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1. 发明专利

IL264727D0 Adhesive films for quick dissolution in managing oral conditions 未知
公开(公告)号：IL264727D0
公开(公告)日：2019-03-31
申请号：IL26472719
申请日：2019-02-07
申请人： PHARMEDICA LTD , RUBIN YORAM , TAVOR DAVID , TAN HOCK , TAIRY ODEYA
发明人： RUBIN YORAM , TAVOR DAVID , TAN HOCK , TAIRY ODEYA
IPC分类号： A61K20060101
摘要： Disclosed is a dissolvable film adapted to adhere to an oral mucosal tissue of a subject, wherein the film comprises at least three indigestible hydrophilic polymers constituting from 35% to 55% of the film dry weight and wherein the at least three polymers comprise xanthan gum and carboxymethyl cellulose (CMC) in a weight ratio of between 1:0.8-1.6, and at least one other cellulose based polymer. Optionally, the film may further include an active agent in an amount of 0.01% to 35% of the film dry weight. Disclosed also is a method for preparing the film and a method for treating or preventing oral conditions comprising implementing the film. Particularly, the film may be applied between dentures and the gums of the user.

2. 发明专利

IL264727A Adhesive films for quick dissolution in managing oral conditions 未知
公开(公告)号：IL264727A
公开(公告)日：2021-08-31
申请号：IL26472719
申请日：2019-02-07
申请人： PHARMEDICA LTD , RUBIN YORAM , TAVOR DAVID , TAN HOCK , TAIRY ODEYA
发明人： RUBIN YORAM , TAVOR DAVID , TAN HOCK , TAIRY ODEYA
IPC分类号： A61K9/00 , A61K6/35 , A61K9/70 , A61K31/131 , A61K31/14 , A61K36/889 , A61K47/32 , A61K47/36 , A61K47/38
摘要： Disclosed is a dissolvable film adapted to adhere to an oral mucosal tissue of a subject, wherein the film comprises at least three indigestible hydrophilic polymers constituting from 35% to 55% of the film dry weight and wherein the at least three polymers comprise xanthan gum and carboxymethyl cellulose (CMC) in a weight ratio of between 1:0.8-1.6, and at least one other cellulose based polymer. Optionally, the film may further include an active agent in an amount of 0.01% to 35% of the film dry weight. Disclosed also is a method for preparing the film and a method for treating or preventing oral conditions comprising implementing the film. Particularly, the film may be applied between dentures and the gums of the user.

3. 发明申请

WO2012104834A1 NEW ORAL DISSOLVING FILMS FOR INSULIN ADMINISTRATION, FOR TREATING DIABETES 审中-公开
标题翻译：用于胰岛素治疗的新口服溶解膜，用于治疗糖尿病
公开(公告)号：WO2012104834A1
公开(公告)日：2012-08-09
申请号：PCT/IL2012/000050
申请日：2012-01-30
申请人： PHARMEDICA LTD. , RUBIN, Yoram , COHEN, Smadar , RON, Eyal
发明人： RUBIN, Yoram , COHEN, Smadar , RON, Eyal
IPC分类号： A61F13/00
CPC分类号： A61K38/28 , A61K9/006 , A61K47/10 , A61K47/32 , A61K47/34 , C07K14/62
摘要： Provided are orally administrable thin film dosage forms adapted to adhere to a mucosal tissue of a patient, wherein said film comprises mixtures of polymers and insulin.
摘要翻译：提供适于粘附到患者的粘膜组织的可口服施用的薄膜剂型，其中所述膜包括聚合物和胰岛素的混合物。

4. 发明申请

WO0206840A3 A RAPID NON-INVASIVE METHOD FOR DIFFERENTIAL ACUTE CARDIOVASCULAR DISEASE DIAGNOSIS 审中-公开
标题翻译：用于差异性急性心肌梗死诊断的快速非侵入性方法
公开(公告)号：WO0206840A3
公开(公告)日：2002-04-25
申请号：PCT/IL0100640
申请日：2001-07-12
申请人： BIOPREVENTIVE LTD , RUBIN YORAM , NIMRI SHAI , GALILI NACHSHON NITSA , ALON SARI NEE BEN YAAKOV , BEN ZVI TZHORI INBAL
发明人： RUBIN YORAM , NIMRI SHAI , GALILI-NACHSHON NITSA , ALON SARI NEE BEN-YAAKOV , BEN-ZVI TZHORI INBAL
IPC分类号： G01N33/88
CPC分类号： G01N33/88

5. 发明申请

WO2002058845A3 REACTION VESSEL AND SYSTEM INCORPORATING SAME 审中-公开
公开(公告)号：WO2002058845A3
公开(公告)日：2002-08-01
申请号：PCT/IL2002/000059
申请日：2002-01-22
申请人： BIOPREVENTIVE LTD. , RUBIN, Yoram , GALILI-NACHSHON, Nitsa , BEN-TZVI TZCHORI, Inbal , MESSINGER, Daniel , ALON, Sari , NIMRI, Shai
发明人： RUBIN, Yoram , GALILI-NACHSHON, Nitsa , BEN-TZVI TZCHORI, Inbal , MESSINGER, Daniel , ALON, Sari , NIMRI, Shai
IPC分类号： B01L3/00
摘要： A reaction vessel for carrying out at a chemical process and for enabling measurement of parameters correlated to the process, and a system incorporating the vessel. The vessel, which is preferably disposable, has a plurality of upper holding chambers for containing chemicals needed for the process, each holding chamber having a lower outlet and an upper inlet. A plug selectively opens and seals the upper inlet of each chamber. The outlets enable the chemicals to flow into a reaction chamber in a desired sequence for carrying out said process only when the corresponding upper inlet is open. The reaction chamber has a vent with respect to the outside of the vessel. A monitoring electrode is exposed to the reaction chamber for measuring parameters associated with the chemical process. A lower waste chamber having an upper outlet is separated from the reaction chamber via a screen element, and a second plug selectively opens and seals this outlet. The screen member is characterized in selectively preventing and allowing liquid communication therethrough, according to whether the upper outlet is sealed or open, respectively.

