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1. 发明申请

WO2007044515A1 AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES 审中-公开
标题翻译： AZETIDINES作为治疗增殖性疾病的MEK抑制剂
公开(公告)号：WO2007044515A1
公开(公告)日：2007-04-19
申请号：PCT/US2006/039126
申请日：2006-10-05
申请人： EXELIXIS, INC. , AAY, Naing , ANAND, Neel Kumar , BOWLES, Owen Joseph , BUSSENIUS, Joerg , COSTANZO, Simona , CURTIS, Jeffry Kimo , DUBENKO, Larisa , JOSHI, Anagha Abhijit , KENNEDY, Abigail R. , KIM, Angie Inyoung , KOLTUN, Elena , MANALO, Jean-Claire Limun , PETO, Csaba J. , RICE, Kenneth D. , TSANG, Tsze H.
发明人： AAY, Naing , ANAND, Neel Kumar , BOWLES, Owen Joseph , BUSSENIUS, Joerg , COSTANZO, Simona , CURTIS, Jeffry Kimo , DUBENKO, Larisa , JOSHI, Anagha Abhijit , KENNEDY, Abigail R. , KIM, Angie Inyoung , KOLTUN, Elena , MANALO, Jean-Claire Limun , PETO, Csaba J. , RICE, Kenneth D. , TSANG, Tsze H.
IPC分类号： C07D205/04 , C07D205/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
CPC分类号： C07D205/04 , C07D205/06 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
摘要翻译：公开了式（I）的化合物及其药学上可接受的盐和溶剂化物。这些化合物是MEK抑制剂，可用于治疗增殖性疾病如癌症。还公开了含有这些化合物的药物组合物以及使用本发明化合物和组合物治疗癌症的方法。

2. 发明申请

WO2010135568A1 BENZOXAZEPINES AS INHIBITORS OF MTOR AND THEIR USE TO TREAT CANCER 审中-公开
标题翻译：苯唑西汀作为MTOR的抑制剂及其用于治疗癌症
公开(公告)号：WO2010135568A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035639
申请日：2010-05-20
申请人： EXELIXIS, INC. , ANAND, Neel, Kumar , BAIK, Tae-Gon , BLAZEY, Charles, M. , BUSSENIUS, Joerg , CURTIS, Jeffry, Kimo , DEFINA, Steven, Charles , DUBENKO, Larisa , HARRIS, Jason, R. , JACKSON-UGUETO, Eileen , JOSHI, Anagha , KIM, Angie, Inyoung , MANALO, Jean-Claire, Limun , PETO, Csaba, J. , RICE, Kenneth, D. , TSANG, Tsze, H.
发明人： ANAND, Neel, Kumar , BAIK, Tae-Gon , BLAZEY, Charles, M. , BUSSENIUS, Joerg , CURTIS, Jeffry, Kimo , DEFINA, Steven, Charles , DUBENKO, Larisa , HARRIS, Jason, R. , JACKSON-UGUETO, Eileen , JOSHI, Anagha , KIM, Angie, Inyoung , MANALO, Jean-Claire, Limun , PETO, Csaba, J. , RICE, Kenneth, D. , TSANG, Tsze, H.
IPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04 , A61K31/553 , A61P35/00
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The invention is directed to inhibitors of mTOR and pharmaceutically acceptable salts or solvates thereof, as well as methods of using them. The inhibitors are generally of structural formula : wherein the combination of R 1 and R 2 are as defined herein, and pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及mTOR及其药学上可接受的盐或溶剂合物的抑制剂，以及使用它们的方法。抑制剂通常具有结构式：其中R 1和R 2的组合如本文所定义，及其药学上可接受的盐。

