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1. 发明授权

US10191041B2 Detection of analytes using metal nanoparticle probes and dynamic light scattering 有权
公开(公告)号：US10191041B2
公开(公告)日：2019-01-29
申请号：US14537324
申请日：2014-11-10
申请人： Qun Huo , Xiong Liu , Qiu Dai
发明人： Qun Huo , Xiong Liu , Qiu Dai
IPC分类号： G01J3/44 , G01N15/02 , G01N33/543 , C12Q1/682 , G01N33/542 , G01N33/58 , C40B60/12
摘要： Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.

2. 发明授权

US09005994B2 Methods for biomolecule and biomolecule complex (BMC) detection and analysis and the use of such for research and medical diagnosis 有权
标题翻译：生物分子和生物分子复合物（BMC）检测和分析方法及其应用于研究和医学诊断
公开(公告)号：US09005994B2
公开(公告)日：2015-04-14
申请号：US13522391
申请日：2011-01-12
申请人： Qun Huo
发明人： Qun Huo
IPC分类号： G01N33/543
CPC分类号： G01N33/54346
摘要： The present application pertains to improved methods of detecting biomolecules in a biological sample (or system), In particular, embodiments discussed herein allow for the detection of biomolecule complexes. The embodiments enable for the first time the elucidation of the significance of biomolecule complexes for certain disease states, which in turn enables the diagnosis of disease states based on the identity and complexing level of a biomolecule complex in a particular biological sample.
摘要翻译：本申请涉及在生物样品（或系统）中检测生物分子的改进方法。特别地，本文讨论的实施方案允许检测生物分子复合物。这些实施方案首次能够阐明生物分子复合物对于某些疾病状态的重要性，其反过来使得能够基于特定生物样品中生物分子复合物的身份和复合水平来诊断疾病状态。

3. 发明申请

US20110294995A1 Functionalized nanoparticles and other particles and methods for making and using same 审中-公开
标题翻译：官能化纳米粒子和其他颗粒及其制造和使用方法
公开(公告)号：US20110294995A1
公开(公告)日：2011-12-01
申请号：US10793592
申请日：2004-03-04
申请人： Qun Huo , James G. Worden
发明人： Qun Huo , James G. Worden
IPC分类号： C07H21/02 , C07H21/04 , B82Y99/00
CPC分类号： B82Y30/00 , B82Y40/00
摘要： Disclosed are nanoparticles which include a nanoparticle core having a core diameter of greater than 5 nm and a single functional moiety bonded to the nanoparticle core. Also disclosed are nanoparticles which include a nanoparticle core having a core diameter of greater than 1.4 nm and a single functional moiety bonded to the nanoparticle core, wherein the single functional moiety does not contain a nucleic acid molecule that includes 100 or more nucleotides. A method for preparing a functionalized nanoparticle is also disclosed. The method includes providing a nanoparticle core and providing a functionalizing moiety that includes a functional group and a reactive group. The functional group is attached to a substrate surface, and the reactive group is capable of bonding to the nanoparticle core's surface. The method further includes contacting the nanoparticle core's surface with the functionalizing moiety under conditions effective to bind the functionalizing moiety's reactive group and the nanoparticle core's surface together.
摘要翻译：公开了纳米颗粒，其包括核直径大于5nm的纳米颗粒核心和与纳米颗粒核心结合的单个功能部分。还公开了纳米颗粒，其包括核直径大于1.4nm的纳米颗粒核心和与纳米颗粒核心结合的单个功能部分，其中单个功能部分不含有包含100个或更多个核苷酸的核酸分子。还公开了制备官能化纳米颗粒的方法。该方法包括提供纳米颗粒核心并提供包含官能团和反应性基团的官能化部分。官能团连接到基底表面，并且反应性基团能够结合到纳米颗粒核心的表面。该方法还包括在有效地将官能化部分的反应性基团和纳米颗粒核心表面结合在一起的条件下使纳米颗粒核心表面与官能化部分接触。

