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1. 发明专利

GB659297A Improvements in or relating to orthodontic screws 未知
公开(公告)号：GB659297A
公开(公告)日：1951-10-24
申请号：GB64049
申请日：1949-01-10
申请人： JAN MAZUR , MAURICE WILLIAM PETER HUDSON
IPC分类号： A61C7/10
摘要： 659,297. Orthodontic screws. MAZUR, J., and HUDSON, M. W. P. Jan. 10, 1949, No. 640. [Class 81(ii)] An orthodontic screw device comprises a pair of socket members 1, 2 in the form of bars adapted to be embedded in two parts 7 , 8 of a dental plate and formed at one end with screw-threaded projections 6 directed away from each other and receiving the ends of an expander screw having right-handed and left-handed screw threads 9, 10, said bars being formed at the opposite end with projections 5 extending towards and slidably engaged with each other by means of a pin 12 carried by one projection engaging a socket 13 in the other projection. Specification 641,139, is referred to.

2. 发明授权

US08202858B2 Vasopressin V1a antagonists 有权
标题翻译：血管加压素V1a拮抗剂
公开(公告)号：US08202858B2
公开(公告)日：2012-06-19
申请号：US11659798
申请日：2005-08-24
申请人： Andrzej Roman Batt , Martin Lee Stockley , Michael Bryan Roe , Celine Marguerite Simone Heeney , Andrew John Baxter , Peter Hudson , Rachel Handy
发明人： Andrzej Roman Batt , Martin Lee Stockley , Michael Bryan Roe , Celine Marguerite Simone Heeney , Andrew John Baxter , Peter Hudson , Rachel Handy
IPC分类号： A61K31/55
CPC分类号： C07D267/14 , C07D215/08 , C07D223/16 , C07D231/42 , C07D265/36 , C07D267/16 , C07D295/088 , C07D333/44 , C07D413/14 , C07D417/10 , C07D487/04 , C07D498/14 , C07D513/04 , C07D513/14
摘要： The present invention concerns compounds inter alia according to general formula 1a. Compounds according to the invention are vasopressin V1a receptor antagonists. Pharmaceutical compositions of the compounds are useful as treatment of dysmenorrhoea.
摘要翻译：本发明尤其涉及根据通式1a的化合物。根据本发明的化合物是加压素V1a受体拮抗剂。化合物的药物组合物可用作治疗痛经。

3. 发明申请

US20120003214A1 Binding Moieties Based On Shark IgNAR Domains 审中-公开
标题翻译：基于鲨鱼IgNAR域的结合部分
公开(公告)号：US20120003214A1
公开(公告)日：2012-01-05
申请号：US13157205
申请日：2011-06-09
申请人： Stewart Nuttall , Victor Streltsov , Katherine Merne Griffiths , Jennifer Ann Carmichael , Peter Hudson , Robert Alexander Irving , Joseph Noozhumurry Varghese , Miles Mackay Barraclough , David Peter Simmons , Kylie Anne Henderson
发明人： Stewart Nuttall , Victor Streltsov , Katherine Merne Griffiths , Jennifer Ann Carmichael , Peter Hudson , Robert Alexander Irving , Joseph Noozhumurry Varghese , Miles Mackay Barraclough , David Peter Simmons , Kylie Anne Henderson
IPC分类号： A61K39/395 , C40B40/08 , C07K16/00
CPC分类号： C07K16/464 , C07K14/461 , C07K16/00 , C07K2299/00 , C07K2317/20 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to immunoglobulin new antigen receptors (IgNARs) from fish and uses thereof. In particular, the present invention relates to modified IgNAR variable domains and to domains from members of the immunoglobulin superfamily that have been modified to include structural features derived from IgNAR variable domains.
摘要翻译：本发明涉及来自鱼的免疫球蛋白新抗原受体（IgNAR）及其用途。特别地，本发明涉及修饰的IgNAR可变结构域和来自免疫球蛋白超家族成员的结构域，其已被修饰以包括来自IgNAR可变结构域的结构特征。

