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1. 发明专利

IL194949D0 2-PYRAZINONE DERIVATIVES FOR THE TREATMENT OF DISEASE OR CONDITION IN WHICH INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY IS BENEFICIAL 未知
公开(公告)号：IL194949D0
公开(公告)日：2009-08-03
申请号：IL19494908
申请日：2008-10-27
申请人： ASTRAZENECA AB , HANSEN PETER , LONN HANS , LAWITZ KAROLINA , NIKITIDIS ANTONIOS , IVARSSON MARIANNE , RAY ASIM
IPC分类号： C07D20100101
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.

2. 发明专利

DK185391D0 未知
公开(公告)号：DK185391D0
公开(公告)日：1991-11-11
申请号：DK185391
申请日：1991-11-11
申请人： MAGNUSSON HANS GOERAN , RAY ASIM KUMAR
发明人： MAGNUSSON HANS GOERAN , RAY ASIM KUMAR
IPC分类号： C07H19/01 , C07K9/00

3. 发明专利

DK88092D0 未知
公开(公告)号：DK88092D0
公开(公告)日：1992-07-03
申请号：DK88092
申请日：1992-07-03
申请人： MAGNUSSON HANS GOERAN , RAY ASIM KUMAR
发明人： MAGNUSSON HANS GOERAN , RAY ASIM KUMAR

4. 发明专利

CH701408A2 Verfahren und Vorschaltgerät zur Speisung einer Leuchtstofflampe. 未知
公开(公告)号：CH701408A2
公开(公告)日：2011-01-14
申请号：CH10492009
申请日：2009-07-07
申请人： RAY ASIM
发明人： RAY ASIM
IPC分类号： H05B41/16 , H05B41/38
摘要： In einem Verfahren zum Speisen einer Standard-Leuchtstofflampe (2) mit integriertem elektronischen Vorschaltgerät wird die Leuchtstofflampe (2) mit einem Vorschaltgerät (1) mit einer aus einer Netz-Wechselspannung erzeugten Gleichspannung einstellbarer Höhe oder einer pulsmodulierten Gleichspannung gespeist, wobei die Höhe der Gleichspannung respektive ein zeitlicher Mittelwert der pulsmodulierten Gleichspannung einstellbar ist. Die Höhe der Gleichspannung respektive der zeitliche Mittelwert der pulsmodulierten Gleichspannung ist beispielsweise in einem Bereich zwischen 100 Volt und 325 Volt einstellbar. Dadurch wird es möglich, Leuchtstofflampen mit integriertem elektronischen Vorschaltgerät ohne Modifikation der Leuchtstofflampen auch im Dimmbetrieb zu verwenden.

5. 发明专利

IL194948D0 2-PYRIDONE DERIVATIVES FOR THE TREATMENT OF DISEASE OR CONDITION IN WHICH INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY IS BENEFICIAL 未知
公开(公告)号：IL194948D0
公开(公告)日：2009-08-03
申请号：IL19494808
申请日：2008-10-27
申请人： ASTRAZENECA AB , LEPISTO MATTI , HANSEN PETER , LONN HANS , LAWITZ KAROLINA , RAY ASIM
IPC分类号： C07D20100101
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.

6. 发明申请

WO2006098684A1 NOVEL COMPOUNDS II 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE. 审中-公开
标题翻译：新型化合物II作为中性弹性蛋白酶抑制剂的2-吡啶衍生物。
公开(公告)号：WO2006098684A1
公开(公告)日：2006-09-21
申请号：PCT/SE2006/000328
申请日：2006-03-14
申请人： ASTRAZENECA AB , BRIMERT, Thomas , LAWITZ, Karolina , LÖNN, Hans , NIKITIDIS, Antonios , RAY, Asim, Kumar , SANDMARK, Jenny
发明人： BRIMERT, Thomas , LAWITZ, Karolina , LÖNN, Hans , NIKITIDIS, Antonios , RAY, Asim, Kumar , SANDMARK, Jenny
IPC分类号： C07D213/82 , A61K31/4412 , A61K31/4427 , A61K31/444 , A61P11/00 , A61P11/06 , A61P29/00 , C07D213/83 , C07D401/12 , C07D409/12 , C07D413/12
CPC分类号： C07D213/82 , C07D413/12 , C07D413/14
摘要： The invention provides compounds of formula wherein R 1 , R 3 , R 4 , R 5 , R 6 , R 14 , X, W and Z are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译：本发明提供下式的化合物其中R 1，R 3，R 4，R 5，R 4， R 6，R 14，X，W和Z如说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。

