专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06482926B1 Antibody compositions for preparing enriched cell preparations 有权
标题翻译：用于制备富集的细胞制剂的抗体组合物
公开(公告)号：US06482926B1
公开(公告)日：2002-11-19
申请号：US09533081
申请日：2000-03-22
申请人： Terry Thomas , Peter Lansdorp
发明人： Terry Thomas , Peter Lansdorp
IPC分类号： C07K1600
CPC分类号： C12N5/0087 , A61K38/00 , C07K16/18 , C07K16/2803 , C07K16/2806 , C07K16/2809 , C07K16/283 , C07K16/289 , C07K16/2896 , C07K16/4283 , C12N5/0647 , C12N5/0693
摘要： The present invention relates to antibody composition that are useful in preparing enriched cell preparations such as human hematopoietic progenitor cells and stem cells and non-hematopoietic tumor cells. The invention also relates to kits for carrying out the processes and to the cell preparations prepared by the processes.
摘要翻译：本发明涉及可用于制备富集的细胞制剂如人造血祖细胞和干细胞以及非造血肿瘤细胞的抗体组合物。本发明还涉及用于进行该方法的试剂盒和通过该方法制备的细胞制备物。

2. 发明授权

US06448075B1 Method for separating cells using immunorosettes 有权
标题翻译：使用免疫球蛋白分离细胞的方法
公开(公告)号：US06448075B1
公开(公告)日：2002-09-10
申请号：US09579463
申请日：2000-05-26
申请人： Terry E. Thomas , Carrie Peters , Peter Lansdorp
发明人： Terry E. Thomas , Carrie Peters , Peter Lansdorp
IPC分类号： C12N500
CPC分类号： G01N33/80 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/31 , G01N33/5094
摘要： The present invention relates to methods for separating cells using immunorosettes. The method involves contacting a sample containing nucleated cells and red blood cells with an antibody composition which allows immunorosettes of the nucleated cells and the red blood cells to form. The antibody composition preferably contains bifunctional antibodies or tetrameric antibody complexes.
摘要翻译：本发明涉及使用免疫球蛋白分离细胞的方法。该方法包括将含有核细胞和红细胞的样品与允许形成有核细胞和红细胞的免疫球蛋白的抗体组合物接触。抗体组合物优选含有双功能抗体或四聚体抗体复合物。

3. 发明授权

US06872567B2 Method for separating cells using immunorosettes 有权
标题翻译：使用免疫球蛋白分离细胞的方法
公开(公告)号：US06872567B2
公开(公告)日：2005-03-29
申请号：US10193092
申请日：2002-07-12
申请人： Terry E. Thomas , Carrie Peters , Peter Lansdorp
发明人： Terry E. Thomas , Carrie Peters , Peter Lansdorp
IPC分类号： G01N33/53 , C07K16/28 , C12N1/00 , C12N5/00 , C12N5/06 , C12N5/08 , G01N33/50 , G01N33/80 , C12Q1/24
CPC分类号： G01N33/80 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/31 , G01N33/5094
摘要： The present invention relates to methods for separating cells using immunorosettes. The method involves contacting a sample containing nucleated cells and red blood cells with an antibody composition which allows immunorosettes of the nucleated cells and the red blood cells to form. The antibody composition preferably contains bifunctional antibodies or tetrameric antibody complexes.
摘要翻译：本发明涉及使用免疫球蛋白分离细胞的方法。该方法包括将含有核细胞和红细胞的样品与允许形成有核细胞和红细胞的免疫球蛋白的抗体组合物接触。抗体组合物优选含有双功能抗体或四聚体抗体复合物。

4. 发明授权

US06750326B2 Method for separating cells using immunorosettes 有权
公开(公告)号：US06750326B2
公开(公告)日：2004-06-15
申请号：US09822823
申请日：2001-04-02
申请人： Terry Thomas , Carrie Peters , Peter Lansdorp
发明人： Terry Thomas , Carrie Peters , Peter Lansdorp
IPC分类号： C07K1628
CPC分类号： G01N33/80 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/31 , G01N33/5094 , Y10S436/819
摘要： The present invention relates to methods for separating cells using immunorosettes. The method involves contacting a sample containing nucleated cells and red blood cells with an antibody composition which allows immunorosettes of the nucleated cells and the red blood cells to form. The antibody composition preferably contains bifunctional antibodies or tetrameric antibody complexes.

