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1. 发明申请

US20110257126A1 WATER SOLUBLE CURCUMIN COMPOSITIONS FOR USE IN ANTI-CANCER AND ANTI-INFLAMMATORY THERAPY 有权
标题翻译：用于抗癌和抗炎治疗的水溶性曲霉素组合物
公开(公告)号：US20110257126A1
公开(公告)日：2011-10-20
申请号：US12995126
申请日：2009-05-26
申请人： Philippe Neven , Didier Serteyn , Jacques Delarge , Eva Scheer , Robert Kiss , Veronique Mathieu , Didier Cataldo , Natacha Rocks
发明人： Philippe Neven , Didier Serteyn , Jacques Delarge , Eva Scheer , Robert Kiss , Veronique Mathieu , Didier Cataldo , Natacha Rocks
IPC分类号： A61K31/724 , A61P35/00 , A61P29/00 , A61P35/02 , A61P17/06 , A61P25/00 , A61P1/00 , A61P25/28 , A61P25/16 , A61P9/10 , A61P3/10 , A61P19/02 , A61P37/06 , A61P37/08 , C08B37/16
CPC分类号： B82Y5/00 , A61K31/724 , A61K45/06 , A61K47/6951 , A61K2300/00
摘要： The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particular an anti-tumour and/or anti-inflammatory activity, and improved physico-chemical properties. In a second aspect, the present invention relates to a method for preparation of said water soluble curcumin derivatives. The invention further relates in a third aspect to a pharmaceutical composition comprising an effective amount of said water soluble curcumin derivatives. In a fourth aspect, the present invention concerns the use of said water soluble cucumin derivatives as a medicament and the use of said water soluble curcumin derivatives for the preparation of a medicament for the treatment of cancer and inflammatory diseases. In a fifth aspect, the present invention relates to the use of a pharmaceutical composition comprising said water soluble curcumin derivatives in the treatment of cancer and inflammatory diseases and to a new pharmaceutical composition comprising said water soluble curcumin derivatives.
摘要翻译：本发明涉及医疗领域。在第一方面，本发明涉及具有药理活性，特别是抗肿瘤和/或抗炎活性以及改善的物理化学性质的新的水溶性环糊精 - 姜黄素复合物。在第二方面，本发明涉及一种制备所述水溶性姜黄素衍生物的方法。本发明在第三方面进一步涉及包含有效量的所述水溶性姜黄素衍生物的药物组合物。在第四方面，本发明涉及所述水溶性姜黄素衍生物作为药物的用途，以及所述水溶性姜黄素衍生物在制备用于治疗癌症和炎性疾病的药物中的用途。在第五方面，本发明涉及包含所述水溶性姜黄素衍生物的药物组合物在治疗癌症和炎性疾病中的用途以及包含所述水溶性姜黄素衍生物的新药物组合物的用途。

2. 发明授权

US08772265B2 Water soluble curcumin compositions for use in anti-cancer and anti-inflammatory therapy 有权
标题翻译：用于抗癌和抗炎治疗的水溶性姜黄素组合物
公开(公告)号：US08772265B2
公开(公告)日：2014-07-08
申请号：US12995126
申请日：2009-05-26
申请人： Philippe Neven , Didier Serteyn , Robert Kiss , Veronique Mathieu , Didier Cataldo , Natacha Rocks , Eva Scheer
发明人： Philippe Neven , Didier Serteyn , Jacques Delarge , Robert Kiss , Veronique Mathieu , Didier Cataldo , Natacha Rocks
IPC分类号： A01N43/04 , A61K31/715
CPC分类号： B82Y5/00 , A61K31/724 , A61K45/06 , A61K47/6951 , A61K2300/00
摘要： The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particular an anti-tumor and/or anti-inflammatory activity, and improved physico-chemical properties. In a second aspect, the present invention relates to a method for preparation of said water soluble curcumin derivatives. The invention further relates in a third aspect to a pharmaceutical composition comprising an effective amount of said water soluble curcumin derivatives. In a fourth aspect, the present invention concerns the use of said water soluble cucumin derivatives as a medicament and the use of said water soluble curcumin derivatives for the preparation of a medicament for the treatment of cancer and inflammatory diseases. In a fifth aspect, the present invention relates to the use of a pharmaceutical composition comprising said water soluble curcumin derivatives in the treatment of cancer and inflammatory diseases and to a new pharmaceutical composition comprising said water soluble curcumin derivatives.
摘要翻译：本发明涉及医疗领域。在第一方面，本发明涉及具有药理活性，特别是抗肿瘤和/或抗炎活性以及改善的物理化学性质的新的水溶性环糊精 - 姜黄素复合物。在第二方面，本发明涉及一种制备所述水溶性姜黄素衍生物的方法。本发明在第三方面进一步涉及包含有效量的所述水溶性姜黄素衍生物的药物组合物。在第四方面，本发明涉及所述水溶性姜黄素衍生物作为药物的用途，以及所述水溶性姜黄素衍生物在制备用于治疗癌症和炎性疾病的药物中的用途。在第五方面，本发明涉及包含所述水溶性姜黄素衍生物的药物组合物在治疗癌症和炎性疾病中的用途以及包含所述水溶性姜黄素衍生物的新药物组合物的用途。

3. 发明授权

US5756546A Water-soluble nimesulide salt and its preparation, aqueous dolution containing it, nimesulide-based combinations and their uses 失效
标题翻译：水溶性尼美舒利盐及其制备方法，含水溶液，尼美舒利组合及其用途
公开(公告)号：US5756546A
公开(公告)日：1998-05-26
申请号：US596348
申请日：1996-06-11
申请人： Bernard Pirotte , Geraldine Piel , Philippe Neven , Isabelle Delneuville , Joszef Geczy
发明人： Bernard Pirotte , Geraldine Piel , Philippe Neven , Isabelle Delneuville , Joszef Geczy
IPC分类号： A61K47/40 , A61K31/18 , A61K31/195 , A61K31/198 , A61K31/205 , A61K31/63 , A61K47/48 , A61P29/00 , C07C229/26 , C07C311/08 , C08B37/00 , C08B37/16 , C08L3/00 , C08L3/02
CPC分类号： B82Y5/00 , A61K47/48023 , A61K47/48038 , A61K47/48969 , C07C229/26 , C07C311/08 , C08B37/0015 , Y10S514/886
摘要： Water-soluble nimesulide salt consisting of the product of reaction of nimesulide and of L-lysine and its preparation, aqueous solution containing it, nimesulide-based combinations with cyclodextrins and their uses.
摘要翻译： PCT No.PCT / BE95 / 00055 Sec。 371日期：1996年6月11日 102（e）日期1996年6月11日PCT归档1995年6月16日PCT Pub。第WO95 / 34533号公报日期1995年12月21日由尼美舒利和L-赖氨酸的反应产物及其制备物，含有它的水溶液，与环糊精的尼美舒利基组合及其用途组成的水溶性尼美舒利盐。

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