4. 发明申请

US20090271080A1 Selector Mechanism for a Motor Vehicle Transmission 有权
标题翻译：机动车辆传动的选择机构
公开(公告)号：US20090271080A1
公开(公告)日：2009-10-29
申请号：US12500921
申请日：2009-07-10
申请人： Carl Pickering , Alister Whelan , Mike Richardson , Rob Jerger , Peter Hudson
发明人： Carl Pickering , Alister Whelan , Mike Richardson , Rob Jerger , Peter Hudson
IPC分类号： F16H59/04 , G06F19/00
CPC分类号： F16H59/08 , B60K37/06 , B60K2350/102 , F16H2059/081 , Y10T74/19251 , Y10T74/2003 , Y10T74/2014
摘要： A rotatable selector mechanism for a motor vehicle transmission has a selector knob rotatable in a housing to select an operating mode of the transmission among a number of selector positions indicated by a label (P, R, N, D, M). The selector mechanism further includes a detent plate which cooperates with a detent pin for maintaining the selector knob in each of positions. The detent plate is connected to position sensors for generating selector signals to a transmission control unit which supplies control signals to an actuator for operate the transmission according to the operating mode selected. The detent plate is also associated to the selector knob and to a drive correction means by means of clutch devices respectively to engage the detent plate to one of the selector knob and the drive correction means. The clutch devices and the drive corrections means are controlled by the transmission control unit to move the detent plate from a selector position selected by the driver to another selector position representative of the operating mode of the transmission by means of the drive correction means without moving the selector knob. The selector knob further includes an illuminated pointer constituted by one of several LEDs controlled by the transmission control unit so as to change the LED illuminated in front of the label according to the position of the detent plate when the latter has been moved by the drive correction means in order to indicate the operating mode of the transmission.
摘要翻译：用于机动车辆变速器的可旋转选择器机构具有可在壳体中旋转的选择旋钮，以在由标签（P，R，N，D，M）指示的多个选择器位置之间选择变速器的操作模式。选择器机构还包括与止动销配合的止动板，用于将选择旋钮保持在每个位置。制动板连接到位置传感器，用于产生选择器信号到传动控制单元，该传动控制单元根据所选择的操作模式将控制信号提供给用于操作变速器的致动器。制动板还通过离合器装置与选择器旋钮和驱动器校正装置相关联，以将制动板接合到选择器旋钮和驱动校正装置中的一个上。离合器装置和驱动校正装置由变速器控制单元控制，以通过驱动校正装置将制动板从驾驶员选择的选择器位置移动到代表变速器的操作模式的另一选择器位置，而不移动选择旋钮所述选择器旋钮还包括由所述变速器控制单元控制的多个LED之一构成的照明指示器，以便根据所述制动板的位置，当所述LED驱动器被驱动校正移动时，根据所述制动板的位置改变在所述标签前面照亮的LED 意味着为了指示传输的操作模式。

5. 发明授权

US07560454B2 Condensed azepines as vasopressin agonists 有权
标题翻译：浓缩吖庚因作为血管加压素激动剂
公开(公告)号：US07560454B2
公开(公告)日：2009-07-14
申请号：US11370861
申请日：2006-03-09
申请人： Doreen Mary Ashworth , Gary Robert William Pitt , Peter Hudson , Christopher Martyn Yea , Richard Jeremy Franklin
发明人： Doreen Mary Ashworth , Gary Robert William Pitt , Peter Hudson , Christopher Martyn Yea , Richard Jeremy Franklin
IPC分类号： A61P13/00 , A61K31/55 , C07D403/12 , C07D495/04 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07D403/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： This invention provides novel compounds according to general formula (1) wherein A is a bicyclic or tricyclic azepine derivative, V1 and V2 are both H, OMe or F, or one of V1 and V2 is Br, Cl, F, OH, OMe, OBn, OPh, O-acyl, N3, NH2, NHBn or NH-acyl and the other is H, or V1 and V2 together are ═O, —O(CH2)pO— or —S(CH2)pS—; W1 is either O or S; X1 and X2 are both H, or together are ═O or ═S; Y is OR5 or NR6R7; R1, R2, R3 and R4 are independently selected from H, lower alkyl, lower alkyloxy, F, Cl and Br; R5 is selected from H and lower alkyl; R6 and R7 are independently selected from H and lower alkyl, or together are —(CH2)n—; n=3, 4, 5, 6; and p is 2 or 3. The compounds are agonists at the vasopressin V2 receptor and are useful as antidiuretics and procoagulants. The invention further comprises pharmaceutical compositions incorporating these vasopressin agonists, which compositions are particularly useful in the treatment of central diabetes insipidus, nocturnal enuresis and nocturia.
摘要翻译：本发明提供根据通式（1）的新化合物，其中A为双环或三环吖庚因衍生物，V1和V2均为H，OMe或F，或V1和V2中的一个为Br，Cl，F，OH，OMe， OBn，OPh，O-酰基，N3，NH2，NHBn或NH-酰基，另一个为H，或V 1和V 2一起为-O，-O（CH 2）p O-或-S（CH 2）p -S-; W1是O或S; X1和X2均为H，或一起为-O或-S; Y为OR5或NR6R7; R 1，R 2，R 3和R 4独立地选自H，低级烷基，低级烷氧基，F，Cl和Br; R5选自H和低级烷基; R6和R7独立地选自H和低级烷基，或一起是 - （CH 2）n - ; n = 3,4,5,6; p是2或3.化合物是加压素V2受体的激动剂，可用作抗利尿剂和促凝剂。本发明还包括掺入这些加压素激动剂的药物组合物，该组合物特别可用于治疗中枢性尿崩症，夜间遗尿和夜尿症。

