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    • 2. 发明申请
    • Proteins related to schizophrenia and uses thereof
    • 与精神分裂症相关的蛋白质及其用途
    • US20080064638A1
    • 2008-03-13
    • US11893494
    • 2007-08-15
    • Peter St. George-HyslopPaul Fraser
    • Peter St. George-HyslopPaul Fraser
    • A61K38/00A61P43/00C12Q1/68G01N33/00G01N33/53
    • C12Q1/6883A01K2217/05A61K38/00C07K14/705C12Q2600/156G01N33/6893G01N33/6896G01N2500/00G01N2800/28G01N2800/30G01N2800/302
    • Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodevelopmental and neuropsychiatric disorders. In a specific embodiment, mutations in PAMP are diagnostic for schizophrenia. The invention further relates to screening, particularly using high-throughput screens and transgenic animal models, for compounds that modulate the activity of PAMP and presenilins. Such compounds, or gene therapy with PAMP, can be used in treating neurodevelopmental and neuropsychiatric disorders, particularly schizophrenia. In addition, the invention provides PAMP mutants, nucleic acids encoding for PAMP mutants, and transgenic animals expressing PAMP mutants, which in a preferred aspect result in biochemical, morphological, or neuropsychological changes similar to those associated with schizophrenia.
    • 提供了早老素联合膜蛋白(PAMP)和编码该蛋白的核酸。 PAMP和PAMP核酸提供诊断和治疗工具,用于评估和治疗或预防神经发育和神经精神障碍。 在具体实施方案中,PAMP中的突变是精神分裂症的诊断。 本发明进一步涉及对调节PAMP和早老素活性的化合物筛选,特别是使用高通量筛选和转基因动物模型。 这些化合物或用PAMP进行的基因治疗可用于治疗神经发育和神经精神障碍,特别是精神分裂症。 此外,本发明提供PAMP突变体,编码PAMP突变体的核酸和表达PAMP突变体的转基因动物,其在优选的方面导致类似于与精神分裂症相关的生化,形态或神经心理学变化。
    • 3. 发明授权
    • Presenilin associated membrane protein and uses thereof
    • 早老素相关膜蛋白及其用途
    • US06812337B1
    • 2004-11-02
    • US09541094
    • 2000-03-31
    • Peter St. George-HyslopPaul E. Fraser
    • Peter St. George-HyslopPaul E. Fraser
    • C07H2104
    • C07K14/705A01K2217/05
    • Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodegenerative diseases. In a specific embodiment, mutations in PAMP are diagnostic for Alzheimer's Disease or spina bifida. The invention further relates to screening, particularly using high-throughput screens and transgenic animal models, for compounds that modulate the activity of PAMP and presenilins. Such compounds, or gene therapy with PAMP, can be used in treating neurodegenerative diseases, particularly Alzheimer's Disease. In addition, the invention provides PAMP mutants, nucleic acids encoding for PAMP mutants, and transgenic animals expressing PAMP mutants, which in a preferred aspect result in biochemical changes similar to those induced by mutations in &bgr;APP, PS1, or PS2, associated with familial Alzheimer's disease.
    • 提供了早老素联合膜蛋白(PAMP)和编码该蛋白的核酸。 PAMP和PAMP核酸提供诊断和治疗工具,用于评估和治疗或预防神经变性疾病。 在具体实施方案中,PAMP中的突变是阿尔茨海默病或脊柱裂的诊断。 本发明进一步涉及对调节PAMP和早老素活性的化合物筛选,特别是使用高通量筛选和转基因动物模型。 这些化合物或用PAMP的基因治疗可用于治疗神经变性疾病,特别是阿尔茨海默病。 此外,本发明提供PAMP突变体,编码PAMP突变体的核酸和表达PAMP突变体的转基因动物,其在优选的方面导致生物化学变化类似于与家族性阿尔茨海默病相关的βAPP,PS1或PS2突变诱导的生物化学变化 疾病。
    • 8. 发明授权
    • Financial transaction processing system and method
    • 金融交易处理系统和方法
    • US07779160B1
    • 2010-08-17
    • US11288719
    • 2005-11-28
    • Robert D. SymondsIrek SingerPeter St. GeorgeRobert Bradley Gill
    • Robert D. SymondsIrek SingerPeter St. GeorgeRobert Bradley Gill
    • G06F17/60G06F15/16G06Q40/00
    • G06Q20/10G06Q20/102G06Q20/1085G06Q20/20G06Q20/202G06Q20/208G06Q20/367G07F19/206G07F19/211H04L67/147
    • A financial transaction processing system (10) enables processing transactions from various types of card activated terminal devices (12) which communicate using a variety of electronic message formats. The transaction processing system may operate to authorize transactions internally using information stored in a relational database (32) or may communicate with external authorization systems (18). The transaction processing system includes among its software components message gateway routers (MGRs) (24, 164) which operate using information stored in the relational database to convert messages from a variety of external message formats used by the external devices and authorization systems, to a common internal message format used within the system. The system further uses database information to internally route messages to message processing programs (MPPs) (108, 138) which process messages and generate messages to the external devices and authorization systems. The MGR also converts the outgoing messages from the internal message format to the external message formats which can be interpreted by the external devices and systems to which the messages are directed.
    • 金融交易处理系统(10)能够处理来自使用各种电子消息格式进行通信的各种类型的卡激活的终端设备(12)的处理。 交易处理系统可以操作以在内部使用存储在关系数据库(32)中的信息来授权交易,或者可以与外部授权系统(18)通信。 交易处理系统包括其软件组件消息网关路由器(MGR)(24,164),其使用存储在关系数据库中的信息进行操作,以将来自外部设备和授权系统使用的各种外部消息格式的消息转换为 在系统中使用的通用内部消息格式。 该系统还使用数据库信息将消息内部路由到消息处理程序(MP)(108,138),消息处理程序(108,138)处理消息并向外部设备和授权系统生成消息。 MGR还将来自内部消息格式的传出消息转换为外部消息格式,外部消息格式可以由消息所针对的外部设备和系统解释。