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1. 发明申请

WO2002093453A3 WEB-BASED GENETIC RESEARCH APPARATUS 审中-公开
公开(公告)号：WO2002093453A3
公开(公告)日：2002-11-21
申请号：PCT/US2002/014665
申请日：2002-05-09
申请人： X-MINE, INC. , HYTOPOULOS, Evangelos , MILLER, Brett, N. , RAY, Sandip
发明人： HYTOPOULOS, Evangelos , MILLER, Brett, N. , RAY, Sandip
IPC分类号： G06F19/00
摘要： An apparatus and method are provided for performing genetic analyses in a client-server environment over a data network. The apparatus includes a data server and an analysis engine. The data server stores genetic micro array data sets corresponding to a plurality of users. The analysis engine is coupled to the data server. The analysis engine acquires the genetic micro array data sets for storage, and performs the genetic analyses on the genetic micro array data sets, and provides results of the genetic analyses. The results are provided to corresponding user computers over a data network, where the corresponding user computers employ a thin web client application to configure the genetic analyses and to receive the results.

2. 发明申请

WO2006133423A1 METHODS AND COMPOSITION FOR DIAGNOSIS OF NEUROLOGICAL DISORDERS IN BODY FLUIDS 审中-公开
标题翻译：用于诊断身体液体中神经疾病的方法和组合
公开(公告)号：WO2006133423A1
公开(公告)日：2006-12-14
申请号：PCT/US2006/022561
申请日：2006-06-08
申请人： SATORIS, INC. , RAY, Sandip , WYSS-CORAY, Anton
发明人： RAY, Sandip , WYSS-CORAY, Anton
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , C12Q1/6883 , G01N2800/28 , G01N2800/2821 , G01N2800/60
摘要： The inventors have discovered a collection of proteinaceous biomarkers (“AD” biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for activity in modulating AD biomarker levels.
摘要翻译：本发明人已经发现了可以在外周生物流体样品中测量的蛋白质生物标志物（“AD”生物标志物）的集合，以帮助诊断神经变性疾病，特别是阿尔茨海默氏病和轻度认知障碍（MCI）。本发明还提供了通过测试预期药剂来调节AD生物标志物水平的活性来鉴定用于治疗阿尔茨海默氏病的候选药物的方法。

3. 发明申请

WO02093453A2 WEB-BASED GENETIC RESEARCH ENGINE 审中-公开
标题翻译：基于WEB的遗传研究引擎
公开(公告)号：WO02093453A2
公开(公告)日：2002-11-21
申请号：PCT/US0214665
申请日：2002-05-09
申请人： MINE INC X , HYTOPOULOS EVANGELOS , MILLER BRETT N , RAY SANDIP
发明人： HYTOPOULOS EVANGELOS , MILLER BRETT N , RAY SANDIP
IPC分类号： G06F19/20 , G06F19/22 , G06F19/28 , G06F19/00
CPC分类号： G06F19/28 , G06F19/20 , G06F19/22 , Y02A90/26
摘要： An apparatus and method are provided for performing genetic analyses in a client-server environment over a data network. The apparatus includes a data server and an analysis engine. The data server stores genetic micro array data sets corresponding to a plurality of users. The analysis engine is coupled to the data server. The analysis engine acquires the genetic micro array data sets for storage, and performs the genetic analyses on the genetic micro array data sets, and provides results of the genetic analyses. The results are provided to corresponding user computers over a data network, where the corresponding user computers employ a thin web client application to configure the genetic analyses and to receive the results.
摘要翻译：提供了一种用于在客户机 - 服务器环境中通过数据网络执行遗传分析的装置和方法。该装置包括数据服务器和分析引擎。数据服务器存储对应于多个用户的遗传微阵列数据集。分析引擎耦合到数据服务器。分析引擎获取存储的遗传微阵列数据集，并对遗传微阵列数据集进行遗传分析，并提供遗传分析结果。将结果通过数据网络提供给相应的用户计算机，其中相应的用户计算机使用瘦网络客户端应用来配置遗传分析并接收结果。

4. 发明申请

WO2007059135A3 METHODS OF TREATING ALZHEIMER'S DISEASE 审中-公开
标题翻译：治疗阿尔茨海默病的方法
公开(公告)号：WO2007059135A3
公开(公告)日：2007-10-11
申请号：PCT/US2006044198
申请日：2006-11-13
申请人： SATORIS INC , RAY SANDIP , WYSS-CORAY ANTON
发明人： RAY SANDIP , WYSS-CORAY ANTON
IPC分类号： A01N37/18 , C07K1/00
CPC分类号： G01N33/6896 , A61K38/185 , A61K38/191 , A61K38/193 , A61K38/2006
摘要： The invention provides biomarkers that are modulated in Alzheimer's disease including IL- la, PDGF-BB, TNF-a, M-CSF, G-CSF, GNDF, eotaxin 2, MCP-3, PARC, AgRP, MSP-a, and BTC. Described are methods for preventing, treating, alleviating symptoms of, or delaying the development of Alzheimer's Disease (AD) in an individual diagnosed with Alzheimer's Disease or at risk for developing the disease by modulating the biological activity of, or the levels of any one or more of these AD-associated biomarkers. 'Modulation of biomarker levels by administration of biomarker proteins, biologically active fragments thereof, agonists, antagonists and antibodies are provided.
摘要翻译：本发明提供在阿尔茨海默氏病中调节的生物标志物，包括IL-1α，PDGF-BB，TNF-α，M-CSF，G-CSF，GNDF，嗜酸细胞活化趋化因子2，MCP-3，PARC，AgRP，MSP-a和BTC 。描述了用于预防，治疗，减轻症状或延迟被诊断患有阿尔茨海默病的个体的阿尔茨海默病（AD）的发展或通过调节任何一种或多种的生物活性或其水平而发展该疾病的风险的方法更多的这些AD相关生物标志物。提供了通过施用生物标志物蛋白质，其生物活性片段，激动剂，拮抗剂和抗体来调节生物标志物水平。

