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1. 发明申请

WO2003104932A3 EVOLUTIONARY ALGORITHM FOR ION CHANNELS 审中-公开
公开(公告)号：WO2003104932A3
公开(公告)日：2003-12-18
申请号：PCT/US2003/017923
申请日：2003-06-06
申请人： EVOLVED DEVICES, LLC , RHODES, Paul, A.
发明人： RHODES, Paul, A.
IPC分类号： G01N31/00
摘要： A method of using experimental data determines the structure and voltage dependence of transition rates for states in models of ion channels.

2. 发明申请

WO2011082178A1 FET - BASED NANOTUBE SENSOR ARRAY 审中-公开
标题翻译：基于FET的纳米管传感器阵列
公开(公告)号：WO2011082178A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/062254
申请日：2010-12-28
申请人： NANOSENSE INC. , RHODES, Paul A. , KHAMIS, Samuel M.
发明人： RHODES, Paul A. , KHAMIS, Samuel M.
IPC分类号： G01N27/414 , G01N33/543 , C12Q1/68 , G01M3/00
CPC分类号： G01N33/0031 , B82Y15/00 , G01M3/20 , G01N27/4141 , G01N27/4145 , G01N27/4146 , G01N27/4148 , G01N33/0047 , G01N33/54373 , H01L27/283 , H01L29/786 , H01L51/0049 , H01L51/0558
摘要： Devices, methods and systems to selectively detect the binding of a molecular species to a biomolecule. In its olfactory sensing application, the hybrid sensor arrays of the present invention provide a high dimensional signature of odorants present that is also readily reversible, together enabling the identification and localization of a source analyte in the presence of the background odorant landscape inherent in a real -world setting.
摘要翻译：用于选择性地检测分子物质与生物分子的结合的装置，方法和系统。在其嗅觉感测应用中，本发明的混合传感器阵列提供了存在的气味剂的高维特征，其也容易可逆，一起使得能够在真实的固有的背景气味景观的存在下识别和定位源分析物世界设置。

3. 发明申请

WO2003104932A2 EVOLUTIONARY ALGORITHM FOR ION CHANNELS 审中-公开
标题翻译：离子通道的演化算法
公开(公告)号：WO2003104932A2
公开(公告)日：2003-12-18
申请号：PCT/US2003/017923
申请日：2003-06-06
申请人： EVOLVED DEVICES, LLC , RHODES, Paul, A.
发明人： RHODES, Paul, A.
IPC分类号： G06F
CPC分类号： C07K14/705
摘要： A method of using experimental data determines the structure and voltage dependence of transition rates for states in models of ion channels.
摘要翻译：使用实验数据的方法确定离子通道模型中状态的转变速率的结构和电压依赖性。

4. 发明申请

WO2015069936A3 CANCER URINE TEST 审中-公开
标题翻译：癌症尿液测试
公开(公告)号：WO2015069936A3
公开(公告)日：2015-06-25
申请号：PCT/US2014064409
申请日：2014-11-06
申请人： MARTINO RAYMOND ANTHONY , LIM SUNG HYUN , RHODES PAUL A
发明人： MARTINO RAYMOND ANTHONY , LIM SUNG HYUN , RHODES PAUL A
IPC分类号： G01N33/493 , G01N33/52
CPC分类号： G01N33/57488 , G01N33/574 , G01N33/57423
摘要： A urine test for diagnosing lung cancer has been developed that uses an artificial nose such as a colorimetric sensor arrays to identify metabolic profiles in urine headspace gas. Cancer cells excrete unique compounds that are a byproduct of their metabolism. The compounds are excreted through a patient's endocrine system by filtration through the kidneys and other organs and are ultimately excreted through the urine. Some of these cancer cell by-products excrete in the urine are small volatile organic compounds (VOCs). Once the urine has exited the body, these VOCs may be outgassed to the environment. Experimental research has determined that a colorimetric sensor array as disclosed is capable of reliably identifying patients with lung cancer based after exposure to the VOCs of the urine headspace gas.
摘要翻译：已经开发了用于诊断肺癌的尿液测试，其使用诸如比色传感器阵列的人造鼻子来识别尿液顶空气体中的代谢谱。癌细胞分泌独特的化合物，它们是新陈代谢的副产物。化合物通过患者的内分泌系统通过肾脏和其他器官过滤排出体外，最终通过尿液排出体外。在尿液中排泄的这些癌细胞副产物中的一些是小的挥发性有机化合物（VOC）。一旦尿液排出体外，这些VOCs可能会排出到环境中。实验研究已经确定，所公开的比色传感器阵列能够在暴露于尿液顶空气体的VOC之后可靠地识别患有肺癌的患者。

