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1. 发明公开

EP3102676A1 LONG NUCLEIC ACID SEQUENCES CONTAINING VARIABLE REGIONS 审中-公开
标题翻译：带可变区龙NUCLEIC序列
公开(公告)号：EP3102676A1
公开(公告)日：2016-12-14
申请号：EP14821405.9
申请日：2014-12-09
申请人： Integrated DNA Technologies Inc. , Allen, Shawn , Beltz, Kristin , Rose, Scott
发明人： ALLEN, Shawn , BELTZ, Kristin , ROSE, Scott
IPC分类号： C12N15/10 , C12N15/66
CPC分类号： C12N15/1031 , C12N15/10 , C12N15/102 , C12N15/1068 , C12N15/66
摘要： This invention pertains to improved methods for the synthesis of long, double stranded nucleic acid sequences containing difficult to clone or variable regions.

2. 发明专利

AU2014363967A1 Long nucleic acid sequences containing variable regions 未知
公开(公告)号：AU2014363967A1
公开(公告)日：2017-01-05
申请号：AU2014363967
申请日：2014-12-09
申请人： ALLEN SHAWN , BELTZ KRISTIN , INTEGRATED DNA TECHNOLOGIES INC , ROSE SCOTT
发明人： ALLEN SHAWN , BELTZ KRISTIN , ROSE SCOTT
IPC分类号： C12N15/10 , C12N15/66
摘要： This invention pertains to improved methods for the synthesis of long, double stranded nucleic acid sequences containing difficult to clone or variable regions.

3. 发明专利

CA2945628A1 LONG NUCEIC ACID SEQUENCES CONTAINING VARIABLE REGIONS 未知
公开(公告)号：CA2945628A1
公开(公告)日：2015-06-18
申请号：CA2945628
申请日：2014-12-09
申请人： INTEGRATED DNA TECH INC , ALLEN SHAWN , BELTZ KRISTIN , ROSE SCOTT
发明人： ALLEN SHAWN , BELTZ KRISTIN , ROSE SCOTT
IPC分类号： C12N15/10 , C12N15/66
摘要： This invention pertains to improved methods for the synthesis of long, double stranded nucleic acid sequences containing difficult to clone or variable regions.

4. 发明申请

WO2023092128A2 APTAMERS FOR THE REVERSIBLE INHIBITION OF DNA POLYMERASES 审中-公开
公开(公告)号：WO2023092128A2
公开(公告)日：2023-05-25
申请号：PCT/US2022/080254
申请日：2022-11-21
申请人： INTEGRATED DNA TECHNOLOGIES, INC. , RUPP, Susan Marie , SHUBHAM, Shambhavi , ROSE, Scott , CAGLE, Brianna
发明人： RUPP, Susan Marie , SHUBHAM, Shambhavi , ROSE, Scott , CAGLE, Brianna
IPC分类号： C12N15/115 , C12N9/12 , C12Q1/6848
摘要： Described herein are methods and compositions for improved polymerase chain reaction (PCR). In one aspect the methods and compositions include improved aptamers to reversibly inhibit polymerase and exonuclease activity of the polymerase enzyme.

5. 发明申请

WO2012135053A2 RNASE H-BASED ASSAYS UTILIZING MODIFIED RNA MONOMERS 审中-公开
标题翻译：使用修饰的RNA单体的RNASE H基测定
公开(公告)号：WO2012135053A2
公开(公告)日：2012-10-04
申请号：PCT/US2012/030413
申请日：2012-03-23
申请人： INTEGRATED DNA TECHNOLOGIES, INC. , BEHLKE, Mark , ROSE, Scott, D. , DOBOSY, Joseph , WALDER, Joseph
发明人： BEHLKE, Mark , ROSE, Scott, D. , DOBOSY, Joseph , WALDER, Joseph
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q2521/327 , C12Q2563/107
摘要： The present invention provides methods of cleaving a nucleic acid strand to initiate, assist, monitor or perform biological assays.
摘要翻译：本发明提供了切割核酸链以启动，辅助，监测或进行生物测定的方法。

