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1. 发明申请

WO2018175327A1 ONYCHOMYCOSIS TREATMENT SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2018175327A1
公开(公告)日：2018-09-27
申请号：PCT/US2018/023154
申请日：2018-03-19
申请人： DEVICEFARM INC. , ROE, Jeffrey, N.
发明人： ROE, Jeffrey, N. , GRAMMER, Timothy, C. , BARRERA-BARRAZA, Raul, Ignacio , TRIDAS, Eric
IPC分类号： A61K33/04 , A61K33/00 , A61K31/02
摘要： A system and method includes delivery of a redox gas solution to treat onychomycosis, wherein the redox gas solution comprises a reactive species dissolved in a perfluorocarbon liquid, and wherein the reactive species may include, alone or in combination, one or more of reactive oxygen, reactive nitrogen, reactive chlorine, or reactive bromine species, and the perfluorocarbon liquid may include perfluorodecalin.

2. 发明申请

WO2007002323A2 SYSTEM AND METHOD FOR MONITORING OF END ORGAN OXYGENATION BY MEASUREMENT OF IN VIVO CELLULAR ENERGY STATUS 审中-公开
标题翻译：通过测量体内细胞能量状态来监测末端器官氧化的系统和方法
公开(公告)号：WO2007002323A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/024359
申请日：2006-06-23
申请人： EPOC, INC. , ARAVANIS, Alexander, Michael , PYLE, Jason, Lee , ROE, Jeffrey, N. , ROSENTHAL, Myer, H.
发明人： ARAVANIS, Alexander, Michael , PYLE, Jason, Lee , ROE, Jeffrey, N. , ROSENTHAL, Myer, H.
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0068 , A61B5/0071 , A61B5/0084 , A61B5/14556 , A61B5/412 , A61B5/413
摘要： A method is provided of measuring in vivo of an endogenous fluorophore in a tissue site. A known excitation wavelength of the endogenous flurophore is selected within a range of wavelengths at which the endogenous flurophore undergoes fluorescence. The tissue site is irradiated with irradiated light having at least the selected excitation wavelength within the range of wavelengths. A fluorescence emission of the tissue site resulting from the irradiation thereof is detected. A relative or absolute concentration of the endogenous fluorophore is determined by multiplying it by a calibration factor that depends one at least one of, a known excitation and emission property of the endogenous fluorophore, an intensity of the irradiated light, optical properties of an excitation probe, and specific properties of the tissue. The relative or absolute concentration of the endogenous fluorphore is used to estimate at least one of a, in vivo cellular energy production status or state of end-organ tissue oxygenation.
摘要翻译：提供了一种测量组织部位内源性荧光团的体内活性的方法。在内源荧光团经历荧光的波长范围内选择内源荧光团的已知激发波长。用在所述波长范围内具有至少所选激发波长的照射光照射所述组织部位。检测由其照射引起的组织部位的荧光发射。内源性荧光团的相对或绝对浓度通过将其乘以校准因子来确定，所述校准因子取决于内源性荧光团的已知激发和发射性质，所照射的光的强度，激发探针的光学性质中的至少一个以及组织的特定性质。使用内源性荧光素的相对或绝对浓度来估计体内细胞能量生产状态或末端器官组织氧合状态中的至少一种。

3. 发明申请

WO2002100274A1 BODILY FLUID SAMPLING DEVICE AND TEST MEDIA CASSETTE TO BE USED WITH SUCH A DEVICE 审中-公开
标题翻译：使用这种设备的体液采样装置和试验介质
公开(公告)号：WO2002100274A1
公开(公告)日：2002-12-19
申请号：PCT/US2002/018159
申请日：2002-06-07
申请人： AMIRA MEDICAL , ROE, Jeffrey, N. , ROE, Steven, N.
发明人： ROE, Jeffrey, N. , ROE, Steven, N.
IPC分类号： A61B5/15
CPC分类号： A61B5/14546 , A61B5/1411 , A61B5/150022 , A61B5/150099 , A61B5/150358 , A61B5/150419 , A61B5/150473 , A61B5/150503 , A61B5/150633 , A61B5/150702 , A61B5/150717 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B5/157 , A61B10/0045 , A61B2562/0295 , G01N33/48 , G01N33/48764 , G01N2001/028 , G01N2035/00019 , Y10T436/25
摘要： A bodily fluid sampling device (30) includes a piercing device (42) and a sensor (56) enclosed in a housing (32). A cassette (54), which contains test media (64), is positioned proximal to the sensor (56) so that the sensor (56) is able to analyze a bodily fluid sample collected on the test media (64). The cassette (54) includes a supply portion (66) from which unused test media (64) is supplied and a storage portion (68) in which contaminated test media (64) is stored after exposure to the bodily fluid. The cassette (54) is adapted to collect a series of bodily fluid samples without requiring disposal of the test media (64).
摘要翻译：体液采样装置（30）包括穿孔装置（42）和封闭在壳体（32）内的传感器（56）。包含测试介质（64）的盒（54）位于传感器（56）的近侧，使得传感器（56）能够分析收集在测试介质（64）上的体液样品。盒（54）包括供应部分（66），供应部分（64）从其供应未使用的测试介质（64）和存储部分（68），其中在暴露于体液之后存储被污染的测试介质（64）。盒（54）适于收集一系列体液样品，而不需要处理测试介质（64）。