5. 发明申请

WO2008115850A3 GENERATING SIMULATED NEURAL CIRCUITS 审中-公开
标题翻译：生成模拟的神经电路
公开(公告)号：WO2008115850A3
公开(公告)日：2008-11-06
申请号：PCT/US2008057197
申请日：2008-03-17
申请人： RHODES PAUL A , TABA BRIAN SEISHO
发明人： RHODES PAUL A , TABA BRIAN SEISHO
IPC分类号： G06G7/00
CPC分类号： G06N3/10
摘要： A first array of simulated neurons having trees of output branches and a second array of simulated neurons having trees of input branches are generated. Thereafter, the output branches of one or more of the simulated neurons of the first array and the input branches of one or more of the simulated neurons of the second array are grown and connections are formed between individual output branches of the simulated neurons of the first array and individual input branches of the simulated neurons of the second array. Connections between output branches and input branches may be stabilized, destabilized, and/or dissolved based on activity in the arrays of simulated neurons. In addition, the arrays of simulated neurons may be grown and wired together in a voxel space.
摘要翻译：生成具有输出分支树的第一模拟神经元阵列和具有输入分支树的第二模拟神经元阵列。之后，生长第一阵列的一个或多个模拟神经元的输出分支和第二阵列的一个或多个模拟神经元的输入分支，并且在第一阵列的模拟神经元的各个输出分支之间形成连接阵列和第二阵列的模拟神经元的单独输入分支。输出分支和输入分支之间的连接可以基于模拟神经元阵列中的活动而被稳定，不稳定和/或溶解。另外，模拟神经元的阵列可以在体素空间中生长和连接在一起。

6. 发明申请

WO2003042766A1 METHOD AND SYSTEM FOR ORTHOGONALIZING INPUT SIGNALS 审中-公开
标题翻译：用于正交信号输入信号的方法和系统
公开(公告)号：WO2003042766A1
公开(公告)日：2003-05-22
申请号：PCT/US2002/036209
申请日：2002-11-13
申请人： THINKING MACHINES, LLC , RHODES, Paul, A.
发明人： RHODES, Paul, A.
IPC分类号： G05B13/02
CPC分类号： G06E3/00 , G06K9/0057 , G06K9/6247
摘要： A method for the orthogonalization of initially overlapping vectors (120), the uses for which include the re-encoding and decoding of representations triggered by sensory arrays.
摘要翻译：一种用于初始重叠向量（120）的正交化的方法，其用途包括由感觉阵列触发的表示的重新编码和解码。

7. 发明申请

WO2015069936A2 CANCER URINE TEST 审中-公开
标题翻译：癌症尿液检测
公开(公告)号：WO2015069936A2
公开(公告)日：2015-05-14
申请号：PCT/US2014/064409
申请日：2014-11-06
申请人： MARTINO, Raymond Anthony , LIM, Sung Hyun , RHODES, Paul A.
发明人： MARTINO, Raymond Anthony , LIM, Sung Hyun , RHODES, Paul A.
CPC分类号： G01N33/57488 , G01N33/574 , G01N33/57423
摘要： A urine test for diagnosing lung cancer has been developed that uses an artificial nose such as a colorimetric sensor arrays to identify metabolic profiles in urine headspace gas. Cancer cells excrete unique compounds that are a byproduct of their metabolism. The compounds are excreted through a patient's endocrine system by filtration through the kidneys and other organs and are ultimately excreted through the urine. Some of these cancer cell by-products excrete in the urine are small volatile organic compounds (VOCs). Once the urine has exited the body, these VOCs may be outgassed to the environment. Experimental research has determined that a colorimetric sensor array as disclosed is capable of reliably identifying patients with lung cancer based after exposure to the VOCs of the urine headspace gas.
摘要翻译：已经开发了用于诊断肺癌的尿液检查，其使用诸如比色传感器阵列的人造鼻来鉴定尿顶空气体中的代谢特征。癌细胞排出作为其代谢副产物的独特化合物。化合物通过患者的内分泌系统通过肾脏和其他器官过滤而排泄，最终通过尿液排泄。这些在尿液中排泄的癌细胞副产物中的一些是挥发性有机化合物（VOC）。一旦尿液已经离开身体，这些挥发性有机物可能会被气化到环境中。实验研究已经确定，所公开的比色传感器阵列能够在暴露于尿顶空气体的VOC之后可靠地识别患有肺癌的患者。

8. 发明申请

WO2008115850A2 GENERATING SIMULATED NEURAL CIRCUITS 审中-公开
标题翻译：产生模拟神经电路
公开(公告)号：WO2008115850A2
公开(公告)日：2008-09-25
申请号：PCT/US2008/057197
申请日：2008-03-17
申请人： RHODES, Paul A. , TABA, Brian Seisho
发明人： RHODES, Paul A. , TABA, Brian Seisho
IPC分类号： G06N3/06
CPC分类号： G06N3/10
摘要： A first array of simulated neurons having trees of output branches and a second array of simulated neurons having trees of input branches are generated. Thereafter, the output branches of one or more of the simulated neurons of the first array and the input branches of one or more of the simulated neurons of the second array are grown and connections are formed between individual output branches of the simulated neurons of the first array and individual input branches of the simulated neurons of the second array. Connections between output branches and input branches may be stabilized, destabilized, and/or dissolved based on activity in the arrays of simulated neurons. In addition, the arrays of simulated neurons may be grown and wired together in a voxel space.
摘要翻译：产生具有输出分支树的模拟神经元的第一阵列和具有输入分支树的模拟神经元的第二阵列。此后，生长第一阵列的一个或多个模拟神经元的输出分支和第二阵列的一个或多个模拟神经元的输入分支，并且在第一阵列的模拟神经元的各个输出分支之间形成连接阵列和第二阵列的模拟神经元的单独输入分支。输出分支和输入分支之间的连接可以基于模拟神经元阵列中的活性而稳定，不稳定和/或溶解。此外，模拟神经元的阵列可以在体素空间中生长和连接在一起。

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