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1. 发明公开

EP1678157A2 HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：其使用杂环化合物和过程与
公开(公告)号：EP1678157A2
公开(公告)日：2006-07-12
申请号：EP04817481.7
申请日：2004-10-28
申请人： Reddy US Therapeutics, Inc. , Rao, Yeleswarapu Koteswar , Pal, Manojit , Sharma, Vedula Manohar , Venkateswarlu, Akella , Pillarisetti, Ram
发明人： RAO, Yeleswarapu K., Fl. 202 Krishna Arcade , PAL, Manojit , SHARMA, Vedula Manohar , VENKATESWARLU, Akella , PILLARISETTI, Ram , PADAKANTI, Srinivas , RAO, Kalleda, Srinivasa
IPC分类号： C07D311/12 , C07D277/34 , C07D487/00 , A61K31/35 , A61K31/497 , A61K31/425
CPC分类号： C07D487/04 , C07D215/56 , C07D239/90 , C07D311/30 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I), and methods and/or compositions comprising compounds that are effective in modulating inflammatory responses, such as those resulting from AGE and glycated protein accumulation are provided. Methods and/or compositions comprising compounds that are effective in modulating smooth muscle cell proliferation and the diseases or conditions related thereto are also provided.

2. 发明专利

AU2004286277A1 Heterocyclic compounds and methods of making and using thereof 未知
公开(公告)号：AU2004286277A1
公开(公告)日：2005-05-12
申请号：AU2004286277
申请日：2004-10-28
申请人： REDDY US THERAPEUTICS INC , YELESWARAPU RAO , PAL MANOJIT , VEDULA SHARMA , VENKATESWARLU AKELLA , PILLARISETTI RAM
发明人： RAO YELESWARAPU KOTESWAR , PILLARISETTI RAM , PAL MANOJIT , VENKATESWARLU AKELLA , SHARMA VEDULA MANOHAR
IPC分类号： C07D311/12 , A61K31/35 , A61K31/425 , A61K31/497 , C07D215/56 , C07D239/90 , C07D277/34 , C07D311/30 , C07D417/12 , C07D417/14 , C07D487/00 , C07D487/04
摘要： Compounds of formula (I), and methods and/or compositions comprising compounds that are effective in modulating inflammatory responses, such as those resulting from AGE and glycated protein accumulation are provided. Methods and/or compositions comprising compounds that are effective in modulating smooth muscle cell proliferation and the diseases or conditions related thereto are also provided.

3. 发明申请

WO2008036835A2 METHODS AND COMPOSITIONS FOR UPREGULATION OF PEROXIREDOXIN ACTIVITY 审中-公开
标题翻译：过氧化物酶活性升高的方法和组合物
公开(公告)号：WO2008036835A2
公开(公告)日：2008-03-27
申请号：PCT/US2007079068
申请日：2007-09-20
申请人： REDDY US THERAPEUTICS , KHANNA ISH , PILLARISETTI RAM , SAXENA UDAY
发明人： KHANNA ISH , PILLARISETTI RAM , SAXENA UDAY
IPC分类号： A61K31/47
CPC分类号： C12Q1/28 , G01N33/92 , G01N2500/10 , G01N2800/044
摘要： A novel method of identifying compounds capable of upregulating Peroxiredoxin activity is disclosed. The method includes providing a sample of cells that express Peroxiredoxin, providing a sample of a candidate compound, contacting the cell sample and the compound sample, and measuring a quantitative indicator of Peroxiredoxin activity within the cell sample after the contacting step. Peroxiredoxin inducers identified by the method and uses therefore to upregulate Peroxiredoxin activity in subjects and to reduce LDL and/or VLDL levels and to prevent or treat atherosclerosis and inflammatory disorders such as arthritis in subjects are also described. The invention also provides a method of treatment of inflammatory and cardiovascular diseases which comprises providing a patient in need of treatment with an effective amount of a composition that increases Peroxiredoxin protein or activity.
摘要翻译：公开了鉴定能够上调过氧化还原毒素活性的化合物的新方法。该方法包括提供表达过氧化还原毒素的细胞样品，提供候选化合物样品，接触细胞样品和化合物样品，以及在接触步骤后测量细胞样品内过氧化还原毒素活性的定量指标。本文还描述了通过该方法和用途鉴定的过氧化还原毒素诱导剂，以上调受试者中的过氧化还原毒素活性并降低LDL和/或VLDL水平，并预防或治疗动脉粥样硬化和炎症性疾病如受试者中的关节炎。本发明还提供了一种治疗炎性和心血管疾病的方法，其包括提供需要治疗的患者，所述治疗有效量的增加过氧化还原蛋白或活性的组合物。