5. 发明授权

US5877299A Methods for preparing enriched human hematopoietic cell preparations 失效
标题翻译：制备富集人造血细胞制剂的方法
公开(公告)号：US5877299A
公开(公告)日：1999-03-02
申请号：US491175
申请日：1995-06-16
申请人： Terry Thomas , Peter Lansdorp
发明人： Terry Thomas , Peter Lansdorp
IPC分类号： A61K38/00 , C07K16/18 , C07K16/28 , C07K16/42 , C12N5/00 , C12N5/0789 , C07K1/00
CPC分类号： C12N5/0087 , C07K16/18 , C07K16/2803 , C07K16/2806 , C07K16/2809 , C07K16/283 , C07K16/289 , C07K16/2896 , C07K16/4283 , C12N5/0647 , A61K38/00
摘要： The present invention relates to an antibody composition which contains antibodies specific for glycophorin A, CD3, CD24, CD16, CD14, and optionally CD45RA, CD36, CD56, CD2, CD19, CD66a and/or CD66b. A process is also provided for enriching and recovering human hematopoietic progenitor cells and stem cells in a sample containing human hematopoietic differentiated, progenitor, and stem cells. The process involves reacting the sample with an antibody composition containing antibodies capable of binding to the antigens glycophorin A, CD3, CD24, CD16, and CD14, and optionally CD45RA, CD36, CD56, CD2, CD19, CD66a and/or CD66b under conditions so that cell conjugates are formed between the antibodies and differentiated cells having the antigens glycophorin A, CD3, CD24, CD16, and CD14, and optionally CD45RA, CD36, CD56, CD2, CD19, CD66a and/or CD66b on their surfaces. The cell conjugates are removed and a cell preparation is obtained which is enriched in human hematopoietic progenitor cells and stem cells. The invention also relates to kits for carrying out this process and to the cell preparations prepared by the process.
摘要翻译：本发明涉及含有对血型糖蛋白A，CD3，CD24，CD16，CD14以及任选的CD45RA，CD36，CD56，CD2，CD19，CD66a和/或CD66b特异性抗体的抗体组合物。还提供了用于富集和回收含有人造血细胞分化，祖细胞和干细胞的样品中的造血祖细胞和干细胞的方法。该方法包括使样品与包含能够结合抗原血型糖蛋白A，CD3，CD24，CD16和CD14以及任选的CD45RA，CD36，CD56，CD2，CD19，CD66a和/或CD66b的抗体的抗体组合物反应，在其表面上具有抗原血型糖蛋白A，CD3，CD24，CD16和CD14以及任选的CD45RA，CD36，CD56，CD2，CD19，CD66a和/或CD66b的抗体和分化细胞之间形成细胞缀合物。去除细胞缀合物，并获得富含人造血祖细胞和干细胞的细胞制剂。本发明还涉及用于实施该方法的试剂盒和本方法制备的细胞制剂。

6. 发明申请

US20070026468A1 Tetrameric antibody complexes for blocking non-specific labeling of antigens 有权
标题翻译：用于阻断抗原非特异性标记的四聚体抗体复合物
公开(公告)号：US20070026468A1
公开(公告)日：2007-02-01
申请号：US11524909
申请日：2006-09-22
申请人： Albertus Wognum , Peter Lansdorp
发明人： Albertus Wognum , Peter Lansdorp
IPC分类号： G01N33/567
CPC分类号： G01N33/5306 , G01N2333/70535 , Y10S435/962 , Y10S436/819 , Y10S436/825
摘要： A method for preventing or inhibiting non-specific binding reactions between a detection reagent and an antigen in an immunological assay is described. The method involves using tetrameric antibody complexes that can bind to the antigen and are comprised of two monoclonal antibodies of a first animal species linked to two monoclonal antibodies of a second animal species that can bind the antibodies of the first animal species. Preferably, the antigen is an Fc Receptor and the method reduces the binding of a detection antibody with Fc receptors present on the surface of many cells.
摘要翻译：描述了在免疫测定中预防或抑制检测试剂和抗原之间的非特异性结合反应的方法。该方法包括使用可与抗原结合的四聚体抗体复合物，并且由与可与第一动物物种结合的第二动物物种的两种单克隆抗体连接的第一动物物种的两种单克隆抗体组成。优选地，抗原是Fc受体，并且该方法降低了检测抗体与许多细胞表面上存在的Fc受体的结合。

7. 发明授权

US06117985A Antibody compositions for preparing enriched cell preparations 失效
公开(公告)号：US06117985A
公开(公告)日：2000-09-12
申请号：US88227
申请日：1998-06-01
申请人： Terry Thomas , Peter Lansdorp
发明人： Terry Thomas , Peter Lansdorp
IPC分类号： A61K38/00 , C07K16/18 , C07K16/28 , C07K16/42 , C12N5/00 , C12N5/0789 , C12N5/09 , A61K39/395 , A01N1/02 , A61K35/12
CPC分类号： C12N5/0087 , C07K16/18 , C07K16/2803 , C07K16/2806 , C07K16/2809 , C07K16/283 , C07K16/289 , C07K16/2896 , C07K16/4283 , C12N5/0647 , C12N5/0693 , A61K38/00
摘要： The present invention relates to antibody composition that are useful in preparing enriched cell preparations such as human hematopoietic progenitor cells and stem cells and non-hematopoietic tumor cells. The invention also relates to kits for carrying out the processes and to the cell preparations prepared by the processes.