6. 发明申请

WO2011120049A1 METHODS FOR ENHANCING NUCLEIC ACID HYBRIDIZATION 审中-公开
标题翻译：增加核酸杂交的方法
公开(公告)号：WO2011120049A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/030215
申请日：2011-03-28
申请人： INTEGRATED DNA TECHNOLOGIES, INC. , ROSE, Scott , BEHLKE, Mark, A. , OWCZARZY, Richard , WALDER, Joseph, A. , THOMAS, Derek, M. , MARVIN, Michael, R.
发明人： ROSE, Scott , BEHLKE, Mark, A. , OWCZARZY, Richard , WALDER, Joseph, A. , THOMAS, Derek, M. , MARVIN, Michael, R.
IPC分类号： C12Q1/68 , A61K31/11
CPC分类号： C12Q1/6832 , C07H21/04 , C12Q1/6818 , C12Q1/6851 , G01N33/5308 , G01N33/542 , C12Q2525/185 , C12Q2525/197 , C12Q2565/101
摘要： A composition, comprising a first oligonucleotide having the structure 5'-Y 1- L 1- X-L 2 _2-Y 2 -3' Y 1 comprises a sequence of four or more DNA or RNA nucleotides, including a first nucleotide N 1 having a 3' phosphate covalently linked to L 1. Y 2 comprises a sequence of four or more DNA or RNA nucleotides, including a second nucleotide N 2 having a 5' phosphate covalently linked to L 2. L 1 and L 2 each independently are a direct bond or a C 1 C 7 alkyl, alkynyl, alkenyl, heteroalkyl, substituted alkyl, aryl, heteroaryl, substituted aryl, cycloalkyl, alkylaryl, or alkoxyl group. X is R\ is a hydrogen or a d-Cg alkyl. M is a quencher. The first oligonucleotide is adapted to hybridize to a second oligonucleotide having the structure 3'-Υ3-Υ4-5'. Y3 comprises a sequence of four or more DNA or RNA nucleotides, including a third nucleotide N3. Y4 comprises a sequence of four or more DNA or RNA nucleotides, including a fourth nucleotide N4 that is directly attached to nucleotide N 3 . If the first oligonucleotide hybridizes to the second oligonucleotide, Ni base pairs with N 3 and N2 base pairs with N4.to form a duplex having a T m that is greater than the T m of a duplex formed between the second oligonucleotide and a third oligonucleotide having the structure 5'-Y 1 -Y 2 - 3'.
摘要翻译：包含结构为5'-Y1-L1-X-L2-2-Y2-3'Y1的第一寡核苷酸的组合物包含四个或更多个DNA或RNA核苷酸的序列，包括具有3'磷酸共价连接的第一个核苷酸N1 到L1。 Y2包含四个或更多个DNA或RNA核苷酸的序列，包括具有与L2共价连接的5'磷酸二酯的第二核苷酸N2。 L 1和L 2各自独立地是直接键或C 1 -C 7烷基，炔基，烯基，杂烷基，取代的烷基，芳基，杂芳基，取代的芳基，环烷基，烷基芳基或烷氧基。 X是R 1是氢或C 1 -C 8烷基。 M是猝灭剂。第一寡核苷酸适于与具有结构3'-β3-3→4-5'的第二寡核苷酸杂交。 Y3包含四个或更多个DNA或RNA核苷酸的序列，包括第三核苷酸N3。 Y4包含四个或更多个DNA或RNA核苷酸的序列，其包括与核苷酸N3直接相连的第四核苷酸N4。如果第一寡核苷酸与第二寡核苷酸杂交，则具有N 3和N 2碱基对的Nε碱基对与N4.形成具有比第二寡核苷酸和具有结构的第三寡核苷酸之间形成的双链体的Tm更大的Tm的双链体 5'-Y1-Y2-3' 。

7. 发明申请

WO2009135093A2 RNASE-H-BASED ASSAYS UTILIZING MODIFIED RNA MONOMERS 审中-公开
标题翻译：基于RNASE-H的测定使用修饰的RNA单体
公开(公告)号：WO2009135093A2
公开(公告)日：2009-11-05
申请号：PCT/US2009/042454
申请日：2009-04-30
申请人： INTEGRATED DNA TECHNOLOGIES, INC. , WALDER, Joseph, Alan , BEHLKE, Mark, Aaron , ROSE, Scott , DOBOSY, Joseph
发明人： WALDER, Joseph, Alan , BEHLKE, Mark, Aaron , ROSE, Scott , DOBOSY, Joseph
IPC分类号： C07H21/02 , C12Q1/68
CPC分类号： C12N9/96 , C12Q1/6844 , C12Q1/6853 , C12Q2549/101 , C12Q2525/186 , C12Q2521/301 , C12Q2525/121
摘要： The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel oligonucleotides comprise a ribonucleic acid domain and a blocking group at or near the 3' end of the oligonucleotide. These compounds offer an added level of specificity previously unseen. Methods for performing nucleic acid amplification, ligation and sequencing are also provided. Additionally, kits containing the oligonucleotides are also disclosed herein.
摘要翻译：本发明涉及用于各种生物测定的新型寡核苷酸化合物，例如核酸扩增，连接和测序反应。该寡核苷酸在寡核苷酸的3'末端或其附近包含核糖核酸结构域和封闭基团。这些化合物提供了先前未见的特异性增加水平。还提供了进行核酸扩增，连接和测序的方法。此外，本文还公开了含有寡核苷酸的试剂盒。

