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1. 发明申请

US20150299224A1 INHIBITORS OF IRAK4 ACTIVITY 有权
标题翻译： IRAK4活性抑制剂
公开(公告)号：US20150299224A1
公开(公告)日：2015-10-22
申请号：US14434344
申请日：2013-10-03
申请人： W. Michael SEGANISH , William T. MCELROY , Stephanie BRUMFIELD , Jason R. HERR , Larry YET , Jinhai YANG , James P. HARDING, III , Ginny Dai HO , Deen B. TULSHIAN , Wensheng YU , Michael K.C. WONG , Brian J. LAVEY , Joseph A. KOZLOWSKI , MERCK SHARP & DOHME CORP.
发明人： W. MICHAEL SEGANISH , WILLIAM T. MCELROY , STEPHANIE BRUMFIELD , JASON R. HERR , LARRY YET , JINHAI YANG , JAMES P. HARDING, III , GINNY DAI HO , DEEN TULSHIAN , WENSHENG YU , MICHAEL K.C. WONG , BRIAN LAVEY , JOSEPH A. KOZLOWSKI
IPC分类号： C07D513/04 , C07D417/04 , C07D417/14 , A61K45/06 , C07D405/14 , A61K31/4436 , A61K31/444 , A61K31/506 , C07D401/04
CPC分类号： C07D513/04 , A61K31/4436 , A61K31/444 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D417/04 , C07D417/14
摘要： The present invention relates to compounds which modulate interleukin-1 (IL-1) receptor-associated kinase 4 (IRAK4) and are useful in the prevention or treatment of inflammatory, cell proliferative and immune-related conditions and diseases. Specifically, provided herein are inhibitors of IRAK4 of Formula I and pharmaceutical compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
摘要翻译：本发明涉及调节白细胞介素-1（IL-1）受体相关激酶4（IRAK4）并可用于预防或治疗炎症，细胞增殖和免疫相关病症和疾病的化合物。具体地，本文提供了式I的IRAK4和包含这些抑制剂的药物组合物的抑制剂，以及其用于治疗IRAK4介导的或相关的病症或疾病的方法。

2. 发明授权

US08212010B2 Sphingosine 1-phosphate antagonism 有权
标题翻译：鞘氨醇1-磷酸拮抗作用
公开(公告)号：US08212010B2
公开(公告)日：2012-07-03
申请号：US12391664
申请日：2009-02-24
申请人： Deron R. Herr , Greg L. Harris
发明人： Deron R. Herr , Greg L. Harris
IPC分类号： C07K16/00 , C12N15/07 , G01N33/53
CPC分类号： C07K16/18 , A61K31/00 , A61K31/138 , A61K31/235 , A61K31/351 , A61K31/4196 , A61K31/4412 , A61K31/517 , A61K31/519 , A61K31/5685 , A61K31/57 , A61K31/65 , A61K31/7068 , A61K31/7076 , A61K2039/505 , A61K2300/00
摘要： Materials and Method for treating cancer and screening for anti-neoplastic agents are provided. These materials and methods can include sphingosine 1-phosphate antagonists that bind to sphingosine-1 phosphate receptor subtype 3. Antibodies and aptamers that selectively bind to an epitope in the extracellular loop between transmembrane domains two and three of sphingosine-1-phosphate receptor subtype 3 are provided.
摘要翻译：提供了治疗癌症的材料和方法以及筛选抗肿瘤剂。这些材料和方法可以包括与鞘氨醇-1磷酸受体亚型3结合的鞘氨醇1-磷酸拮抗剂。选择性结合鞘氨醇-1-磷酸受体亚型3的跨膜结构域之间的细胞外环中的表位的抗体和适配体被提供。

3. 发明授权

US5169220A Rotating shelf apparatus 失效
标题翻译：旋转架设备
公开(公告)号：US5169220A
公开(公告)日：1992-12-08
申请号：US804421
申请日：1991-12-10
申请人： Martin R. Herr , David L. Herr
发明人： Martin R. Herr , David L. Herr
IPC分类号： A47B49/00
CPC分类号： A47B49/006
摘要： Rotating "lazy susan" shelf hardware for the interior of a cabinet. The apparatus uses a cam action to move the door back toward the axis and way from the cabinet edges as rotation begins upon opening, at the same time releasing a detent on the rotational motion of the shelves. As the rotation position approaches the closure position of the door, the door moves gently out toward its closed position, and the door is automatically aligned. This is accomplished with a spring loaded arm on the rotating shelf assembly which carries a roller that follows a stationary circualr cam that has an indentation in it to activate the door's front to back movement. The forward motion of the door caused by the spring action is also slowed by a movement damper.
摘要翻译：旋转“懒惰苏珊”货架内部的硬件。当打开时旋转开始时，该装置使用凸轮动作将门从壳体边缘向后移动，同时在搁架的旋转运动上释放制动器。当旋转位置接近门的关闭位置时，门轻轻地向其关闭位置移动，并且门自动对准。这是通过在旋转的架子组件上的弹簧加载的臂来实现的，其携带跟随在其中具有凹陷的静止的循环凸轮的辊，以激活门的前后运动。由弹簧作用引起的门的向前运动也被运动阻尼器减慢。

