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1. 发明授权

US4086274A N-(2-mercapto-ethyl)alkanamides from H.sub.2 S and 2-H-2-oxazolines or 2-alkyl-2-oxazolines 失效
标题翻译：来自H（HD 2 {B S和2-H-2-恶唑啉或2-烷基-2-恶唑啉）的N-（2-巯基乙基）烷酰胺
公开(公告)号：US4086274A
公开(公告)日：1978-04-25
申请号：US743888
申请日：1976-11-22
申请人： Mark E. Kaiser , Peter W. Owen
发明人： Mark E. Kaiser , Peter W. Owen
IPC分类号： C07C231/00 , C07C233/16 , C07C102/00 , C07C85/00
CPC分类号： C07C231/00 , C07C233/16
摘要： N-(2-mercaptoethyl)alkanamides are produced by reacting hydrogen sulfide with 2-H-2-oxazolines or 2-alkyl-2-oxazolines. For example, N-(2-mercaptoethyl)acetamide was prepared in excellent yields by incrementally adding 2-methyl-2-oxazoline to a stirred solution of hydrogen sulfide in methanol under autogeneous pressure at about 100.degree. C.
摘要翻译： N-（2-巯基乙基）烷酰胺通过使硫化氢与2-H-2-恶唑啉或2-烷基-2-恶唑啉反应来制备。例如，通过在约100℃的自发压力下向搅拌的硫化氢在甲醇中的溶液中逐渐加入2-甲基-2-恶唑啉，以优异的产率制备N-（2-巯基乙基）乙酰胺。

2. 发明授权

US4376861A Method for preparing 2-alkenyl-2-oxazolines 失效
标题翻译： 2-链烯基-2-恶唑啉的制备方法
公开(公告)号：US4376861A
公开(公告)日：1983-03-15
申请号：US327299
申请日：1981-12-03
申请人： James W. Lalk , Gerald C. Kolb , Donald A. Tomalia , Peter W. Owen
发明人： James W. Lalk , Gerald C. Kolb , Donald A. Tomalia , Peter W. Owen
IPC分类号： C07D263/12 , C07D263/14
CPC分类号： C07D263/14 , C07D263/12
摘要： The process comprises the steps of:(A) reacting by contacting an anhydrous or substantially anhydrous 2-alkyl-2-oxazoline with formaldehyde in a molar ratio of at least about 1.5 moles of 2-alkyl-2-oxazoline per mole of formaldehyde, thereby forming 2-(.alpha.-hydroxymethylalkyl)-2-oxazoline,(B) recovering the 2-(.alpha.-hydroxymethylalkyl)-2-oxazoline from the reaction product of step (A), and(C) reacting by contacting the 2-(.alpha.-hydroxymethylalkyl)-2-oxazoline and step B with an alkali or alkaline earth metal hydroxide, thereby forming 2-alkenyl-2-oxazoline.As an example, step A was conducted by reacting 2-ethyl-2-oxazoline (4 moles) having less than 1,000 ppm of water with paraformaldehyde (1 mole) at a reaction temperature of 100.degree. C. for approximately 5.5 hours. The excess oxazoline reactant was removed along with water as "overheads" by fractional distillation of the reaction product, leaving the 2-(.alpha.-hydroxymethylethyl)-2-oxazoline in approximately 96 percent yield. Step C was then conducted by continuously adding the 2-(.alpha.-hydroxymethylethyl)-2-oxazoline to a stirred solution of sodium hydroxide in the mono-methyl ether of triethylene glycol at a temperature of from 100.degree.-105.degree. C. Under these conditions, the 2-isopropenyl-2-oxazoline and water were volatilized and recovered from the overheads. The product yield was approximately 98 percent of theory.
摘要翻译：该方法包括以下步骤：（A）使无水或基本上无水的2-烷基-2-恶唑啉与甲醛的摩尔比为至少约1.5摩尔的2-烷基-2-恶唑啉/摩尔甲醛，从而形成2-（α-羟甲基烷基）-2-恶唑啉，（B）从步骤（A）的反应产物中回收2-（α-羟甲基烷基）-2-恶唑啉，和（C）（α-羟甲基烷基）-2-恶唑啉和步骤B与碱金属或碱土金属氢氧化物反应，从而形成2-链烯基-2-恶唑啉。作为实例，通过在100℃的反应温度下使具有小于1000ppm水的2-乙基-2-恶唑啉（4摩尔）与多聚甲醛（1摩尔）反应约5.5小时来进行步骤A. 通过反应产物的分馏，将过量的恶唑啉反应物与水一起作为“塔顶馏出物”除去，留下2-（α-羟基甲基乙基）-2-恶唑啉约96％产率。然后通过将2-（α-羟基甲基乙基）-2-恶唑啉连续加入到三乙二醇的单甲基醚的搅拌的氢氧化钠溶液中，在100〜105℃的温度下进行步骤C.在这些条件下，将2-异丙烯基-2-恶唑啉和水挥发并从塔顶馏出物中回收。产品产量约为理论的98％。

