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1. 发明申请

WO1996033162A1 COMPOUNDS CONTAINING A SUBSTANTIALLY PLANAR, FUSED RING SYSTEM WITH AT LEAST 4 AROMATIC RINGS AND THEIR USE AS A CHIRAL STATIONARY PHASE IN ENANTIOMERIC SEPARATION 审中-公开
标题翻译：含有大量平面的化合物，具有至少4个芳香环的熔融环系统，以及作为固体分离中的手持式相的用途
公开(公告)号：WO1996033162A1
公开(公告)日：1996-10-24
申请号：PCT/GB1996000966
申请日：1996-04-22
申请人： RHONE-POULENC LIMITED , LIFE SCIENCE INTERNATIONAL (EUROPE) LIMITED , RAMAGE, Robert , KNOX, John, Henderson , RADISSON, Xavier , DUTTON, Jonathan, Keith
发明人： RHONE-POULENC LIMITED , LIFE SCIENCE INTERNATIONAL (EUROPE) LIMITED
IPC分类号： C07C237/22
CPC分类号： C07K5/0606 , C07C211/31 , C07C235/06 , C07C237/06 , C07C271/28 , C07C2603/54 , C07K5/0215 , C07K5/06026 , C07K5/06086 , C07K9/008
摘要： Compounds of the formula: Ar-L-(*)m in which Ar represents a substantially planar, fused ring system which contains at least 4 aromatic rings and which is of formula (I) wherein: n is 0 or 1; 0 means that the surrounding ring is aromatic when n is 1 and non-aromatic when n is 0; p is 0 or 1; and p is 0 when n is 0; R1 and R2, on the one hand, and R3 and R4, on the other hand, are chosen so that each forms a fused aromatic ring system together with the carbon atoms to which they are attached; R' is an alkyl group or hydrogen; and R5 is a group which, together with the atoms to which it is attached, forms one or more supplementary rings; L is a stable chain having at least two atoms in which the atoms are independently selected from carbon, oxygen, sulphur, nitrogen and phosphorus, where appropriate the chain atoms being optionally substituted by one or more C1-6 alkyl groups which may be the same or different, one or more chain atoms forming part of one or more aromatic or heteroaromatic groups and where a carbon is adjacent to a nitrogen atom the carbon atom being optionally substituted by an oxygen atom; and * is a radical with at least one chiral centre; and m is 1, 2 or 3; with the proviso that when * is a peptide or naturally occuring amino acid then the two chain atoms nearest the group Ar are carbon atoms. Kits for separating enantiomers comprising them; and processes for the separation of enantiomers using them are disclosed.
摘要翻译：其中Ar表示包含至少4个芳环并且具有式（I）的基本上平面的稠环体系，其中：n为0或1; 0表示当n为1时环绕芳环，n为0时为芳香族; p为0或1; 当n为0时，p为0; 另一方面，R1和R2一方面选择R3和R4，使得它们各自与它们所连接的碳原子一起形成稠合芳族环系统; R'是烷基或氢; 并且R 5是与其连接的原子一起形成一个或多个辅助环的基团; L是具有至少两个原子的稳定链，其中原子独立地选自碳，氧，硫，氮和磷，在适当的情况下，链原子任选地被一个或多个可以相同的C 1-6烷基取代或不同的一个或多个链原子形成一个或多个芳族或杂芳族基团的一部分，并且其中碳与氮原子相邻，碳原子任选被氧原子取代; 和*是至少有一个手性中心的激进的; m为1,2或3; 条件是当*是肽或天然存在的氨基酸时，最接近基团Ar的两个链原子是碳原子。用于分离包含它们的对映异构体的试剂盒; 并且公开了使用它们分离对映异构体的方法。