5. 发明申请

WO2007059135A2 METHODS OF TREATING ALZHEIMER'S DISEASE 审中-公开
标题翻译：治疗阿尔茨海默病的方法
公开(公告)号：WO2007059135A2
公开(公告)日：2007-05-24
申请号：PCT/US2006/044198
申请日：2006-11-13
申请人： SATORIS, INC. , RAY, Sandip , WYSS-CORAY, Anton
发明人： RAY, Sandip , WYSS-CORAY, Anton
IPC分类号： A61K39/395
CPC分类号： G01N33/6896 , A61K38/185 , A61K38/191 , A61K38/193 , A61K38/2006
摘要： The invention provides biomarkers that are modulated in Alzheimer's disease including IL- lα, PDGF-BB, TNF-α, M-CSF, G-CSF, GNDF, eotaxin 2, MCP-3, PARC, AgRP, MSP-α, and BTC. Described are methods for preventing, treating, alleviating symptoms of, or delaying the development of Alzheimer's Disease (AD) in an individual diagnosed with Alzheimer's Disease or at risk for developing the disease by modulating the biological activity of, or the levels of any one or more of these AD-associated biomarkers. 'Modulation of biomarker levels by administration of biomarker proteins, biologically active fragments thereof, agonists, antagonists and antibodies are provided.
摘要翻译：本发明提供了在阿尔茨海默病中调节的生物标志物，包括IL-1α，PDGF-BB，TNF-α，M-CSF，G-CSF，GNDF，eotaxin 2，MCP-3，PARC， AgRP，MSP-α和BTC。描述了用于预防，治疗，缓解阿尔茨海默氏病（AD）症状或延迟阿尔茨海默氏病（AD）患者的发展的方法，所述阿尔茨海默病患者或具有通过调节所述患者的生物学活性或任何一种更多这些AD相关生物标志物。 '通过施用生物标志物蛋白质，其生物活性片段，激动剂，拮抗剂和抗体来调节生物标志物水平。

6. 发明申请

WO2005052592A2 METHODS AND COMPOSITIONS FOR DIAGNOSIS, STRATIFICATION, AND MONITORING OF ALZHEIMER’S DISEASE AND OTHER NEUROLOGICAL DISORDERS IN BODY FLUIDS 审中-公开
标题翻译：用于诊断，分析和监测身体液体中的阿尔茨海默病和其他神经疾病的方法和组合物
公开(公告)号：WO2005052592A2
公开(公告)日：2005-06-09
申请号：PCT/US2004/039275
申请日：2004-11-19
申请人： SATORIS, INC. , RAY, Sandip , WYSS-CORAY, Anton
发明人： RAY, Sandip , WYSS-CORAY, Anton
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4745 , G01N2800/2821
摘要： The inventors have discovered a collection of proteinaceous biomarkers ("AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for activity in modulating AD biomarker levels.
摘要翻译：本发明人已经发现了可以在外周生物流体样品中测量的蛋白质生物标志物（“AD生物标志物”）的集合，以帮助诊断神经变性疾病，特别是阿尔茨海默氏病和轻度认知障碍（MCI）。本发明还提供鉴定方法通过测试预期药物调节AD生物标志物水平的活性来治疗阿尔茨海默氏病的候选药物。

7. 发明申请

WO2005052592A3 METHODS FOR DIAGNOSIS, STRATIFICATION, AND MONITORING OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：阿尔茨海默病的诊断，分析和监测方法
公开(公告)号：WO2005052592A3
公开(公告)日：2005-09-29
申请号：PCT/US2004039275
申请日：2004-11-19
申请人： SATORIS INC , RAY SANDIP , WYSS-CORAY ANTON
发明人： RAY SANDIP , WYSS-CORAY ANTON
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/567 , G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4745 , G01N2800/2821
摘要： The inventors have discovered a collection of proteinaceous biomarkers ("AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for activity in modulating AD biomarker levels.
摘要翻译：本发明人已经发现了可以在外围生物流体样品中测量的蛋白质生物标志物（“AD生物标志物”）的集合，以帮助诊断神经变性疾病，特别是阿尔茨海默氏病和轻度认知障碍（MCI）。本发明还提供鉴定方法通过测试预期药物调节AD生物标志物水平的活性来治疗阿尔茨海默病的候选药物。

8. 发明申请

US20140011689A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS, STRATIFICATION, AND MONITORING OF ALZHEIMER'S DISEASE AND OTHER NEUROLOGICAL DISORDERS IN BODY FLUIDS 审中-公开
标题翻译：用于诊断，分析和监测身体液体中的阿尔茨海默病和其他神经疾病的方法和组合物
公开(公告)号：US20140011689A1
公开(公告)日：2014-01-09
申请号：US13766613
申请日：2013-02-13
申请人： Ray Sandip , Anton Wyss-Coray
发明人： Ray Sandip , Anton Wyss-Coray
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , C12Q1/6883 , G01N2800/28 , G01N2800/2821 , G01N2800/60
摘要： The inventors have discovered a collection of proteinaceous biomarkers (“AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for activity in modulating AD biomarker levels.
摘要翻译：本发明人已经发现了可以在外周生物流体样品中测量的蛋白质生物标志物（“AD生物标志物”）的集合，以帮助诊断神经变性疾病，特别是阿尔茨海默氏病和轻度认知障碍（MCI）。本发明还提供鉴定方法通过测试预期药物调节AD生物标志物水平的活性来治疗阿尔茨海默氏病的候选药物。

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