专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

BG102558A QUINOLINE DERIVATIVES 未知
公开(公告)号：BG102558A
公开(公告)日：1999-03-31
申请号：BG10255898
申请日：1998-06-18
申请人： GIARDINA GIUSEPPE A , GRUGNI MARIO , RAVEGLIA LUCA F , FARINA CARLO
发明人： GIARDINA GIUSEPPE A , GRUGNI MARIO , RAVEGLIA LUCA F , FARINA CARLO
IPC分类号： A61K31/00 , A61K31/47 , A61P11/00 , A61P11/06 , C07D215/52
摘要： The invention relates to compounds or their solvates or saltswith the formulawhere Ar means optionally substituted aryl or C5-7cycloalkyldienyl group, or optionally substituted aromaticheterocyclic group; R, R1, R2 and R3 have the meanings listed inthe description. The invention also relates to a method for thepreparation of the compounds, to pharmaceutical compositionscontaining them, or to compositions applicable in medicine.20 claims

2. 发明申请

WO2006016219A3 DERIVATIVES OF 1-PHENYLALKANECARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开
标题翻译： 1-苯基烷烃羧酸衍生物治疗神经退行性疾病
公开(公告)号：WO2006016219A3
公开(公告)日：2006-04-27
申请号：PCT/IB2005002189
申请日：2005-07-26
申请人： CHIESI FARMA SPA , RAVEGLIA LUCA , PERETTO ILARIA , RADAELLI STEFANO , IMBIMBO BRUNO PIETRO , RIZZI ANDREA , VILLETTI GINO
发明人： RAVEGLIA LUCA , PERETTO ILARIA , RADAELLI STEFANO , IMBIMBO BRUNO PIETRO , RIZZI ANDREA , VILLETTI GINO
IPC分类号： C07C233/51
CPC分类号： C07C237/22
摘要： The present invention concerns novel derivatives of 1-phenylalkanecarboxylic acids, pharmaceutical compositions thereof, a process for their preparation and their use for the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.
摘要翻译：本发明涉及1-苯基链烷羧酸的新衍生物，其药物组合物，其制备方法及其用于治疗和/或预防神经变性疾病如阿尔茨海默氏病的用途。

3. 发明专利

BG102557A DERIVATIVES OF QUINOLINE-4-CARBOXAMIDES, METHOD FOR THEIR PREPARATION AND APPLICATION AS NEUROKININ 3(NK-3) AND NEUROKININ 2(NK-2) RECEPTOR ANTAGONISTS 未知
公开(公告)号：BG102557A
公开(公告)日：1999-03-31
申请号：BG10255798
申请日：1998-06-18
申请人： GIARDINA GIUSEPPE A , GRUGNI MARIO , RAVEGLIA LUCA F , FARINA CARLO
发明人： GIARDINA GIUSEPPE A , GRUGNI MARIO , RAVEGLIA LUCA F , FARINA CARLO
IPC分类号： A61K31/47 , C07D215/52 , C07D401/06 , C07D401/12 , C07D487/04 , C07D521/00
摘要： The invention relates to compounds with the formulawhere Ar means optionally a substituted aryl or C5-7cycloalkyldienyl group, or optionally substituted aromaticheterocyclic group containing one ring or condensed rings; R meansC1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkylalkyl, optionallysubstituted phenyl or phenyl C1-6 alkyl, optionally substituted5-atom heteroaromatic ring containing up to 4 heteroatoms selectedfrom 0 and N, hydroxy C1-6 alkyl, amino C1-6 alkyl, C1-6alkylaminoalkyl, di C1-6 alkylaminoalkyl, C1-6 acylaminoalkyl,C1-6 alkoxyalkyl, C1-6 alkylcarbonyl, carboxy, C1-6alkoxacyrbonyl, C1-6 alkoxycarbonyl-C1-6 alkyl, aminocarbonyl,C1-6 alkylaminocarbonyl, di C1-6 alkylaminocarbonyl, halogeno C1-6alkyl or R is a group - (CH2)p where p has the value of 2 or 3 andwhich forms a ring with a carbon atom from Ar; R1 is hydrogen oroptionally up to four subsituents selected from C1-6 alkyl, C1-6alkenyl, aryl, C1-6 alkoxy, hydroxy, halogen, nitro, cyano,carboxy, carboxyanido, sulphonamido, C1-6 alkoxycarbonyl,trifluoromethyl, acyloxy, phthalimido, amino or mono- and di C1-6alkylamino; R2 means hydrogen, C1-6 alkyl, hydroxy, halogen,cyano, amino, mono- or di C1-6 alkylamino, alkylsulphonylamino,mono- or di C1-6 alkanoylamino where each alkyl group isoptionally substituted by an aminogroup or by mono- ordialkylaminogroup, or R2 is a residue - X-(CH2)n-Y, where X is abond or -O- and n has the value of 1 to 5, provided that when X is-O-, n has the value of only 2 to 5, and Y means a NY1Y2 groupwhere Y1 and Y2 are separately selected from hydrogen, C1-6 alkyl,C1-6 alkenyl, aryl or aryl C1-6 alkyl or Y is hydroxy, halogen oroptionally substituted N-bound single or condensed ringheterocyclic group; R3 means a straight or branching chain C1-6alkyl, C3-7 cycloalkyl, C4-7 cycloalkylalkyl, optionallysubstituted aryl or substituted single or condensed aromaticheterocyclic group, and R4 means hydrogen or C1-6 alkyl. Theinvention also relates to solvates or salts of the compound withformula I.20 claims

