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1. 发明申请

US20130089597A1 MicroRNA-130a,b as a Tumor Suppressor and Sensitizing Agent for Chemotherapy 有权
标题翻译： MicroRNA-130a，b作为肿瘤抑制剂和化疗敏化剂
公开(公告)号：US20130089597A1
公开(公告)日：2013-04-11
申请号：US13437251
申请日：2012-04-02
申请人： Preethi H. Gunaratne , Ashley L. Benham , Matthew L. Anderson
发明人： Preethi H. Gunaratne , Ashley L. Benham , Matthew L. Anderson
IPC分类号： A61K31/713 , A61K9/127 , A61K33/24
CPC分类号： A61K31/713 , A61K9/127 , A61K31/7105 , A61K33/24 , A61K45/06 , C12N15/113 , C12N2310/141 , C12N2320/31 , C12Q1/6886 , C12Q2600/178 , A61K2300/00
摘要： The present invention provides a method of improving a therapeutic response to a cancer treatment, in a subject, the method comprising administering an effective amount of an agent that enhances the expression of microRNA-130 or an agent that mimics the effects of microRNA-130. Further provided is a method of treating a cancer in a subject in need of such treatment comprising the step of administering an effective amount of a microRNA-130 or an agent that enhances the expression of microRNA-130.
摘要翻译：本发明提供了在受试者中改善对癌症治疗的治疗反应的方法，所述方法包括施用有效量的增强微小RNA-130的表达的试剂或模拟微小RNA-130的作用的试剂。还提供了治疗需要这种治疗的受试者的癌症的方法，包括施用有效量的微小RNA-130或增强微小RNA-130表达的试剂的步骤。

2. 发明申请

US20120269883A1 MicroRNA-140-5P as a Tumor Suppressor and Sensitizing Agent for Chemotherapy 有权
标题翻译： MicroRNA-140-5P作为肿瘤抑制剂和化疗敏化剂
公开(公告)号：US20120269883A1
公开(公告)日：2012-10-25
申请号：US13453553
申请日：2012-04-23
申请人： Preethi H. Gunaratne , Jason M. Shohet
发明人： Preethi H. Gunaratne , Jason M. Shohet
IPC分类号： A61K31/7105 , A61P35/00 , A61K39/395 , A61K38/19 , C12Q1/68 , A61K31/704 , A61K9/127 , C40B40/06 , C07H21/00 , A61K31/713 , A61K33/24
CPC分类号： A61K33/24 , A61K9/0019 , A61K31/198 , A61K31/36 , A61K31/4745 , A61K31/475 , A61K31/555 , A61K31/675 , A61K31/704 , A61K31/713 , A61K38/193 , A61K38/2013 , A61K45/06 , C12N15/113 , C12N2310/141 , C12Q1/6886 , C12Q2600/118 , C12Q2600/178 , G01N2800/52 , A61K2300/00
摘要： The present invention provides a method of improving a therapeutic response to a cancer treatment, in a subject, the method comprising administering an effective amount of an agent that enhances the expression of microRNA-140-5p or an agent that mimics the effects of microRNA-140-5p. Further provided is a method of treating a cancer in a subject in need of such treatment comprising the step of administering an effective amount of a microRNA-140-5p or an agent that enhances the expression of microRNA-140-5p.
摘要翻译：本发明提供一种在受试者中改善癌症治疗的治疗反应的方法，所述方法包括施用有效量的增强微小RNA-140-5p表达的试剂或模拟微小RNA- 140-5p。还提供了治疗需要这种治疗的受试者的癌症的方法，包括施用有效量的微小RNA-140-5p或增强微小RNA-140-5p的表达的试剂的步骤。

3. 发明申请

US20120251619A1 MicroRNA-29a,b,c as a Tumor Suppressor and Sensitizing Agent for Chemotherapy 审中-公开
标题翻译： MicroRNA-29a，b，c作为肿瘤抑制剂和化疗敏化剂
公开(公告)号：US20120251619A1
公开(公告)日：2012-10-04
申请号：US13437128
申请日：2012-04-02
申请人： Preethi H. Gunaratne
发明人： Preethi H. Gunaratne
IPC分类号： A61K31/713 , A61K9/127 , A61N5/00 , C40B30/04 , C12Q1/68 , A61K33/24 , A61P35/00
CPC分类号： A61K45/06 , A61K31/337 , A61K31/555 , A61K31/713 , A61K33/24 , A61N2005/1098 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178 , A61K2300/00
摘要： The present invention provides a method of improving a therapeutic response to a cancer treatment, in a subject, the method comprising administering an effective amount of an agent that enhances the expression of microRNA 29 or an agent that mimics the effects of microRNA 29. Further provided is a method of treating a cancer in a subject in need of such treatment comprising the step of administering an effective amount of a microRNA 29 or an agent that enhances the expression of microRNA 29.
摘要翻译：本发明提供一种在受试者中改善癌症治疗的治疗反应的方法，该方法包括施用有效量的增强微小RNA 29表达的试剂或模拟微小RNA 29的作用的试剂。进一步提供是治疗需要这种治疗的受试者的癌症的方法，包括施用有效量的微小RNA 29或增强微小RNA 29表达的试剂的步骤。