3. 发明申请

WO2009055077A1 TROPANE COMPOUNDS 审中-公开
标题翻译： TROPANE化合物
公开(公告)号：WO2009055077A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/012221
申请日：2008-10-27
申请人： EXELIXIS, INC. , RICE, Kenneth D. , AAY, Naing , ANAND, Neel Kumar , ARCALAS, Arlyn , BAIK, Tae-Gon , BLAZEY, Charles M. , BOWLES, Owen Joseph , BUHR, Chris A. , BUSSENIUS, Joerg , COSTANZO, Simona , CURTIS, Jeffry Kimo , DEFINA, Steven Charles , DUBENKO, Larisa , KENNEDY, Abigail R. , KIM, Angie Inyoung , LARA, Katherine , MA, Sunghoon , MANALO, Jean-Claire Limun , PETO, Csaba J. , TSANG, Tsze H. , WANG, Longcheng
发明人： RICE, Kenneth D. , AAY, Naing , ANAND, Neel Kumar , ARCALAS, Arlyn , BAIK, Tae-Gon , BLAZEY, Charles M. , BOWLES, Owen Joseph , BUHR, Chris A. , BUSSENIUS, Joerg , COSTANZO, Simona , CURTIS, Jeffry Kimo , DEFINA, Steven Charles , DUBENKO, Larisa , KENNEDY, Abigail R. , KIM, Angie Inyoung , LARA, Katherine , MA, Sunghoon , MANALO, Jean-Claire Limun , PETO, Csaba J. , TSANG, Tsze H. , WANG, Longcheng
IPC分类号： C07D451/02 , A61K31/46 , A61P35/00
CPC分类号： C07D451/02
摘要： A compound according to Formula I or II: (I) or (II) wherein R 1 , R 1b , R 2 , L 1 , and L 2 and L 2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译：根据式I或II的化合物：（I）或（II）其中R1，R1b，R2，L1和L2和L2b如说明书中所定义，其药物组合物及其使用方法。

4. 发明申请

WO2007048064A2 AMINO-PYRIMIDINES AS CASEIN KINASE II (CK2) MODULATORS 审中-公开
标题翻译：氨基嘧啶作为CASEIN KINASE II（CK2）调节剂
公开(公告)号：WO2007048064A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/041501
申请日：2006-10-23
申请人： EXELIXIS, INC. , RICE, Kenneth D. , BLAZEY, Charles M. , EPSHTEYN, Sergey , IBRAHIM, Mohamed Abdulkader , JOHNSON, Henry William Beecroft , KENNEDY, Abigail R. , MANALO, Jean-Claire Limun , PETO, Csaba J.
发明人： RICE, Kenneth D. , BLAZEY, Charles M. , EPSHTEYN, Sergey , IBRAHIM, Mohamed Abdulkader , JOHNSON, Henry William Beecroft , KENNEDY, Abigail R. , MANALO, Jean-Claire Limun , PETO, Csaba J.
CPC分类号： C07D487/04
摘要： A compound having Formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , and Z are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
摘要翻译：具有式（I）的化合物或其药学上可接受的盐，其中R 1，R 2，R 3和Z如上所定义在规范中; 其药物组合物; 及其使用方法。

5. 发明申请

WO2004006846A2 RECEPTOR-TYPE KINASE MODULATORS AND METHODS OF USE 审中-公开
标题翻译：受体型激酶调节剂和使用方法
公开(公告)号：WO2004006846A2
公开(公告)日：2004-01-22
申请号：PCT/US2003/021923
申请日：2003-07-14
申请人： EXELIXIS, INC. , RICE, Kenneth, D. , ANAND, Neel, Kumar , BUSSENIUS, Joerg , COSTANZA, Simona , KENNEDY, Abigail, R. , KIM, Angie, I. , PETO, Csaba, J. , TSANG, Tsze, H. , BLAZEY, Charles, M.
发明人： RICE, Kenneth, D. , ANAND, Neel, Kumar , BUSSENIUS, Joerg , COSTANZA, Simona , KENNEDY, Abigail, R. , KIM, Angie, I. , PETO, Csaba, J. , TSANG, Tsze, H. , BLAZEY, Charles, M.
IPC分类号： A61K
CPC分类号： C07D403/12 , A61K31/517 , A61K31/5377 , A61K31/5383 , A61K31/5513 , A61K31/553 , A61K31/7064 , C07D239/94 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D451/06 , C07D471/04 , C07D487/04 , C07D493/04
摘要： The present invention provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by receptor kinase activity utilizing the compounds and pharmaceutical compositions thereof. Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i.e. tumor growth), programmed cell death ( apoptosis), cell migration and invasion and angiogenesis associated with tumor growth. Compounds of the invention include "spectrum selective" kinase modulators, compounds that inhibit, regulate and/or mo dulate signal transduction across subfamilies of receptor-type tyrosine kinases, including ephrin and EGFR.
摘要翻译：本发明提供了用于调节受体激酶活性的化合物，特别是肝配蛋白和EGFR，以及利用该化合物及其药物组合物治疗由受体激酶活性介导的疾病的方法。受体激酶活性介导的疾病包括但不限于部分表现为异常细胞增殖水平（即肿瘤生长），程序性细胞死亡（凋亡），细胞迁移和侵袭以及与肿瘤生长有关的血管生成的疾病。本发明的化合物包括“光谱选择性” 激酶调节剂，抑制，调节和/或调节跨受体型酪氨酸激酶（包括肝配蛋白和EGFR）亚家族的信号转导的化合物。

