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1. 发明申请

WO2005039625A1 GROWTH HORMONE SECRETAGOGUE RECEPTOR AGONISTS 审中-公开
标题翻译：生长激素秘密吸收激素
公开(公告)号：WO2005039625A1
公开(公告)日：2005-05-06
申请号：PCT/DK2004/000717
申请日：2004-10-19
申请人： RHEOSCIENCE A/S , LARSEN, Philip, Just
发明人： LARSEN, Philip, Just
IPC分类号： A61K38/25
CPC分类号： A61K45/06 , A61K38/27 , A61K2300/00
摘要： The present invention relates to growth hormone secretagogue (GHS) receptor agonists. In particular, the present invention relates to novel therapeutic uses of GHS receptor agonists. The novel applications of GHS receptor agonists relate to thermic control of body temperature which has proven to be beneficial in a number of pathologic conditions.
摘要翻译：本发明涉及生长激素促分泌素（GHS）受体激动剂。特别地，本发明涉及GHS受体激动剂的新型治疗用途。 GHS受体激动剂的新应用涉及体温的热控制，这已被证明在许多病理状况下是有益的。

2. 发明公开

EP1718671A2 PEPTIDE YY ANALOGUES 审中-公开
标题翻译： PEPTID-YY-ANALOGA
公开(公告)号：EP1718671A2
公开(公告)日：2006-11-08
申请号：EP05715468.4
申请日：2005-02-23
申请人： Rheoscience A/S
发明人： LARSEN, Bjarne, Due , HANSEN, Lars, Bo, Laurenborg
IPC分类号： C07K14/575 , A61K38/22
CPC分类号： C07K14/575 , A61K38/00
摘要： Analogues of the peptide PYY (1-36) are described in which the tertiary structure of the peptide is preserved and stabilised particularly to enhance binding and activation of the Y2 receptor by the use of cross links or rigid bends in the peptide to constrain conformationally the positions of the N-terminal part of the peptide sequence and amino acid 34. The analogues are useful in the control of food intake.
摘要翻译：描述肽PYY（1-36）的类似物，其中肽的三级结构被保存和稳定，特别是通过使用肽中的交联或刚性弯曲来增强Y2受体的结合和活化，从而构象地限制肽序列的N-末端部分的位置和氨基酸34.该类似物可用于控制食物摄取。

3. 发明公开

EP1523576A2 METHODS FOR IDENTIFYING GENES RELATED TO MALFUNCTIONS OF THE CENTRAL NERVOUS SYSTEM 审中-公开
标题翻译：方法基因的鉴定与故障中枢神经系统是
公开(公告)号：EP1523576A2
公开(公告)日：2005-04-20
申请号：EP03740117.1
申请日：2003-07-23
申请人： Rheoscience A/S
发明人： LARSEN, Leif, Kongskov , VRANG, Niels , LARSEN, Philip, Just
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention relates to methods for identification of genes related to malfunctions of the central nervous system. In particular the present invention relates to identification of genes that are differentially expressed in hypothalamic subregions. Further aspects of the present invention relates to DNA sequences as well as recombinant polypeptides and uses thereof in prophylaxis, diagnosis and treatment of hypothalamic disorders.
摘要翻译：本发明涉及一种用于相关的中枢神经系统的故障的基因的鉴定方法。特别地，本发明涉及的基因的鉴定差异过表达确实是下丘脑次区域。本发明的进一步的方面涉及DNA序列以及重组多肽和在预防，诊断和治疗下丘脑疾病的用途。

4. 发明公开

EP2512483A2 BALAGLITAZONE COMPOSITIONS AND METHODS 审中-公开
标题翻译： BALAGLITAZONE组合物和方法
公开(公告)号：EP2512483A2
公开(公告)日：2012-10-24
申请号：EP10837126.1
申请日：2010-12-17
申请人： Dr Reddy's Laboratories Limited , Rheoscience A/s
发明人： RIIS, Bente , HENRIKSEN, Kim , KUMAR, Rajinder
IPC分类号： A61K31/517
CPC分类号： A61K31/517 , A61K38/28 , A61K45/06
摘要： Methods for reducing bone loss in a subject suffering from a condition benefiting from a decrease in insulin resistance, by balaglitazone administration to the subject.
摘要翻译：通过对受试者施用balaglitazone来减少患有受益于胰岛素抗性降低的病症的受试者的骨损失的方法。

