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1. 发明授权

EP1367963B1 STENT AND KIT COMPRISING A STENT AND A BALLOON FOR IMPROVING BLOOD FLOW 有权
标题翻译：支架及支架及气球的系统，以改善血液流动
公开(公告)号：EP1367963B1
公开(公告)日：2009-09-30
申请号：EP02721371.9
申请日：2002-03-13
申请人： Richter, Yoram , Edelman, Elazer
发明人： Richter, Yoram , Edelman, Elazer
IPC分类号： A61F2/82
CPC分类号： A61F2/90 , A61F2/06 , A61F2/86 , A61F2/958 , A61F2002/068 , A61F2230/0006 , A61F2250/0039 , A61M25/1002
摘要： A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site. First stent segment (12), second stent segment (14) and thrid stent segement (16) show a schematic view of the stent envelope or profile.

2. 发明公开

EP2158875A1 Stent and kit comprising a stent and a balloon for improving blood flow 有权
标题翻译：支架和试剂盒einem支架和einem Ballon zur Verbesserung des Blutflusses
公开(公告)号：EP2158875A1
公开(公告)日：2010-03-03
申请号：EP09004580.8
申请日：2002-03-13
申请人： Richter, Yoram , Edelman, Elazer
发明人： Richter, Yoram , Edelman, Elazer
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2/06 , A61F2/86 , A61F2/958 , A61F2002/068 , A61F2230/0006 , A61F2250/0039 , A61M25/1002
摘要： A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site.
摘要翻译：一种在管腔中产生更有利的流动状态的方法和装置。产生管腔中的人造形状用于消除流动干扰中的至少一种，并增强通过治疗部位的流体流动的方面。

3. 发明公开

EP1367963A2 METHOD AND APPARATUS FOR STENTING 有权
标题翻译：在巴生ZUR VERBESSERUNG DES BLUTFLUSSES系统的系统
公开(公告)号：EP1367963A2
公开(公告)日：2003-12-10
申请号：EP02721371.9
申请日：2002-03-13
申请人： Richter, Yoram , Edelman, Elazer
发明人： Richter, Yoram , Edelman, Elazer
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2/06 , A61F2/86 , A61F2/958 , A61F2002/068 , A61F2230/0006 , A61F2250/0039 , A61M25/1002
摘要： A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site. First stent segment (12), second stent segment (14) and thrid stent segement (16) show a schematic view of the stent envelope or profile.
摘要翻译：一种在管腔中产生更有利的流动状态的方法和装置。产生管腔中的人造形状用于消除流动干扰中的至少一种，并增强通过治疗部位的流体流动的方面。

4. 发明公开

EP2145608A1 Stent for improved blood flow 有权转让
标题翻译：支架动物desserten Blutfluss
公开(公告)号：EP2145608A1
公开(公告)日：2010-01-20
申请号：EP09005594.8
申请日：2002-03-13
申请人： Richter, Yoram , Edelman, Elazer
发明人： Richter, Yoram , Edelman, Elazer
IPC分类号： A61F2/86 , A61F2/84
CPC分类号： A61F2/90 , A61F2/06 , A61F2/86 , A61F2/958 , A61F2002/068 , A61F2230/0006 , A61F2250/0039 , A61M25/1002
摘要： A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site.
摘要翻译：一种在管腔中产生更有利的流动状态的方法和装置。产生管腔中的人造形状用于消除流动干扰中的至少一种，并增强通过治疗部位的流体流动的方面。

5. 发明公开

EP1367963A4 METHOD AND APPARATUS FOR STENTING 有权
标题翻译： VERFAHREN UNDGERÄTFÜRDIE STENTABLAGE
公开(公告)号：EP1367963A4
公开(公告)日：2007-06-20
申请号：EP02721371
申请日：2002-03-13
申请人： RICHTER YORAM , EDELMAN ELAZER
发明人： RICHTER YORAM , EDELMAN ELAZER
IPC分类号： A61F2/00 , A61F2/06 , A61F2/86
CPC分类号： A61F2/90 , A61F2/06 , A61F2/86 , A61F2/958 , A61F2002/068 , A61F2230/0006 , A61F2250/0039 , A61M25/1002