6. 发明申请

WO2003093297A3 PROTEIN KINASE MODULATORS AND METHODS OF USE 审中-公开
公开(公告)号：WO2003093297A3
公开(公告)日：2003-11-13
申请号：PCT/US2003/013869
申请日：2003-05-02
申请人： EXELIXIS, INC. , BUHR, Chris, A. , BAIK, Tae-Gon , MA, Sunghoon , TESFAI, Zerom , WANG, Longcheng , CO, Erick, Wang , EPSHTEYN, Sergey , KENNEDY, Abigail, R. , CHEN, Baili , DUBENKO, Larisa , ANAND, Neel Kumar , TSANG, Tsze, H. , NUSS, John, M. , PETO, Csaba, J. , RICE, Kenneth, D. , IBRAHIM, Mohamed, Abdulkader , SCHNEPP, Kevin, Luke , SHI, Xian , LEAHY, James, William , CHEN, Jeff , DALRYMPLE, Lisa, Esther , FORSYTH, Thimothy, Patrick , HUYNH, Tai, Phat , MANN, Grace , MANN, Lary, Wayne , TAKEUCHI, Craig, Stacy
发明人： BUHR, Chris, A. , BAIK, Tae-Gon , MA, Sunghoon , TESFAI, Zerom , WANG, Longcheng , CO, Erick, Wang , EPSHTEYN, Sergey , KENNEDY, Abigail, R. , CHEN, Baili , DUBENKO, Larisa , ANAND, Neel Kumar , TSANG, Tsze, H. , NUSS, John, M. , PETO, Csaba, J. , RICE, Kenneth, D. , IBRAHIM, Mohamed, Abdulkader , SCHNEPP, Kevin, Luke , SHI, Xian , LEAHY, James, William , CHEN, Jeff , DALRYMPLE, Lisa, Esther , FORSYTH, Thimothy, Patrick , HUYNH, Tai, Phat , MANN, Grace , MANN, Lary, Wayne , TAKEUCHI, Craig, Stacy
IPC分类号： A61K31/4965
摘要： This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.