3. 发明公开

EP0369637A3 Sulfonamide resistance genes and their use 失效
标题翻译：磺胺抗性基因及其使用
公开(公告)号：EP0369637A3
公开(公告)日：1991-02-27
申请号：EP89311269.8
申请日：1989-10-31
申请人： ADVANCED TECHNOLOGIES (CAMBRIDGE) LIMITED , AGRICULTURAL GENETICS COMPANY LIMITED , BioTal Limited , BP NUTRITION LIMITED , CIBA-GEIGY PLC , ZENECA LIMITED , RHONE-POULENC LIMITED , AgrEvo UK Limited , NICKERSON BIOCEM LIMITED , TWYFORD SEEDS LIMITED , UNILEVER U.K. CENTRAL RESOURCES LIMITED
发明人： Guerineau, Jean François , Mullineaux, Philip Mark , Parnell, Edgar William
IPC分类号： C12N15/31 , C12N15/62 , C12N15/84 , A01H1/00
CPC分类号： C12N9/1085 , A01H1/00 , C07K2319/00 , C12N15/8274
摘要： Plant cells are transformed by:
(i) transforming a plant cell whose growth is sensitive to inhibition by a sulfonamide or a salt thereof with a chimaeric gene comprising (a) a plant promoter, (b) a sulfonamide resistance gene having a sequence encoding a transit peptide fused to the 5′-end of the resistance gene and (c) a plant polyadenylation/terminator sequence; (ii) selecting a transformed plant cell whose growth is resistant to inhibition by a sulfonamide or salt thereof; (iii) optionally, regenerating from the transformed plant cell a genetically transformed plant which exhibit the said resistance; (iv) optionally, obtaining seed from the regenerated plant; and (v) optionally, propagating plants from the seed. The growth of weeds can be controlled at a locus where a transgenic plant obtained as above is being cultivated by applying to the locus an effective amount of a herbicide, such as asulam, which acts by inhibiting dihydropteroate synthase. The sulfonamide resistance gene can be also used as a selectable marker. The sequence of a Sulfonamide resistance gene is presented.

4. 发明公开

EP0369637A2 Sulfonamide resistance genes and their use 失效
标题翻译：磺酰胺抗生素和我的Verwendung。
公开(公告)号：EP0369637A2
公开(公告)日：1990-05-23
申请号：EP89311269.8
申请日：1989-10-31
申请人： ADVANCED TECHNOLOGIES (CAMBRIDGE) LIMITED , AGRICULTURAL GENETICS COMPANY LIMITED , BioTal Limited , BP NUTRITION LIMITED , CIBA-GEIGY PLC , ZENECA LIMITED , RHONE-POULENC LIMITED , AgrEvo UK Limited , NICKERSON BIOCEM LIMITED , TWYFORD SEEDS LIMITED , UNILEVER U.K. CENTRAL RESOURCES LIMITED
发明人： Guerineau, Jean François , Mullineaux, Philip Mark , Parnell, Edgar William
IPC分类号： C12N15/31 , C12N15/62 , C12N15/84 , A01H1/00
CPC分类号： C12N9/1085 , A01H1/00 , C07K2319/00 , C12N15/8274
摘要： Plant cells are transformed by:

(i) transforming a plant cell whose growth is sensitive to inhibition by a sulfonamide or a salt thereof with a chimaeric gene comprising (a) a plant promoter, (b) a sulfonamide resistance gene having a sequence encoding a transit peptide fused to the 5′-end of the resistance gene and (c) a plant polyadenylation/terminator sequence;
(ii) selecting a transformed plant cell whose growth is resistant to inhibition by a sulfonamide or salt thereof;
(iii) optionally, regenerating from the transformed plant cell a genetically transformed plant which exhibit the said resistance;
(iv) optionally, obtaining seed from the regenerated plant; and
(v) optionally, propagating plants from the seed.

The growth of weeds can be controlled at a locus where a transgenic plant obtained as above is being cultivated by applying to the locus an effective amount of a herbicide, such as asulam, which acts by inhibiting dihydropteroate synthase. The sulfonamide resistance gene can be also used as a selectable marker. The sequence of a Sulfonamide resistance gene is presented.
摘要翻译：通过以下方式转化植物细胞：（i）用嵌合基因转化生长对磺酰胺或其盐的抑制敏感的植物细胞，所述嵌合基因包含（a）植物启动子，（b）磺酰胺抗性基因，其具有编码与抗性基因的5分钟融合的转运肽和（c）植物多腺苷酸化/终止子序列; （ii）选择生长受磺胺或其盐抑制作用的转化植物细胞; （iii）任选地，从转化的植物细胞再生表现出所述抗性的遗传转化植物; （iv）任选地，从再生植物获得种子; 和（v）任选地，从种子繁殖植物。杂草的生长可以通过将有效量的除草剂（如asulam）施用于通过抑制二氢异戊酸合酶起作用的场所来控制如上培养的转基因植物。磺酰胺抗性基因也可以用作选择标记。提出了磺酰胺抗性基因的序列。

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