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1. 发明专利

AU4004401A Method and apparatus for treatment of cardiac electromechanical dissociation 未知
公开(公告)号：AU4004401A
公开(公告)日：2001-09-17
申请号：AU4004401
申请日：2001-03-06
申请人： INTERMEDICS INC , ROSBOROUGH JOHN P , DENO CURTIS D , STOTTS LAWRENCE J
发明人： ROSBOROUGH JOHN P , DENO D CURTIS , STOTTS LAWRENCE J
IPC分类号： A61N1/38 , A61N1/39 , A61N1/00
摘要： An apparatus and method for treating post-defibrillation electromechanical dissociation ("EMD") or pulseless electrical activity ("PEA"). A first embodiment comprises an implantable defibrillator with the capability of detecting and treating post defibrillation EMD. The stimulator/defibrillator has one or more leads with electrodes and at least one electrode for defibrillation. A sense circuit senses the electrical condition of the heart of the patient. A second sensor senses a parameter correlated to the state of blood flow. The cardiac stimulator/defibrillator detects and terminates ventricular tachyarrhythmia or fibrillation. If the stimulator/defibrillator detects the presence of electrical rhythm in the heart correlated, however, with inadequate blood flow to sustain life (EMD), the device provides an output to stimulate the heart to overcome EMD. The device may also be an external defibrillator. The method for treating the heart to restore blood flow where electromechanical dissociation occurs after termination of a ventricular tachyarrhythmia or ventricular fibrillation comprises identifying electromechanical disassociation after termination of a ventricular tachyarrhythmia or a fibrillation and inducing or re-inducing ventricular fibrillation and subsequently applying defibrillating shocks to terminate the fibrillation.

2. 发明申请

WO0166180A3 METHOD AND APPARATUS FOR TREATMENT OF CARDIAC ELECTROMECHANICAL DISSOCIATION 审中-公开
标题翻译：用于治疗心脏电生理分解的方法和装置
公开(公告)号：WO0166180A3
公开(公告)日：2002-02-21
申请号：PCT/US0106987
申请日：2001-03-06
申请人： INTERMEDICS INC , ROSBOROUGH JOHN P , DENO D CURTIS , STOTTS LAWRENCE J
发明人： ROSBOROUGH JOHN P , DENO D CURTIS , STOTTS LAWRENCE J
IPC分类号： A61N1/38 , A61N1/39
CPC分类号： A61N1/385 , A61N1/39 , A61N1/3962
摘要： An apparatus and method for treating post-defibrillation electromechanical dissociation ("EMD") or pulseless electrical activity ("PEA"). A first embodiment comprises an implantable defibrillator with the capability of detecting and treating post defibrillation EMD. The stimulator/defibrillator has one or more leads with electrodes and at least one electrode for defibrillation. A sense circuit senses the electrical condition of the heart of the patient. A second sensor senses a parameter correlated to the state of blood flow. The cardiac stimulator/defibrillator detects and terminates ventricular tachyarrhythmia or fibrillation. If the stimulator/defibrillator detects the presence of electrical rhythm in the heart correlated, however, with inadequate blood flow to sustain life (EMD), the device provides an output to stimulate the heart to overcome EMD. The device may also be an external defibrillator. The method for treating the heart to restore blood flow where electromechanical dissociation occurs after termination of a ventricular tachyarrhythmia or ventricular fibrillation comprises identifying electromechanical disassociation after termination of a ventricular tachyarrhythmia or a fibrillation and inducing or re-inducing ventricular fibrillation and subsequently applying defibrillating shocks to terminate the fibrillation.
摘要翻译：用于治疗除颤后机电解离（“EMD”）或无脉动电活动（“PEA”）的装置和方法。第一实施例包括具有检测和治疗除颤后EMD能力的可植入除颤器。刺激器/除纤颤器具有一个或多个具有电极的引线和至少一个用于除颤的电极。感测电路感测患者心脏的电气状况。第二传感器检测与血流状态相关的参数。心脏刺激器/除颤器检测并终止室性快速性心律失常或颤动。然而，如果刺激器/除颤器检测到心脏中存在电气节律，则维持生命（EMD）的血液流量不足，该装置提供刺激心脏以克服EMD的输出。该装置也可以是外部除颤器。用于治疗心脏以恢复血流的方法，其中机电解离发生在室性心动过速或心室颤动终止之后发生，包括在终止室性快速性心律失常或原纤维化并诱导或再诱导心室颤动并随后将去纤颤性休克终止原纤化。

3. 发明申请

WO1996038201A1 APPARATUS AND METHOD FOR DISCRIMINATING FLOW OF BLOOD IN A CARDIOVASCULAR SYSTEM 审中-公开
标题翻译：用于分辨血管内血液流动的装置和方法
公开(公告)号：WO1996038201A1
公开(公告)日：1996-12-05
申请号：PCT/US1996008180
申请日：1996-05-31
申请人： INTERMEDICS, INC. , ROSBOROUGH, John, P. , MUNSHI, Mohammed, Z. , BONNERUP, Chris, A.
发明人： INTERMEDICS, INC.
IPC分类号： A61N01/39
CPC分类号： A61N1/3918
摘要： An implantable cardiac stimulator includes means for delivering a first electrical shock via implantable stimulating electrodes at a time when there is substantially no flow of blood, as determined by conventional fibrillation detection means. At least one of the stimulating electrodes is disposed in a blood flow path of the cardiovascular system. The first shock is preferably of insufficient energy level to cause defibrillation. A potential is measured as a function of time between the blood-contacting electrode and a reference electrode following delivery of the first shock to obtain a first potential equilibration function under no-flow conditions. A second therapeutic electrical shock, preferably of sufficient energy level to effect defibrillation, is delivered via the stimulating electrodes. A second potential equilibration function is measured following delivery of the second shock. The first and second potential equilibration functions are compared, and if the two functions are sufficiently different in morphology, it is determined that blood is flowing.
摘要翻译：植入式心脏刺激器包括用于在基本上没有血液流动的时候通过可植入刺激电极传递第一次电击的装置，如通过常规原纤维检测装置确定的。刺激电极中的至少一个设置在心血管系统的血流路径中。第一冲击优选是能量水平不足以引起除颤。在第一冲击传递之后，测量作为血液接触电极和参考电极之间的时间的函数的电位，以在无流动条件下获得第一电位平衡功能。通过刺激电极输送优选具有足够能量水平以实现除颤的第二疗效电击。在传送第二次冲击后测量第二个潜在的平衡功能。比较第一和第二潜在平衡功能，如果两种功能在形态上有很大差异，则确定血液流动。

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