6. 发明申请

US20060154916A1 Condensed azepines as vasopressin agonists 有权
标题翻译：浓缩吖庚因作为血管加压素激动剂
公开(公告)号：US20060154916A1
公开(公告)日：2006-07-13
申请号：US11370861
申请日：2006-03-09
申请人： Doreen Ashworth , Gary Pitt , Peter Hudson , Christopher Yea , Richard Franklin
发明人： Doreen Ashworth , Gary Pitt , Peter Hudson , Christopher Yea , Richard Franklin
IPC分类号： A61K31/553 , A61K31/551
CPC分类号： C07D403/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： This invention provides novel compounds according to general formula (1) wherein A is a bicyclic or tricyclic azepine derivative, V1 and V2 are both H, OMe or F, or one of V1 and V2 is Br, Cl, F, OH, OMe, OBn, OPh, O-acyl, N3, NH2, NHBn or NH-acyl and the other is H, or V1 and V2 together are ═O, —O(CH2)pO— or —S(CH2)pS—; W1 is either O or S; X1 and X2 are both H, or together are ═O or ═S; Y is OR5 or NR6R7; R1, R2, R3 and R4 are independently selected from H, lower alkyl, lower alkyloxy, F, Cl and Br; R5 is selected from H and lower alkyl; R6 and R7 are independently selected from H and lower alkyl, or together are —(CH2)n; n=3, 4, 5, 6; and p is 2 or 3. The compounds are agonists at the vasopressin V2 receptor and are useful as antidiuretics and procoagulants. The invention further comprises pharmaceutical compositions incorporating these vasopressin agonists, which compositions are particularly useful in the treatment of central diabetes insipidus, nocturnal enuresis and nocturia.
摘要翻译：本发明提供了根据通式（1）的新化合物，其中A是双环或三环吖庚因衍生物，V 1和V 2均为H，OMe或F，或 V 1和V 2之一是Br，Cl，F，OH，OMe，OBn，OPh，O-酰基，N 3， NH 2，NHBn或NH-酰基，另一个是H，或V 1和V 2一起是-O，-O（CH O - 或-S（CH 2）n -S-; -S-（CH 2）n - O 1或O 2是O或S; X 1和X 2均为H或一起为-O或-S; Y是OR 5或NR 6 R 7; R 1，R 2，R 3和R 4独立地选自H，低级烷基，低级烷氧基，F，Cl和Br; R 5选自H和低级烷基; R 6和R 7独立地选自H和低级烷基，或者一起是 - （CH 2）n ; n = 3,4,5,6; p是2或3.化合物是加压素V2受体的激动剂，可用作抗利尿剂和促凝剂。本发明还包括掺入这些加压素激动剂的药物组合物，该组合物特别可用于治疗中枢性尿崩症，夜间遗尿和夜尿症。

