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1. 发明申请

WO2004072226A2 MARKER FOR UNDIFFERENTIATED STATE OF CELL AND COMPOSITION AND METHOD FOR SEPARATION AND PREPARATION OF STEM CELLS 审中-公开
标题翻译：细胞和组合物不稳定状态的标记和分离和制备干细胞的方法
公开(公告)号：WO2004072226A2
公开(公告)日：2004-08-26
申请号：PCT/JP2004/001520
申请日：2004-02-12
申请人： REPROCELL INC. , President, Kyoto University , NAKATSUJI, Norio , TADA, Takashi , TADA, Masako
发明人： NAKATSUJI, Norio , TADA, Takashi , TADA, Masako
IPC分类号： C12N
CPC分类号： C07K14/47 , C12N5/0607 , C12N2510/00
摘要： A gene is provided, which can be used as a marker for determining whether a certain cell, particularly an undifferentiated cell including a tissue stem cell, has pluripotency or an undifferentiated state. The gene is called Stm and includes a Stm1 gene, which is expressed specifically in a cell under an undifferentiated state if the cell has pluripotency. A kit for determining a differentiated state of a cell is also provided. The kit comprises (a) an agent capable of reacting specifically with a Stm gene or a Stm gene product; and (b) means for determining whether or not the Stm gene is expressed in the cell.
摘要翻译：提供了可用作确定特定细胞，特别是包括组织干细胞的未分化细胞是否具有多能性或未分化状态的标记的基因。该基因称为Stm，包括Stm1基因，如果细胞具有多能性，其在未分化状态的细胞中特异性表达。还提供了用于确定细胞分化状态的试剂盒。试剂盒包含（a）能够与Stm基因或Stm基因产物特异性反应的试剂; 和（b）用于确定Stm基因是否在细胞中表达的手段。

2. 发明公开

EP1842909A1 METHOD FOR REMOVING DESIRED CHROMOSOME AND TAILOR-MADE MEDICAL TREATMENT UTILIZING THE SAME 审中-公开
标题翻译：方法除去其IN USE所需的染色体和量身定制的治疗医疗
公开(公告)号：EP1842909A1
公开(公告)日：2007-10-10
申请号：EP06702679.9
申请日：2006-01-12
申请人： President, Kyoto University , ReproCELL Inc.
发明人： TADA, Takashi c/o Institute for Frontier Medical , NAKATSUJI, Norio c/o Institute for Frontier Medica , MATSUMURA, Hiroyuki c/o Institute for Frontier Med , TADA, Masako
IPC分类号： C12N15/00 , A61K35/48 , A61L27/00 , C12N5/10 , C12N15/09
CPC分类号： A61K35/48 , C12N5/0081 , C12N5/12 , C12N15/907 , C12N2510/00 , C12N2800/30 , C12N2840/203
摘要： It is intended to provide a regenerable cell in which a desired chromosome has been deleted, a method for producing the cell, and a gene cassette and a kit to be used for the method. More particularly, it is intended to obtain an individual corresponding pluripotent stem cell easily and simply. More specifically, it is intended to efficiently establish a cell, tissue or organ that can be a donor for treating a disease without causing immune rejection response, without newly obtaining and establishing a stem cell such as ES cell from the individual, and without using an ovum as a material. It was achieved by a gene cassette in which not two recombinase recognition sites in a cis orientation are inserted, but one recombinase recognition site or two recombinase recognition sites in an opposite orientation is/are inserted and a marker gene is connected, and by application of the gene cassette to a cell fusion technique.
摘要翻译：它的目的是提供可再生的细胞，其中，期望的染色体已被删除，用于生产细胞的方法，以及基因盒和试剂盒可以用于该方法。更具体地，它的目的在单独的相应的多能干细胞容易且简单地得到。更具体地，其目的是为了有效地建立细胞，组织或器官确实可以用于治疗的疾病，而不会引起免疫排斥反应，而不用新获取并建立的干细胞的供体：如从各个ES细胞，并且不使用在卵子作为材料。它是由其中在顺方向不是两个重组酶识别位点插入的基因盒实现的，但是一个重组酶识别位点或在相反的方向两个重组酶识别位点被插入/和标记基因连接，并通过应用所述基因盒的细胞融合技术。