6. 发明申请

WO2011086401A1 SELF-ASSEMBLING MODULAR PERCUTANEOUS VALVE AND METHODS OF FOLDING, ASSEMBLY AND DELIVERY 审中-公开
标题翻译：自组装模块式阀门及折叠，组装和运输方法
公开(公告)号：WO2011086401A1
公开(公告)日：2011-07-21
申请号：PCT/IB2010/000049
申请日：2010-01-13
申请人： VALVE MEDICAL LTD , RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
发明人： RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A61F2/24 , A61F2/2406 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/844 , A61F2210/0014 , A61F2230/0091 , A61F2250/006
摘要： The present invention provides a modular prosthetic valve device designed as two or more device modules that may be delivered to a body lumen unassembled and then assembled into the assembled valve device in the body at least in part using a self-assembly member at or near the site of valve implantation. The device modules may include a support structure and a valve module. The valve module may be delivered in an unassembled, folded delivery configuration, and unfolded and assembled into a working configuration via the self-assembly member. In its unassembled form, the valve module may be a single-piece leaflets substructure or a plurality of valve sections. The self-assembly member has a delivery configuration and a preset configuration, and may be triggered to revert to the preset configuration to assemble the valve module. The modular valve device may be folded in a manner not possible with current valve devices, for example, by rolling the unassembled valve module along its circumferential axis in the direction of its height, so that the diameter of the folded valve module may be equivalent to that of one rolled leaflet. This feature of the invention provides a percutaneous valve device having a smaller delivery diameter than pre-assembled valve devices. This in turn permits use of a delivery device of reduced diameter and increases the flexibility of the loaded delivery device compared to percutaneous valve devices in the art. The invention further provides a system for and method of folding and delivering such a modular valve device and assembling it using the self-assembly member, preferably in the body.
摘要翻译：本发明提供了一种设计为两个或更多个装置模块的模块化假体瓣膜装置，其可以被输送到未被组装的身体腔体，然后至少部分地使用位于或靠近该组件的自组装构件瓣膜植入部位。装置模块可以包括支撑结构和阀模块。阀模块可以以未组装的折叠输送构造递送，并且经由自组装构件展开并组装成工作构型。在其组装形式中，阀模块可以是单件式叶片子结构或多个阀部分。自组装构件具有输送配置和预设配置，并且可以被触发以恢复到预设配置以组装阀模块。模块化阀装置可以以当前阀装置不可能的方式进行折叠，例如通过沿着其周向轴线在其高度方向上滚动未组装的阀模块，使得折叠的阀模块的直径可以等于一个滚动的小叶。本发明的该特征提供了一种具有比预组装阀装置更小的输送直径的经皮瓣膜装置。这又允许使用减小直径的输送装置，并且与本领域中的经皮瓣膜装置相比增加了装载的输送装置的灵活性。本发明还提供了一种用于折叠和传送这种模块化阀装置的系统和方法，并且使用自组装构件优选地在身体中组装它。

7. 发明申请

WO2005002545A8 METHOD OF TREATING ACUTE CORONARY SYNDROMES 审中-公开
标题翻译：治疗急性冠状动脉综合征的方法
公开(公告)号：WO2005002545A8
公开(公告)日：2006-02-16
申请号：PCT/US2004020487
申请日：2004-06-24
申请人： BIOREST LTD , RICHTER YORAM , EDELMAN ELAZER R , GOLOMB GERSHON , DANENBERG HAIM D
发明人： EDELMAN ELAZER R , GOLOMB GERSHON , DANENBERG HAIM D
IPC分类号： A61K31/663 , A61K9/127
CPC分类号： A61K31/663
摘要： The present invention relates to methods and compositions designed for the treatment or management of acute coronary syndromes, particularly, unstable angina and acute myocardial infarction. The methods of the invention comprise the administration of an effective amount of a formulation containing one or more therapeutic agents which specifically decreases or inhibits the activity of phagocytic cells and/or eliminates or diminishes the amount of phagocytic cells including, but not limited to, macrophages and monocytes. The formulations are specifically targeted to phagocytic cells. The invention also provides pharmaceutical compositions of formulations containing one or more therapeutic agents of the invention for administration to subjects currently suffering from or having recently suffered an acture coronary syndrome such as unstable angina and acute myocardial infarction.
摘要翻译：本发明涉及设计用于治疗或治疗急性冠状动脉综合征，特别是不稳定性心绞痛和急性心肌梗塞的方法和组合物。本发明的方法包括施用有效量的含有一种或多种治疗剂的制剂，其特异性降低或抑制吞噬细胞的活性和/或消除或减少吞噬细胞的量，包括但不限于巨噬细胞和单核细胞。制剂专门针对吞噬细胞。本发明还提供了含有本发明的一种或多种治疗剂的制剂的药物组合物，用于给予目前患有或最近患有冠状动脉综合征如不稳定型心绞痛和急性心肌梗死的受试者。

