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1. 发明授权

US08163763B2 Pyrimidine compounds, compositions and methods of use 有权
标题翻译：嘧啶化合物，组合物和使用方法
公开(公告)号：US08163763B2
公开(公告)日：2012-04-24
申请号：US12533935
申请日：2009-07-31
申请人： Philippe Bergeron , Frederick Cohen , Anthony Estrada , Michael F. T. Koehler , Kevin Hon Luen Lau , Cuong Ly , Joseph P. Lyssikatos , Daniel Ortwine , Zhonghua Pei , Xianrui Zhao
发明人： Philippe Bergeron , Frederick Cohen , Anthony Estrada , Michael F. T. Koehler , Kevin Hon Luen Lau , Cuong Ly , Joseph P. Lyssikatos , Daniel Ortwine , Zhonghua Pei , Xianrui Zhao
IPC分类号： A61K31/519 , C07D471/04
CPC分类号： C07D471/18 , C07D471/14
摘要： Disclosed are compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).
摘要翻译：公开了式I化合物，其包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐，其可用于调节PIKK相关激酶信号传导，例如mTOR和用于治疗疾病（例如癌症），至少部分地由PIKK信号通路的失调（例如mTOR）介导。

2. 发明授权

US07939538B2 Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases 失效
标题翻译：用于预防和治疗炎性和免疫调节性疾病和疾病的化合物，组合物和方法
公开(公告)号：US07939538B2
公开(公告)日：2011-05-10
申请号：US11168005
申请日：2005-06-27
申请人： Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic , Jiwen Liu
发明人： Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic , Jiwen Liu
IPC分类号： A61K31/519 , C07D471/04 , C07D239/90 , C07D239/91
CPC分类号： C07D471/04 , C07D239/91 , C07D401/12
摘要： Compounds are provided having the formula: wherein variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
摘要翻译：提供具有下式的化合物：其中如本文所述的变量Ra，R1，R2，R3，R4，A1，A4，L，Q，X和下标n。本发明化合物可用于治疗炎症和免疫疾病和疾病。还提供了使用本发明化合物的组合物和治疗方法。例如，本发明的方法可用于治疗炎症和免疫疾病以及诸如多发性硬化症，类风湿性关节炎，牛皮癣和炎症性肠病等疾病。

3. 发明授权

US07893077B2 Bisaryl-sulfonamides 有权
标题翻译：二芳基磺酰胺
公开(公告)号：US07893077B2
公开(公告)日：2011-02-22
申请号：US12291756
申请日：2008-11-12
申请人： Philippe Bergeron , Christopher N. Farthing , Stuart D. Jones , John W. Liebeschuetz , Sarah E. Lively , Lawrence R. McGee , Sharon McKendry , David Sheppard , Stephen C. Young
发明人： Philippe Bergeron , Christopher N. Farthing , Stuart D. Jones , John W. Liebeschuetz , Sarah E. Lively , Lawrence R. McGee , Sharon McKendry , David Sheppard , Stephen C. Young
IPC分类号： C07D237/20 , C07D403/12 , A61K31/506
CPC分类号： C07D239/47 , C07D213/75 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/52 , C07D239/54 , C07D239/58
摘要： Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARγ or PPARδ. In particular, the compounds of the invention modulate the function of PPARγ or PPARδ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.
摘要翻译：提供了可用于治疗或预防由PPARγ或PPARδ介导的病症或病症的化合物，组合物和方法。特别是本发明化合物调节PPARγ或PPARδ的功能。本发明的方法在治疗和/或预防糖尿病，肥胖，高胆固醇血症，类风湿性关节炎和动脉粥样硬化方面特别有用。