3. 发明公开

EP1445630A3 Two-dimensional photonic crystal cavity and channel add/drop filter 有权转让
标题翻译：二维光子晶体腔和通道分插滤波器
公开(公告)号：EP1445630A3
公开(公告)日：2004-11-24
申请号：EP04002784.9
申请日：2004-02-09
申请人： President, Kyoto University , SUMITOMO ELECTRIC INDUSTRIES, Ltd
发明人： Noda, Susumu , Asano, Takashi , Akahane, Yoshihiro
IPC分类号： G02B6/12
CPC分类号： B82Y20/00 , G02B6/1225 , H01S5/105
摘要： In 2D photonic crystals, cavities having a heightened Q factor are made available, wherein combining the high Q cavities with waveguides affords channel add/drop filters having high resolution. In a cavity constituted by a point defect within a 2D photonic crystal, the 2D photonic crystal is configured by an arrangement, in a two-dimensional lattice of points defined in a slab (1), of low-refractive-index substances (2) having a low refractive index relative to the slab (1) and being of identical dimension and shape. The point defect (4) contains a plurality of three or more lattice points that neighbor one another, and in these lattice points no low-refractive-index substances (2) are arranged; therein the low-refractive-index substance (2) that should be arranged to correspond to at least one of the lattice points nearest the point defect (4) is arranged displaced by a predetermined distance from that lattice point.
摘要翻译：在2D光子晶体中，具有提高的Q因子的空腔可用，其中将高Q空腔与波导结合提供具有高分辨率的通道分插滤波器。在由2D光子晶体内的点缺陷构成的空腔中，2D光子晶体通过在板（1）中限定的点的二维点阵中由低折射率物质（2）构成，具有相对于平板（1）的低折射率并具有相同的尺寸和形状。点缺陷（4）包含多个彼此相邻的三个或更多个格点，并且在这些格点中没有排列低折射率物质（2）; 其中应布置成对应于最靠近点缺陷（4）的格点中的至少一个格栅点的低折射率物质（2）被布置从该格点偏移预定距离。

4. 发明公开

EP1331550A2 Visualization processing system, visualization processing method, and visualization processing program product 审中-公开
标题翻译： Gerät，-Verfahren，und Programm Produkt zur Darstellungsverwaltung
公开(公告)号：EP1331550A2
公开(公告)日：2003-07-30
申请号：EP03001296.7
申请日：2003-01-22
申请人： President, Kyoto University
发明人： Kunugi, Tomoaki, 1121, Fujinomori-Godo-Shukusha , Yoshikawa, Masaaki
IPC分类号： G06F3/14
CPC分类号： G06F3/1454
摘要： A system of this invention includes terminals (51, 61) each of which makes a display device display a visualized image on the basis of visualized image data, and a main Web server (11) which is connected to the terminals (51, 61) via a network (1000), assigns a visualization job ID used to identify a visualization job to a visualization request from the terminal (51, 61) in response to that visualization request, manages the visualization job by associating visualized image data with the visualization job ID, displays selectable visualization jobs, visualized images of which are being displayed on any of the terminals (51, 61), on the display device of the terminal (51, 61) to prompt the user to select a desired visualization job, acquires visualized image data associated with the visualization job ID selected by the user, and controls to transmit the visualized image data to the terminal (51, 61).
摘要翻译：本发明的系统包括基于可视化图像数据使显示装置显示可视化图像的端子（51,61）和连接到端子（51,61）的主Web服务器（11）通过网络（1000），响应于该可视化请求，将用于识别可视化作业的可视化作业ID分配给来自终端（51,61）的可视化请求，通过将可视化图像数据与可视化作业相关联来管理可视化作业 ID，显示可选择的可视化作业，其可视化图像正在显示在终端（51,61）的显示设备上的任何终端（51,61）上，以提示用户选择期望的可视化作业，获取可视化的与由用户选择的可视化作业ID相关联的图像数据，并且控制将可视化图像数据发送到终端（51,61）。

5. 发明公开

EP2319959A1 Method for producing aromatic iodine compound 有权
标题翻译： Verfahren zur Herstellung einer aromatischen Iodverbindung
公开(公告)号：EP2319959A1
公开(公告)日：2011-05-11
申请号：EP11001638.3
申请日：2008-03-07
申请人： Japan Science And Technology Agency , President, Kyoto University , Nippoh Chemicals Co., Ltd
发明人： Yoshida, Junichi , Suga, Seiji , Kataoka, Kazuhide , Midorikawa, Koji , Hagiwara, Yuji
IPC分类号： C25B1/24 , C07B39/00 , C07C17/12 , C07C25/02 , C07C25/18 , C07C25/22 , C07C37/62 , C07C39/27 , C07C41/22 , C07C43/225 , C07C209/74
CPC分类号： C07C17/02 , C07B39/00 , C07C17/12 , C07C37/62 , C07C41/22 , C07C209/74 , C07C253/30 , C25B1/24 , C25B3/06 , C07C25/18 , C07C25/22 , C07C211/52 , C07C255/50 , C07C39/27 , C07C43/225
摘要： A method of the present invention, for producing an aromatic iodine compound, includes the step of causing an iodizing agent, and an aromatic compound whose nucleus has one or more substituent groups and two or more hydrogen atoms, to react with each other under the presence of a certain ether compound. This realizes such a method of producing an aromatic iodine compound that position selectivity in iodizing reaction of an aromatic compound is improved.
摘要翻译：本发明的芳香族碘化合物的制造方法，其特征在于，包括使碘化剂和其中具有一个以上取代基和两个以上氢原子的芳香族化合物在存在下反应的工序的某种醚化合物。这实现了提高芳族化合物的碘化反应中选择性的芳香族碘化合物的制造方法。