5. 发明申请

WO2008065624A1 INTERACTION PARTNER OF NEURONATIN PROTEIN AND USES THEREOF 审中-公开
标题翻译：神经元蛋白质的相互合作伙伴及其用途
公开(公告)号：WO2008065624A1
公开(公告)日：2008-06-05
申请号：PCT/IB2007/054827
申请日：2007-11-28
申请人： RHEOSCIENCE A/S , LARSEN, Leif Kongskov , VRANG, Niels , LARSEN, Philip Just
发明人： LARSEN, Leif Kongskov , VRANG, Niels , LARSEN, Philip Just
IPC分类号： A61K38/17 , A61P3/04 , A61P3/10
CPC分类号： A61K38/1709 , C07K14/4702 , G01N33/74 , G01N2800/042 , G01N2800/044
摘要： The present disclosure relates to neuronatin interaction partner, amyloid precursor protein binding protein-2 (APPBP2) as a target for the treatment of obesity and/ or diabetes. The disclosure also relates to the interaction between APPBP2 and neuronatin and the 5 compound that enhances such interaction. The present disclosure further relates to modulation of the activity of neuronatin interaction partner as a tool in diagnosing, treating or preventing diabetes and/or obesity. The disclosure further provides a method of screening of various compounds for targeting neuronatin interaction partner useful in treating, alleviating, preventing or diagnosing diabetes and/or obesity. The present 10 disclosure also provides a pharmaceutical composition useful in diagnosing, treating or preventing diabetes and/or obesity.
摘要翻译：本公开涉及作为治疗肥胖和/或糖尿病的靶标的神经元蛋白相互作用伴侣淀粉样蛋白前体蛋白结合蛋白-2（APPBP2）。本公开还涉及APPBP2和神经元蛋白与增强这种相互作用的5种化合物之间的相互作用。本公开还涉及神经元素相互作用配偶体作为诊断，治疗或预防糖尿病和/或肥胖的工具的活性的调节。本公开进一步提供了用于靶向用于治疗，减轻，预防或诊断糖尿病和/或肥胖症的神经元相互作用配偶体的各种化合物的方法。本发明还提供了可用于诊断，治疗或预防糖尿病和/或肥胖症的药物组合物。

6. 发明申请

WO2007134613A1 MODULATION OF GPR120 ACTIVITY IN ADIPOCYTES/FAT TISSUE 审中-公开
标题翻译： ADIPOCYTES / FAT组织中GPR120活性的调节
公开(公告)号：WO2007134613A1
公开(公告)日：2007-11-29
申请号：PCT/DK2007/050060
申请日：2007-05-24
申请人： RHEOSCIENCE A/S , VRANG, Niels , LARSEN, Philip Just , LARSEN, Leif Kongskov
发明人： VRANG, Niels , LARSEN, Philip Just , LARSEN, Leif Kongskov
IPC分类号： G01N33/74
CPC分类号： G01N33/74 , G01N2500/04 , G01N2800/042 , G01N2800/044
摘要： The present invention relates to a G protein coupled receptor, GPR120 expressed in various mammalian tissue. The present invention further relates to modulation of the activity of these receptors as a tool in diagnosing, treating or preventing diabetes and/or obesity. The present invention also relates to screening of various compounds for targeting GPR120 receptors useful in treating, alleviating, preventing or diagnosing diabetes and/or obesity. The present invention further relates to a pharmaceutical composition useful in diagnosing, treating or preventing diabetes and/or obesity.
摘要翻译：本发明涉及在各种哺乳动物组织中表达的G蛋白偶联受体GPR120。本发明还涉及这些受体作为诊断，治疗或预防糖尿病和/或肥胖的工具的活性的调节。本发明还涉及用于靶向用于治疗，缓解，预防或诊断糖尿病和/或肥胖症的GPR120受体的各种化合物的筛选。本发明还涉及可用于诊断，治疗或预防糖尿病和/或肥胖症的药物组合物。

