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1. 发明公开

EP3307737A2 POLYMORPHIC FORMS OF AFATINIB FREE BASE AND AFATINIB DIMALEATE 审中-公开
标题翻译： AFATINIB FREE BASE和AFATTINIB DIMALEATE的多态性
公开(公告)号：EP3307737A2
公开(公告)日：2018-04-18
申请号：EP16738552.5
申请日：2016-06-10
申请人： Fresenius Kabi Oncology Ltd , Cabri, Walter , Lahiri, Saswata , Mishra, Bhuwan Bhaskar , Azim, Abul , Panda, Nilendu , Bhavanam, Poli Reddy , Ray, Krishanu , Kachhadia, Nikunj , Singh, Kumber
发明人： CABRI, Walter , LAHIRI, Saswata , MISHRA, Bhuwan Bhaskar , AZIM, Abul , PANDA, Nilendu , BHAVANAM, Poli Reddy , RAY, Krishanu , KACHHADIA, Nikunj , SINGH, Kumber
IPC分类号： C07D407/12 , A61K31/517 , A61P35/00
CPC分类号： C07D405/12 , C07B2200/13 , C07C57/145 , C07D407/12
摘要： The present invention relates to crystalline forms of Afatinib and its dimaleate salt. The present invention also relates to processes for the preparation of crystalline forms of Afatinib and its dimaleate salt. The present invention further relates to pharmaceutical compositions of such crystalline forms of Afatinib dimaleate and use thereof in the treatment of a patient in need thereof.

2. 发明申请

WO2016199076A3 POLYMORPHIC FORMS OF AFATINIB FREE BASE AND AFATINIB DIMALEATE 审中-公开
标题翻译： AFATINIB自由基和AFATINIB DIMALEATE的多形态
公开(公告)号：WO2016199076A3
公开(公告)日：2017-03-09
申请号：PCT/IB2016053420
申请日：2016-06-10
申请人： FRESENIUS KABI ONCOLOGY LTD , CABRI WALTER , LAHIRI SASWATA , MISHRA BHUWAN BHASKAR , AZIM ABUL , PANDA NILENDU , BHAVANAM POLI REDDY , RAY KRISHANU , KACHHADIA NIKUNJ , SINGH KUMBER
发明人： CABRI WALTER , LAHIRI SASWATA , MISHRA BHUWAN BHASKAR , AZIM ABUL , PANDA NILENDU , BHAVANAM POLI REDDY , RAY KRISHANU , KACHHADIA NIKUNJ , SINGH KUMBER
IPC分类号： C07D407/12 , A61K31/517 , A61P35/00
CPC分类号： C07D407/12
摘要： The present invention relates to crystalline forms of Afatinib and its dimaleate salt. The present invention also relates to processes for the preparation of crystalline forms of Afatinib and its dimaleate salt. The present invention further relates to pharmaceutical compositions of such crystalline forms of Afatinib dimaleate and use thereof in the treatment of a patient in need thereof.
摘要翻译：本发明涉及阿片素及其二马来酸盐的结晶形式。本发明还涉及制备阿拉非尼及其二马来酸盐的结晶形式的方法。本发明还涉及此类结晶形式的阿片素二马来酸二乙酯的药物组合物及其在治疗有需要的患者中的用途。

3. 发明申请

WO2016199076A2 POLYMORPHIC FORMS OF AFATINIB FREE BASE AND AFATINIB DIMALEATE 审中-公开
标题翻译： AFATINIB自由基和AFATINIB DIMALEATE的多形态
公开(公告)号：WO2016199076A2
公开(公告)日：2016-12-15
申请号：PCT/IB2016/053420
申请日：2016-06-10
申请人： FRESENIUS KABI ONCOLOGY LTD. , CABRI, Walter , LAHIRI, Saswata , MISHRA, Bhuwan Bhaskar , AZIM, Abul , PANDA, Nilendu , BHAVANAM, Poli Reddy , RAY, Krishanu , KACHHADIA, Nikunj , SINGH, Kumber
发明人： CABRI, Walter , LAHIRI, Saswata , MISHRA, Bhuwan Bhaskar , AZIM, Abul , PANDA, Nilendu , BHAVANAM, Poli Reddy , RAY, Krishanu , KACHHADIA, Nikunj , SINGH, Kumber
IPC分类号： C07D407/12 , A61K31/517 , A61P35/00
CPC分类号： C07D407/12
摘要： The present invention relates to crystalline forms of Afatinib and its dimaleate salt. The present invention also relates to processes for the preparation of crystalline forms of Afatinib and its dimaleate salt. The present invention further relates to pharmaceutical compositions of such crystalline forms of Afatinib dimaleate and use thereof in the treatment of a patient in need thereof.
摘要翻译：本发明涉及阿片素及其二马来酸盐的结晶形式。本发明还涉及制备阿拉非尼及其二马来酸盐的结晶形式的方法。本发明进一步涉及这种阿伐他汀二马来酸的结晶形式的药物组合物及其在治疗有需要的患者中的用途。

4. 发明申请

WO2011055376A1 BIOLOGICAL LASER PLASMA X-RAY POINT SOURCE 审中-公开
标题翻译：生物激光等离子体X射线源
公开(公告)号：WO2011055376A1
公开(公告)日：2011-05-12
申请号：PCT/IN2009/000632
申请日：2009-11-09
申请人： TATA INSTITUTE OF FUNDAMENTAL RESEARCH , MANCHIKANTI, Krishnamurthy , RAY, Krishanu , GATTAMARAJU, Ravindra Kumar
发明人： MANCHIKANTI, Krishnamurthy , RAY, Krishanu , GATTAMARAJU, Ravindra Kumar
IPC分类号： H05G2/00
CPC分类号： H05G2/001
摘要： The invention provides targets coated with structured biological materials, which are employed in laser produced plasma systems. The biological materials selected from cells of microbial, protozoan or plankton origin are applied on a portion of a solid target, like polished glass plate which then form a target system that absorbs the intense laser pulses, generates hot dense plasma and results in the emission of the X-rays. The method of coating structured biomaterial decreases the usable laser intensity required for producing the hot plasma, while increasing the X-ray yield. The coatings are easy to prepare and it is possible to vary the nature and shape of the cellular material in order to control/regulate the interaction with the light and thereby optimize the resultant plasma generation and X-ray emission. The increase in temperature of the plasma and the increase in yield demonstrate that the method is suitable for enhancing the emission yield in the Ultra Violet, Extreme Ultra violet, x-ray and the hard x-ray regimes.
摘要翻译：本发明提供涂覆有结构化生物材料的靶，其用于激光制备的等离子体系统中。从微生物，原生动物或浮游生物来源的细胞中选出的生物材料应用于固体靶的一部分，如抛光玻璃板，然后形成吸收激光脉冲的目标系统，产生热致密的等离子体，并导致发射 X光片。涂覆结构化生物材料的方法降低了生产热等离子体所需的可用激光强度，同时提高了X射线产率。涂层易于制备，并且可以改变多孔材料的性质和形状，以便控制/调节与光的相互作用，从而优化所得的等离子体产生和X射线发射。等离子体的温度升高和产量的增加表明，该方法适用于提高超紫，极紫外，X射线和硬x射线体系中的发射产率。

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