6. 发明授权

EP1445630B1 Two-dimensional photonic crystal cavity and channel add/drop filter 有权转让
标题翻译：二维光子晶体腔和通道分插滤波器
公开(公告)号：EP1445630B1
公开(公告)日：2011-04-06
申请号：EP04002784.9
申请日：2004-02-09
申请人： President, Kyoto University , Sumitomo Electric Industries, Ltd.
发明人： Noda, Susumu , Asano, Takashi , Akahane, Yoshihiro
IPC分类号： G02B6/12
CPC分类号： B82Y20/00 , G02B6/1225 , H01S5/105

7. 发明公开

EP2123795A1 METHOD FOR PRODUCING IODIZING AGENT AND METHOD FOR PRODUCING AROMATIC IODINE COMPOUND 有权
标题翻译：用于生产制备芳族碘化合物A碘化AND METHOD
公开(公告)号：EP2123795A1
公开(公告)日：2009-11-25
申请号：EP08721602.4
申请日：2008-03-07
申请人： Japan Science and Technology Agency , President, Kyoto University , Nippoh Chemicals Co., Ltd
发明人： YOSHIDA Junichi c/o Graduate School of Engineering Kyoto University , SUGA Seijic/o Graduate School of Engineering Kyoto University , KATAOKA Kazuhide , MIDORIKAWA Koji c/o Nippoh Chemicals Co., Ltd , HAGIWARA Yuji c/o Nippoh Chemicals Co., Ltd
IPC分类号： C25B1/24 , C07B39/00 , C07C17/12 , C07C25/02 , C07C25/18 , C07C25/22 , C07C37/62 , C07C39/27 , C07C41/22 , C07C43/225 , C07C209/74 , C07C211/52 , C07C253/30 , C07C255/50
CPC分类号： C07C17/02 , C07B39/00 , C07C17/12 , C07C37/62 , C07C41/22 , C07C209/74 , C07C253/30 , C25B1/24 , C25B3/06 , C07C25/18 , C07C25/22 , C07C211/52 , C07C255/50 , C07C39/27 , C07C43/225
摘要： A method of the present invention, for producing an iodizing agent, includes the step of electrolyzing iodine molecules in a solution by using an acid as a supporting electrolyte. This realizes (i) a method of producing an iodine cation suitable for use as an iodizing agent that does not require a sophisticated separation operation after iodizing reaction is completed, and (ii) an electrolyte used in the method. Further, a method of the present invention, for producing an aromatic iodine compound, includes the step of causing an iodizing agent, and an aromatic compound whose nucleus has one or more substituent groups and two or more hydrogen atoms, to react with each other under the presence of a certain ether compound. This realizes such a method of producing an aromatic iodine compound that position selectivity in iodizing reaction of an aromatic compound is improved.
摘要翻译：本发明的方法，在碘化剂制造方法，包括通过使用酸作为支持电解质在溶液中电解碘分子的步骤。这实现的方法中使用（ⅰ）在适合于使用碘阳离子产生作为碘化剂确实碘化反应完成后，不需要复杂的分离手术的方法，和（ii）的电解质。此外，本发明的方法中，在芳族碘化合物制备，包括使以碘化剂的步骤，和芳族化合物是谁的核上具有一个或多个取代基和两个或更多个氢原子，下相互反应的存在某醚化合物。这实现了寻求芳香族碘化合物的的制造方法做了在碘化的芳族化合物的反应的位置选择性得到改善。

