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1. 发明申请

WO2009134475A1 THERAPY PROGRAM MODIFICATION BASED ON A THERAPY FIELD MODEL 审中-公开
标题翻译：基于治疗场模型的治疗方案修改
公开(公告)号：WO2009134475A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/031650
申请日：2009-01-22
申请人： MEDTRONIC, INC. , RONDONI, John, C. , GERBER, Martin, T.
发明人： RONDONI, John, C. , GERBER, Martin, T.
IPC分类号： A61N1/372 , G06F19/00
CPC分类号： A61M5/1723 , A61M5/14276 , A61M2205/054 , A61M2210/0693 , A61N1/36003 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/37235 , A61N1/37247 , A61N1/37264 , G06F19/00 , G16H40/63 , G16H50/50
摘要： Techniques for modeling therapy fields for therapy delivered by medical devices are described. Each therapy field model is based on a set of therapy parameters and represents where therapy will propagate from the therapy system delivering therapy according to the set of therapy parameters. Therapy field models may be useful in guiding the modification of therapy parameters. As one example, a processor compares an algorithmic model of a therapy field to a reference therapy field and adjusts at least one therapy parameter based on the comparison. As another example, a processor adjusts at least one therapy parameter to increase an operating efficiency of the therapy system while substantially maintaining the modeled therapy field.
摘要翻译：描述了医疗器械治疗治疗领域的建模技术。每个治疗领域模型基于一组治疗参数，并且表示治疗将根据治疗参数集合递送疗法的治疗系统传播的地方。治疗领域模型可能有助于指导治疗参数的修改。作为一个示例，处理器将治疗领域的算法模型与参考治疗领域进行比较，并且基于该比较来调整至少一个治疗参数。作为另一示例，处理器调整至少一个治疗参数以增加治疗系统的操作效率，同时基本上维持建模的治疗领域。

2. 发明申请

WO2008147612A1 COLLECTING ACTIVITY DATA FOR EVALUATION OF PATIENT INCONTINENCE 审中-公开
标题翻译：收集患者不良的评估活动数据
公开(公告)号：WO2008147612A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/061504
申请日：2008-04-25
申请人： MEDTRONIC, INC. , GERBER, Martin T. , RONDONI, John C.
发明人： GERBER, Martin T. , RONDONI, John C.
IPC分类号： A61B5/11 , A61B5/20
CPC分类号： A61B5/1116 , A61B5/02055 , A61B5/02438 , A61B5/0488 , A61B5/0816 , A61B5/091 , A61B5/202 , A61B5/6823 , A61B5/6825 , A61B5/686 , A61B2562/0219 , G06F19/00
摘要： Systems and methods for determining whether an involuntary voiding event was attributable to stress or urge incontinence include determining an activity level of a patient that coincides with the occurrence of the involuntary voiding event or the activity level within a certain time range of the involuntary voiding event. Patient activity data may be collected via a signal that varies as a function of patient activity. The signal may be generated with one or more sensors that detect motion, such as an accelerometer or a piezoelectric crystal, and/or one or more sensors that monitor a physiological parameter of the patient that varies as a function of patient activity, such as heart rate, respiratory rate, electrocardiogram morphology, respiration rate, respiratory volume, core temperature, muscular activity level or subcutaneous temperature of the patient.
摘要翻译：用于确定非自愿排尿事件是否归因于压力或急迫性尿失禁的系统和方法包括确定与非自愿排尿事件的发生或非自愿排尿事件的特定时间范围内的活动水平一致的患者的活动水平。患者活动数据可以通过根据患者活动而变化的信号来收集。可以用一个或多个检测运动的传感器（例如加速度计或压电晶体）和/或监测根据患者活动而变化的患者的生理参数的一个或多个传感器来生成信号，例如心脏速率，呼吸频率，心电图形态，呼吸频率，呼吸体积，核心温度，肌肉活动水平或皮下温度。

