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1. 发明授权

US07645369B2 Separation method and device for protein mixtures 失效
标题翻译：蛋白质混合物的分离方法和装置
公开(公告)号：US07645369B2
公开(公告)日：2010-01-12
申请号：US11120098
申请日：2005-05-02
申请人： Hans-Joachim Hoeltke , Albert Roeder , Alois Rainer , Peter Berndt , Carlo Effenhauser , Hanno Langen , Remo Anton Hochstrasser
发明人： Hans-Joachim Hoeltke , Albert Roeder , Alois Rainer , Peter Berndt , Carlo Effenhauser , Hanno Langen , Remo Anton Hochstrasser
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44773
摘要： A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation element 10 for the two-dimensional and preferable electrophoretic separation of components of the sample material is provided in area 30 of a separation plane. According to the invention it is proposed that the separation element 10 has a channel or transfer structure 14 for the locally resolved discharge of separated sample components in a transport direction that is at right angles to the separation plane onto a support surface 16 that is preferably suitable for mass spectroscopic analyses.
摘要翻译：用于生物分子样品材料，特别是蛋白质混合物的分离装置和分离方法。为此，在分离平面的区域30中提供用于样品材料的组分的二维和优选的电泳分离的分离元件10。根据本发明，提出了分离元件10具有通道或转移结构14，用于将分离的样品组分在与分离平面成直角的运输方向上局部分解排放到支撑表面16上，其优选地适合用于质谱分析。

2. 发明授权

US07566542B2 Use of protein ASC as a marker for breast cancer 失效
标题翻译：使用蛋白质ASC作为乳腺癌的标志物
公开(公告)号：US07566542B2
公开(公告)日：2009-07-28
申请号：US11404218
申请日：2006-04-14
申请人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
发明人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
IPC分类号： G01N33/53 , G01N33/574 , G01N33/48 , G01N33/536 , G01N33/537 , G01N33/577
CPC分类号： G01N33/57415
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein ASC in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring ASC in the sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of breast cancer.
摘要翻译：本发明涉及乳腺癌的诊断。它公开了蛋白质ASC在乳腺癌诊断中的应用。它涉及一种通过测量样品中的ASC从个体获得的来自液体样品的乳腺癌诊断方法。 ASC的测量可以例如用于乳腺癌的早期检测或诊断。

3. 发明申请

US20060141543A1 Cellular retinoic acid binding protein II as a marker for breast cancer 失效
公开(公告)号：US20060141543A1
公开(公告)日：2006-06-29
申请号：US11294176
申请日：2005-12-05
申请人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
发明人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N33/57473 , G01N2333/70567
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein cellular retinoic acid binding protein II in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring cellular retinoic acid binding protein II in said sample. Measurement of cellular retinoic acid binding protein II can, e.g., be used in the early detection or diagnosis of breast cancer.

4. 发明申请

US20070196844A1 Protein PDX1 as a marker for breast cancer 审中-公开
标题翻译：蛋白PDX1作为乳腺癌的标志物
公开(公告)号：US20070196844A1
公开(公告)日：2007-08-23
申请号：US11640523
申请日：2006-12-14
申请人： Gabriele Pestlin , Herbert Andres , Marie-Luise Hagmann , Johann Karl , Michael Thierolf , Werner Zolg , Peter Berndt , Hanno Langen
发明人： Gabriele Pestlin , Herbert Andres , Marie-Luise Hagmann , Johann Karl , Michael Thierolf , Werner Zolg , Peter Berndt , Hanno Langen
IPC分类号： C12Q1/68 , G01N33/574 , C12M3/00
CPC分类号： C12Q1/6886
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein PDX1 (peroxiredoxin 1) in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring PDX1 in said sample. Measurement of PDX1 can, e.g., be used in the early detection or diagnosis of breast cancer.
摘要翻译：本发明涉及乳腺癌的诊断。它公开了蛋白质PDX1（过氧化物氧还蛋白1）在乳腺癌诊断中的应用。本发明涉及通过测定所述样品中的PDX1从个体得到的来自液体样品的乳腺癌诊断方法。 PDX1的测量可以例如用于乳腺癌的早期检测或诊断。

5. 发明申请

US20060194266A1 Use of protein RLA-0 as a marker for colorectal cancer 审中-公开
标题翻译：使用蛋白质RLA-0作为结肠直肠癌的标志物
公开(公告)号：US20060194266A1
公开(公告)日：2006-08-31
申请号：US11348889
申请日：2006-02-07
申请人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
发明人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein RLA-0 (60S acidic ribosomal protein P0) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring RLA-0 in said sample. Measurement of RLA-0 can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质RLA-0（60S酸性核糖体蛋白质P0）在结直肠癌诊断中的应用。本发明涉及通过测量所述样品中的RLA-0从个体获得的来自液体样品的结肠直肠癌的诊断方法。 RLA-0的测定可以例如用于结肠直肠癌的早期检测或诊断。

6. 发明申请

US20060121540A1 Use of protein MASP as a marker for colorectal cancer 审中-公开
标题翻译：使用蛋白质MASP作为结肠直肠癌的标志物
公开(公告)号：US20060121540A1
公开(公告)日：2006-06-08
申请号：US11287575
申请日：2005-11-23
申请人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
发明人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/8107 , G01N2800/52
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein MASP in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring MASP in said sample. Measurement of MASP can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质MASP在结直肠癌诊断中的应用。本发明涉及一种通过测量所述样品中的MASP从个体获得的来自液体样品的结肠直肠癌的诊断方法。 MASP的测量可以例如用于结肠直肠癌的早期检测或诊断。

