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1. 发明专利

GB1119911A Improvements relating to electromechanical vibrators 未知
公开(公告)号：GB1119911A
公开(公告)日：1968-07-17
申请号：GB4403464
申请日：1964-10-28
申请人： DERRITRON LTD , PETER GROOTENHUIS , JAMES WALTER GEARING
IPC分类号： B06B1/04 , G01M7/04 , H02K33/18
摘要： 1,119,911. Vibratory electric motors. DERRITRON Ltd., P. GROOTENHUIS, and J. W. GEARING. 26 Oct., 1965 [28 Oct., 1964], No. 44034/64. Heading H2A. The moving coil of a powerful vibrator has internal passages for cooling fluid. The coil is arranged in two coaxial layers 16, 17 of conductors which are either spaced by longitudinal spacers (18, Figs. 2, 3, not shown) to leave passages 19 between them, or as shown, flattened longitudinal tubes 21 are interposed between the layers. Bracing rods 22 may extend between header members at top and bottom of the coil. Air, water or refrigerant fluid may be used. A re-cycling cooling system is described. The cooling passages may be helical and may be in several layers.

2. 发明专利

GB981217A Improvements relating to electromechanical vibrators 未知
公开(公告)号：GB981217A
公开(公告)日：1965-01-20
申请号：GB315461
申请日：1961-01-26
申请人： PETER GROOTENHUIS , DERRITON LTD
IPC分类号： H02K33/18
摘要： 981,217. Vibratory electric motors. DERRIBRON Ltd., and P. GROOTENHUIS. Jan. 22, 1962 [Jan. 26, 1961], No. 3154/61. Heading H2A. In a vibrator of moving-coil type for driving a testing table 25, the tubular support 31 of the moving coil 32 is braced by radial webs 30 secured to the table, and accommodated in radial slots 37 in the central polepiece. The table has a central boss 27, a stiffening rib 29 and a peripheral skirt 28 to which a flange 33 on the coil-supporting tube is bolted. The coil supporting tube is of fibreglass and has an axial flange 34 at its lower edge. The bracing webs radiate from the central boss and are bonded to the coil supporting tube and also bolted to its lower flange 34 by bolts 35 which also secure the lower supporting diaphragm 42. Two other diaphragms 40 and 41 are secured to top and bottom of the tableflange 28. The upper diaphragm 40 is faced with rubberized fabric and forms an airtight compartment into which cooling air may be forced at 46, this air being withdrawn at 45. This feature enables the table to be supported by air-pressure if required. Downward movement is limited by a rubber buffer 48 at the bottom of the central recess in the central pole, and buffers may be provided to limit the upward movement. Lateral buffer pillars 52, 53 may carry a degaussing coil 55.

3. 发明专利

DE1150442B 未知
公开(公告)号：DE1150442B
公开(公告)日：1963-06-20
申请号：DEG0034122
申请日：1962-01-26
申请人： PETER GROOTENHUIS , DERRITRON LTD
发明人： GROOTENHUIS PETER
IPC分类号： H02K33/18

4. 发明申请

US20150031708A1 MODULATORS OF CFTR 有权
标题翻译： CFTR调制器
公开(公告)号：US20150031708A1
公开(公告)日：2015-01-29
申请号：US12117941
申请日：2008-05-09
申请人： Sara Hadida-Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
发明人： Sara Hadida-Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
IPC分类号： C07D405/14 , A61K45/06 , G01N33/68 , A61K31/497 , G06F19/18 , A61K31/444 , C07D401/04
CPC分类号： C07D405/14 , A61K31/444 , C07D213/75 , C07D401/04 , G01N33/502 , G01N2333/705 , G01N2500/04 , G01N2500/10
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.
摘要翻译：本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗CFTR介导的疾病的方法。