4. 发明申请

WO2008117175A3 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE 审中-公开
标题翻译：新颖的苯甲酸衍生物作为激素激素的调节剂
公开(公告)号：WO2008117175A3
公开(公告)日：2009-04-30
申请号：PCT/IB2008000985
申请日：2008-03-19
申请人： ADDEX PHARMA SA , BONNET BEATRICE , CAMPO BRICE , RAVEGLIA LUCA , RICCABONI MAURO
发明人： BONNET BEATRICE , CAMPO BRICE , RAVEGLIA LUCA , RICCABONI MAURO
IPC分类号： C07C233/15 , C07C233/24
CPC分类号： C07C235/56 , C07C235/60 , C07C311/08 , C07C311/16 , C07C2601/02 , C07C2601/08
摘要： The present invention provides new compounds of formula I, wherein Q, R1, R2, R4, R5, R6, Xi, R7, R8, M and G1 n are defined as in formula I; invention compounds are modulators of follicle-stimulating hormone - ("FSH") which are useful for male and female contraception as well as other disorders modulated by FSH receptor.
摘要翻译：本发明提供了新的式I化合物，其中Q，R 1，R 2，R 4，R 5，R 6，X 1，R 7，R 8，M和G n如式I中所定义; 发明化合物是促卵泡激素（“FSH”）的调节剂，其可用于男性和女性避孕以及由FSH受体调节的其它障碍。

5. 发明申请

WO2004074232A8 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：用于治疗神经损伤性疾病的1-苯甲酰氧基酸衍生物
公开(公告)号：WO2004074232A8
公开(公告)日：2005-09-09
申请号：PCT/EP2004001596
申请日：2004-02-19
申请人： CHIESI FARMA SPA , RAVEGLIA LUCA , PERETTO ILARIA , RADAELLI STEFANO , IMBIMBO BRUNO PIETRO , RIZZI ANDREA , VILLETTI GINO
发明人： RAVEGLIA LUCA , PERETTO ILARIA , RADAELLI STEFANO , IMBIMBO BRUNO PIETRO , RIZZI ANDREA , VILLETTI GINO
IPC分类号： A61P25/28 , C07C57/60 , C07C57/62 , C07C69/65 , C07C233/11 , A61K31/19 , A61K31/215
CPC分类号： C07C69/65 , C07C57/60 , C07C57/62 , C07C61/40 , C07C233/11 , C07C2601/02
摘要： 1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.
摘要翻译： 1-苯基链烷酸羧酸衍生物，其制备方法及其在治疗和/或预防神经变性疾病如阿尔茨海默氏病中的应用。

6. 发明申请

WO2004074232A1 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：用于治疗神经损伤性疾病的1-苯甲酰氧基酸衍生物
公开(公告)号：WO2004074232A1
公开(公告)日：2004-09-02
申请号：PCT/EP2004/001596
申请日：2004-02-19
申请人： CHIESI FARMACEUTICI S.P.A. , RAVEGLIA, Luca , PERETTO, Llaria , RADAELLI, Stefano , IMBIMBO, Bruno, Pietro , RIZZI, Andrea , VILLETTI, Gino
发明人： RAVEGLIA, Luca , PERETTO, Llaria , RADAELLI, Stefano , IMBIMBO, Bruno, Pietro , RIZZI, Andrea , VILLETTI, Gino
IPC分类号： C07C57/60
CPC分类号： C07C69/65 , C07C57/60 , C07C57/62 , C07C61/40 , C07C233/11 , C07C2601/02
摘要： 1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.
摘要翻译： 1-苯基链烷酸羧酸衍生物，其制备方法及其在治疗和/或预防神经变性疾病如阿尔茨海默氏病中的应用。