4. 发明授权

US08026108B1 Detection of biotargets using bioreceptor functionalized nanoparticles 失效
标题翻译：使用生物受体功能化纳米粒子检测生物靶
公开(公告)号：US08026108B1
公开(公告)日：2011-09-27
申请号：US11875252
申请日：2007-10-19
申请人： Qun Huo , Xiong Liu , Qiu Dai
发明人： Qun Huo , Xiong Liu , Qiu Dai
IPC分类号： G01N21/00 , G01N33/53 , G01N33/536 , G01N33/553
CPC分类号： G01N33/54346
摘要： An ultra sensitive method for detection of biomolecules includes the step of providing a plurality of bioreceptor functionalized nanoparticle probes. The nanoparticles can include metal, semiconductor, radioactive isotope or fluorescent dye molecules. A sample solution suspected of including the target is contacted with the probes, wherein if present, the target binds to the bioreceptor. After such binding a separating step follows. In the separating step, probes having the target bound thereto are separated from probes not having the target bound thereto. In one embodiment probes having the target bound thereto are then decomposed to generate ions, or broken into discrete radioactive isotopes or fluorescent dye molecules to form a solution including a large plurality of metal ions, radioactive isotopes or dye molecules. A concentration of ions, radioactive isotopes, or dye molecules in the solution is then determined and using this information the concentration of the target in the original sample solution is determined.
摘要翻译：用于检测生物分子的超灵敏方法包括提供多个生物受体官能化纳米颗粒探针的步骤。纳米颗粒可以包括金属，半导体，放射性同位素或荧光染料分子。将涉及包含目标物的样品溶液与探针接触，如果存在，则靶标与生物受体结合。在这种结合之后，分离步骤如下。在分离步骤中，将与其结合的靶的探针从不具有与其结合的靶的探针分离。在一个实施方案中，将与其结合的靶标的探针然后分解产生离子，或者分解成离散的放射性同位素或荧光染料分子，以形成包含大量金属离子，放射性同位素或染料分子的溶液。然后确定溶液中离子，放射性同位素或染料分子的浓度，并使用该信息确定原始样品溶液中靶的浓度。

5. 发明授权

US07951850B2 Polymer composites having highly dispersed carbon nanotubes and methods for forming same 失效
标题翻译：具有高度分散的碳纳米管的聚合物复合材料及其形成方法
公开(公告)号：US07951850B2
公开(公告)日：2011-05-31
申请号：US12050780
申请日：2008-03-18
申请人： Qun Huo , Saiful Khondaker , Jianhua Zou , Lei Zhai , Hui Chen , Harish Muthuraman
发明人： Qun Huo , Saiful Khondaker , Jianhua Zou , Lei Zhai , Hui Chen , Harish Muthuraman
IPC分类号： B60C1/00 , C08K3/04
CPC分类号： H01B1/24 , H01B1/127 , Y10S977/742
摘要： A method of forming carbon nanotube-polymer composites includes the steps of forming a mixture solution including a plurality of carbon nanotubes dispersed in a co-solvent. The co-solvent includes an organic solvent and a second solvent being a short chain fluorinated carboxylic acid having a boiling point below 150° C. which is less oxidizing than nitric acid, and is soluble in both the organic solvent and water. The first polymer is mixed with the mixture solution to form a polymer including mixture. The co-solvent is removed from the polymer mixture to form a dispersed nanotube-polymer composite. The second solvent can be trifluoroacetic acid.
摘要翻译：形成碳纳米管 - 聚合物复合材料的方法包括形成包含分散在共溶剂中的多个碳纳米管的混合溶液的步骤。共溶剂包括有机溶剂，第二溶剂是沸点低于150℃的短链氟化羧酸，其比硝酸氧化性低，并且可溶于有机溶剂和水。将第一聚合物与混合溶液混合以形成包含混合物的聚合物。从聚合物混合物中除去共溶剂以形成分散的纳米管 - 聚合物复合材料。第二溶剂可以是三氟乙酸。

