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1. 发明公开

EP1962803A1 PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE 审中-公开
标题翻译：用于递送受体酪氨酸激酶抑制（RTKi）化合物至眼睛的药物制剂
公开(公告)号：EP1962803A1
公开(公告)日：2008-09-03
申请号：EP06846687.9
申请日：2006-12-19
申请人： Alcon, Inc. , Bingaman, David P. , Robertson, Stella M.
发明人： GHOSH, Malay , HAN, Wesley, Wehsin , LIN, Way-yu
IPC分类号： A61K9/10
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/08 , A61K31/416
摘要： The present invention relates to development of efficacious intravitreal pharmaceutical compositions comprising a poorly water soluble agent with anti-angiogenic and/or anti vascular leakage properties in a therapeutically effective amount and a co-solvent in a suitable amount to treat or prevent diseases due to ocular neovascularization and enhanced vascular permeability.
摘要翻译：本发明涉及有效玻璃体内药物组合物的开发，其包含治疗有效量的具有抗血管生成和/或抗血管渗漏特性的水溶性差的试剂和适量的共溶剂，以治疗或预防由于眼部疾病新血管形成和增强的血管通透性。

2. 发明申请

WO2004073608A2 FORMULATIONS OF GLUCOCORTICOIDS TO TREAT PATHOLOGIC OCULAR ANGIOGENESIS 审中-公开
标题翻译：葡萄糖结合蛋白治疗病态性血管生成的方法
公开(公告)号：WO2004073608A2
公开(公告)日：2004-09-02
申请号：PCT/US2004003515
申请日：2004-02-05
申请人： ALCON INC , BINGAMAN DAVID P , CLARK ABBOT F , JANI RAJNI , ROBERTSON STELLA M
发明人： BINGAMAN DAVID P , CLARK ABBOT F , JANI RAJNI , ROBERTSON STELLA M
IPC分类号： A61K31/573 , A61K31/58 , A61K
CPC分类号： A61K31/58 , A61K31/573 , A61K2300/00
摘要： Formulations of glucocorticoids alone and in combination with anecortave acetate are useful for preventing and treating pathologic ocular angiogenesis and associated edema.
摘要翻译：糖皮质激素单独配制与醋酸艾司他丁配方可用于预防和治疗病理性眼血管生成及相关性水肿。

3. 发明申请

WO02072105A9 IMPROVED PROSTANOID THERAPIES FOR THE TREATMENT OF GLAUCOMA 审中-公开
标题翻译：改善治疗GLAUCOMA的前列腺治疗
公开(公告)号：WO02072105A9
公开(公告)日：2004-01-15
申请号：PCT/US0205130
申请日：2002-02-21
申请人： ALCON INC , ROBERTSON STELLA M
发明人： ROBERTSON STELLA M
IPC分类号： A61K31/5575 , A61P27/06
CPC分类号： A61K31/5575
摘要： Compositions and methods for the treatment of glaucoma and/or ocular hypertension in humans utilizing improved doses of certain prostaglandin derivatives and analogs are disclosed.
摘要翻译：公开了利用改善剂量的某些前列腺素衍生物和类似物治疗人类青光眼和/或高眼压症的组合物和方法。

4. 发明申请

WO2004012742A1 USE OF ANECORTAVE ACETATE FOR THE PROTECTION OF VISUAL ACUITY IN PATIENTS WITH AGE RELATED MACULAR DEGENERATION 审中-公开
标题翻译：用于保护与年龄相关的患者视力下降的醋酸异丙酯
公开(公告)号：WO2004012742A1
公开(公告)日：2004-02-12
申请号：PCT/US2003/020154
申请日：2003-06-26
申请人： ALCON, INC. , JERDAN, Janice, A. , ZILLIOX, Patricia , ROBERTSON, Stella, M.
发明人： JERDAN, Janice, A. , ZILLIOX, Patricia , ROBERTSON, Stella, M.
IPC分类号： A61K31/56
CPC分类号： A61K31/57 , A61K9/0024 , A61K31/56
摘要： The present invention is directed to the use of anercortave acetate or the alcohol thereof for the protection of visual acuity in patients with age related macular degeneration.
摘要翻译：本发明涉及醋酸埃托伐他汀或其醇用于保护患有年龄相关性黄斑变性的患者的视力。

5. 发明申请

WO02072105A2 IMPROVED PROSTANOID THERAPIES FOR THE TREATMENT OF GLAUCOMA 审中-公开
标题翻译：改善治疗GLAUCOMA的前列腺治疗
公开(公告)号：WO02072105A2
公开(公告)日：2002-09-19
申请号：PCT/US0205130
申请日：2002-02-21
申请人： ALCON UNIVERSAL LTD , ROBERTSON STELLA M
发明人： ROBERTSON STELLA M
IPC分类号： A61K31/5575 , A61P27/06
CPC分类号： A61K31/5575
摘要： Compositions and methods for the treatment of glaucoma and/or ocular hypertension in humans utilizing improved doses of certain prostaglandin derivatives and analogs are disclosed.
摘要翻译：公开了利用改善剂量的某些前列腺素衍生物和类似物治疗人类青光眼和/或高眼压症的组合物和方法。

6. 发明申请

WO2004073607A3 USE OF STEROIDS TO TREAT OCULAR DISORDERS 审中-公开
公开(公告)号：WO2004073607A3
公开(公告)日：2004-09-02
申请号：PCT/US2004/003138
申请日：2004-02-04
申请人： ALCON, INC. , BINGAMAN, David, P. , CLARK, Abbot, F. , JANI, Rajni , ROBERTSON, Stella, M.
发明人： BINGAMAN, David, P. , CLARK, Abbot, F. , JANI, Rajni , ROBERTSON, Stella, M.
IPC分类号： A61K31/56
摘要： Methods and compositions for treating retinal edema and NPDR are disclosed.