3. 发明申请

WO2008137306A1 MULTI-LOCATION POSTURE SENSING 审中-公开
标题翻译：多位置姿态感知
公开(公告)号：WO2008137306A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/061100
申请日：2008-04-22
申请人： MEDTRONIC, INC. , GERBER, Martin T. , RONDONI, John C.
发明人： GERBER, Martin T. , RONDONI, John C.
IPC分类号： A61N1/36
CPC分类号： A61N1/36135 , A61N1/0551 , A61N1/36514 , A61N1/36535 , A61N1/36542
摘要： Techniques for controlling therapy delivery based on the relative orientation and/or motion of a device accelerometer and a lead accelerometer are described. In one embodiment, a therapy system includes an electrical stimulator and a lead. The electrical stimulator comprises a processor that controls delivery of a therapy to a target stimulation site in a patient and a device accelerometer coupled to the electrical stimulator. The lead is coupled to the electrical stimulator to deliver the therapy from the electrical stimulator to the target stimulation site in the patient, and includes a lead accelerometer. The processor compares signals from the accelerometers, and controls delivery of the therapy to the patient based on the comparison. In this manner, the processor may adjust stimulation to, for example, address movement of electrodes relative to target tissue when a patient changes postures.
摘要翻译：描述了基于设备加速度计和线加速度计的相对取向和/或运动来控制治疗递送的技术。在一个实施例中，治疗系统包括电刺激器和引线。电刺激器包括处理器，其控制对患者的目标刺激部位的治疗传递和耦合到电刺激器的装置加速度计。引线耦合到电刺激器以将治疗从电刺激器传递到患者中的目标刺激部位，并且包括引线加速度计。处理器比较来自加速度计的信号，并且基于比较来控制对患者的治疗传递。以这种方式，当患者改变姿势时，处理器可以将刺激调整为例如电极相对于靶组织的地址移动。

4. 发明申请

WO2008070142A2 USER INTERFACE WITH TOOLBAR FOR PROGRAMMING ELECTRICAL STIMULATION THERAPY 审中-公开
标题翻译：用户界面与工具栏编程电刺激治疗
公开(公告)号：WO2008070142A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/024969
申请日：2007-12-06
申请人： MEDTRONIC, INC. , GOETZ, Steven, M. , KEACHER, Jeffrey, T. , SAHASRABUDHE, Rajeev , DEWING, Wende, L. , DAVIS, Jon, P. , RONDONI, John , MIYAZAWA, Gabriela, C. , KING, Gary, W.
发明人： GOETZ, Steven, M. , KEACHER, Jeffrey, T. , SAHASRABUDHE, Rajeev , DEWING, Wende, L. , DAVIS, Jon, P. , RONDONI, John , MIYAZAWA, Gabriela, C. , KING, Gary, W.
IPC分类号： G06F19/00
CPC分类号： A61N1/37247 , A61N1/36185
摘要： The disclosure is directed to a user interface with a menu that facilitates stimulation therapy programming. The user interface displays a representation of the electrical leads implanted in the patient and at least one menu with icons that the user can use to adjust the stimulation therapy. The user may drag one or more field shapes from a field shape selection menu onto the desired location relative to the electrical leads. A manipulation tool menu may also allow the user to adjust the field shapes placed on the electrical leads, which represent the stimulation region. The programmer that includes the user interface then generates electrical stimulation parameter values for the stimulator to deliver stimulation according to the field shapes or field shape groups defined/located by the user. The field shapes may represent different types of stimulation representations, such as current density, activation functions, and neuron models.
摘要翻译：本公开针对具有促进刺激治疗编程的菜单的用户界面。用户界面显示植入患者体内的电导线的表示，以及至少一个带有图标的菜单，用户可以使用这些菜单来调整刺激治疗。用户可以将一个或多个场形状从场形状选择菜单拖动到相对于电导线的期望位置。操纵工具菜单还可以允许用户调整放置在代表刺激区域的电导线上的场形状。包括用户界面的编程器然后生成用于刺激器的电刺激参数值，以根据用户定义/定位的场形状或场形状组来递送刺激。场形状可以表示不同类型的刺激表示，例如电流密度，激活函数和神经元模型。

5. 发明申请

WO2007130239A1 EXTERNAL VOIDING SENSOR SYSTEM 审中-公开
标题翻译：外部无声传感器系统
公开(公告)号：WO2007130239A1
公开(公告)日：2007-11-15
申请号：PCT/US2007/007834
申请日：2007-03-29
申请人： MEDTRONIC, INC. , RONDONI, John, C. , GERBER, Martin, T.
发明人： RONDONI, John, C. , GERBER, Martin, T.
IPC分类号： A61B5/20 , A61F13/42
CPC分类号： A61B5/6808 , A61B5/01 , A61B5/202 , A61F13/42
摘要： The disclosure describes an absorbent pad worn by a patient that measures one or more urinary voiding parameters. One or more sensors that measure voiding parameters are integrally formed with the pad, e.g., interwoven with the absorbent pad material or positioned to form one or more sensor layers between layers of absorbent material. The sensors store measured parameters as information in a memory, e.g., as a log, locally or in a separate device. In some embodiments, the pad includes an electrical stimulator that provides stimulation therapy for urinary incontinence based on measured parameters.
摘要翻译：本公开描述了由患者佩戴的测量一个或多个排尿参数的吸收垫。测量空隙参数的一个或多个传感器与垫整体形成，例如与吸收垫材料交织或定位成在吸收材料层之间形成一个或多个传感器层。传感器将测量参数作为信息存储在存储器中，例如作为日志在本地或在单独的设备中存储。在一些实施例中，垫包括电刺激器，其基于测量的参数提供针对尿失禁的刺激治疗。