3. 发明授权

US4281137A Purification of 2-oxazolines 失效
标题翻译： 2-恶唑啉的纯化
公开(公告)号：US4281137A
公开(公告)日：1981-07-28
申请号：US122946
申请日：1980-02-20
申请人： James W. Sanner , Peter W. Owen
发明人： James W. Sanner , Peter W. Owen
IPC分类号： C07D263/12
CPC分类号： C07D263/12
摘要： Residual amounts of water and color-causing impurities can be removed from a 2-oxazoline compound by introducing from 0.01 to 25 weight percent of a dialkyl hydrogen phosphite or a halosilane compound to the 2-oxazoline and then distilling the oxazoline. For example, 0.5 weight percent of bis(2-ethylhexyl)hydrogen phosphite was introduced into 100 grams of 2-ethyl-2-oxazoline containing 1000 parts per million (ppm) of water and the mixture was then distilled to yield 2-ethyl-2-oxazoline containing less than 10 ppm of water.
摘要翻译：通过将0.01至25重量％的亚磷酸氢二氢亚烷基酯或卤代硅烷化合物引入2-恶唑啉，然后蒸馏出恶唑啉，可以从2-恶唑啉化合物中除去残留量的水和着色杂质。例如，将0.5重量％的双（2-乙基己基）亚磷酸氢盐引入含有1000份（ppm）水的100克2-乙基-2-恶唑啉中，然后将混合物蒸馏得到2-乙基-2- 含有少于10ppm水的2-恶唑啉。

4. 发明授权

US4199561A Coated nutrients and medicaments for veterinary use 失效
标题翻译：用于兽医用途的涂层营养和药物
公开(公告)号：US4199561A
公开(公告)日：1980-04-22
申请号：US15037
申请日：1979-02-26
申请人： Harold H. Roth , Peter W. Owen , Thomas T. Chiu
发明人： Harold H. Roth , Peter W. Owen , Thomas T. Chiu
IPC分类号： A23K1/00 , A61K9/16 , A61K9/50 , C08F8/32 , A61K31/74 , A61K9/32
CPC分类号： A61K9/5026 , A23K40/35 , A61K9/1635 , C08F8/32 , C08F2800/20
摘要： An imidazoline modified styrene-acrylonitrile polymer composition which is substantially insoluble in aqueous media at about pH 6 or more but swellable or soluble at pH 3 or less is employed as a coating for nutrient or therapeutic substances for administration to ruminants. The substances thus are rendered resistant to attack and breakdown in the rumen yet remain susceptible to release and digestion within the abomasum or small intestine of the animal.
摘要翻译：使用基本上不溶于水性介质的咪唑啉改性苯乙烯 - 丙烯腈聚合物组合物，其pH值大约为6或更高，但在3或更低的pH下可膨胀或可溶，作为用于给反刍动物施用的营养物或治疗物质的涂层。因此，这些物质对瘤胃的攻击和破坏具有抗性，但仍然易于在动物的皱胃或小肠内释放和消化。

