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1. 发明授权

US4737585A Process for the preparation of sodium amoxycillin 失效
标题翻译：制备阿莫西林钠的方法
公开(公告)号：US4737585A
公开(公告)日：1988-04-12
申请号：US921105
申请日：1986-10-21
申请人： Augustin Perez-Aranda Ortega , Santiago C. Ruzafa , Fernando R. Serra
发明人： Augustin Perez-Aranda Ortega , Santiago C. Ruzafa , Fernando R. Serra
IPC分类号： C07D499/00 , C07D499/16 , C07D499/68
CPC分类号： C07D499/00
摘要： Sodium amoxycillin, of use for example by parenteral administration, is prepared by:(a) suspending amoxycillin trihydrate in a mixture comprising an aprotic organic solvent and a lower alcohol;(b) solubilizing the amoxycillin trihydrate by the addition of a low molecular weight amine of the group of cyclic or heterocyclic aliphatics;(c) adding to such solution the sodium salt of diethyloxalacetic acid, agitating the reaction mixture at a temperature of from -10.degree. C. to ambient temperature and finally isolating the sodium amoxycillin by filtration after its precipitation in the reaction medium by the addition of an aprotic organic solvent.
摘要翻译：例如通过肠胃外给药使用的阿莫西林钠通过以下方法制备：（a）将阿莫西林三水合物悬浮于包含非质子有机溶剂和低级醇的混合物中; （b）通过加入环状或杂环脂族基团的低分子量胺来增溶阿莫西林三水合物; （c）向该溶液中加入二乙氧基乙酸钠盐，将反应混合物在-10℃的温度下搅拌至环境温度，最后通过在反应介质中沉淀后通过过滤分离出阿莫西林钠，非质子有机溶剂。

2. 发明申请

US20070049973A1 Method and device for treating adenomyosis and endometriosis 审中-公开
标题翻译：治疗子宫腺肌症和子宫内膜异位症的方法和装置
公开(公告)号：US20070049973A1
公开(公告)日：2007-03-01
申请号：US11214606
申请日：2005-08-29
申请人： Fred Burbank , Michael Jones , R. Serra , Greig Altieri , Jill Uyeno , Yu-Tung Wong , Randy Werneth
发明人： Fred Burbank , Michael Jones , R. Serra , Greig Altieri , Jill Uyeno , Yu-Tung Wong , Randy Werneth
IPC分类号： A61N1/00
CPC分类号： A61B17/2812 , A61B5/026 , A61B8/06 , A61B8/12 , A61B17/122 , A61B17/282 , A61B17/2833 , A61B17/42 , A61B2017/00106 , A61B2017/2808 , A61B2017/4216
摘要： The invention provides devices, systems and methods for reducing or abolishing blood flow by occluding uterine arteries for treating adenomyosis and endometriosis. A non-invasive uterine artery occlusion device embodying features of the invention includes a pair of pressure-applying members with opposed tissue-contacting surfaces, a supporting shaft configured to adjust the distance between tissue-contacting surfaces, and at least one sensor for locating a uterine artery disposed on at least one pressure-applying member. Uterine arteries are occluded by indirectly compressing the artery by compressing tissue near to an artery. One uterine artery may be occluded or both may be occluded simultaneously. A uterine artery may be accessed via a body cavity, such as a patient's vagina, and may be occluded by compressing a portion of the vaginal wall around a portion of a uterine artery.
摘要翻译：本发明提供了用于通过闭塞子宫动脉来治疗子宫腺肌症和子宫内膜异位症来减少或消除血流的装置，系统和方法。体现本发明特征的非侵入性子宫动脉阻塞装置包括一对具有相对的组织接触表面的压力施加构件，配置成调节组织接触表面之间的距离的支撑轴和至少一个用于定位子宫动脉设置在至少一个压力施加构件上。通过压迫动脉附近的组织间接压迫动脉来闭塞子宫动脉。一个子宫动脉可能被闭塞，或两者可能同时闭塞。子宫动脉可以通过体腔（例如患者的阴道）进入，并且可以通过在子宫动脉的一部分周围压缩阴道壁的一部分来封闭子宫动脉。

3. 发明申请

US20050101974A1 Vascular clamp for caesarian section 有权
标题翻译：剖宫产血管夹
公开(公告)号：US20050101974A1
公开(公告)日：2005-05-12
申请号：US10359386
申请日：2003-02-05
申请人： Fred Burbank , Michael Jones , R. Serra , Greig Altieri , Jill Uyeno
发明人： Fred Burbank , Michael Jones , R. Serra , Greig Altieri , Jill Uyeno
IPC分类号： A61B20060101 , A61B17/08
CPC分类号： A61B17/122 , A61B5/026 , A61B5/489 , A61B8/06 , A61B8/12 , A61B2017/2825 , A61B2017/4216 , A61B2090/08021
摘要： The invention provides devices, systems and methods for clamping arteries which are useful in reducing or abolishing blood flow in an artery, and may be used to control hemorrhage following a caesarian delivery. A clamping device embodying features of the invention includes a pair of clamping members with opposed pressure-applying members having facing pressure-applying surfaces, at least one of which is a yieldable pressure-applying surface. The yieldable pressure-applying surface is preferably resilient. The clamping members are configured to adjust the distance between pressure-applying surfaces, and a blood flow sensor is disposed on at least one of the pressure-applying members to aid in locating the target artery and also to monitor blood flow through the artery. The clamping device is particularly suitable for occluding uterine arteries by compressing the broad ligament which contains the uterine artery and which is connected to the patient's uterus with the arterial clamp.
摘要翻译：本发明提供用于夹紧动脉的装置，系统和方法，其可用于减少或消除动脉中的血液流动，并且可用于控制切片输送之后的出血。体现本发明特征的夹紧装置包括一对夹紧构件，其具有相对的施加压力的构件，其具有面对的压力施加表面，其中至少一个是可屈服的施加压力表面。可屈服的施加压力的表面优选是弹性的。夹紧构件被构造成调节压力施加表面之间的距离，并且血压传感器设置在至少一个压力施加构件上，以帮助定位目标动脉并且还监测通过动脉的血流。夹紧装置特别适用于通过压缩包含子宫动脉的宽韧带并用动脉夹连接到患者的子宫来闭塞子宫动脉。

4. 发明申请

US20060074328A1 Doppler directed suturing and compression device and method 失效
公开(公告)号：US20060074328A1
公开(公告)日：2006-04-06
申请号：US11284658
申请日：2005-11-22
申请人： Fred Burbank , Michael Jones , Greig Altieri , R. Serra
发明人： Fred Burbank , Michael Jones , Greig Altieri , R. Serra
IPC分类号： A61B5/02
CPC分类号： A61B17/0482 , A61B5/026 , A61B8/06 , A61B8/12 , A61B17/122 , A61B17/282 , A61B17/42
摘要： A compression and ligation device includes a pair of jaws including one or more Doppler chips oriented to send and receive Doppler signals across the jaws, to assist a practitioner in determining whether or not a uterine artery is between the jaws. A suture leader with an attached suture can be pushed through a channel on one of the jaws, through tissue behind the uterine artery, into another channel on the other jaw, and proximally out the device so that the practitioner can ligate the artery and effect hemostasis.

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