8. 发明申请

WO2010079426A1 METHOD AND APPARATUS FOR FINE ADJUSTMENT OF A PERCUTANEOUS VALVE STRUCTURE 审中-公开
标题翻译：精密调节阀门结构的方法和装置
公开(公告)号：WO2010079426A1
公开(公告)日：2010-07-15
申请号：PCT/IB2010/000051
申请日：2010-01-13
申请人： VALVE MEDICAL LTD , RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
发明人： RICHTER, Yoram , RICHTER, Jacob , WEISZ, Ety
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2427 , A61F2230/0013 , A61F2250/0006 , A61F2250/0008 , A61F2250/006
摘要： The invention provides a device for fine adjustment of a prosthetic valve device and a method of adjusting the position of a prosthetic valve after implantation. The adjustment mechanism includes complementary structures on a valve member and device frame that cooperate to provide relative axial and/or angular motion between the valve member and device frame (and thus the native vessel). The adjustment mechanism of the invention may also include a means for selectively maintaining the relative position of the valve member and device frame. The device and method are particularly applicable for use with a modular prosthetic valve device that is assembled in the body lumen.
摘要翻译：本发明提供了一种用于精细调节假体瓣膜装置的装置和调节植入后假体瓣膜位置的方法。调节机构包括在阀构件和装置框架上的互补结构，其协作以在阀构件和装置框架之间提供相对的轴向和/或角运动（因此也是本机容器）。本发明的调节机构还可以包括用于选择性地保持阀构件和装置框架的相对位置的装置。该装置和方法特别适用于组装在体腔中的模块化的人造瓣膜装置。

9. 发明申请

WO02071975A9 METHOD AND APPARATUS FOR STENTING 审中-公开
标题翻译：方法和装置
公开(公告)号：WO02071975A9
公开(公告)日：2004-01-08
申请号：PCT/US0207529
申请日：2002-03-13
申请人： RICHTER YORAM , EDELMAN ELAZER
发明人： RICHTER YORAM , EDELMAN ELAZER
IPC分类号： A61F2/00 , A61F2/06 , A61F2/86
CPC分类号： A61F2/90 , A61F2/06 , A61F2/86 , A61F2/958 , A61F2002/068 , A61F2230/0006 , A61F2250/0039 , A61M25/1002
摘要： A method and an apparatus to create a more favorable flow regime in a lumen. An artificial shape in the lumen is created to at least one of eliminate flow disturbances and enhance aspects of fluid flow through a treatment site. First stent segment (12), second stent segment (14) and thrid stent segement (16) show a schematic view of the stent envelope or profile.
摘要翻译：一种在管腔中产生更有利的流动状态的方法和装置。产生管腔中的人造形状用于消除流动干扰中的至少一种并增强通过治疗部位的流体流动的方面。第一支架段（12），第二支架段（14）和支架支架（16）示出了支架包膜或轮廓的示意图。

10. 发明申请

WO2014140670A1 LIPOSOME FORMULATION AND MANUFACTURE 审中-公开
标题翻译：药物制剂和制造
公开(公告)号：WO2014140670A1
公开(公告)日：2014-09-18
申请号：PCT/IB2013/000951
申请日：2013-03-14
申请人： BIOREST LTD. , RICHTER, Yoram , ZELIG, Yehuda , ELMALAK, Omar , EYAL, Dror
发明人： RICHTER, Yoram , ZELIG, Yehuda , ELMALAK, Omar , EYAL, Dror
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/1277 , A61K31/663
摘要： The present invention relates to a liposomal formulation containing a therapeutic agent and a process for producing the formulation. The liposomal formulation comprises particular characteristics that enhance uniformity and stability of the formulation. The manufacturing process is a novel process that produces a liposomal formulation of a uniform size with many desirable properties that may be independently controlled. Further, the invention relates to a liposome formulation made in accordance with the manufacturing process.
摘要翻译：本发明涉及含有治疗剂的脂质体制剂及其制备方法。脂质体制剂包含增强制剂的均匀性和稳定性的特定特征。制造过程是产生具有许多可以独立控制的所需性质的具有均匀尺寸的脂质体制剂的新方法。此外，本发明涉及根据制造方法制备的脂质体制剂。

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