7. 发明申请

WO1998045275A1 COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH SERINE PROTEASE, PARTICULARLY TRYPTASE, ACTIVITY 审中-公开
标题翻译：用于治疗与丝氨酸蛋白酶，特异性TRYPTASE，活性相关的疾病的化合物和组合物
公开(公告)号：WO1998045275A1
公开(公告)日：1998-10-15
申请号：PCT/US1997021849
申请日：1997-12-01
申请人： AXYS PHARMACEUTICALS CORPORATION , CHURCH, Timothy, J. , CUTSHALL, Neil, Scott , GANGLOFF, Anthony, R. , JENKINS, Thomas, E. , LINSELL, Martin, S. , LITVAK, Joane , RICE, Kenneth, D. , SPENCER, Jeffrey, R. , WANG, Vivian, R.
发明人： AXYS PHARMACEUTICALS CORPORATION
IPC分类号： C07D235/20
CPC分类号： C07D231/12 , C07D233/56 , C07D235/20 , C07D249/08 , C07D401/14 , C07D403/14 , C07D413/06 , C07D413/14 , C07D471/04 , C07F7/0812
摘要： Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. A preferred aspect of the invention are compounds of Formula (II) in which: the dashed lines independently represent optional bonds; each R independently is (C1-6)alkyl, (C1-6)alkyloxy, halo or hydroxy; each R independently is (C1-6)alkyl, (C1-6)alkyloxy, halo or hydroxy; X is -C(O)- or -CR R -, X is -CH(R )n1- or -C(R )n1=, wherein R is amino(N1-4)azolidinyl, amino(N1-4)azolyl, (N1-4)azolidinyl, (N1-4)azolyl, -NHC(NH)NR R , -C(NR )R , -C(NH)NHR , -C(NH)NR R or -(CR R )yNH2, or X is -N= or -NH(R )n1-, wherein R is -C(NR )R , -C(NH)NHR or -C(NH)NR R , wherein each R independently is hydrogen or (C1-6)alkyl and each R independently is (C1-6)alkyl; and X is -CH(R )- or -C(R )=, wherein R is -R , -OR , -N(R )R , -SR , -S(O)R , -S(O)2R , -S(O)2OR , -S(O)2N(R )R , -N(R )S(O)2R , -C(O)R , -C(O)OR , -C(O)N(R )R , -N(R )C(O)R , -OC(O)N(R )R , -N(R )C(O)OR , -(CH2)n4N(R )C(O)N(R )R , -OP(O)(OR )OR or -C(O)N(R )CH(COOH)R , or X is -N= or -N(R )-, wherein R is -C(O)R , -C(O)OR , -C(O)N(R )R , -OC(O)N(R )R or -C(O)N(R )CH(COOH)R , wherein R , R and R are as defined in the Summary of the Invention; R is hydrogen or (C1-4)alkyl, R is hydrogen or (C1-4) alkyl, which alkyl optionally is substituted with one to two substituents independently selected from (C1-4)alkyloxy, hydroxy and sulfo, R is hydrogen or methyl and R is hydrogen, methyl or hydroxy. The compounds, compositions and methods are effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis, as well as other types of immunomediated inflammatory disorders, such as rheumatoid arthritis, conjunctivitis and inflammatory bowel disease, various dermatological conditions, as well as certain viral conditions. The compounds comprise potent and selective inhibitors of the mast cell protease tryptase. The compositions for treating these conditions include oral, inhalant, topical and parenteral preparations as well as devices comprising such preparations.
摘要翻译：描述了有效预防和治疗肥大细胞介导的炎症性疾病的新型化合物，组合物和方法。本发明的优选方面是式（II）的化合物，其中：虚线独立地表示任选的键; 每个R 2独立地为（C 1-6）烷基，（C 1-6）烷氧基，卤素或羟基; 每个R 3独立地为（C 1-6）烷基，（C 1-6）烷氧基，卤素或羟基; X 3为-C（O） - 或-CR 7 R 8 - ，X 8为-CH（R 1）n1或-C（R 1）n1 = 其中R 1是氨基（N1-4）唑烷基，氨基（N1-4）唑基，（N1-4）唑烷基，（N1-4）唑基，-NHC（NH）NR9R9， -C（NR 9）R 9，-C（NH）NHR 10，-C（NH）NR 10 R 10或 - （CR 11 R 11）y NH 2，或X 8是-N =或-NH（R 1）n1-，其中R 1是-C（NR 9）R 9，-C（NH）NHR 10或 -C（NH）NR 10 R 10，其中每个R 9独立地是氢或（C 1-6）烷基，每个R 10独立地是（C 1-6）烷基; 并且X 9为-CH（R 4） - 或-C（R 4）=，其中R 4为-R 12，-OR 12，-N（R 13））R 12，-SR 12，-S（O）R 12，-S（O）2 R 12，-S（O）2OR 12，-S（O）2 N（ R 13），-N（R 13）S（O）2 R 12，-C（O）R 12，-C（O）OR 12，-C（ O）N（R 13）R 12，-N（R 13）C（O）R 12，-OC（O）N（R 13）R 12，-N （R 13）C（O）OR 12， - （CH 2）n 4 N（R 13）C（O）N（R 13）R 12，-OP（O） 13）或OR 12或-C（O）N（R 14）CH（COOH）R 12或X 9是-N =或-N（R 4） - ，其中 R 4是-C（O）R 12，-C（O）OR 12，-C（O）N（R 13）R 12，-OC（O） R 12或-C（O）N（R 14）CH（COOH）R 12，其中R 12，R 13和R 14如发明概述; R 5为氢或（C 1-4）烷基，R 6为氢或（C 1-4）烷基，该烷基任选被一至两个独立地选自（C 1-4）烷氧基，羟基和磺基，R 7是氢或甲基，R 8是氢，甲基或羟基。化合物，组合物和方法对于预防和治疗与呼吸道相关的炎性疾病如哮喘和过敏性鼻炎以及其它类型的免疫性炎症性疾病如类风湿性关节炎，结膜炎和炎性肠病是有效的，各种皮肤病学条件，以及某些病毒状况。这些化合物包括肥大细胞蛋白酶类胰蛋白酶的有效和选择性抑制剂。用于治疗这些病症的组合物包括口服，吸入，局部和肠胃外制剂以及包含这些制剂的装置。