4. 发明申请

WO0021437A2 INFRARED ATR GLUCOSE MEASUREMENT SYSTEM 审中-公开
标题翻译：红外ATR葡萄糖测量系统
公开(公告)号：WO0021437A2
公开(公告)日：2000-04-20
申请号：PCT/US9923823
申请日：1999-10-12
申请人： BERMAN HERBERT L , ROE JEFFREY N
发明人： BERMAN HERBERT L , ROE JEFFREY N
IPC分类号： G01N21/27 , A61B5/00 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532
摘要： This involves a non-invasive glucose measurement device and a process for determining blood glucose level in the human body using the device. In typical operation, the glucose measurement device is self-normalizing in that it does not employ an independent reference sample in its operation. The device uses attenuated total reflection (ATR) infrared spectroscopy. Preferably, the device is used on a fingertip and compares two specific regions of a measured infrared spectrum to determine the blood glucose level of the user. Clearly, this device is especially suitable for monitoring glucose levels in the human body, and is especially beneficial to users having diabetes mellitus. The device and procedure may be used for other analyte materials which exhibit unique mid-IR signatures of the type described herein and that are found in appropriate regions of the outer skin.
摘要翻译：这涉及非侵入性葡萄糖测量装置和使用该装置来测定人体血糖水平的方法。在典型的操作中，葡萄糖测量装置是自标准化的，因为其操作中不使用独立的参考样品。该设备使用衰减全反射（ATR）红外光谱。优选地，将该装置用于指尖，并比较测量的红外光谱的两个特定区域以确定用户的血糖水平。显然，该装置特别适用于监测人体内的葡萄糖水平，对于患有糖尿病的使用者尤其有益。该装置和程序可以用于其它分析物质，其表现出本文所述类型的独特的中期IR特征并且在外皮的合适区域中发现。

5. 发明申请

WO2005122897A1 DISPOSABLE LANCET AND LANCING CAP COMBINATION FOR INCREASED HYGIENE 审中-公开
标题翻译：增加的卫生间的可配置的LANCET和LANCING CAP组合
公开(公告)号：WO2005122897A1
公开(公告)日：2005-12-29
申请号：PCT/EP2005/006668
申请日：2005-06-21
申请人： ROCHE DIAGNOSTICS GMBH , F.HOFFMANN-LA ROCHE AG , THYM, Detlef , ROE, Jeffrey, N.
发明人： THYM, Detlef , ROE, Jeffrey, N.
IPC分类号： A61B5/15
CPC分类号： A61B5/15142 , A61B5/150022 , A61B5/150068 , A61B5/150297 , A61B5/150358 , A61B5/150412 , A61B5/150519 , A61B5/150717 , A61B5/15107 , A61B5/15115 , A61B5/1519 , A61B5/15192 , A61B2562/0295
摘要： A body fluid testing device includes a test strip, an incision forming member, and a housing. The test strip includes an expression surface. In addition, the test strip is attached to the housing to form a cavity, and the cavity slidably receives the incision forming member. The body fluid testing device is positioned over the incision site where the incision forming member makes an incision. The user presses the expression surface against the skin to express body fluid. The cavity collects body fluid via capillary action, and the test strip analyzes the body fluid.
摘要翻译：体液检查装置包括测试条，切口形成部件和壳体。测试条包括表达表面。此外，测试条附接到壳体以形成空腔，并且空腔可滑动地容纳切口形成构件。体液检查装置位于切口形成部件进行切口的切口部位上。用户将表达表面压在皮肤上以表达体液。空腔通过毛细作用收集体液，测试条分析体液。