7. 发明申请

US20060150442A1 Article of cleated footwear having medial and lateral sides with differing properties 有权
标题翻译：具有不同性质的内侧和外侧的鞋底的物品
公开(公告)号：US20060150442A1
公开(公告)日：2006-07-13
申请号：US11128417
申请日：2005-05-13
申请人： Perry Auger , Troy Lindner , Peter Hudson , Erez Morag
发明人： Perry Auger , Troy Lindner , Peter Hudson , Erez Morag
IPC分类号： A43B13/00 , A43B5/02
CPC分类号： A43C15/162 , A43B5/02
摘要： An article of footwear includes a sole having a different performing lateral and medial regions. Ground engaging members, such as cleats, provide traction and one of the regions, preferably the lateral region, includes a stability member extending from the sole and spanning between a pair of adjacent ground engaging members in a heel to toe direction. The ground engaging members may have a body and a tip portion. Each tip portion may be integrally formed with all or a portion of its respective body. The medial and lateral regions include buttressing member having different characteristics and dimensions for strengthening the ground engaging members with providing enhanced flexibility.
摘要翻译：鞋类物品包括具有不同的执行横向和中间区域的鞋底。诸如防滑钉的地面接合构件提供牵引力，并且优选地，横向区域中的一个区域包括从鞋底延伸并且跨越一对相邻的地面接合构件之间的脚跟和脚趾方向的稳定构件。地面接合构件可以具有主体和尖端部分。每个尖端部分可以与其相应主体的全部或一部分一体形成。内侧和外侧区域包括具有不同特征和尺寸的支撑构件，用于加强地面接合构件并提供增强的柔性。

8. 发明申请

US20060037424A1 Selector mechanism for a motor vehicle transmission 有权
公开(公告)号：US20060037424A1
公开(公告)日：2006-02-23
申请号：US11205486
申请日：2005-08-17
申请人： Carl Pickering , Alister Whelan , Mike Richardson , Rob Jerger , Peter Hudson
发明人： Carl Pickering , Alister Whelan , Mike Richardson , Rob Jerger , Peter Hudson
IPC分类号： F16H59/04
CPC分类号： F16H59/08 , B60K37/06 , B60K2350/102 , F16H2059/081 , Y10T74/19251 , Y10T74/2003 , Y10T74/2014
摘要： A rotatable selector mechanism for a motor vehicle transmission has a selector knob rotatable in a housing to select an operating mode of the transmission among a number of selector positions indicated by a label (P,R,N,D,M). The selector mechanism further includes a detent plate which cooperates with a detent pin for maintaining the selector knob in each of positions. The detent plate is connected to position sensors for generating selector signals to a transmission control unit which supplies control signals to an actuator for operate the transmission according to the operating mode selected. The detent plate is also associated to the selector knob and to a drive correction means by means of clutch devices respectively to engage the detent plate to one of the selector knob and the drive correction means. The clutch devices and the drive corrections means are controlled by the transmission control unit to move the detent plate from a selector position selected by the driver to another selector position representative of the operating mode of the transmission by means of the drive correction means without moving the selector knob. The selector knob further includes an illuminated pointer constituted by one of several LEDs controlled by the transmission control unit so as to change the LED illuminated in front of the label according to the position of the detent plate when the latter has been moved by the drive correction means in order to indicate the operating mode of the transmission.

9. 发明申请

US20060010718A1 Article footwear with removable heel pad 有权
标题翻译：文章鞋带可拆卸脚跟垫
公开(公告)号：US20060010718A1
公开(公告)日：2006-01-19
申请号：US10891837
申请日：2004-07-15
申请人： Perry Auger , Neil Crumbleholme , Brian Baker , Peter Hudson
发明人： Perry Auger , Neil Crumbleholme , Brian Baker , Peter Hudson
IPC分类号： A43B23/08
CPC分类号： A43B17/18 , A43B3/0047 , A43B21/32 , A43B23/088
摘要： An article of footwear includes a sole assembly, an upper secured to the sole assembly, a heel counter secured to the upper, and a heel pad removably attached to an inner surface of the heel counter.
摘要翻译：鞋类物品包括鞋底组件，固定到鞋底组件的鞋面，固定到鞋面上的鞋后跟，以及可拆卸地附接到脚后跟计数器的内表面的脚跟垫。

10. 外观设计

USD420500S Side element of a shoe upper 失效
公开(公告)号：USD420500S
公开(公告)日：2000-02-15
申请号：US108090
申请日：1999-07-19
申请人： Peter Hudson
设计人： Peter Hudson

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