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1. 发明申请

WO2008128171A3 DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF 审中-公开
公开(公告)号：WO2008128171A3
公开(公告)日：2008-10-23
申请号：PCT/US2008/060215
申请日：2008-04-14
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , WANG, Shaomeng , PENG, Yuefeng , SUN, Haiying , CAI, Qian , NIKOLOVSKA-COLESKA, Zaneta , LU, Jianfeng , QIU, Su
发明人： WANG, Shaomeng , PENG, Yuefeng , SUN, Haiying , CAI, Qian , NIKOLOVSKA-COLESKA, Zaneta , LU, Jianfeng , QIU, Su
IPC分类号： A61K31/55 , A61P35/00 , C07D487/00
摘要： The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

2. 发明申请

WO2006091646A2 SMALL MOLECULE INHIBITORS OF MDM2 AND USES THEREOF 审中-公开
标题翻译： MDM2的小分子抑制剂及其用途
公开(公告)号：WO2006091646A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/006221
申请日：2006-02-22
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , WANG, Shaomeng , DING, Ke , LU, Yipin , NIKOLOVSKA-COLESKA, Zaneta , QIU, Su , WANG, Guoping , QIN, Dongguang , SHANGARY, Sanjeev
发明人： WANG, Shaomeng , DING, Ke , LU, Yipin , NIKOLOVSKA-COLESKA, Zaneta , QIU, Su , WANG, Guoping , QIN, Dongguang , SHANGARY, Sanjeev
IPC分类号： A61K31/407 , C07D209/54
CPC分类号： C07D209/54 , C07D487/10 , C07D491/107
摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
摘要翻译：本发明涉及作为p53和MDM2相互作用抑制剂的小分子。本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

3. 发明申请

WO2008128171A2 DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF 审中-公开
标题翻译： DIAZO BICYCLIC SMAC MIMETICS及其用途
公开(公告)号：WO2008128171A2
公开(公告)日：2008-10-23
申请号：PCT/US2008060215
申请日：2008-04-14
申请人： UNIV MICHIGAN , WANG SHAOMENG , PENG YUEFENG , SUN HAIYING , CAI QIAN , NIKOLOVSKA-COLESKA ZANETA , LU JIANFENG , QIU SU
发明人： WANG SHAOMENG , PENG YUEFENG , SUN HAIYING , CAI QIAN , NIKOLOVSKA-COLESKA ZANETA , LU JIANFENG , QIU SU
IPC分类号： G01N33/53
CPC分类号： G01N33/5011 , C07D487/04
摘要： The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
摘要翻译：本发明涉及Smac的重氮双环模拟物，其作为细胞凋亡蛋白抑制剂的抑制剂起作用。本发明还涉及这些模拟物用于诱导凋亡细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。

4. 发明申请

WO2007130626A3 BIVALENT SMAC MIMETICS AND THE USES THEREOF 审中-公开
标题翻译：双重SMAC的MIME类型及其用途
公开(公告)号：WO2007130626A3
公开(公告)日：2008-01-17
申请号：PCT/US2007010924
申请日：2007-05-04
申请人： UNIV MICHIGAN , WANG SHAOMENG , SUN HAIYING , QIN DONGGUANG , NIKOLOVSKA-COLESKA ZANETA , LU JIANFENG , QIU SU , PENG YUEFENG , CAI QIAN
发明人： WANG SHAOMENG , SUN HAIYING , QIN DONGGUANG , NIKOLOVSKA-COLESKA ZANETA , LU JIANFENG , QIU SU , PENG YUEFENG , CAI QIAN
IPC分类号： A61K31/00
CPC分类号： C07D519/00 , A61K38/191 , C07D487/04
摘要： The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
摘要翻译：本发明涉及Smac的二价模拟物，其作为细胞凋亡蛋白抑制剂的抑制剂。本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。

