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    • 1. 发明申请
    • BIO-INTERVENTIONAL THERAPEUTIC TREATMENTS FOR CARDIOVASCULAR DISEASES
    • 生物传染性治疗心脏病的治疗方法
    • WO2007106175A3
    • 2008-08-28
    • PCT/US2006060034
    • 2006-10-17
    • BIOCARDIA INCMILLER AARONBENTLEY LORENALTMAN PETER AROSENMAN DANIEL D
    • MILLER AARONBENTLEY LORENALTMAN PETER AROSENMAN DANIEL D
    • A61M5/00
    • A61B17/3478A61B2017/00243A61B2017/00247A61B2018/00392A61M25/0084
    • Catheter-based systems are disclosed for geometrically and temporally controlled deliveries of fluid agents to the heart. Each system includes an elongate catheter shaft, a helical, linear or curved tissue penetration element at the distal end of the shaft, and a handle at the proximal end of the shaft for manipulating the penetrating element through the catheter shaft. The penetrating element and a conductive coil near the shaft distal end provide a pair of electrodes for bipolar sensing of tissue electrical activity. One version of the system includes a fluid lumen through the penetrating element and a contrast fluid lumen open at the catheter shaft distal end. In other version of the catheter system, the penetrating element contains two fluid lumens. These systems facilitate a variety of tissue mapping and therapeutic agent delivery protocols in which several agents can be simultaneously delivered at different depths within the heart tissue.
    • 公开了基于导管的系统,用于几何和时间上控制向心脏传递流体剂。 每个系统包括细长的导管轴,在轴的远端处的螺旋,线性或弯曲的组织穿透元件,以及在轴的近端处的手柄,用于通过导管轴操纵穿透元件。 穿透元件和靠近轴远端的导电线圈提供了一对用于组织电活动的双极感测的电极。 系统的一个版本包括通过穿透元件的流体腔和在导管轴远端开口的造影液腔。 在其他版本的导管系统中,穿透元件包含两个流体流明。 这些系统促进了各种组织图和治疗剂递送方案,其中可以在心脏组织内的不同深度同时递送几种试剂。
    • 2. 发明申请
    • BIO-INTERVENTIONAL THERAPEUTIC TREATMENTS FOR CARDIOVASCULAR DISEASES
    • 生物传染性治疗心脏病的治疗方法
    • WO2007106175A2
    • 2007-09-20
    • PCT/US2006/060034
    • 2006-10-17
    • BIOCARDIA, INC.MILLER, AaronBENTLEY, LorenALTMAN, Peter, A.ROSENMAN, Daniel, D.
    • MILLER, AaronBENTLEY, LorenALTMAN, Peter, A.ROSENMAN, Daniel, D.
    • A61N1/30
    • A61B17/3478A61B2017/00243A61B2017/00247A61B2018/00392A61M25/0084
    • Catheter-based systems are disclosed for geometrically and temporally controlled deliveries of fluid agents to the heart. Each system includes an elongate catheter shaft, a helical, linear or curved tissue penetration element at the distal end of the shaft, and a handle at the proximal end of the shaft for manipulating the penetrating element through the catheter shaft. The penetrating element and a conductive coil near the shaft distal end provide a pair of electrodes for bipolar sensing of tissue electrical activity. One version of the system includes a fluid lumen through the penetrating element and a contrast fluid lumen open at the catheter shaft distal end. In other versions of the catheter system, the penetrating element contains two fluid lumens. These systems facilitate a variety of tissue mapping and therapeutic agent delivery protocols in which several agents can be simultaneously delivered at a depth within heart tissue, prevented from intermingling until they reach the tissue. Treatment and contrast agents can be delivered simultaneously or temporally spaced, directed to the same region in tissue or to different regions separated by intervening tissue.
    • 公开了基于导管的系统,用于几何和时间上控制向心脏传递流体剂。 每个系统包括细长的导管轴,在轴的远端处的螺旋,线性或弯曲的组织穿透元件,以及在轴的近端处的手柄,用于通过导管轴操纵穿透元件。 穿透元件和靠近轴远端的导电线圈提供了一对用于组织电活动的双极感测的电极。 系统的一个版本包括通过穿透元件的流体腔和在导管轴远端开口的造影液腔。 在导管系统的其它形式中,穿透元件包含两个流体腔。 这些系统促进了各种组织图和治疗剂递送方案,其中可以在心脏组织内的深度同时递送多种试剂,防止混合直到它们到达组织。 治疗和造影剂可以同时或时间间隔地递送,指向组织中的相同区域或通过中间组织分开的不同区域。