5. 发明授权

US4024184A Preparation of N-(2-alkoxyethyl)alkanamides and 2-alkoxyethyl amines from 2-oxazolines 失效
标题翻译：从2-恶唑啉制备N-（2-烷氧基乙基）烷酰胺和2-烷氧基乙胺
公开(公告)号：US4024184A
公开(公告)日：1977-05-17
申请号：US698446
申请日：1976-05-21
申请人： Mark E. Kaiser , Peter W. Owen
发明人： Mark E. Kaiser , Peter W. Owen
IPC分类号： C07C231/00 , C07C233/16 , C07C102/00 , C07C85/00
CPC分类号： C07C231/00 , C07C233/16
摘要： N-(2-alkoxyethyl)alkanamides, such as N-(2-ethoxyethyl)ethanamide and N-(2-methoxyethyl)propanamide, are prepared by reacting a 2-oxazoline with methanol or ethanol in the presence of a strong base, such as sodium methoxide. Subsequent hydrolysis of such amides provides a convenient means for obtaining 2-alkoxyethyl amines.
摘要翻译： N-（2-烷氧基乙基）烷酰胺如N-（2-乙氧基乙基）乙酰胺和N-（2-甲氧基乙基）丙酰胺通过2-恶唑啉与甲醇或乙醇在强碱存在下反应来制备，作为甲醇钠。随后水解这些酰胺提供了获得2-烷氧基乙基胺的便利方式。

6. 发明授权

US4014880A Process for making imidazolines and tetrahydropyrimidines from oxazolines and alkylenediamines 失效
标题翻译：由恶唑啉和亚烷基二胺制备咪唑啉和四氢嘧啶的方法
公开(公告)号：US4014880A
公开(公告)日：1977-03-29
申请号：US656558
申请日：1976-02-09
申请人： William Dowd , Peter W. Owen
发明人： William Dowd , Peter W. Owen
IPC分类号： C07D233/06 , C07D239/06 , C07D239/00
CPC分类号： C07D239/06 , C07D233/06
摘要： The reaction of 2-oxazolines with 1,2- or 1,3-alkylenediamines to form 2-imidazolines or 1,4,5,6-tetrahydropyrimidines is catalyzed by Lewis acids.
摘要翻译： 2-恶唑啉与1,2-或1,3-亚烷基二胺形成2-咪唑啉或1,4,5,6-四氢嘧啶的反应由路易斯酸催化。

7. 发明授权

US4265825A Process for the preparation of N-(haloalkyl)sulfonamide 失效
标题翻译：制备N-（卤代烷基）磺酰胺的方法
公开(公告)号：US4265825A
公开(公告)日：1981-05-05
申请号：US76111
申请日：1979-09-17
申请人： Peter W. Owen , Zita K. Harmon , Donald A. Tomalia
发明人： Peter W. Owen , Zita K. Harmon , Donald A. Tomalia
IPC分类号： C07C311/00 , C07C143/72
CPC分类号： C07C311/00
摘要： N-(haloalkyl)sulfonamides represented by the formula ##STR1## wherein R.sub.1 is a C.sub.1 -C.sub.20 aryl, alkaryl, aralkyl or alkyl group; R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen or methyl groups; n is the integer 0 or 1 and X is a chloro, bromo or iodo group, are prepared by reacting an N-(haloalkyl)sulfonyl imide with a C.sub.1 -C.sub.6 alkanol.
摘要翻译：由式（I）表示的N-（卤代烷基）磺酰胺其中R 1是C 1 -C 20芳基，烷芳基，芳烷基或烷基; R2，R3和R4各自独立地为氢或甲基; n是整数0或1，X是氯，溴或碘基团，通过使N-（卤代烷基）磺酰亚胺与C 1 -C 6烷醇反应制备。

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