6. 发明申请

WO2004066822A3 INTEGRATED LANCING TEST STRIP 审中-公开
标题翻译：集成测试条
公开(公告)号：WO2004066822A3
公开(公告)日：2004-12-02
申请号：PCT/US2004002476
申请日：2004-01-29
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , ROE STEVEN N , RANEY CHARLES C , ZIMMER VOLKER , ROE JEFFREY N
发明人： ROE STEVEN N , RANEY CHARLES C , ZIMMER VOLKER , ROE JEFFREY N
IPC分类号： A61B5/00 , A61B5/15
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150198 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150564 , A61B5/150824 , A61B5/15117 , A61B5/15144 , A61B2562/0295
摘要： An integrated bodily fluid sampling device (60) is used to sample a bodily fluid from an incision in skin. The device includes a lancet (62) for forming the incision in the skin. A housing is coupled to the lancet (62). The housing defines at least in part a capillary channel (98) with an opening (100). The capillary channel (98) is sized to draw the bodily fluid from the incision via capillary action. A test size (72) is positioned along the capillary channel (98) for analyzing the fluid. In one form, a flexible sheet (76) extends from the housing proximal the opening (100) of the capillary channel (98) for drawing the bodily fluid into the opening (100) of the capillary channel (98). In another form, the lancet (62) is slidably received inside the channel (98). During lancing, the lancet (62) extends from the housing to form the incision. Fluid from the incision is drawn into the channel (98) and is deposited on the test strip (72) for anaylsis.
摘要翻译：一体式体液取样装置（60）用于从皮肤切口取样体液。该装置包括用于在皮肤中形成切口的刺血针（62）。壳体联接到刺血针（62）。壳体至少部分地限定具有开口（100）的毛细通道（98）。毛细通道（98）的尺寸设定成通过毛细管作用从切口中吸取体液。测试尺寸（72）沿毛细通道（98）定位，用于分析流体。在一种形式中，柔性片（76）从靠近毛细通道（98）的开口（100）的壳体延伸，用于将体液吸入毛细通道（98）的开口（100）。在另一种形式中，刺血针（62）可滑动地容纳在通道（98）内。在穿刺期间，柳叶刀（62）从壳体延伸以形成切口。将来自切口的流体吸入通道（98）并沉积在测试条（72）上用于分析。

7. 发明申请

WO2004066822A2 INTEGRATED LANCING TEST STRIP 审中-公开
标题翻译：集成测试条
公开(公告)号：WO2004066822A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/002476
申请日：2004-01-29
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROE, Steven, N. , RANEY, Charles, C. , ZIMMER, Volker , ROE, Jeffrey, N.
发明人： ROE, Steven, N. , RANEY, Charles, C. , ZIMMER, Volker , ROE, Jeffrey, N.
IPC分类号： A61B
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150198 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150564 , A61B5/150824 , A61B5/15117 , A61B5/15144 , A61B2562/0295
摘要： An integrated bodily fluid sampling device (60) is used to sample a bodily fluid from an incision in skin. The device includes a lancet (62) for forming the incision in the skin. A housing is coupled to the lancet (62). The housing defines at least in part a capillary channel (98) with an opening (100). The capillary channel (98) is sized to draw the bodily fluid from the incision via capillary action. A test size (72) is positioned algon the capillary channel (98) for analyzing the fluid. In one form, a flexible sheet (76) extends from the housing proximal the opening (100) of the capillary channel (98) for drawing the bodily fluid into the opening (100) of the capillary channel (98). In another form, the lancet (62) is slidably received inside the channel (98). During lancing, the lancet (62) extends from the housing to form the incision. Fluid from the incision is drawn into the channel (98) and is deposited on the test strip (72) for anaylsis.
摘要翻译：一体式体液取样装置（60）用于从皮肤切口取样体液。该装置包括用于在皮肤中形成切口的刺血针（62）。壳体联接到刺血针（62）。壳体至少部分地限定具有开口（100）的毛细通道（98）。毛细通道（98）的尺寸设定成通过毛细管作用从切口中吸取体液。测试尺寸（72）位于毛细通道（98）的Algon处，用于分析流体。在一种形式中，柔性片（76）从靠近毛细通道（98）的开口（100）的壳体延伸，用于将体液吸入毛细通道（98）的开口（100）。在另一种形式中，刺血针（62）可滑动地容纳在通道（98）内。在穿刺期间，柳叶刀（62）从壳体延伸以形成切口。将来自切口的流体吸入通道（98）并沉积在测试条（72）上用于分析。

