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1. 发明公开

EP2797598A1 TREATMENT OF DISEASE OR DISORDERS CAUSED BY INDUCED NFkB TRANSCRIPTIONAL ACTIVITY 审中-公开
标题翻译：疾病或障碍所致NF-κB转录活性治疗
公开(公告)号：EP2797598A1
公开(公告)日：2014-11-05
申请号：EP12831933.2
申请日：2012-09-13
申请人： Roninson, Igor
发明人： Roninson, Igor
IPC分类号： A61K31/517
CPC分类号： C07D239/94 , A61K31/517
摘要： The invention provides a method for treating a disease or disorder in a mammal which is caused by induced NFkB transcriptional activity in cells of the mammal, the method comprising administering to the mammal a compound that specifically inhibits one or more of CDK8 and CDK19.

2. 发明公开

EP2797598A4 TREATMENT OF DISEASE OR DISORDERS CAUSED BY INDUCED NFkB TRANSCRIPTIONAL ACTIVITY 审中-公开
标题翻译：疾病或障碍所致NF-κB转录活性治疗
公开(公告)号：EP2797598A4
公开(公告)日：2015-08-12
申请号：EP12831933
申请日：2012-09-13
申请人： RONINSON IGOR
发明人： RONINSON IGOR
IPC分类号： A61K31/517
CPC分类号： C07D239/94 , A61K31/517
摘要： The invention provides a method for treating a disease or disorder in a mammal which is caused by induced NFkB transcriptional activity in cells of the mammal, the method comprising administering to the mammal a compound that specifically inhibits one or more of CDK8 and CDK19.

3. 发明专利

EA027531B1 ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ И НАРУШЕНИЙ, ВЫЗВАННЫХ АКТИВНОСТЬЮ ТРАНСКРИПЦИОННОГО ФАКТОРА NF-κB 未知
公开(公告)号：EA027531B1
公开(公告)日：2017-08-31
申请号：EA201490614
申请日：2012-09-13
申请人： RONINSON IGOR
发明人： RONINSON IGOR
IPC分类号： A61K31/517
摘要： Раскрытспособлечениязаболеванияилинарушенияу млекопитающих, вызванногоиндукциейтранскрипционнойактивностифактора NF-κB вклеткахмлекопитающих, включающийвведениемлекопитающимсоединения, специфическиингибирующегоодногоилиболее CDK8 и CDK19, гдесоединениеимеетструктуругде Rпредставляетсобойаралкил, гдеарилпредставляетсобойнафтил, которыйнезамещенилиможетбытьмонозамещеннымилидизамещеннымоднимилиболеенизшималкилом, О-низшималкилом, NO, галогеном, ацетамидогруппойи аминогруппой; Rвыбранизнизшегоалкилаи водорода; Авыбранизводородаилинизшегоалкилаи Ввыбранизгалогена, циано, трифторметила, NHAc, NOиО-низшегоалкила. Такжеописанспособингибированиятранскрипционнойактивности, индуцированной NF-κВ, вклеткемлекопитающегос использованиемсоединенияформулы I.