6. 发明申请

US20070298242A1 LENSES HAVING DISPERSED METAL NANOPARTICLES FOR OPTICAL FILTERING INCLUDING SUNGLASSES 审中-公开
标题翻译：具有分散金属纳米粒子的透镜，用于光学过滤，包括太阳镜
公开(公告)号：US20070298242A1
公开(公告)日：2007-12-27
申请号：US11768561
申请日：2007-06-26
申请人： Qun Huo
发明人： Qun Huo
IPC分类号： B32B5/16 , B32B27/36 , B32B27/30
CPC分类号： G02C5/00 , G02C7/108 , G02C2202/16 , Y10T428/25 , Y10T428/256 , Y10T428/31507 , Y10T428/31935
摘要： Lenses appropriate for use as sunglasses and other optical filtering devices include one or more composite layers including metal nanoparticles dispensed in a polymer matrix. The entire lens can be a single layer of the composite or the composite can be a coating on one or both faces of the lens. Gold nanoparticles can be dispersed in a poly(methylmethacrylate) or polycarbonate polymer at 0.01 to 1 weight percent.
摘要翻译：适合用作太阳镜和其它光学过滤装置的透镜包括一个或多个复合层，包括分散在聚合物基质中的金属纳米颗粒。整个透镜可以是复合材料的单层，或者复合材料可以是透镜的一个或两个表面上的涂层。金纳米颗粒可以以0.01至1重量％的比例分散在聚（甲基丙烯酸甲酯）或聚碳酸酯聚合物中。

7. 发明申请

US20130052661A1 Methods for Biomolecule and Biomolecule Complex (BMC) Detection and Analysis and the Use of Such for Research and Medical Diagnosis 有权
标题翻译：生物分子和生物分子复合物（BMC）检测与分析方法及其在医学诊断中的应用
公开(公告)号：US20130052661A1
公开(公告)日：2013-02-28
申请号：US13522391
申请日：2011-01-12
申请人： Qun Huo
发明人： Qun Huo
IPC分类号： G01N33/566 , G01N21/47
CPC分类号： G01N33/54346
摘要： The present application pertains to improved methods of detecting biomolecules in a biological sample (or system), In particular, embodiments discussed herein allow for the detection of biomolecule complexes. The embodiments enable for the first time the elucidation of the significance of biomolecule complexes for certain disease states, which in turn enables the diagnosis of disease states based on the identity and complexing level of a biomolecule complex in a particular biological sample.
摘要翻译：本申请涉及在生物样品（或系统）中检测生物分子的改进方法。特别地，本文讨论的实施方案允许检测生物分子复合物。这些实施方案首次能够阐明生物分子复合物对于某些疾病状态的重要性，其反过来使得能够基于特定生物样品中生物分子复合物的身份和复合水平来诊断疾病状态。

8. 发明授权

US07973094B2 Laser irradiation of metal nanoparticle/polymer composite materials for chemical and physical transformations 有权
标题翻译：金属纳米颗粒/聚合物复合材料的激光照射用于化学和物理转化
公开(公告)号：US07973094B2
公开(公告)日：2011-07-05
申请号：US11770279
申请日：2007-06-28
申请人： Qun Huo , Jianhua Zou , Hui Chen
发明人： Qun Huo , Jianhua Zou , Hui Chen
IPC分类号： B05D3/06 , C08F290/06 , B29C25/08
CPC分类号： C08J5/005 , B82Y30/00
摘要： A metal nanoparticle supported on or dispersed in a polymer is irradiated with photons from a laser source to address the nanoparticles. The polymer is transmissive to the photons and addressed nanoparticles transform the energy of the photon to heat which is transferred to a material in the vicinity of the nanoparticle. The locally heated material undergoes a physical or chemical transformation upon heating. The transformed material can be a material in the proximity of the metal nanoparticle supported polymer or metal nanoparticle/polymer composite. In this manner thermally induced physical or chemical transformations can be carried out in very small volumes of material without significant heating to the bulk of the material.
摘要翻译：负载在或分散在聚合物中的金属纳米颗粒用来自激光源的光子照射以解决纳米颗粒。聚合物对光子是透射的，并且所寻址的纳米粒子将光子的能量转化为热，其转移到纳米颗粒附近的材料。局部加热的材料在加热时经历物理或化学转化。转化的材料可以是金属纳米颗粒负载的聚合物或金属纳米颗粒/聚合物复合材料附近的材料。以这种方式，热诱导的物理或化学转化可以在非常小体积的材料中进行，而不显着加热到大部分材料。