7. 发明申请

WO2004073607A2 USE OF STEROIDS TO TREAT PERSONS SUFFERING FROM OCULAR DISORDERS 审中-公开
标题翻译：使用STEROIDS治疗患有OCOLAR DISORDERS的人
公开(公告)号：WO2004073607A2
公开(公告)日：2004-09-02
申请号：PCT/US2004003138
申请日：2004-02-04
申请人： ALCON INC , BINGAMAN DAVID P , CLARK ABBOT F , JANI RAJNI , ROBERTSON STELLA M
发明人： BINGAMAN DAVID P , CLARK ABBOT F , JANI RAJNI , ROBERTSON STELLA M
IPC分类号： A61K9/00 , A61K31/56 , A61K31/573 , A61K
CPC分类号： A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K31/56 , A61K31/573 , A61K2300/00
摘要： Methods and compositions for treating retinal edema and NPDR are disclosed.
摘要翻译：公开了用于治疗视网膜水肿和NPDR的方法和组合物。

8. 发明申请

WO2002072105A3 IMPROVED PROSTANOID THERAPIES FOR THE TREATMENT OF GLAUCOMA 审中-公开
公开(公告)号：WO2002072105A3
公开(公告)日：2002-09-19
申请号：PCT/US2002/005130
申请日：2002-02-21
申请人： ALCON, INC. , ROBERTSON, Stella, M.
发明人： ROBERTSON, Stella, M.
IPC分类号： A61K31/5575
摘要： Compositions and methods for the treatment of glaucoma and/or ocular hypertension in humans utilizing improved doses of certain prostaglandin derivatives and analogs are disclosed.

9. 发明申请

WO1986002733A1 SANDWICH IMMUNOASSAY OF ANTIGENS INVOLVED IN OPHTHALMIC DISORDERS 审中-公开
标题翻译：涉及眼底疾病的抗精神病药物的免疫免疫学
公开(公告)号：WO1986002733A1
公开(公告)日：1986-05-09
申请号：PCT/US1985002146
申请日：1985-10-31
申请人： ALCON LABORATORIES, INCORPORATED , ROBERTSON, Stella, M.
发明人： ALCON LABORATORIES, INCORPORATED
IPC分类号： G01N33/52
CPC分类号： G01N33/56927 , G01N33/543 , G01N33/54386 , G01N33/544 , G01N33/56983 , G01N33/56994
摘要： A diagnostic kit for detecting disorders attributable to antigens, particularly ocular Herpes Simplex Virus infections, utilizing immunological principles, and a method for detecting such disorders using this kit. In one embodiment, the kit includes a monoclonal antibody attached to a solid substrate, a probe solution containing labeled monoclonal antibodies which are complementary to the subject antigen, and at least two neutral, sterile wash solutions. In use, a fluid specimen, such as a tear drop, urine, saliva, blood, spinal fluid, or fluid containing a solubilized tissue scraping of the affected area, is contacted with the substrate. The substrate is then washed and contacted with a solution containing labeled monoclonal antibodies which are complementary to the antigen. Detection of the labeled monoclonal antibody, as with light, is effected to provide a positive color, precipitation spot, or agglutination.
摘要翻译：用于检测归因于抗原的病症的诊断试剂盒，特别是使用免疫学原理的眼单纯疱疹病毒感染，以及使用该试剂盒检测此类病症的方法。在一个实施方案中，试剂盒包括连接到固体底物的单克隆抗体，含有与受试抗原互补的标记单克隆抗体的探针溶液和至少两种中性无菌洗涤溶液。在使用中，将液体样品，例如泪滴，尿液，唾液，血液，脊髓液或含有受影响区域的溶解组织刮擦的流体与基底接触。然后洗涤底物并与含有与抗原互补的标记的单克隆抗体的溶液接触。如同用光一样检测标记的单克隆抗体，以提供正色，沉淀点或凝集。

10. 发明申请

WO2007076358A1 PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE 审中-公开
标题翻译：用于将受体酪氨酸激酶抑制（RTKi）化合物递送至眼睛的药物制剂
公开(公告)号：WO2007076358A1
公开(公告)日：2007-07-05
申请号：PCT/US2006/062303
申请日：2006-12-19
申请人： ALCON, INC. , BINGAMAN, David, P. , ROBERTSON, Stella, M. , GHOSH, Malay , HAN, Wesley, Wehsin , LIN, Way-yu
发明人： GHOSH, Malay , HAN, Wesley, Wehsin , LIN, Way-yu
IPC分类号： A61K9/10
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/08 , A61K31/416
摘要： The present invention relates to development of efficacious intravitreal pharmaceutical compositions comprising a poorly water soluble agent with anti-angiogenic and/or anti vascular leakage properties in a therapeutically effective amount and a co-solvent in a suitable amount to treat or prevent diseases due to ocular neovascularization and enhanced vascular permeability.
摘要翻译：本发明涉及有效的玻璃体内药物组合物的开发，其包含治疗有效量的具有抗血管生成和/或抗血管渗透性能的水溶性差的药剂，以及适当量的用于治疗或预防由于眼睛引起的疾病的共溶剂新血管形成和血管通透性增强。

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