4. 发明申请

WO2004005462A3 REAGENTS AND METHODS FOR IDENTIFYING AND MODULATING EXPRESSION OF TUMOR SENESCENCE GENES 审中-公开
标题翻译：鉴定和调节肿瘤发生基因表达的试剂和方法
公开(公告)号：WO2004005462A3
公开(公告)日：2006-09-14
申请号：PCT/US0320425
申请日：2003-06-27
申请人： UNIV ILLINOIS , RONINSON IGOR B , CHANG BEY-DIH
发明人： RONINSON IGOR B , CHANG BEY-DIH
IPC分类号： C12Q1/68 , C12N20060101 , C12N1/00 , C12N15/00 , C12Q1/02 , G01N33/53
CPC分类号： G01N33/5011 , C12Q1/6886 , C12Q2600/136
摘要： This invention identifies tumor senescence genes induced by treatment with cytotoxic agents. The invention provides reagents and methods for identifying compounds that induce expression of these cellular genes and produce cellular senescence, particularly senescence in tumor cells. The invention also provides reagents that are recombinant mammalian cells containing recombinant expression constructs that express a reporter gene under the transcriptional control of a promoter for a gene the expression of which is modulated in senescent cells, and methods for using such cells to identify compounds that modulate expression of these cellular genes.
摘要翻译：本发明鉴定了用细胞毒性剂治疗诱导的肿瘤衰老基因。本发明提供用于鉴定诱导这些细胞基因表达并产生细胞衰老，特别是肿瘤细胞衰老的化合物的试剂和方法。本发明还提供了重组哺乳动物细胞的重组哺乳动物细胞，所述重组哺乳动物细胞含有重组表达构建体，所述重组表达构建体在其表达在衰老细胞中调节的基因的启动子的转录控制下表达报告基因，以及使用这些细胞鉴定调节化合物的方法这些细胞基因的表达。

5. 发明申请

WO2004037198A2 ANTIBODY-MEDIATED INDUCTION OF TUMOR CELL DEATH 审中-公开
标题翻译：抗体介导的肿瘤细胞死亡诱导
公开(公告)号：WO2004037198A2
公开(公告)日：2004-05-06
申请号：PCT/US2003/033712
申请日：2003-10-23
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , PRIMIANO, Thomas , RONINSON, Igor, B.
发明人： PRIMIANO, Thomas , RONINSON, Igor, B.
IPC分类号： A61K
CPC分类号： C07K16/2803 , C07K2317/73
摘要： This invention provides methods and reagents for inducing cell death in tumor cells. The invention provides said reagents relating to inducing tumor cell death that are antibodies to a specific target, L1CAM, and methods for using said antibodies for inducing cell death. Pharmaceutical compositions of the L1CAM antibodies for use in the practice of the methods of the invention are also disclosed.
摘要翻译：本发明提供用于诱导肿瘤细胞中的细胞死亡的方法和试剂。本发明提供了涉及诱导肿瘤细胞死亡的试剂，其是针对特异性靶标的抗体，L1CAM以及使用所述抗体诱导细胞死亡的方法。还公开了用于实施本发明方法的L1CAM抗体的药物组合物。

6. 发明申请

WO2003073062A3 REAGENTS AND METHODS FOR IDENTIFYING AND MODULATING EXPRESSION OF GENES REGULATED BY CDK INHIBITORS 审中-公开
公开(公告)号：WO2003073062A3
公开(公告)日：2003-09-04
申请号：PCT/US2002/027584
申请日：2002-08-29
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , RONINSON, Igor, B. , POOLE, Jason
发明人： RONINSON, Igor, B. , POOLE, Jason
IPC分类号： C12N15/00
摘要： This invention provides methods and reagents for identifying compounds that inhibit the induction of genes involved in viral infection, cancer and age-related diseases, such genes being induced by cyclin-dependent kinase inhibitors.

7. 发明申请

WO2003007884A3 METHOD AND REAGENTS FOR IDENTIFYING GENE TARGETS FOR TREATING BREAST CANCER 审中-公开
公开(公告)号：WO2003007884A3
公开(公告)日：2003-01-30
申请号：PCT/US2002/022868
申请日：2002-07-19
申请人： BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , PRIMIANO, Thomas , CHANG, Bey-Dih , RONINSON, Igor, B.
发明人： PRIMIANO, Thomas , CHANG, Bey-Dih , RONINSON, Igor, B.
IPC分类号： C12Q1/68
摘要： The invention provides methods and reagents for identifying mammalian genes necessary for tumor cell growth as target for developing drug that inhibit expression of said genes and inhibit tumor cell growth thereby.