9. 发明申请

US20080004364A1 LASER IRRADIATION OF METAL NANOPARTICLE/POLYMER COMPOSITE MATERIALS FOR CHEMICAL AND PHYSICAL TRANSFORMATIONS 有权
标题翻译：用于化学和物理变换的金属纳米颗粒/聚合物复合材料的激光辐照
公开(公告)号：US20080004364A1
公开(公告)日：2008-01-03
申请号：US11770279
申请日：2007-06-28
申请人： Qun HUO , Jianhua ZOU , Hui CHEN
发明人： Qun HUO , Jianhua ZOU , Hui CHEN
IPC分类号： B05D3/06
CPC分类号： C08J5/005 , B82Y30/00
摘要： A metal nanoparticle supported on or dispersed in a polymer is irradiated with photons from a laser source to address the nanoparticles. The polymer is transmissive to the photons and addressed nanoparticles transform the energy of the photon to heat which is transferred to a material in the vicinity of the nanoparticle. The locally heated material undergoes a physical or chemical transformation upon heating. The transformed material can be a material in the proximity of the metal nanoparticle supported polymer or metal nanoparticle/polymer composite. In this manner thermally induced physical or chemical transformations can be carried out in very small volumes of material without significant heating to the bulk of the material.
摘要翻译：负载在或分散在聚合物中的金属纳米颗粒用来自激光源的光子照射以解决纳米颗粒。聚合物对光子是透射的，并且所寻址的纳米粒子将光子的能量转化为热，其转移到纳米颗粒附近的材料。局部加热的材料在加热时经历物理或化学转化。转化的材料可以是金属纳米颗粒负载的聚合物或金属纳米颗粒/聚合物复合材料附近的材料。以这种方式，热诱导的物理或化学转化可以在非常小体积的材料中进行，而不显着加热到大部分材料。

10. 发明授权

US08709292B2 Polymer composites having highly dispersed carbon nanotubes 有权
标题翻译：具有高分散碳纳米管的聚合物复合材料
公开(公告)号：US08709292B2
公开(公告)日：2014-04-29
申请号：US13149338
申请日：2011-05-31
申请人： Qun Huo , Saiful Khondaker , Jianhua Zou , Lei Zhai , Hui Chen , Harish Muthuraman
发明人： Qun Huo , Saiful Khondaker , Jianhua Zou , Lei Zhai , Hui Chen , Harish Muthuraman
IPC分类号： H01B1/06
CPC分类号： H01B1/24 , H01B1/127 , Y10S977/742
摘要： A carbon nanotube-polymer composite includes a polymer continuous phase having at least a first polymer, and a plurality of carbon nanotubes dispersed in the polymer continuous phase. The carbon nanotubes are non-functionalized nanotubes. The carbon nanotubes are between 0.05 and 40 weight % of the composite. At least 98% of the carbon nanotubes are not involved in nanotube bundles.
摘要翻译：碳纳米管 - 聚合物复合材料包括具有至少第一聚合物的聚合物连续相和分散在聚合物连续相中的多个碳纳米管。碳纳米管是非功能化的纳米管。碳纳米管是复合材料的0.05-40重量％。至少98％的碳纳米管不参与纳米管束。

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