4. 发明申请

US20100253700A1 Real-Time 3-D Interactions Between Real And Virtual Environments 审中-公开
标题翻译：真实和虚拟环境之间的实时3-D交互
公开(公告)号：US20100253700A1
公开(公告)日：2010-10-07
申请号：US12752822
申请日：2010-04-01
申请人： Philippe Bergeron
发明人： Philippe Bergeron
IPC分类号： G09G5/00 , G03B35/00
CPC分类号： G03B35/00 , A63J5/02 , A63J5/021 , G02B27/2207 , G02B27/2292 , G06F3/011
摘要： Systems and methods providing for real and virtual object interactions are presented. Images of virtual objects can be projected onto the real environment, now augmented. Images of virtual objects can also be projected to an off-stage invisible area, where the virtual objects can be perceived as holograms through a semi-reflective surface. A viewer can observe the reflected images while also viewing the augmented environment behind the pane, resulting in one perceived uniform world, all sharing the same Cartesian coordinates. One or more computer-based image processing systems can control the projected images so they appear to interact with the real-world object from the perspective of the viewer.
摘要翻译：提出了提供真实和虚拟对象交互的系统和方法。虚拟对象的图像可以投射到真实的环境中，现在已经扩大了。虚拟物体的图像也可以投影到非正常的不可见区域，虚拟物体可以通过半反射面被感知为全息图。观察者可以观察反射的图像，同时也观察窗格后面的增强环境，导致一个感觉到的均匀的世界，所有这些都共享相同的笛卡尔坐标。一个或多个基于计算机的图像处理系统可以控制投影图像，使得它们从观看者的角度看来与真实世界对象交互。

5. 发明授权

US07799795B2 Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders 有权
标题翻译：芳基腈化合物及其组合物及其在治疗炎症和相关疾病中的用途
公开(公告)号：US07799795B2
公开(公告)日：2010-09-21
申请号：US11475653
申请日：2006-06-26
申请人： Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Julio C. Medina , Jeffrey T. Mihalic , George R. Tonn
发明人： Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Julio C. Medina , Jeffrey T. Mihalic , George R. Tonn
IPC分类号： C07D471/04 , A61K31/519 , A61P29/00 , A61P11/06 , A61P27/14 , A61P19/02 , A61P9/10 , A61P17/06 , C07D487/04 , C07D513/04 , C07D239/26 , C07D233/22 , C07D495/04 , C07D491/04 , C07D233/68 , C07D235/10 , C07D239/90
CPC分类号： C07D233/64 , C07D235/14 , C07D239/26 , C07D239/90 , C07D401/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Provided herein are compounds of the formula where A1, A2, A3, A4, L, Q, R1, R2, R3, R4, Rx, Ry, Rz, X, Y1, Y2, Y4 and Z are as described herein, and compositions thereof that are useful in the treatment of inflammatory and immune conditions and diseases. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor.
摘要翻译：本文提供的化合物是其中A1，A2，A3，A4，L，Q，R1，R2，R3，R4，Rx，Ry，Rz，X，Y1，Y2，Y4和Z如本文所述，其可用于治疗炎症和免疫病症和疾病。特别地，本发明提供了调节趋化因子受体的表达和/或功能的芳基腈化合物。

6. 发明授权

US07375102B2 Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use 失效
标题翻译：四氢喹唑啉-4（3H） - 酮相关和四氢吡啶并[2,3-D]嘧啶-4（3H） - 酮相关化合物，其使用的组合物和方法
公开(公告)号：US07375102B2
公开(公告)日：2008-05-20
申请号：US11168006
申请日：2005-06-27
申请人： Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic , Jiwen Liu
发明人： Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic , Jiwen Liu
IPC分类号： C07D471/04 , C07D487/04 , C07D239/72 , A61K31/513 , A61K31/519 , A61P29/00
CPC分类号： C07D471/04 , C07D239/91 , C07D401/12 , C07D403/12 , C07D409/12
摘要： Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
摘要翻译：提供具有下式的化合物：其中变量A 1，A 2，A 3，A 4，R 4， R 1，R 2，R 3，R 4，Q和L如本文所述。本发明化合物可用于治疗炎症和免疫疾病和疾病。还提供了使用本发明化合物的组合物和治疗方法。例如，本发明的方法可用于治疗炎症和免疫疾病以及诸如多发性硬化症，类风湿性关节炎，牛皮癣和炎症性肠病等疾病。