8. 发明授权

EP1460461B1 Channel add/drop filter and channel monitor employing two-dimensional photonic crystal 有权转让
标题翻译：信道加入/分向滤波器和信道监测器的二维光子晶体
公开(公告)号：EP1460461B1
公开(公告)日：2007-10-24
申请号：EP04005960.2
申请日：2004-03-12
申请人： President, Kyoto University , Sumitomo Electric Industries, Ltd.
发明人： Noda, Susumu , Akahane, Yoshihiro , Matsuura, Takashi
IPC分类号： G02B6/293 , G02B6/12
CPC分类号： G02B6/1225 , B82Y20/00

9. 发明公开

EP2268809A1 METHOD OF NUCLEAR REPROGRAMMING 有权转让
标题翻译：核复制方法
公开(公告)号：EP2268809A1
公开(公告)日：2011-01-05
申请号：EP09738908.4
申请日：2009-05-01
申请人： President, Kyoto University
发明人： YAMANAKA, Shinya , OKITA, Keisuke
IPC分类号： C12N15/09 , C12N5/10
CPC分类号： C12N5/0696 , C12N15/79 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2506/02 , C12N2506/13 , C12N2506/1307 , C12N2506/1361 , C12N2510/00
摘要： A method of producing an induced pluripotent stem cell includes introducing into a somatic cell one or more non-viral expression vectors. The vectors include one or more of an Oct family gene, a Klf family gene, a Sox family gene, a Myc family gene, a Lin family gene, and Nanog gene. The somatic cell is then cultured in a medium that supports pluripotent stem cells. At least a portion of the one or more introduced non-viral expression vectors is not substantially integrated in the chromosome.
摘要翻译：产生诱导性多能干细胞的方法包括将一种或多种非病毒表达载体引入体细胞中。载体包括Oct家族基因，Klf家族基因，Sox家族基因，Myc家族基因，Lin家族基因和Nanog基因中的一种或多种。然后将体细胞在支持多能干细胞的培养基中培养。一种或多种引入的非病毒表达载体的至少一部分基本上不整合到染色体中。

10. 发明公开

EP2138192A1 AGENT FOR ENHANCING THE RESISTANCE OF LIPOSOME AGAINST BIOLOGICAL COMPONENT, AND LIPOSOME MODIFIED WITH THE AGENT 审中-公开
标题翻译：手段加强抗脂质体抗生物组成部分和中等改性LIPOSOME
公开(公告)号：EP2138192A1
公开(公告)日：2009-12-30
申请号：EP08720286.7
申请日：2008-02-27
申请人： National University Corporation Hokkaido University , President, Kyoto University , Shionogi Co., Ltd.
发明人： HARASHIMA, Hideyoshi , KOGURE, Kentaro , AKITA, Hidetaka , IWASA, Akitada , NAKAMURA, Yoshio , FUTAKI, Shiroh
IPC分类号： A61K47/42 , A61K9/127 , A61K47/24 , B01J13/04 , C07K14/00
CPC分类号： A61K9/127 , A61K38/00 , A61K47/42 , C07K14/00
摘要： It is intended to provide a positively charged liposome, particularly having a polyarginine peptide on a surface thereof, which is capable of increasing the resistance to a negatively charged biological component such as a protein in the blood and maintaining a high ability to deliver a substance even in the blood. An agent for enhancing the resistance of liposome against biological component comprising a peptide having at least one of the following characteristics (a) and (b) as an active ingredient:
(a) A peptide comprising an amino acid sequence represented by SEQ ID No: 1 or 2; and
(b) A peptide comprising an amino acid sequence represented by SEQ ID No: 1 or 2, in which one or more amino acids are deleted, substituted or added, and having an activity for promoting lipid membrane fusion under acidic condition. An agent for enhancing the resistance of liposome against biological component in this invention, being included in a liposome, is capable of increasing the resistance to a negatively charged biological component such as a protein in the blood and maintaining a high ability to deliver a substance even in the blood.
摘要翻译：它的目的是提供一个带正电荷的脂质体，特别是具有在其表面，在所有其能够电阻增加至带负电荷的生物成分的在聚精氨酸的肽：如在血液中的蛋白质和维护，即使传递的物质的能力高在血液中。用于增强脂质体的抵抗生物组分，其包含具有至少一个下列特征的肽的试剂（a）和（b）中作为活性成分的：（a）一个肽，其包含由SEQ ID NO所示的氨基酸序列组成： 1或2; 和（b）的氨基酸序列的肽，其包含由SEQ ID NO：1或2，在其中一个或多个氨基酸被缺失，substituiertem奥德加入，并且具有用于在酸性条件下促进脂质膜融合的活性。为增强抗生物成分的脂质体的电阻在本发明中，被包括在脂质体中的药剂，能够将电阻增加带负电荷的生物成分的：如在血液中的蛋白质和维护，即使传递的物质的能力高在血液中。

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