8. 发明申请

WO02061134A9 REAGENTS AND METHODS FOR IDENTIFYING AND MODULATING EXPRESSION OF TUMOR SENESCENCE GENES 审中-公开
标题翻译：鉴定和调节肿瘤衰老基因表达的试剂和方法
公开(公告)号：WO02061134A9
公开(公告)日：2002-12-05
申请号：PCT/US0150574
申请日：2001-12-21
申请人： UNIV ILLINOIS , RONINSON IGOR B , CHANG BEY-DIH
发明人： RONINSON IGOR B , CHANG BEY-DIH
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： G01N33/5011 , C12Q1/6897
摘要： This invention identifies tumor senescence genes induced by treatment with cytotoxic agents. The invention provides reagents and methods for identifying compounds that induce expression of these cellular genes and produce cellular senescence, particularly senescence in tumor cells. The invention also provides reagents that are recombinant mammalian cells containing recombinant expression constructs that express a reporter gene under the transcriptional control of a promoter for a gene the expression of which is modulated in senescent cells, and methods for using such cells to identify compounds that modulate expression of these cellular genes.
摘要翻译：本发明鉴定了用细胞毒剂治疗诱导的肿瘤衰老基因。本发明提供了用于鉴定诱导这些细胞基因表达并产生细胞衰老，特别是在肿瘤细胞中衰老的化合物的试剂和方法。本发明还提供了重组哺乳动物细胞的试剂，所述试剂含有重组表达构建体，所述重组表达构建体在启动子的转录控制下表达报道基因，所述基因的表达在衰老细胞中被调节，所述细胞用于鉴定调节这些细胞基因的表达。

9. 发明申请

WO2002066681A2 REAGENTS AND METHODS FOR IDENTIFYING AND MODULATING EXPRESSION OF GENES REGULATED BY CDK INHIBITORS 审中-公开
标题翻译：鉴定和调节CDK抑制剂调节基因表达的试剂和方法
公开(公告)号：WO2002066681A2
公开(公告)日：2002-08-29
申请号：PCT/US2002/002784
申请日：2002-02-01
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , POOLE, Jason , RONINSON, Igor, B. , CHANG, Bey-dih
发明人： POOLE, Jason , RONINSON, Igor, B. , CHANG, Bey-dih
IPC分类号： C12Q1/68
CPC分类号： G01N33/5011 , G01N33/5008 , G01N2510/00
摘要： This invention provides methods and reagents for identifying compounds that inhibit the induction of genes involved in cancer and age-related diseases, such genes being induced by cyclin-dependent kinase inhibitors.
摘要翻译：本发明提供用于鉴定抑制癌症和年龄相关疾病参与的基因的诱导的化合物的方法和试剂，所述基因由细胞周期蛋白依赖性激酶抑制剂诱导。

10. 发明申请

WO2007133772A2 CDKI PATHWAY INHIBITORS AS SELECTIVE INHIBITORS OF TUMOR CELL GROWTH 审中-公开
标题翻译： CDKI途径抑制剂作为肿瘤细胞生长的选择性抑制剂
公开(公告)号：WO2007133772A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011622
申请日：2007-05-15
申请人： SENEX BIOTECHNOLOGY, INC. , CHANG, Bey-Dih , RONINSON, Igor, B. , PORTER, Donald
发明人： CHANG, Bey-Dih , RONINSON, Igor, B. , PORTER, Donald
IPC分类号： A61K39/42
CPC分类号： A61K31/40 , A61K31/4045
摘要： The invention provides new methods for inhibiting the CDKI pathway and specifically inhibiting tumor cell growth. The invention further provides new and specific inhibitors of tumor cell growth, as well as means for discovery of additional such inhibitors. The present inventors have surprisingly discovered that Cyclin-Dependent Kinase 3 (CDK3) is specifically required for tumor cell growth, in contrast to other members of the CDK family.
摘要翻译：本发明提供抑制CDKI途径和特异性抑制肿瘤细胞生长的新方法。本发明还提供了新的和具体的肿瘤细胞生长抑制剂，以及用于发现另外的这种抑制剂的手段。本发明人惊奇地发现，与CDK家族的其他成员相反，细胞周期蛋白依赖性激酶3（CDK3）是肿瘤细胞生长所必需的。

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