8. 发明授权

US5514340A Device for separating magnetically labelled cells 失效
标题翻译：用于分离磁性标记细胞的装置
公开(公告)号：US5514340A
公开(公告)日：1996-05-07
申请号：US185064
申请日：1994-01-24
申请人： Peter Lansdorp , Terry Thomas
发明人： Peter Lansdorp , Terry Thomas
IPC分类号： B03C1/00 , B03C1/025 , B03C1/031 , B03C1/034 , C12M1/26 , C12M1/42 , C12M3/06 , C12N1/02 , G01N33/543 , G01N33/569 , B07C5/344
CPC分类号： G01N33/56972 , B03C1/002 , B03C1/025 , B03C1/031 , B03C1/034 , C12N1/02 , G01N33/54326 , C12M47/04
摘要： A device for separating magnetically labelled cells in a sample using an applied magnetic field having a housing; an inlet element at the top portion of the housing having an input end and an output end; a filter chamber adjacent to the output end of the inlet element for filtering the magnetically labelled cells from the fluid while allowing unlabelled cells to pass through when a magnetic field is applied thereto, and containing a multiplicity of magnetic matrix elements extending transversely across the filter chamber; and an outlet element for collecting the fluid which passes through the filter chamber having an input end coupled to the filter chamber and an output end. The device has one or more of the following features: (i) the inlet and/or outlet element having flow distribution means for distributing the flow from the inlet element generally uniformly across the filter chamber; (ii) the peripheries of the magnetic matrix elements are connected to the housing by a junction which is substantially impenetrable to the fluid; and (iii) the magnetic matrix elements are ordered and spaced apart so as to maximize the magnetic capture of magnetically labelled cells onto the magnetic matrix element when a magnetic field is applied. Methods of using the device and a hematopoietic cell preparation obtained using the device of the invention are also described.
摘要翻译：一种用于使用具有壳体的施加磁场分离样品中的磁性标记细胞的装置; 壳体顶部的入口元件具有输入端和输出端; 与入口元件的输出端相邻的过滤室，用于从流体过滤磁性标记的细胞，同时允许未标记的细胞在施加磁场时通过，并且包含横向延伸穿过过滤器室的多个磁性矩阵元件 ; 以及用于收集通过过滤室的流体的出口元件，其具有联接到过滤室的输入端和输出端。该装置具有一个或多个以下特征：（i）入口和/或出口元件具有流量分配装置，用于将来自入口元件的流体大致均匀地分布在过滤室上; （ii）磁矩阵元件的周边通过基本上不透过流体的接头连接到壳体; 和（iii）磁矩阵元件被排序并间隔开，以便当施加磁场时，使磁性标记的细胞在磁矩阵元件上的磁捕获最大化。还描述了使用本发明的装置获得的使用该装置和造血细胞制剂的方法。

9. 发明授权

US06514693B1 Method for detecting multiple copies of a repeat sequence in a nucleic acid molecule 失效
公开(公告)号：US06514693B1
公开(公告)日：2003-02-04
申请号：US08730635
申请日：1996-10-11
申请人： Peter Lansdorp
发明人： Peter Lansdorp
IPC分类号： C12Q168
CPC分类号： C12Q1/6876 , C12Q1/6841 , C12Q1/6886 , C12Q2600/136 , C12Q2525/151 , C12Q2525/113 , C12Q2525/107
摘要： A method for detecting or quantitating multiple copies of a repeat sequence in a nucleic acid molecule involving treating the nucleic acid molecule with a probe which is a nucleic acid analogue which is capable of hybridizing to the repeat sequence in the nucleic acid molecule and which is labelled with a detectable substance. The nucleic acid molecule is treated with the probe under conditions permitting the probe to hybridize to the repeat sequences in the nucleic acid molecule. Probe hybridized to complementary repeat sequences is identified in the nucleic acid molecule by directly or indirectly detecting the detectable substance. The method is preferably used for quantitating multiple copies of a repeat sequence in a nucleic acid molecule, preferably a telomere or centromere repeat sequence. Novel probes for use in the method of the invention and kits are described.

10. 发明授权

US06491918B1 Antibody compositions for preparing enriched dendritic cell preparations 有权
标题翻译：用于制备富集的树突状细胞制剂的抗体组合物
公开(公告)号：US06491918B1
公开(公告)日：2002-12-10
申请号：US09428923
申请日：1999-10-28
申请人： Terry Thomas , Peter Lansdorp
发明人： Terry Thomas , Peter Lansdorp
IPC分类号： A61K39395
CPC分类号： C12N5/0087 , A61K38/00 , C07K16/18 , C07K16/2803 , C07K16/2806 , C07K16/2809 , C07K16/283 , C07K16/289 , C07K16/2896 , C07K16/4283 , C12N5/0647 , C12N5/0693
摘要： The present invention relates to antibody composition that are useful in preparing enriched cell preparations such as human hematopoietic progenitor cells and stem cells and non-hematopoietic tumor cells. The invention also relates to kits for carrying out the processes and to the cell preparations prepared by the processes.
摘要翻译：本发明涉及可用于制备富集的细胞制剂如人造血祖细胞和干细胞以及非造血肿瘤细胞的抗体组合物。本发明还涉及用于进行该方法的试剂盒和通过该方法制备的细胞制备物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式