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1. 发明授权

US08865212B2 Stable pharmaceutical formulation of an acid labile compound and process for preparing the same 有权
标题翻译：酸不稳定化合物的稳定药物制剂及其制备方法
公开(公告)号：US08865212B2
公开(公告)日：2014-10-21
申请号：US12087085
申请日：2006-11-20
申请人： Pradip Ghosh , Gour Mukherji
发明人： Pradip Ghosh , Gour Mukherji
IPC分类号： A61K9/20 , A61K9/28 , A61K31/44
CPC分类号： A61K9/2886 , A61K31/44
摘要： The disclosed invention provides oral pharmaceutical formulations of an acid labile benzimidazole derivative comprising (a) a core comprising an acid labile benzimidazole derivative, (b) a seal coating layer, and (c) an enteric coating layer, wherein the core of the composition is devoid of any disintegrant.
摘要翻译：所公开的发明提供了酸不稳定苯并咪唑衍生物的口服药物制剂，其包含（a）包含酸不稳定苯并咪唑衍生物的核心，（b）密封涂层，和（c）肠溶包衣层，其中组合物的核心是没有任何崩解剂。

2. 发明申请

US20090022795A1 Stable Pharmaceutical Formulation of an Acid Labile Compound and Process for Preparing the Same 有权
标题翻译：酸不稳定化合物的稳定药物制剂及其制备方法
公开(公告)号：US20090022795A1
公开(公告)日：2009-01-22
申请号：US12087085
申请日：2006-11-20
申请人： Pradip Ghosh , Gour Mukherji
发明人： Pradip Ghosh , Gour Mukherji
IPC分类号： A61K9/28
CPC分类号： A61K9/2886 , A61K31/44
摘要： The disclosed invention provides oral pharmaceutical formulations of an acid labile benzimidazole derivative comprising (a) a core comprising an acid labile benzimidazole derivative, (b) a seal coating layer, and (c) an enteric coating layer, wherein the core of the composition is devoid of any disintegrant.
摘要翻译：所公开的发明提供了酸不稳定苯并咪唑衍生物的口服药物制剂，其包含（a）包含酸不稳定苯并咪唑衍生物的核心，（b）密封涂层，和（c）肠溶包衣层，其中组合物的核心是没有任何崩解剂。

3. 发明申请

US20060237510A1 Short bar separation and recovery system and method 失效
标题翻译：短棒分离回收系统及方法
公开(公告)号：US20060237510A1
公开(公告)日：2006-10-26
申请号：US11401527
申请日：2006-04-11
申请人： Pradip Ghosh , Bruno Maggioni
发明人： Pradip Ghosh , Bruno Maggioni
IPC分类号： B26F3/02
CPC分类号： B07B13/05 , B21B39/00 , B21B39/004 , Y10T225/329
摘要： A system and method are disclosed for separating and recovering short bars from full length bars in a rolling mill. The bars are initially conveyed on a run-out roller table from a shear to a transfer station where they are accumulated in a layer. The layer is transferred laterally from the transfer station onto a separation roller table at a separation station. An elevator lifts the tail ends of the full length bars off of the separation roller table, and the separation roller table then conveys the short bars to a recovery station. The remaining full length bars are then returned to the transfer station, from where they are sent on to a bundling station.
摘要翻译：公开了一种用于在轧机中从全长杆分离和回收短棒的系统和方法。这些钢筋最初是在一个偏离辊台上从一个剪力传递到一个转运站，在这些工位上它们被堆积在一层中。该层从转移站横向转移到分离站处的分离辊台上。电梯将全长杆的尾端提升离开分离辊台，然后分离辊台将短条传送到回收站。剩余的全长条然后返回到转运站，从那里他们被发送到捆绑站。