4. 发明授权

US4272764A Self contained head mountable sleep inhibiting device 失效
标题翻译：自装头戴式睡眠抑制装置
公开(公告)号：US4272764A
公开(公告)日：1981-06-09
申请号：US111711
申请日：1980-01-14
申请人： Myron R. Herr , Austin E. Elmore
发明人： Myron R. Herr , Austin E. Elmore
IPC分类号： B60K28/06 , G08B21/06 , G08B21/00
CPC分类号： G08B21/06 , B60K28/066
摘要： Self contained head mountable sleep inhibiting device comprising a container having two interfitting parts for housing the electrical and mechanical components of the device and employing an L-shaped clamp member pivotally mounted at the intersection of the legs of the clamp on a corner of the housing. The clamp firmly grips the stem of glasses or the rim or band of a hat for ease in mounting the device on a user.
摘要翻译：自包含的头部安装的睡眠抑制装置包括具有用于容纳装置的电气和机械部件的两个相互配合部件的容器，并且采用可枢转地安装在壳体的角部上的夹具的相交处的L形夹具。夹具牢牢地夹住眼镜杆或帽子的边缘或带子，以便将设备安装在用户身上。

5. 发明申请

US20120225064A1 Sphingosine 1-Phosphate Antagonism 审中-公开
标题翻译：鞘氨醇1-磷酸拮抗作用
公开(公告)号：US20120225064A1
公开(公告)日：2012-09-06
申请号：US13471441
申请日：2012-05-14
申请人： Deron R. HERR , Greg L. HARRIS
发明人： Deron R. HERR , Greg L. HARRIS
IPC分类号： A61K39/395 , A61P31/12 , A61P35/00 , C12N5/16 , C07K16/28
CPC分类号： C07K16/18 , A61K31/00 , A61K31/138 , A61K31/235 , A61K31/351 , A61K31/4196 , A61K31/4412 , A61K31/517 , A61K31/519 , A61K31/5685 , A61K31/57 , A61K31/65 , A61K31/7068 , A61K31/7076 , A61K2039/505 , A61K2300/00
摘要： Materials and Method for treating cancer and screening for anti-neoplastic agents are provided. These materials and methods can include sphingosine 1-phosphate antagonists that bind to sphingosine-1 phosphate receptor subtype 3. Antibodies and aptamers that selectively bind to an epitope in the extracellular loop between transmembrane domains two and three of sphingosine-1-phosphate receptor subtype 3 are provided.
摘要翻译：提供了治疗癌症的材料和方法以及筛选抗肿瘤剂。这些材料和方法可以包括与鞘氨醇-1磷酸受体亚型3结合的鞘氨醇1-磷酸拮抗剂。选择性结合鞘氨醇-1-磷酸受体亚型3的跨膜结构域之间的细胞外环中的表位的抗体和适配体被提供。

6. 发明申请

US20060135409A1 Process for and intermediates in the preparation of canfosfamide and its salts 失效
标题翻译：用于制备卡非司酮及其盐的方法和中间体
公开(公告)号：US20060135409A1
公开(公告)日：2006-06-22
申请号：US11018391
申请日：2004-12-21
申请人： William Boulanger , Steven Collier , Stephen Eastham , Dennis Edie , Ronan Guevel , Pedro Abad , R. Herr , Hans Kjaersgaard , Harold Meckler , Robert Polomski , Steven Schow , Pavel Zhichkin
发明人： William Boulanger , Steven Collier , Stephen Eastham , Dennis Edie , Ronan Guevel , Pedro Abad , R. Herr , Hans Kjaersgaard , Harold Meckler , Robert Polomski , Steven Schow , Pavel Zhichkin
IPC分类号： A61K38/05 , C07K5/06
CPC分类号： C07K5/0205 , A61K38/00 , C07F9/2408 , C07F9/2458 , C07K5/0215 , C07K5/0606 , C07K5/06191
摘要： A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
摘要翻译：一种在制备头孢噻吩及其盐的过程和中间体。一些中间体具有抗癌活性。

7. 发明申请

US20090226453A1 SPHINGOSINE 1-PHOSPHATE ANTAGONISM 有权
标题翻译：丝氨酸1-磷酸酯拮抗剂
公开(公告)号：US20090226453A1
公开(公告)日：2009-09-10
申请号：US12391664
申请日：2009-02-24
申请人： Deron R. Herr , Greg L. Harris
发明人： Deron R. Herr , Greg L. Harris
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , G01N33/574
CPC分类号： C07K16/18 , A61K31/00 , A61K31/138 , A61K31/235 , A61K31/351 , A61K31/4196 , A61K31/4412 , A61K31/517 , A61K31/519 , A61K31/5685 , A61K31/57 , A61K31/65 , A61K31/7068 , A61K31/7076 , A61K2039/505 , A61K2300/00
摘要： Materials and Method for treating cancer and screening for anti-neoplastic agents are provided. These materials and methods can include sphingosine 1-phosphate antagonists that bind to sphingosine-1 phosphate receptor subtype 3. Antibodies and aptamers that selectively bind to an epitope in the extracellular loop between transmembrane domains two and three of sphingosine-1-phosphate receptor subtype 3 are provided.
摘要翻译：提供了治疗癌症的材料和方法以及抗肿瘤剂的筛选。这些材料和方法可以包括与鞘氨醇-1磷酸受体亚型3结合的鞘氨醇1-磷酸拮抗剂。选择性结合鞘氨醇-1-磷酸受体亚型3的跨膜结构域之间的细胞外环中的表位的抗体和适配体被提供。

