembly including (1) an optical carrier having a reflective distal end, and (2) at least one resonator coupled with the optical carrier. This sensor may be provided in a system including a light source, a light detector, and a data analysis component. A method for determining the presence or concentration of a target substance in body fluid may be performed using such a system.
摘要翻译：基于注射器的耳语画廊模式传感器包括一个注射器，其包括提供其针的组件，该组件包括（1）具有反射远端的光学载体，和（2）至少一个与光学载体耦合的谐振器。该传感器可以设置在包括光源，光检测器和数据分析部件的系统中。可以使用这样的系统来执行用于确定体液中目标物质的存在或浓度的方法。

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