7. 发明申请

WO2007129963A1 2-PYRAZINONE DERIVATIVES FOR THE TREATMENT OF DISEASE OR CONDITION IN WHICH INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY IS BENEFICIAL. 审中-公开
标题翻译：用于治疗抑制中性粒细胞活化的疾病或病症的2-吡嗪酮衍生物是有益的。
公开(公告)号：WO2007129963A1
公开(公告)日：2007-11-15
申请号：PCT/SE2007/000442
申请日：2007-05-07
申请人： ASTRAZENECA AB , HANSEN, Peter , IVARSSON, Marianne , LAWITZ, Karolina , LÖNN, Hans , NIKITIDIS, Antonios , RAY, Asim
发明人： HANSEN, Peter , IVARSSON, Marianne , LAWITZ, Karolina , LÖNN, Hans , NIKITIDIS, Antonios , RAY, Asim
IPC分类号： C07D403/04 , A61K31/497 , A61P1/04 , A61P11/00 , A61P11/06 , A61P29/00 , C07D401/14 , C07D403/14
CPC分类号： C07D401/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要： The invention provides compounds of formula (I) wherein R 1 , R 3 , R 4 , R 5 , R 14 , X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译：本发明提供式（I）化合物，其中R 1，R 3，R 4，R 5， R 14，X和W如说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。

8. 发明申请

WO2007129962A1 2-PYRIDONE DERIVATIVES FOR THE TREATMENT OF DISEASE OR CONDITION IN WHICH INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY IS BENEFICIAL. 审中-公开
标题翻译：用于治疗抑制中性粒细胞活化的疾病或病症的2-吡啶酮衍生物是有益的。
公开(公告)号：WO2007129962A1
公开(公告)日：2007-11-15
申请号：PCT/SE2007/000441
申请日：2007-05-07
申请人： ASTRAZENECA AB , HANSEN, Peter , LAWITZ, Karolina , LEPISTÖ, Matti , LÖNN, Hans , RAY, Asim
发明人： HANSEN, Peter , LAWITZ, Karolina , LEPISTÖ, Matti , LÖNN, Hans , RAY, Asim
IPC分类号： C07D401/04 , A61K31/4439 , A61P1/04 , A61P11/00 , A61P11/06 , A61P29/00 , C07D413/04 , C07D417/04
CPC分类号： C07D401/04 , C07D413/04 , C07D417/04
摘要： The invention provides compounds of formula (1) wherein R 1 , R 3 , R 4 , R 5 , R 6 , R 14 , X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译：本发明提供式（1）的化合物，其中R 1，R 3，R 4，R 5， R 6，R 14，X和W如说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。

