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1. 发明申请

US20080160099A1 Methods For Treating or Preventing a Vascular Disease 审中-公开
标题翻译：治疗或预防血管疾病的方法
公开(公告)号：US20080160099A1
公开(公告)日：2008-07-03
申请号：US11667326
申请日：2005-11-09
申请人： Peter D. Collin , Martin D. Tilson III
发明人： Peter D. Collin , Martin D. Tilson III
IPC分类号： A61K35/56 , A61K31/353 , A61K31/715
CPC分类号： A61K31/7048
摘要： The present invention relates to green tea and sea cucumber extracts, compositions thereof, and methods of treating or preventing a cardiovascular disease, a peripheral vascular disease, or an aneurysm in a subject, the methods comprising administering to the subject an effective amount of a green tea extract, a sea cucumber extract, or a compound derived from a green tea extract or a sea cucumber extract.
摘要翻译：本发明涉及绿茶和海参提取物，其组合物，以及治疗或预防受试者的心血管疾病，外周血管疾病或动脉瘤的方法，所述方法包括向受试者施用有效量的绿色茶提取物，海参提取物或来自绿茶提取物或海参提取物的化合物。

2. 发明申请

US20200054657A1 Compositions of Matter and Methoods to Treat Cancer 审中-公开
公开(公告)号：US20200054657A1
公开(公告)日：2020-02-20
申请号：US15999295
申请日：2018-08-20
申请人： Thomas E Adrian , Peter D Collin , Robert A Newman
发明人： Thomas E Adrian , Peter D Collin , Robert A Newman
IPC分类号： A61K31/704 , A61K31/341 , A61P35/00 , A61K9/48
摘要： The named inventors claim discovery of synergistic anti-cancer effects of combinations of one or more sea cucumber glycosides such as Frondoside A or other sea cucumber glycosides and Andrographolide or an Andrographolide analog, wherein the biological effects are may be more beneficial than the single components making up the said invention. The inventors claim new methods and compositions of matter to treat cancer in mammals, and additionally a method to effectively treat cancer stem cells in mammals, with a composition comprised of one or more sea cucumber glycosides and Andrographolide, or an andrographolide analog.

3. 发明授权

US07387797B2 Compositions derived from Modiolus modiolus and methods for making and using same 失效
标题翻译：衍生自Modiolus modiolus的组合物及其制备和使用方法
公开(公告)号：US07387797B2
公开(公告)日：2008-06-17
申请号：US10239345
申请日：2001-03-22
申请人： Peter D. Collin , Thomas E. Adrian
发明人： Peter D. Collin , Thomas E. Adrian
IPC分类号： A61K35/56 , A61K9/14
CPC分类号： A61K35/618
摘要： Disclosed are compositions which include an isolated soft tissue from Modiolus modiolus (“MM”) and compositions which include an oil isolated from MM or a portion thereof. Also disclosed are methods of treating adenocarcinoma in a subject; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; methods of inhibiting the activity of 5-lipoxygenase or 12-lipoxygenase or both in cells; and methods of treating a subject suffering from a disease or condition associated with excessive 5-lipoxygenase activity or 12-lipoxygenase activity or both. A process for preparing an MM extract by contacting MM or a portion thereof with a solvent under conditions effective to extract one or more materials from the MM or portion thereof is also described.
摘要翻译：公开了包括来自Modiolus modiolus（“MM”）的分离的软组织的组合物和包含从MM或其一部分分离的油的组合物。还公开了在受试者中治疗腺癌的方法; 降低腺癌细胞增殖或诱导腺癌细胞凋亡或诱导腺癌细胞分化为非癌细胞的方法; 抑制5-脂氧合酶或12-脂氧合酶或两者在细胞中的活性的方法; 以及治疗患有与过量的5-脂氧合酶活性或12-脂肪氧合酶活性或两者有关的疾病或病症的受试者的方法。还描述了在有效从MM或其部分提取一种或多种材料的条件下使MM或其一部分与溶剂接触来制备MM提取物的方法。

4. 发明授权

US07335382B1 Compositions and methods for the treatment and prevention of cancer 有权
标题翻译：用于治疗和预防癌症的组合物和方法
公开(公告)号：US07335382B1
公开(公告)日：2008-02-26
申请号：US11066802
申请日：2005-02-25
申请人： Xian-Zhong Ding , Thomas E. Adrian , Peter D. Collin
发明人： Xian-Zhong Ding , Thomas E. Adrian , Peter D. Collin
IPC分类号： A61K35/36 , A61K35/12
CPC分类号： A61K35/616
摘要： The present invention relates to new classes of anti-cancer agents. In particular, the present invention provides materials derived from natural sources as anti-cancer agents, alone, or in combination with other anti-cancer agents or therapies.
摘要翻译：本发明涉及新类型的抗癌剂。特别地，本发明提供源自天然来源的作为抗癌剂的材料，单独或与其它抗癌剂或疗法组合。