5. 发明授权

US08153642B2 Quinazolines useful as modulators of ion channels 失效
标题翻译：喹唑啉可用作离子通道的调节剂
公开(公告)号：US08153642B2
公开(公告)日：2012-04-10
申请号：US12714871
申请日：2010-03-01
申请人： Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
发明人： Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
IPC分类号： A61K31/517 , A61P19/02 , A61P25/06 , A61P25/08 , A61P29/02 , A61P35/00 , C07D239/94 , C07D403/12
CPC分类号： C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

6. 发明申请

US20100227888A1 MODULATORS OF CFTR 有权
标题翻译： CFTR调制器
公开(公告)号：US20100227888A1
公开(公告)日：2010-09-09
申请号：US12782967
申请日：2010-05-19
申请人： Sara S. Hadida Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
发明人： Sara S. Hadida Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
IPC分类号： A61K31/443 , A61K31/4418 , A61P3/00 , A61P25/00 , A61P27/02 , A61P37/00
CPC分类号： C07D213/75 , C07D405/12 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译：本发明化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTC”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

7. 发明授权

US07754739B2 Modulators of CFTR 有权
标题翻译： CFTR调制器
公开(公告)号：US07754739B2
公开(公告)日：2010-07-13
申请号：US12117948
申请日：2008-05-09
申请人： Sara S. Hadida Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
发明人： Sara S. Hadida Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
IPC分类号： A61K31/4418 , A61K31/443 , C07D405/02 , C07D213/72
CPC分类号： C07D213/75 , C07D405/12 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译：本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

8. 发明申请

US20090143381A1 MODULATORS OF ATP-BINDING CASSETTE-TRANSPORTERS 有权
标题翻译： ATP-结合CASSETTE-TRANSPORTERS的调节剂
公开(公告)号：US20090143381A1
公开(公告)日：2009-06-04
申请号：US12271088
申请日：2008-11-14
申请人： SARA S. HADIDA RUAH , Mark Miller , Jinglan Zhou , Brian Bear , Peter Grootenhuis
发明人： SARA S. HADIDA RUAH , Mark Miller , Jinglan Zhou , Brian Bear , Peter Grootenhuis
IPC分类号： A61K31/5377 , C07D405/02 , A61K31/4709 , C07D401/02 , A61K31/497 , C07D413/02
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D217/22 , C07D401/04 , C07D405/12 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译：本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

9. 发明申请

US20070105833A1 Modulators of ATP-binding cassette transporters 有权
标题翻译： ATP结合盒转运蛋白的调节剂
公开(公告)号：US20070105833A1
公开(公告)日：2007-05-10
申请号：US11438636
申请日：2006-05-22
申请人： Sara Ruah , Anna Hazlewood , Peter Grootenhuis , Ashvani Singh , Thomas Cleveland , Frederick Van-Goor
发明人： Sara Ruah , Anna Hazlewood , Peter Grootenhuis , Ashvani Singh , Thomas Cleveland , Frederick Van-Goor
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/506 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D405/12 , C07D239/42 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/02 , C07D417/02 , C07D491/10
摘要： 4-amido-pyrimidine compounds, derivatives and compositions thereof, and synthetic methods described herein are useful for modulating ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 4-氨基 - 嘧啶化合物，其衍生物和组合物以及本文所述的合成方法可用于调节ATP结合盒（“ABC”）转运蛋白或其片段，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

10. 发明授权

US08829204B2 Modulators of ATP-binding cassette transporters 有权
公开(公告)号：US08829204B2
公开(公告)日：2014-09-09
申请号：US11841646
申请日：2007-08-20
申请人： Sara Hadida-Ruah , Anna Hazlewood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida-Ruah , Anna Hazlewood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC分类号： C07D209/04 , C07D217/06 , C07D215/56 , C07D413/12 , C07D215/233 , C07D417/12 , C07D409/12 , C07D215/38 , C07D223/16 , C07D405/12 , C07D311/58 , C07D215/227 , C07D209/18 , C07D213/73 , C07D209/42 , C07D213/20 , C07D209/14 , C07D209/08 , C07D279/16 , C07D265/36 , C07D209/94 , C07D471/10 , C07D401/12 , C07C215/76 , C07D401/14
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

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