4. 发明授权

US09192622B2 MicroRNA-130a,b as a tumor suppressor and sensitizing agent for chemotherapy 有权
标题翻译： MicroRNA-130a，b作为肿瘤抑制剂和化疗敏化剂
公开(公告)号：US09192622B2
公开(公告)日：2015-11-24
申请号：US13437251
申请日：2012-04-02
申请人： Preethi H. Gunaratne , Ashley L. Benham , Matthew L. Anderson
发明人： Preethi H. Gunaratne , Ashley L. Benham , Matthew L. Anderson
IPC分类号： A61K48/00 , A61K31/713 , A61K31/7105 , A61K33/24 , A61K45/06 , C12Q1/68 , A61K9/127 , C12N15/113
CPC分类号： A61K31/713 , A61K9/127 , A61K31/7105 , A61K33/24 , A61K45/06 , C12N15/113 , C12N2310/141 , C12N2320/31 , C12Q1/6886 , C12Q2600/178 , A61K2300/00
摘要： The present invention provides a method of improving a therapeutic response to a cancer treatment, in a subject, the method comprising administering an effective amount of an agent that enhances the expression of microRNA-130 or an agent that mimics the effects of microRNA-130. Further provided is a method of treating a cancer in a subject in need of such treatment comprising the step of administering an effective amount of a microRNA-130 or an agent that enhances the expression of microRNA-130.
摘要翻译：本发明提供了在受试者中改善对癌症治疗的治疗反应的方法，所述方法包括施用有效量的增强微小RNA-130的表达的试剂或模拟微小RNA-130的作用的试剂。还提供了治疗需要这种治疗的受试者的癌症的方法，包括施用有效量的微小RNA-130或增强微小RNA-130表达的试剂的步骤。

5. 发明授权

US08765707B2 MicroRNA-140-5p as a tumor suppressor and sensitizing agent for chemotherapy 有权
标题翻译： MicroRNA-140-5p作为肿瘤抑制剂和化疗敏化剂
公开(公告)号：US08765707B2
公开(公告)日：2014-07-01
申请号：US13453553
申请日：2012-04-23
申请人： Preethi H. Gunaratne , Jason M. Shohet
发明人： Preethi H. Gunaratne , Jason M. Shohet
IPC分类号： C12N15/11
CPC分类号： A61K33/24 , A61K9/0019 , A61K31/198 , A61K31/36 , A61K31/4745 , A61K31/475 , A61K31/555 , A61K31/675 , A61K31/704 , A61K31/713 , A61K38/193 , A61K38/2013 , A61K45/06 , C12N15/113 , C12N2310/141 , C12Q1/6886 , C12Q2600/118 , C12Q2600/178 , G01N2800/52 , A61K2300/00
摘要： The present invention provides a method of improving a therapeutic response to a cancer treatment, in a subject, the method comprising administering an effective amount of an agent that enhances the expression of microRNA-140-5p or an agent that mimics the effects of microRNA-140-5p. Further provided is a method of treating a cancer in a subject in need of such treatment comprising the step of administering an effective amount of a microRNA-140-5p or an agent that enhances the expression of microRNA-140-5p.
摘要翻译：本发明提供一种在受试者中改善癌症治疗的治疗反应的方法，所述方法包括施用有效量的增强微小RNA-140-5p表达的试剂或模拟微小RNA- 140-5p。还提供了治疗需要这种治疗的受试者的癌症的方法，包括施用有效量的微小RNA-140-5p或增强微小RNA-140-5p的表达的试剂的步骤。