9. 发明申请

WO2004004726A1 MCHIR ANTAGONISTS 审中-公开
标题翻译：妇幼保健
公开(公告)号：WO2004004726A1
公开(公告)日：2004-01-15
申请号：PCT/GB2003/002884
申请日：2003-07-04
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , RAY, Asim, Kumar , SIGFRIDSSON, Emma, Margareta , LINUSSON, Anna, Stina, Maria , SANDBERG, Pernilla, Marie , INGHARDT, Tord , SVENSSON, Anette, Marie , BRICKMANN, Kay
发明人： RAY, Asim, Kumar , SIGFRIDSSON, Emma, Margareta , LINUSSON, Anna, Stina, Maria , SANDBERG, Pernilla, Marie , INGHARDT, Tord , SVENSSON, Anette, Marie , BRICKMANN, Kay
IPC分类号： A61K31/47
CPC分类号： C07D215/38 , C07D401/12 , C07D405/12 , C07D407/12 , C07D409/12
摘要： The present invention provides compounds of formula (I), wherein R 1 represents a C 1-4 alkoxy group optionally substituted by one or more fluoro or a C 1-4 alkyl group optionally substituted by one or more fluoro; n represents 0 or 1; R 2 represents a C 1-4 alkyl group optionally substituted by one or more fluoro or a C 1-4 alkoxy group optionally substituted by one or more fluoro; m represents 0 or 1; R 3 represents H or a C 1-4 alkyl group; L 1 represents an alkylene chain (CH 2 ) r in which r represents 2 or 3 or L 1 represents a cyclohexyl group wherein the two nitrogens bearing R 3 and R 4 , respectively, are linked to the cyclohexyl group either via the 1,3 or the 1,4 positions of the cyclohexyl group or L 1 represents a cyclopentyl group wherein the two nitrogens bearing R 3 and R 4 , respectively, are linked to the cyclopentyl group via the 1,3 position of the cyclopentyl group and additionally when R 5 represents 9, 10-methanoanthracen-9(10 H )-yl the group -L 1 -N(R 4 )- together represents a piperidyl ring which is linked to L 2 through the piperidinyl nitrogen and to N-R 3 via the 4 position of the piperidyl ring with the proviso that when R 5 represents 9, 10-methanoanthracen-9(10 H )-yl then r is only 2; R 4 represents H or a C 1-4 alkyl group optionally substituted by one or more of the following: an aryl group or a heteroaryl group; L 2 represents a bond or an alkylene chain (CH 2 ) s in which s represents 1, 2 or 3 wherein the alkylene chain is optionally substituted by one or more of the following: a C 1-4 alkyl group, phenyl or heteroaryl; R 5 represents aryl, a heterocyclic group or a C 3-8 cycloalkyl group which is optionally fused to a phenyl or to a heteroaryl group; as well as optical isomers and racemates thereof as well as pharmaceutically acceptable salts, thereof; with provisos, processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea and Alzheier's disease and pain related disorders and to pharmaceutical compositions containing them.
摘要翻译：本发明提供式（I）化合物，其中R 1表示任选被一个或多个氟取代的C 1-4烷氧基或任选被一个或多个氟取代的C 1-4烷基; n表示0或1; R 2表示任选被一个或多个氟取代或任选被一个或多个氟取代的C 1-4烷氧基取代的C 1-4烷基; m表示0或1; R 3表示H或C 1-4烷基; L 1表示亚烷基链（CH 2）r，其中r表示2或3或L 1表示环己基，其中分别具有R 3和R 4的两个氮分别连接到环己基通过环己基的1,3或1,4位或L 1表示环戊基，其中分别具有R 3和R 4的两个氮分别连接到环戊基，通过环戊基的1,3位，另外当R 5代表基团-L 1 -N（R 4）的9,10-甲基蒽醌-9（10H） - 基时）一起代表哌啶环其通过哌啶基环与L 2连接，通过哌啶环的4位与NR 3连接，条件是当R 5代表9,10-甲基蒽醌-9（10H） - 基，然后r 只有2个; R 4表示H或被以下一个或多个取代的C 1-4烷基：芳基或杂芳基; L 2表示键或亚烷基链（CH 2）s，其中s表示1,2或3，其中亚烷基链任选被以下一个或多个取代：C 1-4烷基，苯基或杂芳基; R 5表示芳基，杂环基或任选与苯基或杂芳基稠合的C 3-8环烷基; 以及其旋光异构体和外消旋物及其药学上可接受的盐; 附带条件，制备这些化合物的方法，它们在治疗肥胖，精神疾病，认知障碍，记忆障碍，精神分裂症，癫痫和相关病症中的用途，以及神经系统疾病如痴呆，多发性硬化，帕金森病，亨廷顿氏舞蹈病和阿尔茨海默病和疼痛相关疾病以及含有它们的药物组合物。

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