7. 发明申请

WO2009149188A1 COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS 审中-公开
标题翻译：用于治疗炎症和纤维性疾病的化合物和方法
公开(公告)号：WO2009149188A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046136
申请日：2009-06-03
申请人： INTERMUNE, INC. , KOSSEN, Karl , SEIWERT, Scott, D. , SEREBRYANY, Vladimir , RUHRMUND, Donald , BEIGELMAN, Leonid , RAVEGLIA, Luca, Francesco Mario , VALLESE, Stefania , BIANCHI, Ivana , HU, Tao
发明人： KOSSEN, Karl , SEIWERT, Scott, D. , SEREBRYANY, Vladimir , RUHRMUND, Donald , BEIGELMAN, Leonid , RAVEGLIA, Luca, Francesco Mario , VALLESE, Stefania , BIANCHI, Ivana , HU, Tao
IPC分类号： A61K31/44 , C07D213/22
CPC分类号： C07D213/63 , C07D213/22 , C07D213/64 , C07D213/69 , C07D213/71 , C07D213/85 , C07D237/14 , C07D239/36 , C07D239/54 , C07D241/18 , C07D251/10 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
摘要翻译：公开了用于治疗炎症和纤维化疾病的化合物和方法，包括用活性化合物调节应激活化蛋白激酶（SAPK）系统的方法，其中活性化合物表现出低的抑制p38MAPK的能力; 并且其中所述接触以对所述化合物抑制p38MAPK的抑制浓度低的SAPK调节浓度进行。还公开了吡非尼酮的衍生物和类似物，其可用于调节应激活化蛋白激酶（SAPK）系统。

8. 发明申请

WO2006066924A3 AZOLE DERIVATIVES WITH ANTIMUSCARINIC ACTIVITY 审中-公开
标题翻译：具有抗微生物活性的AZOLE衍生物
公开(公告)号：WO2006066924A3
公开(公告)日：2006-08-31
申请号：PCT/EP2005013887
申请日：2005-12-22
申请人： CHIESI FARMA SPA , PERETTO ILARIA , SCARPITTA FRANCESCA , LA PORTA ELENA , RAVEGLIA LUCA , GIARDINA GIUSEPPE ARNALDO MARI , IMBIMBO BRUNO PIETRO , RIZZI ANDREA , VILLETTI GINO
发明人： PERETTO ILARIA , SCARPITTA FRANCESCA , LA PORTA ELENA , RAVEGLIA LUCA , GIARDINA GIUSEPPE ARNALDO MARI , IMBIMBO BRUNO PIETRO , RIZZI ANDREA , VILLETTI GINO
IPC分类号： C07D401/04 , A61K31/454 , A61P1/00 , A61P11/00
CPC分类号： C07D401/14 , C07D401/04
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, x, X, Y and B are as defined in the description for the treatment of muscarinic acetylcholine receptor mediated diseases, in particular M3 muscarinic receptor mediated diseases.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2，x，X，Y和B如在用于治疗毒蕈碱性乙酰胆碱受体介导的疾病，特别是M3毒蕈碱性受体介导的疾病的描述中所定义。

9. 发明申请

WO2004004715A3 NOVEL DELTA OPIOID RECEPTOR LIGANDS 审中-公开
标题翻译：新西兰阿片类受体配偶
公开(公告)号：WO2004004715A3
公开(公告)日：2004-05-06
申请号：PCT/EP0307400
申请日：2003-07-08
申请人： GLAXOSMITHKLINE SPA , DONDIO GIULIO , MACECCHINI SILVIA , RAVEGLIA LUCA FRANCESCO
发明人： DONDIO GIULIO , MACECCHINI SILVIA , RAVEGLIA LUCA FRANCESCO
IPC分类号： A61K31/44 , C07D213/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/443 , A61K31/444
CPC分类号： C07D213/74 , A61K31/44 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14
摘要： A method for the modulation of conditions associated with the delta opioid receptor, which method comprises the administration to the mammal in need thereof an effective or prophylactic amount of a compound of formula (I): wherein X, Y, Z, R1, and R2 are as defined in the specification; to compounds for use in such a method, to processes for their preparation, and to their use in medicine.
摘要翻译：调节与阿片样物质受体相关的病症的方法，该方法包括向有需要的哺乳动物施用有效或预防量的式（I）化合物：其中X，Y，Z，R 1和R 2 如规范中所定义; 用于这种方法的化合物，其制备方法及其在医药中的用途。

10. 发明申请

WO2008117175A2 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE 审中-公开
标题翻译：新颖的苯甲酸衍生物作为激素激素的调节剂
公开(公告)号：WO2008117175A2
公开(公告)日：2008-10-02
申请号：PCT/IB2008/000985
申请日：2008-03-19
申请人： ADDEX PHARMA SA , BONNET, Béatrice , CAMPO, Brice , RAVEGLIA, Luca , RICCABONI, Mauro
发明人： BONNET, Béatrice , CAMPO, Brice , RAVEGLIA, Luca , RICCABONI, Mauro
IPC分类号： C07C233/15 , C07C233/24
CPC分类号： C07C235/56 , C07C235/60 , C07C311/08 , C07C311/16 , C07C2601/02 , C07C2601/08
摘要： The present invention provides new compounds of formula I, wherein Q, R 1, R 2 , R 4 , R 5 , R 6 , X i , R 7 , R 8 , M and G 1 n are defined as in formula I; invention compounds are modulators of follicle-stimulating hormone - ("FSH") which are useful for male and female contraception as well as other disorders modulated by FSH receptor.
摘要翻译：本发明提供了新的式I化合物，其中Q 1，R 1，R 2，R 4，R 5， R 6，R 6，R 11，R 7，R 8，M和G 1

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式