6. 发明申请

US20140128451A1 Compositions and Methods for Delivery of MicroRNA to Cells 审中-公开
标题翻译：将微RNA转运至细胞的组合物和方法
公开(公告)号：US20140128451A1
公开(公告)日：2014-05-08
申请号：US14059027
申请日：2013-10-21
申请人： Preethi H Gunaratne , Lalithya C Singh , Matthew L Anderson
发明人： Preethi H Gunaratne , Lalithya C Singh , Matthew L Anderson
IPC分类号： A61K31/7105 , A61K47/48
CPC分类号： A61K31/7105 , A61K31/282 , A61K31/519 , A61K33/00 , A61K47/6923 , A61K47/6929 , B82Y5/00 , C12N15/111 , C12N2310/141 , C12N2320/32 , Y02A50/395 , A61K2300/00
摘要： Provided herein are gold nanoparticles mediated non-viral delivery of miRNAs, siRNAs, genes and drugs. Nanoparticle platforms and combinatorial drug delivery vehicles comprises gold nanoparticles with a plurality of thilolated hyperbranched dendrons conjugated to the nanoparticle surface. The thiolated hyperbranched dendrons comprise chemically-modifiable surface groups, functionalized interior groups and nano-cavities within the hyperbranched structure to which a variety of payload molecules may be conjugated, optionally via a linker. Payload molecules may comprise nucleic acids, anticancer drugs and small molecule inhibitors, optionally with, non-cytotoxic signaling agents, for example, fluoroscein isothiocyanate. Successful manipulation of the degree of PEGylation and the amount of gold nanoparticles in a polyelectrolyte complex to evaluate the best formulation for highest payload delivery of chemically unmodified miRNA duplexes and stemloops is presented. Also provided are methods for delivering one or more therapeutic agents to a cell or tissue or for treating a pathophysiological condition in a subject by delivering the combinatorial drug delivery vehicles to a cell or tissue associated with the pathophysiological condition to facilitate internalization of the vehicle to effect treatment.
摘要翻译：本文提供金纳米颗粒介导的miRNA，siRNA，基因和药物的非病毒递送。纳米颗粒平台和组合药物递送载体包含金纳米颗粒，其具有与纳米颗粒表面缀合的多个噻唑化的超分支树突。硫醇化的超支化树突包含可超过分支结构的化学修饰的表面基团，官能化的内部基团和纳米空穴，可任选地通过连接体将各种有效载荷分子缀合到其上。有效载荷分子可以包含核酸，抗癌药物和小分子抑制剂，任选地含有非细胞毒性信号传导剂，例如异硫氰酸荧光素。提出了聚乙二醇化程度的成功操作和聚电解质复合物中金纳米颗粒的量，以评估化学未修饰的miRNA双链体和茎突的最高有效载荷的最佳配方。还提供了将一种或多种治疗剂递送至细胞或组织或通过将组合药物递送载体递送至与病理生理条件相关联的细胞或组织来治疗受试者的病理生理状况的方法，以促进载体的内化治疗。

7. 发明申请

US20120029062A1 Interior functionalized hyperbranched dendron-conjugated nanoparticles and uses thereof 审中-公开
标题翻译：内部官能化超支化树枝状结合纳米颗粒及其用途
公开(公告)号：US20120029062A1
公开(公告)日：2012-02-02
申请号：US13136498
申请日：2011-08-02
申请人： Preethi H. Gunaratne , Lalithya C. Jayarathne , Matthew L. Anderson
发明人： Preethi H. Gunaratne , Lalithya C. Jayarathne , Matthew L. Anderson
IPC分类号： A61K31/7088 , C12N5/02 , A61P35/00 , C07H21/04 , C07H21/02 , C07F1/12 , C12Q1/02 , A61K31/28
CPC分类号： A61K31/519 , A61K31/282 , A61K31/7088 , A61K47/6923 , A61K47/6929 , B82Y5/00 , C08G83/005
摘要： Provided herein are nanoparticle platforms and combinatorial drug delivery vehicles comprising gold nanoparticles with a plurality of thilolated hyperbranched dendrons conjugated to the nanoparticle surface. The thiolated hyperbranched dendrons comprise chemically-modifiable surface groups, functionalized interior groups and nano-cavities within the hyperbranched structure to which a variety of payload molecules may be conjugated, optionally via a linker. Payload molecules may comprise nucleic acids, anticancer drugs and small molecule inhibitors, optionally with, non-cytotoxic signaling agents, for example, fluoroscein isothiocyanate. Also provided are methods for delivering one or more therapeutic agents to a cell or tissue or for treating a pathophysiological condition in a subject by delivering the combinatorial drug delivery vehicles to a cell or tissue associated with the pathophysiological condition to facilitate internalization of the vehicle to effect treatment.
摘要翻译：本文提供了纳米颗粒平台和组合药物递送载体，其包含金纳米颗粒，其具有与纳米颗粒表面缀合的多个硫化的超支化树突状体。硫醇化的超支化树突包含可超过分支结构的化学修饰的表面基团，官能化的内部基团和纳米空穴，可任选地通过连接体将各种有效载荷分子缀合到其上。有效载荷分子可以包含核酸，抗癌药物和小分子抑制剂，任选地含有非细胞毒性信号传导剂，例如异硫氰酸荧光素。还提供了将一种或多种治疗剂递送至细胞或组织或通过将组合药物递送载体递送至与病理生理条件相关联的细胞或组织来治疗受试者的病理生理状况的方法，以促进载体的内化治疗。

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