6. 发明申请

WO2007130173A1 PATIENT-INDIVIDUALIZED EFFICACY RATING 审中-公开
标题翻译：患者个性化效能评分
公开(公告)号：WO2007130173A1
公开(公告)日：2007-11-15
申请号：PCT/US2007/001940
申请日：2007-01-25
申请人： MEDTRONIC, INC. , GERBER, Martin, T. , RONDONI, John, C.
发明人： GERBER, Martin, T. , RONDONI, John, C.
IPC分类号： A61N1/372 , G06F19/00
CPC分类号： A61N1/37247 , G16H50/50
摘要： The disclosure is directed to techniques for providing a patient- individualized efficacy rating. Different stimulation parameters impact efficacy. For example, efficacy may be a function of parameters such as electrode combination, stimulation amplitude, pulse width, and pulse rate. Efficacy may vary from patient-to-patient. For example, efficacy may vary according to age, gender, physiology, disease state, activity level, or activity profile. Comparable stimulation programs may provide' different efficacy levels for different patients, according to patient characteristics or desires. Patients may rank efficacy parameters differently. The efficacy parameters may include desirable therapeutic effects and undesirable side effects. For one patient, optimization of a particular efficacy parameter may be the paramount concern. Other patients may be willing to compromise the outcome of the same parameter in favor of better outcomes with other efficacy parameters. A patient-individualized efficacy rating permits a patient and clinician to customize efficacy evaluation according to the patient's condition or needs.
摘要翻译：本公开涉及用于提供患者个体化功效评级的技术。不同刺激参数影响疗效。例如，功效可以是诸如电极组合，刺激幅度，脉冲宽度和脉率之类的参数的函数。疗效可能因患者而异。例如，功效可以根据年龄，性别，生理，疾病状态，活动水平或活动情况而变化。可比较的刺激方案可以根据患者的特征或欲望为不同的患者提供不同的功效水平。患者可以不同地对功效参数进行排序。功效参数可以包括期望的治疗效果和不期望的副作用。对于一个患者，特定功效参数的优化可能是至关重要的。其他患者可能愿意危及相同参数的结果，有利于其他功效参数的更好结局。患者个性化的功效评级允许患者和临床医生根据患者的状况或需要定制功效评估。

7. 发明申请

WO2007127455A2 TREE-BASED ELECTRICAL STIMULATOR PROGRAMMING FOR PAIN THERAPY 审中-公开
标题翻译：用于疼痛治疗的基于TREE的电刺激器编程
公开(公告)号：WO2007127455A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010381
申请日：2007-04-30
申请人： MEDTRONIC, INC. , GERBER, Martin, T. , RONDONI, John, C.
发明人： GERBER, Martin, T. , RONDONI, John, C.
CPC分类号： A61N1/36071 , A61N1/37247 , G06F19/00
摘要： The disclosure describes an implantable stimulation system that guides programming with a therapeutic tree. All possible stimulation parameters are arranged on the therapeutic tree, with each level of the therapeutic tree containing a different stimulation parameter type. Each level includes nodes that are connected to nodes of adjacent levels. A program path is created by moving through nodes of lower levels. The stimulation parameter types are arranged so that coarse adjustments occur at higher levels of the tree and fine adjustments occur at lower levels of the tree. The nodes of the program path define the stimulation parameters of the delivered stimulation therapy. The user may provide information such as efficacy input and/or medication dosage information to the system for identifying the most efficacious program path in treating pain of the patient. Additionally or alternatively, efficacy feedback may be received from physiological parameter sensors.
摘要翻译：本公开描述了一种用治疗树引导编程的可植入刺激系统。所有可能的刺激参数被布置在治疗树上，治疗树的每个水平含有不同的刺激参数类型。每个级别包括连接到相邻级别的节点的节点。通过移动较低级别的节点创建程序路径。刺激参数类型被布置为使得在较高级别的树上进行粗调，并且在较低级别处发生精细调整。程序路径的节点定义了递送的刺激疗法的刺激参数。用户可以向系统提供诸如功效输入和/或药物剂量信息的信息，以识别治疗患者疼痛的最有效的程序路径。附加地或替代地，可以从生理参数传感器接收功效反馈。