7. 发明申请

WO2011073788A2 BALAGLITAZONE COMPOSITIONS AND METHODS 审中-公开
标题翻译： BALAGLITAZONE组合物和方法
公开(公告)号：WO2011073788A2
公开(公告)日：2011-06-23
申请号：PCT/IB2010/003287
申请日：2010-12-17
申请人： DR REDDY'S LABORATORIES, LIMITED , RHEOSCIENCE A/S , RIIS, Bente , HENRIKSEN, Kim , KUMAR, Rajinder
发明人： RIIS, Bente , HENRIKSEN, Kim , KUMAR, Rajinder
IPC分类号： A61K31/517
CPC分类号： A61K31/517 , A61K38/28 , A61K45/06
摘要： Methods for reducing bone loss in a subject suffering from a condition benefiting from a decrease in insulin resistance, by balaglitazone administration to the subject.
摘要翻译：用于通过向对象施用balaglitazone来减轻患有受益于胰岛素抗性降低的病症的受试者中骨损失的方法。

8. 发明申请

WO2009083553A1 AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS 审中-公开
标题翻译： AZINE化合物作为GLUCOKINASE激活剂
公开(公告)号：WO2009083553A1
公开(公告)日：2009-07-09
申请号：PCT/EP2008/068232
申请日：2008-12-23
申请人： RHEOSCIENCE A/S , BADIGER, Sangamesh Eshwarappa , FOSGERAU, Keld Fogtmann , VRANG, Niels , CHAUDHARI, Vinod Dinkar , NAIK, Jyoti Jeevu , AUXCILIA, Judy , REDDY, Rajasekhar Rammohan , SUBRAMANYA, Hosahalli S , REDDY, P Venkataramana , REDDY, B Naga Sashi
发明人： BADIGER, Sangamesh Eshwarappa , FOSGERAU, Keld Fogtmann , VRANG, Niels , CHAUDHARI, Vinod Dinkar , NAIK, Jyoti Jeevu , AUXCILIA, Judy , REDDY, Rajasekhar Rammohan , SUBRAMANYA, Hosahalli S , REDDY, P Venkataramana , REDDY, B Naga Sashi
IPC分类号： C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/53 , A61P3/04 , A61P3/10
CPC分类号： C07D417/12 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： Azine derivatives, of the general structural Formula (I) wherein G 1 and G 2 are selected independently from N and CH; R is halogen, or -OG 3 , or NHG 3 where G 3 is selected from the group consisting of hydrogen, C 1-6 , alkyl or alkylene, wherein the said alkyl or alkylene is straight chain or branched unsubstituted or substituted wherein; the substituents are selected from halogen, hydroxyl, amino, C 1-2 alkylamino, C 1-4 alkoxy, oxo, and CO 2 H, Z is O, NH, S or SO 2 G 5 is selected from the group consisting of: optionally substituted -C 1 -12 alkyl, -C 2-12 alkenyl, -(CH 2 )n-aryl, -(CH 2 )n- heteroaryl, -(CH 2 )n-heterocyclyl, or -(CH 2 )n-C 3-8 cycloalkyl; Y is either O or S; and G 4 represents optionally substituted mono or fused cycles selected from heteroaryl moieties; or salts, solvates, hydrates, or prodrugs thereof are useful in treating hyperglycemia and diabetes.
摘要翻译：通式（I）的氨基衍生物，其中G1和G2独立地选自N和CH; R是卤素，或-G3或NHG3，其中G3选自氢，C1-6，烷基或亚烷基，其中所述烷基或亚烷基是未取代或取代的直链或支链，其中：取代基选自卤素，羟基，氨基，C 1-2烷基氨基，C 1-4烷氧基，氧代和CO 2 H，Z是O，NH，S或SO 2 G 5选自：任选取代的-C 1-12烷基，（CH 2）n - 杂芳基， - （CH 2）n - 杂环基或 - （CH 2）n -C 3-8环烷基; Y是O或S; 并且G4代表任选取代的选自杂芳基部分的单或稠合循环; 或其盐，溶剂合物，水合物或前药可用于治疗高血糖症和糖尿病。