7. 发明申请

US20060069127A1 Imidazolo-related compounds, compositions and methods for their use 失效
标题翻译：咪唑唑相关化合物，其使用的组合物和方法
公开(公告)号：US20060069127A1
公开(公告)日：2006-03-30
申请号：US11168193
申请日：2005-06-27
申请人： Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
发明人： Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
IPC分类号： A61K31/454 , A61K31/4439 , A61K31/4178 , C07D403/02
CPC分类号： C07D233/64 , C07D233/68 , C07D233/90 , C07D235/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/12
摘要： Compounds are provided having the formula: wherein variables R0, R1, R2, R3, R4, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
摘要翻译：提供具有下式的化合物：

8. 发明申请

US20060069106A1 Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use 失效
标题翻译：四氢喹唑啉-4（3H） - 酮相关和四氢吡啶并[2,3-D]嘧啶-4（3H） - 酮相关化合物，其使用的组合物和方法
公开(公告)号：US20060069106A1
公开(公告)日：2006-03-30
申请号：US11168006
申请日：2005-06-27
申请人： Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
发明人： Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04 , C07D239/91 , C07D401/12 , C07D403/12 , C07D409/12
摘要： Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
摘要翻译：提供具有下式的化合物：

9. 发明申请

US20120165313A1 PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：吡咯烷酮化合物，组合物和使用方法
公开(公告)号：US20120165313A1
公开(公告)日：2012-06-28
申请号：US13410246
申请日：2012-03-01
申请人： Philippe Bergeron , Frederick Cohen , Anthony Estrada , Michael F.T. Koehler , Kevin Hon Luen Lau , Coung Ly , Joseph P. Lyssikatos , Daniel Ortwine , Zhonghua Pei , Xianrui Zhao
发明人： Philippe Bergeron , Frederick Cohen , Anthony Estrada , Michael F.T. Koehler , Kevin Hon Luen Lau , Coung Ly , Joseph P. Lyssikatos , Daniel Ortwine , Zhonghua Pei , Xianrui Zhao
IPC分类号： A61K31/553 , A61K31/5377 , C07D491/048 , A61K31/519 , C07D471/04 , A61P35/02 , A61K31/55 , C07D471/14 , C07D491/08 , C07D471/18 , A61P35/00 , C07D487/04 , A61K31/5386
CPC分类号： C07D471/18 , C07D471/14
摘要： Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).
摘要翻译：公开了式I化合物，包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐，其可用于调节PIKK相关激酶信号传导，例如mTOR，以及用于治疗疾病（例如癌症）至少部分地由PIKK信号通路的失调（例如mTOR）介导。

10. 发明授权

US07544702B2 Bisaryl-sulfonamides 失效
标题翻译：二芳基磺酰胺
公开(公告)号：US07544702B2
公开(公告)日：2009-06-09
申请号：US11203006
申请日：2005-08-11
申请人： Philippe Bergeron , Christopher N. Farthing , Stuart D. Jones , John W. Liebeschuetz , Sarah E. Lively , Lawrence R. McGee , Sharon McKendry , David Sheppard , Stephen C. Young
发明人： Philippe Bergeron , Christopher N. Farthing , Stuart D. Jones , John W. Liebeschuetz , Sarah E. Lively , Lawrence R. McGee , Sharon McKendry , David Sheppard , Stephen C. Young
IPC分类号： C07D417/02 , C07D413/02 , C07D403/02 , A61K31/4427
CPC分类号： C07D239/47 , C07D213/75 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/52 , C07D239/54 , C07D239/58
摘要： Bisaryl-sulfonamide compounds having the formula wherein Ar, R1, R2, L, B, W, X, Y, and Z, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARγ or PPARδ. In particular, the compounds of the invention modulate the function of PPARγ or PPARδ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.
摘要翻译：提供了具有下式的二芳基磺酰胺化合物其中Ar，R 1，R 2，L，B，W，X，Y和Z的组合物和方法可用于治疗或预防由PPARgamma或PPARdelta介导的病症或障碍。特别地，本发明的化合物调节PPARγ或PPARδ的功能。本发明的方法在治疗和/或预防糖尿病，肥胖，高胆固醇血症，类风湿性关节炎和动脉粥样硬化方面特别有用。

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