5. 发明授权

US06541519B2 Methods and compositions for treating lipoxygenase-mediated disease states 失效
标题翻译：用于治疗脂氧合酶介导的疾病状态的方法和组合物
公开(公告)号：US06541519B2
公开(公告)日：2003-04-01
申请号：US09827361
申请日：2001-04-06
申请人： Peter D. Collin , Peiying Yang , Robert Newman
发明人： Peter D. Collin , Peiying Yang , Robert Newman
IPC分类号： A61K3120
CPC分类号： A61K31/20 , A61K31/19 , Y10S514/824 , Y10S514/946
摘要： Methods and compositions are disclosed for prevention and/or treatment of diseases in which 5- and 12-lipoxygenase activity contributes to the pathological condition, by administration of 12-methyletradecanoic acids alone and in conjunction with other therapeutic compounds. Methods to inhibit lipoxygenase-mediated inflammations are disclosed.
摘要翻译：公开了通过单独施用12-甲基十一烷酸和与其它治疗化合物联合来预防和/或治疗5-和12-脂肪氧合酶活性有助于病理状况的疾病的方法和/或治疗。公开了抑制脂氧合酶介导的炎症的方法。

6. 发明授权

US07163702B1 Process for isolating sea cucumber saponin Frondoside A, and immunomodulatory methods of use 失效
标题翻译：海参皂苷Frondoside A分离方法及免疫调节方法
公开(公告)号：US07163702B1
公开(公告)日：2007-01-16
申请号：US11145580
申请日：2005-06-06
申请人： Sergey Anatolievuch Avilov , Vladimir Ivanovich Kalinin , Alexandra Sergeevna Silchenko , Dmitry Lvovich Aminin , Irina Grigorevna Agafonova , Valentin Aronovich Stonik , Peter D. Collin , Carl Woodward
发明人： Sergey Anatolievuch Avilov , Vladimir Ivanovich Kalinin , Alexandra Sergeevna Silchenko , Dmitry Lvovich Aminin , Irina Grigorevna Agafonova , Valentin Aronovich Stonik , Peter D. Collin , Carl Woodward
IPC分类号： A61K35/56 , A61K31/70 , A61K35/12 , A01N63/02 , A61P37/02
CPC分类号： A61K35/616 , A61K31/70 , Y10S514/885
摘要： This present invention discloses use of a chloroform/solvent mixture extraction at different solvent-to-feed ratios, followed by evaporation and extraction with ethyl acetate/water; followed by chromatography of the water phase in Teflon or other non-polar resin and Silica gel column chromatography for recovering of individual triterpene glycosides (saponins) of high purity from the freeze dried or spray dried cooking water or dried powderized tissues of the industrial processed sea cucumber Cucumaria frondosa. A resulting glycoside Frondoside A stimulates lysosomal activity of peritoneal macrophages, phagocytosis and oxidative burst in the macrophages at concentrations significantly less than for acute toxicity, hemolysis and sea urchin embryo toxicity.
摘要翻译：本发明公开了以不同溶剂与进料比进行氯仿/溶剂混合萃取，然后蒸发并用乙酸乙酯/水萃取; 然后在Teflon或其他非极性树脂中进行水相色谱法和硅胶柱层析，从冷冻干燥或喷雾干燥的蒸煮水或工业加工海的干粉末组织中回收高纯度的单一三萜糖苷（皂苷）黄瓜黄瓜（Cucumaria frondosa）。产生的糖苷Frondoside A以显着低于急性毒性，溶血和海胆胚胎毒性的浓度刺激巨噬细胞中腹膜巨噬细胞，吞噬作用和氧化爆发的溶酶体活性。

7. 发明授权

US07144867B2 Anticancer glycoside compounds 有权
标题翻译：抗癌糖苷化合物
公开(公告)号：US07144867B2
公开(公告)日：2006-12-05
申请号：US11044496
申请日：2005-01-27
申请人： Thomas E. Adrian , Peter D. Collin
发明人： Thomas E. Adrian , Peter D. Collin
IPC分类号： A01N43/04 , A61K31/70 , A01N57/00 , A61K31/665
CPC分类号： A61K31/704
摘要： The present invention relates to new classes of anti-cancer compounds. In particular, the present invention provides glycoside compounds as anti-cancer agent, alone, or in combination with other anti-cancer agents or therapies.
摘要翻译：本发明涉及新类型的抗癌化合物。特别地，本发明提供作为抗癌剂的糖苷化合物，单独使用或与其它抗癌剂或疗法组合。

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