4. 发明申请

WO2006034474A2 NOVEL PYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新型吡啶化合物及其制备方法及其组合物
公开(公告)号：WO2006034474A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/034244
申请日：2005-09-23
申请人： REDDY US THERAPEUTICS, INC. , KALLEDA, Srinivas , PADAKANTI, Srinivas , KUMARSAMY, Nalivela , ALEXANDER, Christopher W. , KHANNA, Ish , IQBAL, Javed , PILLARISETTI, Ram , MAITRA, Santanu , ROBERTS, Gayla, R. , SAGI, Lavanya
发明人： KALLEDA, Srinivas , PADAKANTI, Srinivas , KUMARSAMY, Nalivela , ALEXANDER, Christopher W. , KHANNA, Ish , IQBAL, Javed , PILLARISETTI, Ram , MAITRA, Santanu , ROBERTS, Gayla, R. , SAGI, Lavanya , YELESWARAPU, Koteswar Rao
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/4439 , A61K31/44 , C07D417/02 , C07D403/02 , C07D413/02 , C07D401/02
CPC分类号： C07D405/14 , C07D239/30 , C07D239/40 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/54 , C07D401/04 , C07D403/12 , C07D405/12
摘要： The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
摘要翻译：本发明提供新的杂环化合物，特别是取代的吡啶，制备和使用这些杂环化合物的方法和组合物，以及用于治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或疾病由Perlecan低表达介导的状态。

5. 发明申请

WO2005042712A3 HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THEREOF 审中-公开
公开(公告)号：WO2005042712A3
公开(公告)日：2005-05-12
申请号：PCT/US2004/035939
申请日：2004-10-28
申请人： REDDY US THERAPEUTICS, INC. , RAO, Yeleswarapu, Koteswar , PAL, Manojit , SHARMA, Vedula, Manohar , VENKATESWARLU, Akella , PILLARISETTI, Ram
发明人： RAO, Yeleswarapu, Koteswar , PAL, Manojit , SHARMA, Vedula, Manohar , VENKATESWARLU, Akella , PILLARISETTI, Ram
IPC分类号： C07D311/12
摘要： Compounds of formula (I), and methods and/or compositions comprising compounds that are effective in modulating inflammatory responses, such as those resulting from AGE and glycated protein accumulation are provided. Methods and/or compositions comprising compounds that are effective in modulating smooth muscle cell proliferation and the diseases or conditions related thereto are also provided.

6. 发明申请

WO2005042712A2 HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：杂环化合物及其制备和使用方法
公开(公告)号：WO2005042712A2
公开(公告)日：2005-05-12
申请号：PCT/US2004035939
申请日：2004-10-28
申请人： REDDY US THERAPEUTICS INC , RAO YELESWARAPU KOTESWAR , PAL MANOJIT , SHARMA VEDULA MANOHAR , VENKATESWARLU AKELLA , PILLARISETTI RAM
发明人： RAO YELESWARAPU KOTESWAR , PAL MANOJIT , SHARMA VEDULA MANOHAR , VENKATESWARLU AKELLA , PILLARISETTI RAM
IPC分类号： C07D215/56 , C07D239/90 , C07D311/30 , C07D417/12 , C07D417/14 , C07D487/04 , C12N
CPC分类号： C07D487/04 , C07D215/56 , C07D239/90 , C07D311/30 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I), and methods and/or compositions comprising compounds that are effective in modulating inflammatory responses, such as those resulting from AGE and glycated protein accumulation are provided. Methods and/or compositions comprising compounds that are effective in modulating smooth muscle cell proliferation and the diseases or conditions related thereto are also provided.
摘要翻译：提供式（I）化合物，以及包含有效调节炎性反应的化合物的方法和/或组合物，例如由AGE和糖化蛋白质积聚产生的那些。还提供了包含有效调节平滑肌细胞增殖的化合物和与之有关的疾病或病症的方法和/或组合物。

7. 发明申请

WO2008036835A3 METHODS AND COMPOSITIONS FOR UPREGULATION OF PEROXIREDOXIN ACTIVITY 审中-公开
公开(公告)号：WO2008036835A3
公开(公告)日：2008-03-27
申请号：PCT/US2007/079068
申请日：2007-09-20
申请人： REDDY US THERAPEUTICS , KHANNA, Ish , PILLARISETTI, Ram , SAXENA, Uday
发明人： KHANNA, Ish , PILLARISETTI, Ram , SAXENA, Uday
IPC分类号： C12Q1/00 , C12Q1/68 , C12Q1/28 , C12N9/02 , A61K38/44
摘要： A novel method of identifying compounds capable of upregulating Peroxiredoxin activity is disclosed. The method includes providing a sample of cells that express Peroxiredoxin, providing a sample of a candidate compound, contacting the cell sample and the compound sample, and measuring a quantitative indicator of Peroxiredoxin activity within the cell sample after the contacting step. Peroxiredoxin inducers identified by the method and uses therefore to upregulate Peroxiredoxin activity in subjects and to reduce LDL and/or VLDL levels and to prevent or treat atherosclerosis and inflammatory disorders such as arthritis in subjects are also described. The invention also provides a method of treatment of inflammatory and cardiovascular diseases which comprises providing a patient in need of treatment with an effective amount of a composition that increases Peroxiredoxin protein or activity.

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