8. 发明授权

US3642987A Lincomycin and tetracycline compositions 失效
标题翻译：林可辛和四环素组合物
公开(公告)号：US3642987A
公开(公告)日：1972-02-15
申请号：US3642987D
申请日：1969-12-23
申请人： MALCOLM E BERGY , ROSS R HERR , DONALD JOSEPH MASON
发明人： BERGY MALCOLM E , HERR ROSS R , MASON DONALD JOSEPH
IPC分类号： A61K21/00
CPC分类号： A61K31/70
摘要： LINCOMYCIN AND TERTACYCLINE COMPOSITION WITH RANGES OF LINCOMYCIN 5-95 PARTS (50-1000 MG.) TO TERTRACYCLINE 95-5 PARTS (50-1000 MG.). THE COMBINATION OF ANTIBIOTICS IS PREPARED WITH PHARMACEUTICAL CARRIES FOR ORAL AND PARENTERAL ADMINSTRATION AND PREVENTS DEVELOPMENTS FO RESISTANCE PATHOGENS AND HAS SYUNERGISTIC ACTIVITY.

9. 发明授权

US5592835A Necklace with means for adding gem stones thereto 失效
标题翻译：项链用于添加宝石的手段
公开(公告)号：US5592835A
公开(公告)日：1997-01-14
申请号：US533117
申请日：1995-09-25
申请人： Andria R. Herr
发明人： Andria R. Herr
IPC分类号： A44C11/00 , A44C15/00 , A44C5/02
CPC分类号： A44C11/007 , A44C15/00
摘要： A necklace formed of a plurality of interconnected globular like beads wherein the beads are adapted to permit installation of gemstones in selected beads, and for adding gemstones at later times. A central pendant includes a central bead having a pair of beads, each of which are permanently attached thereto at about a 45 degree angle with respect to a vertical center line of the central bead. A pair of strings of single beads is formed with one of each attached to the pendant. The single beads are movably linked to form two strings thereof having clasp for forming a necklace. Each of the pendant beads and the string beads are globular in shape, and include a partial rear central bore therein. At any time, a bead can easily be modified to form a gemstone setting in the front face thereof, and a stone installed therein. Thus, the necklace of the invention can provide a means for celebrating anniversaries and other special occasions.
摘要翻译：由多个相互连接的球状珠形成的项链，其中所述珠适于允许将宝石安装在所选择的珠粒中，并且用于在稍后时间添加宝石。中央吊坠包括具有一对珠的中心珠，每一个珠相对于中心珠的垂直中心线以大约45度的角度永久地附着在其上。形成一对单个珠子串，其中一个连接到垂饰件上。单个珠子可移动地连接以形成具有用于形成项链的扣环的两个绳子。吊坠珠和弦珠中的每一个都是球形的，并且在其中包括部分后中心孔。在任何时候，可以容易地改变珠子以在其前面形成宝石镶嵌物，并且安装在其中的石头。因此，本发明的项链可以提供庆祝周年纪念等特殊场合的手段。

10. 发明申请

US20140336365A1 CDR REGIONS OF MONOCLONAL ANTIBODY THAT ANTAGONIZE SPHINOGOSINE 1-PHOSPHATE AND RELATED METHODS 审中-公开
标题翻译：拮抗单磷酸1-磷酸的单克隆抗体的CDR区和相关方法
公开(公告)号：US20140336365A1
公开(公告)日：2014-11-13
申请号：US14237338
申请日：2012-08-06
申请人： Deron R. Herr , Greg L. Harris
发明人： Deron R. Herr , Greg L. Harris
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , C07K14/705 , C07K2317/73 , C07K2317/76
摘要： Materials and method for treating cancer and screening for anti-neoplastic agents are provided. These materials and methods can include sphingosine 1-phosphate antagonists that bind to sphingosine-1 phosphate receptor subtype 3. Antibodies and aptamers that selectively bind to an epitope in the extracellular loop between transmembrane domains two and three of sphingosine-1-phosphate receptor subtype 3 are provided.
摘要翻译：提供了治疗癌症的材料和方法以及抗肿瘤剂的筛选。这些材料和方法可以包括与鞘氨醇-1磷酸受体亚型3结合的鞘氨醇1-磷酸拮抗剂。选择性结合鞘氨醇-1-磷酸受体亚型3的跨膜结构域之间的细胞外环中的表位的抗体和适配体被提供。

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