9. 发明申请

WO2006007854A1 GUS3 NEUROPEPTIDES FOR REGULATING HYPOTHALAMIC FUNCTION 审中-公开
标题翻译： GUS3神经细胞用于调节神经功能
公开(公告)号：WO2006007854A1
公开(公告)日：2006-01-26
申请号：PCT/DK2005/000505
申请日：2005-07-21
申请人： RHEOSCIENCE A/S , LARSEN, Leif, Kongskov , PAULSEN, Sarah
发明人： LARSEN, Leif, Kongskov , PAULSEN, Sarah
IPC分类号： A61K38/08
CPC分类号： A61K38/08 , A61K38/1709
摘要： The present invention relates to use of GUS3 neuropeptides or functional variants in a medicament. The invention furthermore relates to specific medical uses of such neuropeptides, for regulating hypothalamic function.
摘要翻译：本发明涉及GUS3神经肽或功能变体在药物中的用途。本发明还涉及这种神经肽的特定医学用途，用于调节下丘脑功能。

10. 发明公开

EP1917007A2 INHIBITORS OF ANOREXIC LIPID HYDROLYSIS FOR THE TREATMENT OF EATING DISORDERS 审中-公开
标题翻译： HEMMER DER ANOREXISCHEN LIPID-HYDROLYSE ZUR BEHANDLUNG VONESSSTÖRUNGEN
公开(公告)号：EP1917007A2
公开(公告)日：2008-05-07
申请号：EP06761875.1
申请日：2006-07-14
申请人： Rheoscience A/S , The University of Copenhagen
发明人： HANSEN, Harald, S. , PETERSEN, Gitte , ARTMANN, Andreas , LARSEN, Philip, J.
IPC分类号： A61K31/165
CPC分类号： A61K31/047 , A61K31/165 , A61K2300/00
摘要： Compounds, pharmaceuticals, cosmetic or dietary supplements for the treatment of overweight, obesity and/or type II diabetes in a mammal (e.g. human) comprising a compound with formula I or formula II for example ceramidase-inhibitor, such as (1S,2R)-D-erythro-2-(N-myristoylamino)-1- phenyl-1-propanol, alone or in combination with an anorexic lipid (or other appetite-inhibiting acylamides or oleoyl-estrone), and methods of treatment comprising administration of said compounds, pharmaceuticals, cosmetic or a dietary supplements. The compounds, pharmaceuticals, cosmetic or dietary supplements and methods of the invention may further be used in modifying the feeding behaviour, suppression of hunger, enhancement of satiety, reduction of energy intake, reduction of fat tissue mass/lean mass ratio in a mammal (e.g. human).
摘要翻译：用于治疗哺乳动物（例如人）中超重，肥胖和/或II型糖尿病的化合物，药物，化妆品或膳食补充剂，其包含式I或式II的化合物，例如神经酰胺酶抑制剂，例如（1S，2R）单独或与厌食性脂质（或其他食欲抑制性酰基酰胺或油酰基 - 雌酮）组合的D-赤式-2-（N-肉豆蔻酰氨基）-1-苯基-1-丙醇，以及包括给药的所述化合物，药物，化妆品或膳食补充剂。本发明的化合物，药物，化妆品或膳食补充剂和方法还可用于改变饲养行为，抑制饥饿，增强饱腹感，减少能量摄入，降低哺乳动物的脂肪组织质量/瘦体重比例如人类）。

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