8. 发明申请

WO2010117810A1 PERCUTANEOUS ACCESS FOR SYSTEMS OF TREATING SLEEP-RELATED DISORDERED BREATHING 审中-公开
标题翻译：治疗与睡眠相关的疾病呼吸系统的PERCUTANEOUS ACCESS
公开(公告)号：WO2010117810A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/029253
申请日：2010-03-30
申请人： INSPIRE MEDICAL SYSTEMS, INC. , CHRISTOPHERSON, Mark A. , NI, Quan , RONDONI, John
发明人： CHRISTOPHERSON, Mark A. , NI, Quan , RONDONI, John
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/3601 , A61B5/0492 , A61B5/0826 , A61B5/4818 , A61B17/3468 , A61B2090/062 , A61N1/0504 , A61N1/0551 , A61N1/0553 , A61N1/0556 , A61N1/0558
摘要： Systems and methods are described and illustrated for percutaneously implanting a stimulation lead for treating sleep-related disordered breathing.
摘要翻译：描述和说明了用于经皮植入用于治疗与睡眠相关的无序呼吸的刺激引线的系统和方法。

9. 发明申请

WO2010039853A1 TRANSVENOUS METHOD OF TREATING SLEEP APNEA 审中-公开
标题翻译：处理睡眠APNEA的多维方法
公开(公告)号：WO2010039853A1
公开(公告)日：2010-04-08
申请号：PCT/US2009/059060
申请日：2009-09-30
申请人： INSPIRE MEDICAL SYSTEMS, INC. , NI, Quan , CHRISTOPHERSON, Mark A. , HERBERT, Timothy P. , RONDONI, John
发明人： NI, Quan , CHRISTOPHERSON, Mark A. , HERBERT, Timothy P. , RONDONI, John
IPC分类号： A61N1/36 , A61N1/372 , A61F2/82
CPC分类号： A61N1/3601 , A61B5/4818 , A61F2/848 , A61F2/86 , A61N1/37205
摘要： A system and method for treating sleep apnea includes inserting an implantable pulse generator subcutaneously within a body of a patient and connecting a lead to the pulse generator. The lead is inserted within the vasculature and advanced transvenously through the vasculature until a stimulation portion of the lead becomes positioned in close proximity to the hypoglossal nerve. A nerve-stimulation signal is applied to the hypoglossal nerve via the stimulation portion of the lead.
摘要翻译：用于治疗睡眠呼吸暂停的系统和方法包括将可植入脉冲发生器皮下插入患者体内并将引线连接到脉冲发生器。铅被插入脉管系统中，并且通过脉管系统递送，直到引线的刺激部分定位在舌下神经附近。神经刺激信号通过铅的刺激部分施加到舌下神经。

10. 发明申请

WO2009134479A1 THERAPY PROGRAM MODIFICATION BASED ON AN ENERGY THRESHOLD 审中-公开
标题翻译：基于能量阈值的治疗方案修改
公开(公告)号：WO2009134479A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/031965
申请日：2009-01-26
申请人： MEDTRONIC, INC. , RONDONI, John, C. , GERBER, Martin, T.
发明人： RONDONI, John, C. , GERBER, Martin, T.
IPC分类号： A61N1/372 , G06F19/00 , A61M5/142 , A61N1/34 , A61N1/36
CPC分类号： A61N1/36185 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61N1/36514 , A61N1/37264 , G06F19/00 , G06F19/3481
摘要： A therapy program is modified to decompose a therapy field generated by therapy delivery by a medical device according to a therapy program into a plurality of subfields based on a comparison between an energy associated with the therapy program and a threshold value. The therapy field defined by the therapy program may be decomposed into a plurality of subfields when an electrical stimulation energy of the stimulation signal defined by the therapy program exceeds the maximum energy output of the medical device or of a channel of the medical device. Therapy subprograms may be generated for each of the therapy subfields. An energy associated with each of the therapy subfields may be less than the energy threshold value of the medical device.
摘要翻译：基于与治疗程序相关联的能量与阈值之间的比较，修改治疗程序以将通过治疗程序的医疗装置的治疗传递产生的治疗场分解成多个子场。当治疗程序定义的刺激信号的电刺激能量超过医疗装置或医疗装置的通道的最大能量输出时，治疗程序定义的治疗领域可以被分解成多个子场。可以为每个治疗子区域产生治疗子程序。与每个治疗子场相关联的能量可以小于医疗装置的能量阈值。

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