6. 发明申请

WO02058845A2 REACTION VESSEL AND SYSTEM INCORPORATING SAME 审中-公开
标题翻译：反应容器和系统
公开(公告)号：WO02058845A2
公开(公告)日：2002-08-01
申请号：PCT/IL0200059
申请日：2002-01-22
申请人： BIOPREVENTIVE LTD , RUBIN YORAM , GALILI-NACHSHON NITSA , BEN-TZVI TZCHORI INBAL , MESSINGER DANIEL , ALON SARI , NIMRI SHAI
发明人： RUBIN YORAM , GALILI-NACHSHON NITSA , BEN-TZVI TZCHORI INBAL , MESSINGER DANIEL , ALON SARI , NIMRI SHAI
IPC分类号： B01L3/00 , G01N27/416 , G01N27/49 , G01N33/543
CPC分类号： G01N33/5438 , B01L3/502 , B01L2300/0645 , B01L2300/0681 , B01L2300/0832 , B01L2300/0867 , B01L2300/087 , B01L2400/0457 , B01L2400/0694 , G01N33/493
摘要： A reaction vessel for carrying out at a chemical process and for enabling measurement of parameters correlated to the process, and a system incorporating the vessel. The vessel, which is preferably disposable, has a plurality of upper holding chambers for containing chemicals needed for the process, each holding chamber having a lower outlet and an upper inlet. A plug selectively opens and seals the upper inlet of each chamber. The outlets enable the chemicals to flow into a reaction chamber in a desired sequence for carrying out said process only when the corresponding upper inlet is open. The reaction chamber has a vent with respect to the outside of the vessel. A monitoring electrode is exposed to the reaction chamber for measuring parameters associated with the chemical process. A lower waste chamber having an upper outlet is separated from the reaction chamber via a screen element, and a second plug selectively opens and seals this outlet. The screen member is characterized in selectively preventing and allowing liquid communication therethrough, according to whether the upper outlet is sealed or open, respectively.
摘要翻译：一种用于在化学过程中进行并用于测量与该过程相关的参数的反应容器和包含该容器的系统。优选为一次性的容器具有多个上部保持室，用于容纳该过程所需的化学品，每个保持室具有下部出口和上部入口。塞子选择性地打开并密封每个室的上部入口。出口使得化学品能够以所需的顺序流入反应室，以便仅在相应的上部入口打开时进行所述方法。反应室相对于容器的外部具有通风口。监测电极暴露于反应室，用于测量与化学过程相关的参数。具有上部出口的下部废物室通过筛网元件与反应室分离，并且第二塞子选择性地打开并密封该出口。屏幕构件的特征在于，分别根据上部出口是否被密封或打开，选择性地防止并允许液体连通。

7. 发明申请

WO0127626A3 MEANS AND SYSTEM FOR CARRYING OUT IMMUNOASSAYS 审中-公开
标题翻译：携带免疫球的手段和体系
公开(公告)号：WO0127626A3
公开(公告)日：2001-10-18
申请号：PCT/IL0000650
申请日：2000-10-12
申请人： BIOPREVENTIVE LTD , RUBIN YORAM , GALILI NACHSHON NITSA
发明人： RUBIN YORAM , GALILI-NACHSHON NITSA
IPC分类号： G01N33/543 , G01N33/548 , G01N33/88 , G01N27/327 , G01N33/58
CPC分类号： G01N33/5438 , G01N33/548 , G01N33/88
摘要： A system and corresponding method for carrying out an amperometric immunoassay of a target antigen in which a solid phase support is provided, having an oxidised cellulose paper on which is immobilised an antibody that specifically binds to target antigen and at least one enzyme. An electrode is juxtaposed with the paper, which is in communication with a reaction chamber having suitable receiving means for providing thereto a test fluid having said target antigen and the chemicals required for the particular immunoassay reaction and a redox reaction occurring in response thereto to be carried out. Suitable electronic measuring means are operatively connected to the electrode for monitoring a response of said at least one electrode to said redox reaction that occurs in the reaction chamber. In particular, the reaction chamber, receiving means, paper and electrode are in the form of a disposable cartridge which is mountable to a separate non-disposable electronic measuring means when the assay is to be performed.
摘要翻译：一种系统和相应的方法，用于进行其中提供固相支持物的靶抗原的电流分析免疫测定，其中具有氧化纤维素纸，其上固定有特异性结合靶抗原的抗体和至少一种酶。电极与纸并置，其与具有合适的接收装置的反应室连通，用于向其提供具有所述靶抗原的测试流体和特定免疫测定反应所需的化学物质以及响应于此而进行的氧化还原反应被携带出。合适的电子测量装置可操作地连接到电极，用于监测所述至少一个电极对发生在反应室中的氧化还原反应的响应。特别地，反应室，接收装置，纸和电极是一次性盒的形式，当要执行测定时，其可安装到单独的非一次性电子测量装置。

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