4. 发明授权

US5464770A DNA encoding (ASP 113) and (LYS 46, ASP 113) thaumatin I 失效
标题翻译： DNA编码（ASP 113）和（LYS 46，ASP 113）thaumatin I
公开(公告)号：US5464770A
公开(公告)日：1995-11-07
申请号：US189250
申请日：1988-05-02
申请人： Joachim L. Weickmann , Pradip Ghosh-Dastidar
发明人： Joachim L. Weickmann , Pradip Ghosh-Dastidar
IPC分类号： C12N15/09 , A23L27/00 , C07H15/12 , C07K14/43 , C12N1/00 , C12N1/16 , C12N1/19 , C12N1/20 , C12N1/21 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/865 , C12N15/29
CPC分类号： C07K14/43
摘要： Genes are disclosed which are capable of directing the synthesis in a selected host microorganism of two thaumatin I analogues both of which have the amino acid sequence of natural thaumatin I including an aspartate amino acid residue in the 113th position from the amino terminal end of the polypeptide and one of which additionally has a lysine amino acid residue substituted for asparagine in the 46th position from the amino terminal end.
摘要翻译：公开了能够将选择的宿主微生物中合成的基因导入两种thaumatin I类似物，两者都具有天然奇异果甜蛋白I的氨基酸序列，其包含天冬氨酸氨基酸残基在该多肽的氨基末端的第113位其中一个另外具有在氨基末端的第46位取代天冬酰胺的赖氨酸氨基酸残基。

5. 发明授权

US4770993A Hybridoma tumor cell lines and their monoclonal antibodies to thaumatin 失效
标题翻译：杂交瘤肿瘤细胞系及其对马齿苋的单克隆抗体
公开(公告)号：US4770993A
公开(公告)日：1988-09-13
申请号：US794247
申请日：1985-10-31
申请人： Pradip Ghosh-Dastidar
发明人： Pradip Ghosh-Dastidar
IPC分类号： G01N33/53 , C07K1/22 , C07K14/005 , C07K14/195 , C07K14/415 , C07K14/43 , C07K16/00 , C07K16/16 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/91 , G01N31/00 , G01N33/531 , G01N33/566 , G01N33/577
CPC分类号： C07K14/43 , C07K16/16 , Y10S435/948 , Y10S436/815 , Y10S530/808 , Y10S530/809
摘要： Disclosed are murine-derived hybridoma tumor cell lines and monoclonal anti-thaumatin antibody substances produced by these cell lines. The monoclonal antibody substances may be used alone or in combination in immunological procedures for isolation of thaumatin and for quantitative detection of thaumatin in fluid samples.
摘要翻译：公开了由这些细胞系产生的鼠衍生的杂交瘤肿瘤细胞系和单克隆抗马齿坦抗体物质。单克隆抗体物质可以单独使用或组合使用于免疫学方法中用于分离曲马糊因并用于定量检测流体样品中的马蹄定蛋白。

6. 发明授权

US06077939A Methods and kits for making polypeptides having a single covalently bound N-terminal water-soluble polymer 失效
标题翻译：用于制备具有单一共价结合的N-末端水溶性聚合物的多肽的方法和试剂盒
公开(公告)号：US06077939A
公开(公告)日：2000-06-20
申请号：US905310
申请日：1997-08-04
申请人： Ziping Wei , Sunitha Menon-Rudolph , Pradip Ghosh-Dastidar
发明人： Ziping Wei , Sunitha Menon-Rudolph , Pradip Ghosh-Dastidar
IPC分类号： A61K38/00 , A61K47/48 , C07K1/107 , C07K14/505 , C07K17/02 , C08G65/32 , C12N11/00 , C07K1/00 , A01N37/18
CPC分类号： A61K47/48215 , C07K1/1077 , C07K14/505
摘要： This invention provides compositions consisting essentially of a polypeptide and a water-soluble polymer covalently bound thereto at the N-terminal .alpha.-carbon atom via a hydrazone or reduced hydrazone bond, or an oxime or reduced oxime bond. This invention also provides methods of making the instant compositions, pharmaceutical compositions comprising same, and kits for use in preparing same.
摘要翻译：本发明提供了基本上由多肽和在N-末端α-碳原子上通过腙或还原的腙键，或肟或还原的肟键共价结合到其上的水溶性聚合物组成的组合物。本发明还提供了制备本发明组合物，包含其的药物组合物和用于制备其的试剂盒的方法。