8. 发明申请

WO2010135524A1 BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES 审中-公开
标题翻译：基于BENZOXAZEPINES的P13K / MT0R抑制剂对抗增殖性疾病
公开(公告)号：WO2010135524A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035565
申请日：2010-05-20
申请人： EXELIXIS, INC. , ANAND, Neel, Kumar , BLAZEY, Charles, M. , BOWLES, Owen, Joseph , BUHR, Chris, Allen , BUSSENIUS, Joerg , CURTIS, Jeffry, Kimo , DEFINA, Steven, Charles , DUBENKO, Larisa , HARRIS, Jason, R. , JACKSON-UGUETO, Eileen , JOSHI, Anagha , KIM, Angie, Inyoung , TSUHAKI, Amy, Lew , MA, Sunghoon , MANALO, Jean-claire, Limun , NG, Stephanie , PETO, Csaba, J. , RICE Kenneth D. , TSANG, Tsze, H. , ZAHARIA, Cristiana, A.
发明人： ANAND, Neel, Kumar , BLAZEY, Charles, M. , BOWLES, Owen, Joseph , BUHR, Chris, Allen , BUSSENIUS, Joerg , CURTIS, Jeffry, Kimo , DEFINA, Steven, Charles , DUBENKO, Larisa , HARRIS, Jason, R. , JACKSON-UGUETO, Eileen , JOSHI, Anagha , KIM, Angie, Inyoung , TSUHAKI, Amy, Lew , MA, Sunghoon , MANALO, Jean-claire, Limun , NG, Stephanie , PETO, Csaba, J. , RICE Kenneth D. , TSANG, Tsze, H. , ZAHARIA, Cristiana, A.
IPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/08 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00 , A61P35/00 , A61K31/553
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/08 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： The invention is directed to compounds of formula (I), and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。

9. 发明申请

WO2007048066A3 PYRAZOLO-PYRIMIDINES AS CASEIN KINASE II (CK2) MODULATORS 审中-公开
标题翻译：吡唑并嘧啶作为酪蛋白激酶II（CK2）调节剂
公开(公告)号：WO2007048066A3
公开(公告)日：2007-06-28
申请号：PCT/US2006041506
申请日：2006-10-23
申请人： EXELIXIS INC , RICE KENNETH D , BUSSENIUS JOERG , COSTANZO SIMONA , KENNEDY ABIGAIL R , KIM ANGIE INYOUNG , MANALO JEAN-CLAIRE LIMUN , PETO CSABA J
发明人： RICE KENNETH D , BUSSENIUS JOERG , COSTANZO SIMONA , KENNEDY ABIGAIL R , KIM ANGIE INYOUNG , MANALO JEAN-CLAIRE LIMUN , PETO CSABA J
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： A compound according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 6 , R 7 and Z are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
摘要翻译：根据式（I）的化合物或其药学上可接受的盐，其中R 1，R 2，R 6，R 5， 7和Z如说明书中所定义; 其药物组合物; 及其使用方法。

10. 发明申请

WO2007048066A2 PYRAZOLO-PYRIMIDINES AS CASEIN KINASE II (CK2) MODULATORS 审中-公开
标题翻译：作为CASEIN KINASE II（CK2）调节剂的吡唑并吡啶
公开(公告)号：WO2007048066A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/041506
申请日：2006-10-23
申请人： EXELIXIS, INC. , RICE, Kenneth D. , BUSSENIUS, Joerg , COSTANZO, Simona , KENNEDY, Abigail R. , KIM, Angie Inyoung , MANALO, Jean-Claire Limun , PETO, Csaba J.
发明人： RICE, Kenneth D. , BUSSENIUS, Joerg , COSTANZO, Simona , KENNEDY, Abigail R. , KIM, Angie Inyoung , MANALO, Jean-Claire Limun , PETO, Csaba J.
CPC分类号： C07D487/04
摘要： A compound according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 6 , R 7 and Z are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.
摘要翻译：根据式（I）的化合物或其药学上可接受的盐，其中R 1，R 2，R 6，R 6， 7和Z如说明书中所定义; 其药物组合物; 及其使用方法。

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