8. 发明申请

WO0179818A3 INFRARED ATR GLUCOSE MEASUREMENT SYSTEM 审中-公开
标题翻译：红外ATR葡萄糖测量系统
公开(公告)号：WO0179818A3
公开(公告)日：2002-07-18
申请号：PCT/US0111860
申请日：2001-04-11
申请人： MEDOPTIX INC , BERMAN HERBERT L , ROE JEFFREY N
发明人： BERMAN HERBERT L , ROE JEFFREY N
IPC分类号： A61B5/00 , G01N21/55 , A61K7/48 , A61K7/50 , G01N21/31 , G01N21/35
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/245 , G01N21/552
摘要： This involves a non-invasive glucose measurement device and a process for determining blood glucose level in the human body using the device. In typical operation, the glucose measurement device is self-normalizing in that it does not employ an independent reference sample in its operation. The device uses attenuated total reflection (ATR) infrared spectroscopy. Preferably, the device is used on a fingertip and compares two specific regions of a measured infrared spectrum to determine the blood glucose level of the user. Clearly, this device is especially suitable for monitoring glucose levels in the human body, and is especially beneficial to users having diabetes mellitus. The device and procedure may be used for other analyte materials which exhibit unique mid-IR signatures of the type described herein and that are found in appropriate regions of the outer skin.
摘要翻译：这涉及非侵入性葡萄糖测量装置和使用该装置来测定人体血糖水平的方法。在典型的操作中，葡萄糖测量装置是自标准化的，因为其操作中不使用独立的参考样品。该装置使用衰减全反射（ATR）红外光谱。优选地，将该装置用于指尖，并比较测量的红外光谱的两个特定区域以确定用户的血糖水平。显然，该装置特别适用于监测人体内的葡萄糖水平，对于患有糖尿病的使用者尤其有益。该装置和程序可用于展示本文所述类型的独特的中红外特征并且存在于外皮的合适区域中的其它分析物质。

9. 发明申请

WO2002100277A1 SAMPLING DEVICES AND METHODS UTILIZING A STEPPED CAPILLARY PASSA GEWAY 审中-公开
标题翻译：采样设备和使用步进毛巾PASSA GEWAY的方法
公开(公告)号：WO2002100277A1
公开(公告)日：2002-12-19
申请号：PCT/US2002/018205
申请日：2002-06-07
申请人： AMIRA MEDICAL, INC. , ROE, Jeffrey, N. , ALLEN, John, J.
发明人： ROE, Jeffrey, N. , ALLEN, John, J.
IPC分类号： A61B5/15
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/1519 , A61B5/15194 , A61B5/157
摘要： Systems and methods for the sampling of bodily fluid from an incision in the skin utilize a capillary passageway (18) having a first, upstream portion (39) and a second, downstream portion (41), with the downstream portion (41) having a higher capillary affinity for the bodily fluid than the upstream portion (39). Therefor, when the first portion (39) is filled and the fluid contacts the second portion (41), the fluid is drawn up into the second portion (41) due to the greater capillary affinity. The capillary affinities are controlled by the cross-sectional area of the passageway (18), the use of different materials or coatings to define the passageway, the treatment of the interior wall of the passageway, the use of wicking materials, and the like. The capillary sampling systems and methods are optionally combined with incising, expressing and/or testing systems, particularly in a single, integrated device.
摘要翻译：用于从皮肤切口取样体液的系统和方法利用具有第一上游部分（39）和第二下游部分（41）的毛细通道（18），其中下游部分（41）具有比上游部分（39）更高的对体液的毛细管亲和力。因此，当第一部分（39）被填充并且流体接触第二部分（41）时，由于更大的毛细管亲和力，流体被拉伸到第二部分（41）中。毛细管亲和力由通道（18）的横截面面积，不同材料或涂层的使用来限定通道，通道的内壁处理，芯吸材料的使用等来控制。毛细管采样系统和方法可选地与切割，表达和/或测试系统组合，特别是在单个集成设备中。

10. 发明申请

WO1998019159A1 SYNCHRONIZED ANALYTE TESTING SYSTEM 审中-公开
标题翻译：同步分析测试系统
公开(公告)号：WO1998019159A1
公开(公告)日：1998-05-07
申请号：PCT/US1997019749
申请日：1997-10-30
申请人： MERCURY DIAGNOSTICS, INC. , DOUGLAS, Joel, S. , DREXLER, Karen, R. , ROE, Jeffrey, N.
发明人： MERCURY DIAGNOSTICS, INC.
IPC分类号： G01N33/52
CPC分类号： G01N33/528 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/150022 , A61B5/150259 , A61B5/150305 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15186 , A61B5/157 , A61B5/415 , A61B2560/0431 , A61B2562/0295 , A61B2562/085 , C12Q1/54 , G01D3/022 , G01N21/8483 , G01N33/48757 , G01N33/48771 , G01N33/525 , G01N33/66 , G01N2035/00138 , Y10S435/808 , Y10S435/817
摘要： An analyte detection system is provided with calibration information uniquely specific to the set of test strips to which the sample is to be applied. The calibration information may be stored in permanent memory of the testing device, such that the device is discarded after use of all the test strips in a kit, or it may be stored in a calibration chip accompanying the set of test strips and distributed therewith, thereby enabling re-use of the testing device with a different set of test strips and associated calibration chip.
摘要翻译：分析物检测系统具有唯一特定于要应用样品的测试条组的校准信息。校准信息可以存储在测试设备的永久存储器中，使得在使用套件中的所有测试条之后丢弃设备，或者可以将其存储在伴随该组测试条的校准芯片中并与其一起分布，从而能够利用不同的测试条和相关联的校准芯片来重新使用测试装置。

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