8. 发明申请

WO2015050934A1 BI-DIRECTIONAL COMMUNICATION WITH A DEVICE UNDER CHARGE 审中-公开
标题翻译：带有装置的双向通信
公开(公告)号：WO2015050934A1
公开(公告)日：2015-04-09
申请号：PCT/US2014/058536
申请日：2014-10-01
申请人： BLACKBERRY LIMITED , MEUNIER, Marc, Élis , MOOSAVI, Vahid , ROSE, Scott, Douglas , WINGER, Lyall, Kenneth , ABDELSAMIE, Ahmed , DWYER, Gerald, Robert
发明人： MEUNIER, Marc, Élis , MOOSAVI, Vahid , ROSE, Scott, Douglas , WINGER, Lyall, Kenneth , ABDELSAMIE, Ahmed , DWYER, Gerald, Robert
IPC分类号： H02J17/00 , H02J7/00
CPC分类号： B60L11/182 , B60L11/1846 , H02J11/00 , Y02T10/7005 , Y02T10/7072 , Y02T90/121 , Y02T90/128 , Y02T90/14 , Y02T90/16 , Y02T90/163 , Y02T90/169 , Y04S30/14
摘要： A first device is wirelessly charged by a second device. Bi-directional communication is performed between the first device and the second device during the wireless charging, where the bi-directional communication includes messaging from the second device to the first device, the messaging including information other than information relating to wireless charging.
摘要翻译：第一设备由第二设备无线充电。在无线充电期间在第一设备和第二设备之间执行双向通信，其中双向通信包括从第二设备到第一设备的消息传送，消息包括除了与无线充电有关的信息之外的信息。

9. 发明申请

WO2013142364A1 MODIFIED RNASE H ENZYMES AND THEIR USES 审中-公开
标题翻译：改良型RNASE H酶及其用途
公开(公告)号：WO2013142364A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/032372
申请日：2013-03-15
申请人： INTEGRATED DNA TECHNOLOGIES, INC. , WALDER, Joseph, Alan , BEHLKE, Mark, Aaron , ROSE, Scott, D. , DOBOSY, Joseph , RUPP, Susan, Marie
发明人： WALDER, Joseph, Alan , BEHLKE, Mark, Aaron , ROSE, Scott, D. , DOBOSY, Joseph , RUPP, Susan, Marie
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6848 , C12N9/22 , C12N9/99 , C12Y301/26004 , C12Q2521/107 , C12Q2521/327 , C12Q2525/186 , C12Q2549/101
摘要： The invention provides a provides improvements to assays that employ RNase H cleavage for biological applications related to nucleic acid amplification and detection, where the RNase H has been reversibly inactivated.
摘要翻译：本发明提供对使用RNase H切割用于与核酸扩增和检测相关的生物学应用的测定法，其中RNase H已被可逆地灭活。

10. 发明申请

WO2012116443A1 WIRELESS COMMUNICATIONS SYSTEM PROVIDING MEDIA CONTENT TRANSFER FEATURES AND RELATED METHODS 审中-公开
标题翻译：提供媒体内容传输功能的无线通信系统及相关方法
公开(公告)号：WO2012116443A1
公开(公告)日：2012-09-07
申请号：PCT/CA2012/050109
申请日：2012-02-23
申请人： RESEARCH IN MOTION LIMITED , ROSE, Scott Douglas , MOOSAVI, Vahid , VERMA, Sushil K.
发明人： ROSE, Scott Douglas , MOOSAVI, Vahid , VERMA, Sushil K.
IPC分类号： H04N21/436 , H04N21/60 , H04W84/18
CPC分类号： H04L67/325 , H04L65/1093 , H04L65/4084 , H04L67/34
摘要： Abstract of the Disclosure A wireless communications system may include a first electronic device comprising a first media content playback device, a first wireless transceiver, and a first controller coupled with the first media content playback device and the first wireless transceiver. The system may further include a second electronic device comprising a second media content playback device, a second wireless transceiver configured to wirelessly communicate with the first wireless transceiver, and a second controller coupled with the second media content playback device and the second wireless transceiver. The first controller may be configured to generate a playback pointer associated with playback of given media content, and wirelessly communicate the playback pointer to the second controller. The second controller may be configured to play back the given media content based upon the playback pointer, and without receiving the given media content from the first electronic device.
摘要翻译：发明内容无线通信系统可以包括第一电子设备，其包括第一媒体内容回放设备，第一无线收发器以及与第一媒体内容回放设备和第一无线收发器耦合的第一控制器。该系统还可以包括第二电子设备，其包括第二媒体内容回放设备，被配置为与第一无线收发器无线通信的第二无线收发器，以及与第二媒体内容回放设备和第二无线收发器耦合的第二控制器。第一控制器可以被配置为生成与给定媒体内容的回放相关联的重放指针，并且将播放指针无线地传送到第二控制器。第二控制器可以被配置为基于播放指针回放给定的媒体内容，并且不从第一电子设备接收给定的媒体内容。

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