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    • 7. 发明授权
    • Protein detector based on molecular controlled semiconductor resistor
    • 基于分子控制半导体电阻的蛋白质检测器
    • US08957460B2
    • 2015-02-17
    • US14124313
    • 2012-05-31
    • Ron NaamanEyal CapuaDanny BavliMaria Tkachev
    • Ron NaamanEyal CapuaDanny BavliMaria Tkachev
    • H01L21/00G01N27/49H01L27/28G01N27/414
    • G01N27/4145
    • The invention provides a semiconductor device for the detection of an active site-containing protein or a ligand thereof in a solution, said device comprising at least one insulating or semi-insulating layer; at least one conducting semiconductor layer, two conducting pads on top of the upper layer making electrical contact with said at least one conducting semiconductor layer, such that electrical current can flow between them at a finite distance from the surface of the device; a protective molecular layer fabricated on top of said upper layer and protecting said layer from corrosion; and said ligand or active site-containing protein linked to said protective molecular layer. Exposure of said ligand or active site-containing protein to a solution containing said active site-containing protein or ligand, respectively, causes a current change through the device when a constant electric potential is applied between the two conducting pads. The semiconductor device can be seen as a molecularly controlled semiconductor resistor (MOCSER) protein sensor based on doped and undoped GaAs stack structure. The GaAs is protected against etching in aqueous environments by the protective molecular layer.
    • 本发明提供一种用于在溶液中检测含活性位点的蛋白质或其配体的半导体器件,所述器件包括至少一个绝缘或半绝缘层; 至少一个导电半导体层,在所述上层顶部上的两个导电焊盘与所述至少一个导电半导体层进行电接触,使得电流可以在它们之间以距离所述器件表面有限的距离流动; 在所述上层顶部制造的保护分子层,并保护所述层免受腐蚀; 和与所述保护性分子层连接的所述配体或含活性位点的蛋白质。 当在两个导电垫之间施加恒定的电位时,所述配体或含活性位点的蛋白质分别暴露于含有所述含活性位点的蛋白质或配体的溶液中,导致通过该装置的电流变化。 半导体器件可以看作是基于掺杂和未掺杂的GaAs堆叠结构的分子控制半导体电阻(MOCSER)蛋白质传感器。 在保护分子层的水溶液环境中保护GaAs不被腐蚀。
    • 9. 发明申请
    • Electronic Device and Method and Performing Logic Functions
    • 电子设备与方法及执行逻辑功能
    • US20080136455A1
    • 2008-06-12
    • US11814544
    • 2006-01-22
    • Gilad DiamantDmitry ShvartsErez HalahmiRon NaamanLeeor Kronik
    • Gilad DiamantDmitry ShvartsErez HalahmiRon NaamanLeeor Kronik
    • H03K19/00
    • H03K17/545
    • An electronic device is presented which is configured to operate as at least one logic gate. The device comprises an electrodes arrangement of one or more basic units, the basic unit being configured to define at least one vacuum space for free charged particles' propagation and comprising an input assembly for supplying an input signal, and a floating electrode assembly accommodated proximal said input assembly and serving for reading an output signal therefrom, the floating electrode arrangement being configured to define at least one source of the free charged particles and at least one target toward which the charged particles are directed and is chargeable and dischargeable in response to the input signal thereby creating the output of the basic unit.
    • 呈现电子设备,其被配置为作为至少一个逻辑门操作。 该装置包括一个或多个基本单元的电极布置,该基本单元被配置为限定至少一个用于自由带电粒子传播的真空空间,并且包括用于提供输入信号的输入组件,以及容纳在所述 输入组件并用于从其读取输出信号,所述浮动电极装置被配置为限定所述自由带电粒子和至少一个目标物的至少一个源,所述带电粒子被引导到所述至少一个物体,并且可响应于所述输入而被充电和放电 从而产生基本单元的输出。