7. 发明授权

US5242823A Cloning of the 38kd Mycoplasma hyorhinis regression-associated antigen 失效
标题翻译：克隆38kd的支原体回归相关抗原
公开(公告)号：US5242823A
公开(公告)日：1993-09-07
申请号：US956546
申请日：1992-10-02
申请人： George C. Fareed , Arup Sen , Pradip Ghosh-Dastidar , Lee Jar-How
发明人： George C. Fareed , Arup Sen , Pradip Ghosh-Dastidar , Lee Jar-How
IPC分类号： A61K38/00 , A61K39/00 , A61K51/10 , C07K14/30 , C07K14/47 , C07K16/30 , G01N33/574
CPC分类号： C07K14/30 , A61K39/0011 , A61K39/0241 , A61K51/1045 , C07K14/47 , C07K16/30 , G01N33/57488 , A61K2039/55566 , A61K2039/585 , A61K2123/00 , A61K38/00 , A61K39/00 , Y10S530/806 , Y10S530/825
摘要： Regression associated antigens (RAAs) are identified in material from neoplastic cells by their immunological reactivity with regression associated antibodies from the serum of patients diagnosed as undergoing regression of a tumor. Regression associated antibodies (RAAbs) are identified by their absence during progression of a neoplastic disease state and by their presence in a diagnosed state of regression. RAAs have been purified and used to monitor the condition of cancer patients. Production of RAAbs and treatments employing those antibodies are described. It is herein disclosed that RAAs are expressed by M. hyorhinis and are also expressed by expression of provided nucleotide sequences in recombinant host cells, particularly nucleotide sequence for 38 kd and 43 kd RAAs as expressed in E. coli. RAAs and nucleic acids encoding RAAs (or portions thereof) and RAAbs may be used in diagnostic assays and immunotherapy. RAAbs and fragments portion thereof may be used in passive immunization therapy and radioisotope or magnetic resonance scanning.
摘要翻译：回归相关抗原（RAAs）通过其与诊断为经历肿瘤消退的患者的血清的回归相关抗体的免疫反应性从肿瘤细胞的材料中鉴定。回归相关抗体（RAAb）通过其在肿瘤疾病状态的进展期间不存在并通过其在诊断的回归状态中的存在来鉴定。 RAAs已被纯化并用于监测癌症患者的状况。描述了使用这些抗体的RAAb和处理的生产。本文公开了RAAs由海参表达，并且还通过在重组宿主细胞中表达所提供的核苷酸序列，特别是在大肠杆菌中表达的38kd和43kd RAAs的核苷酸序列来表达。编码RAAs（或其部分）和RAAb的RAAs和核酸可用于诊断测定和免疫治疗。 RAAb及其片段部分可用于被动免疫治疗和放射性同位素或磁共振扫描。

8. 发明申请

US20060122871A1 Methods and systems for providing GMWB hedging and GMDB reinsurance 有权
标题翻译：提供GMWB对冲和GMDB再保险的方法和系统
公开(公告)号：US20060122871A1
公开(公告)日：2006-06-08
申请号：US11213042
申请日：2005-08-25
申请人： Alex Cowley , Craig Sabal , Dmitry Noraev , Doug McBeth , Llewellyn Connolly , Martin Klein , Pradip Ghosh , Russ Hackmann
发明人： Alex Cowley , Craig Sabal , Dmitry Noraev , Doug McBeth , Llewellyn Connolly , Martin Klein , Pradip Ghosh , Russ Hackmann
IPC分类号： G06Q40/00
CPC分类号： G06Q40/08 , G06Q40/00
摘要： In one aspect, the invention comprises computer processors operable to identify a block of idealized policies, computer processors operable to calculate risk related to the block of idealized policies based on specified actuarial assumptions; and computer processors operable to provide a customized option designed to pay guaranteed minimum withdrawal benefits on the block of idealized policies; wherein the block of idealized policies is designed to replicate a current policy mix of an insurance company. In another aspect, the invention comprises computer processors operable to identify a block of idealized policies, computer processors operable to calculate risk related to the block of idealized policies based on specified actuarial assumptions; and computer processors operable to provide a reinsurance contract designed to pay guaranteed minimum death benefits on the block of idealized policies; wherein the block of idealized policies is designed to replicate a current policy mix of an insurance company.
摘要翻译：一方面，本发明包括可操作以识别理想化策略块的计算机处理器，可操作以基于指定的精算假设来计算与理想化策略块相关的风险的计算机处理器; 以及计算机处理器，其可操作以提供定制的选项，其设计用于在理想化策略块上支付最低提款收益; 其中理想化策略的块被设计为复制保险公司的当前策略组合。在另一方面，本发明包括可操作以识别理想化策略块的计算机处理器，可用于基于指定的精算假设来计算与理想化策略块相关的风险的计算机处理器; 以及计算机处理器，可操作地提供再保险合同，旨在为理想化政策的阻止支付最低的死亡保障金; 其中理想化策略的块被设计为复制保险公司的当前策略组合。