5. 发明申请

WO2007130626A2 BIVALENT SMAC MIMETICS AND THE USES THEREOF 审中-公开
标题翻译：双重SMAC的MIME类型及其用途
公开(公告)号：WO2007130626A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/010924
申请日：2007-05-04
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , WANG, Shaomeng , SUN, Haiying , QIN, Dongguang , NIKOLOVSKA-COLESKA, Zaneta , LU, Jianfeng , QIU, Su , PENG, Yuefeng , CAI, Qian
发明人： WANG, Shaomeng , SUN, Haiying , QIN, Dongguang , NIKOLOVSKA-COLESKA, Zaneta , LU, Jianfeng , QIU, Su , PENG, Yuefeng , CAI, Qian
IPC分类号： A61K31/43
CPC分类号： C07D519/00 , A61K38/191 , C07D487/04
摘要： The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
摘要翻译：本发明涉及Smac的二价模拟物，其作为细胞凋亡蛋白抑制剂的抑制剂。本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。

6. 发明申请

WO2006091646A3 SMALL MOLECULE INHIBITORS OF MDM2 AND USES THEREOF 审中-公开
标题翻译： MDM2的小分子抑制剂及其用途
公开(公告)号：WO2006091646A3
公开(公告)日：2006-11-30
申请号：PCT/US2006006221
申请日：2006-02-22
申请人： UNIV MICHIGAN , WANG SHAOMENG , DING KE , LU YIPIN , NIKOLOVSKA-COLESKA ZANETA , QIU SU , WANG GUOPING , QIN DONGGUANG , SHANGARY SANJEEV
发明人： WANG SHAOMENG , DING KE , LU YIPIN , NIKOLOVSKA-COLESKA ZANETA , QIU SU , WANG GUOPING , QIN DONGGUANG , SHANGARY SANJEEV
IPC分类号： C07D487/10
CPC分类号： C07D209/54 , C07D487/10 , C07D491/107
摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
摘要翻译：本发明涉及起p53和MDM2之间相互作用抑制剂作用的小分子。本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对另外的药剂敏化的用途。

7. 发明申请

US20050059771A1 Polyisoprene emulsion, latex articles and processes for preparing thereof 审中-公开
标题翻译：聚异戊二烯乳液，乳胶制品及其制备方法
公开(公告)号：US20050059771A1
公开(公告)日：2005-03-17
申请号：US10769698
申请日：2004-01-30
申请人： Zong-Qiu Su
发明人： Zong-Qiu Su
IPC分类号： C08F236/08 , C08J5/02 , C08K3/00
CPC分类号： C08J5/02 , C08F236/08 , C08J2309/00 , C08F2/22
摘要： A polyisoprene emulsion is provided, being made from 60˜100 parts by weight of isoprene monomer and 5˜50 parts by weight of one or more monomers selected from the group consisting of styrene, acrylates and organic acids, by using a free radical emulsion polymerization in the presence of an emulsifier and an initiator, said polyisoprene emulsion having a weight average molecular weight of 104˜105, pH of 6.0˜7.0, viscosity of 5˜20 cp (25° C.), solid content of 30˜50%, and colloidal particle size of 100˜200 nm. The polyisoprene emulsion thus obtained has excellent film-forming property; the latex articles made therefrom are suitable for use in the areas of medicine-hygiene, electronic industries, science and technology for national defense, and daily life.
摘要翻译：提供聚异戊二烯乳液，其由60〜100重量份的异戊二烯单体和5〜50重量份的选自苯乙烯，丙烯酸酯和有机酸的一种或多种单体通过使用自由基乳液聚合在乳化剂和引发剂的存在下，所述聚异戊二烯乳液的重均分子量为10 -4〜10 5，pH为6.0〜7.0，粘度为5〜20cp（25℃），固体含量30〜50％，胶体粒径100〜200 nm。由此获得的聚异戊二烯乳液具有优异的成膜性; 其制成的乳胶制品适用于医药卫生，电子工业，国防科技和日常生活等领域。

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