9. 发明授权

US08744877B2 Methods and systems for providing GMWB hedging and GMDB reinsurance 有权
标题翻译：提供GMWB对冲和GMDB再保险的方法和系统
公开(公告)号：US08744877B2
公开(公告)日：2014-06-03
申请号：US11213042
申请日：2005-08-25
申请人： Alex Cowley , Craig Sabal , Dmitry Noraev , Doug McBeth , Llewellyn C. Connolly , Martin Klein , Pradip Ghosh , Russ Hackman
发明人： Alex Cowley , Craig Sabal , Dmitry Noraev , Doug McBeth , Llewellyn C. Connolly , Martin Klein , Pradip Ghosh , Russ Hackman
IPC分类号： G06Q40/00
CPC分类号： G06Q40/08 , G06Q40/00
摘要： In one aspect, the invention comprises computer processors operable to identify a block of idealized policies, computer processors operable to calculate risk related to the block of idealized policies based on specified actuarial assumptions; and computer processors operable to provide a customized option designed to pay guaranteed minimum withdrawal benefits on the block of idealized policies; wherein the block of idealized policies is designed to replicate a current policy mix of an insurance company. In another aspect, the invention comprises computer processors operable to identify a block of idealized policies, computer processors operable to calculate risk related to the block of idealized policies based on specified actuarial assumptions; and computer processors operable to provide a reinsurance contract designed to pay guaranteed minimum death benefits on the block of idealized policies; wherein the block of idealized policies is designed to replicate a current policy mix of an insurance company.
摘要翻译：一方面，本发明包括可操作以识别理想化策略块的计算机处理器，可操作以基于指定的精算假设来计算与理想化策略块相关的风险的计算机处理器; 以及计算机处理器，其可操作以提供定制的选项，其设计用于在理想化策略块上支付最低提款收益; 其中理想化策略的块被设计为复制保险公司的当前策略组合。在另一方面，本发明包括可操作以识别理想化策略块的计算机处理器，可用于基于指定的精算假设来计算与理想化策略块相关的风险的计算机处理器; 以及计算机处理器，可操作地提供再保险合同，旨在为理想化政策的阻止支付最低的死亡保障金; 其中理想化策略的块被设计为复制保险公司的当前策略组合。

10. 发明申请

US20110097268A1 RADIOHALOIMATINIBS AND METHODS OF THEIR SYNTHESIS AND USE IN PET IMAGING OF CANCERS 审中-公开
标题翻译：放射性蛋白酶及其合成及其在PET成像中的应用
公开(公告)号：US20110097268A1
公开(公告)日：2011-04-28
申请号：US12310333
申请日：2007-08-22
申请人： William Bornmann , Mian Alauddin , Juri Gelovani , Pradip Ghosh , Liwei Guo , Dongmei Han , David Maxwell , Uday Mukhopadhyay , Zhenghong Peng , Aleksandr Shavrin , Yunming Ying
发明人： William Bornmann , Mian Alauddin , Juri Gelovani , Pradip Ghosh , Liwei Guo , Dongmei Han , David Maxwell , Uday Mukhopadhyay , Zhenghong Peng , Aleksandr Shavrin , Yunming Ying
IPC分类号： A61K51/04 , C07D403/14 , A61P35/00
CPC分类号： A61K51/0491
摘要： We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells.
摘要翻译：我们公开了合成放射性有机化合物的方法及其在癌细胞正电子发射断层扫描（PET）成像中的应用。

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