7. 发明申请

US20060000712A1 Separation method and device for protein mixtures 失效
标题翻译：蛋白质混合物的分离方法和装置
公开(公告)号：US20060000712A1
公开(公告)日：2006-01-05
申请号：US11120098
申请日：2005-05-02
申请人： Hans-Joachim Hoeltke , Albert Roeder , Alois Rainer , Peter Berndt , Carlo Effenhauser , Hanno Langen , Remo Hochstrasser
发明人： Hans-Joachim Hoeltke , Albert Roeder , Alois Rainer , Peter Berndt , Carlo Effenhauser , Hanno Langen , Remo Hochstrasser
IPC分类号： B01D57/02 , C02F1/40
CPC分类号： G01N27/44773
摘要： A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation element 10 for the two-dimensional and preferable electrophoretic separation of components of the sample material is provided in area 30 of a separation plane. According to the invention it is proposed that the separation element 10 has a channel or transfer structure 14 for the locally resolved discharge of separated sample components in a transport direction that is at right angles to the separation plane onto a support surface 16 that is preferably suitable for mass spectroscopic analyses.
摘要翻译：用于生物分子样品材料，特别是蛋白质混合物的分离装置和分离方法。为此，在分离平面的区域30中提供用于样品材料的组分的二维和优选的电泳分离的分离元件10。根据本发明，提出了分离元件10具有通道或转移结构14，用于将分离的样品组分在与分离平面成直角的运输方向上局部分解排放到支撑表面16上，其优选地适合用于质谱分析。

8. 发明申请

US20050136464A1 Quantitation of biomolecule in a complex mixture by serial combinatorial dilution 审中-公开
标题翻译：通过连续组合稀释在复杂混合物中定量生物分子
公开(公告)号：US20050136464A1
公开(公告)日：2005-06-23
申请号：US11016588
申请日：2004-12-17
申请人： Peter Berndt , Stefan Evers , Hanno Langen
发明人： Peter Berndt , Stefan Evers , Hanno Langen
IPC分类号： G01N27/62 , C12Q1/06 , C12Q1/68 , G01N1/38 , G01N27/447 , G01N30/02 , G01N30/72 , G01N33/48 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/68 , G01N33/92 , G01N35/00
CPC分类号： G01N33/6803
摘要： The invention provides a method for the quantification of a biomolecule in a complex mixture of biomolecules which comprises a fractionation of the mixture of biomolecules providing at least two fractions with at least one distinct component each. These fractions are then subjected to serial combinatorial dilution. Subsequently, the biomolecule is detected and identified in the fractions by a method providing a sensitivity threshold and identify information. The quantity of the biomolecule is determined by summarizing the number of identifications of the biomolecule in each fraction on each dilution level in consideration of the respective dilution factor. For purpose of normalization this sum may be divided by the total number of identifications of all biomolecules in all fractions on all dilution levels.
摘要翻译：本发明提供了一种在生物分子的复杂混合物中定量生物分子的方法，其包括生物分子的混合物的分馏，其提供至少两个级分和至少一种不同的组分。然后对这些级分进行连续组合稀释。随后，通过提供灵敏度阈值和识别信息的方法在分数中检测和鉴定生物分子。考虑各自的稀释因子，通过总结每个稀释级别中每个级分中的生物分子的鉴定数来确定生物分子的量。为了归一化，这个总和可以除以所有稀释水平上所有级分中所有生物分子的标识总数。

9. 发明授权

US08192697B2 Sorption micro-array 有权
标题翻译：吸附微阵列
公开(公告)号：US08192697B2
公开(公告)日：2012-06-05
申请号：US12079334
申请日：2008-03-25
申请人： Christoph Fattinger , Peter Berndt
发明人： Christoph Fattinger , Peter Berndt
IPC分类号： B01L3/00 , G01N21/01 , G01N21/51 , G01N23/10 , G01N23/12
CPC分类号： G01N1/28 , B01L3/0255 , B01L3/5023 , B01L3/5025 , B01L3/502753 , B01L3/5085 , B01L2300/069 , B01L2300/0819 , G01N2001/282 , G01N2001/2826
摘要： A sorption micro-array (1) for sorbing a substance off an assay sample comprises a support (11) and a plurality of sorption elements (14). The plurality of sorption elements (14) is arranged in a well defined geometry in connection with the support (11), wherein the distance between each sorption element (14) and its adjacent sorption element (14) is predefined. Since all of the sorption elements (14) are arranged at a well defined location of the sorption micro-array (1), e.g. in a row with well defined distances from each other, the output of an analysis of substances sorbed by each of the sorption elements (14) can exactly be allocated to a well defined location of an assay sample from which the substances have been sorbed. Like this, it is possible to provide an exact chemical output image of the micro-distribution of the substances of the assay sample. The sorption micro-array according to the invention allows a gentle fluidic pick up of substances essentially without impairing the substances wherein the location of the pick up on the assay sample is well defined.
摘要翻译：用于从测定样品上吸附物质的吸附微阵列（1）包括支撑体（11）和多个吸附元件（14）。多个吸附元件（14）以与支撑件（11）连接的良好限定的几何形状布置，其中每个吸附元件（14）与其相邻的吸附元件（14）之间的距离是预定义的。由于所有吸附元件（14）都布置在吸附微阵列（1）的明确定义的位置，例如，在彼此具有良好限定的距离的情况下，由每个吸附元件（14）吸收的物质的分析的输出可以精确地分配给已经从其吸收的物质的测定样品的明确定义的位置。像这样，可以提供测定样品的物质的微量分布的精确化学输出图像。根据本发明的吸附微阵列允许温和地流体吸收物质，基本上不损害物质，其中检测样品上的拾取位置被很好地限定。

10. 发明申请

US20070218510A1 Use of protein PSA3 as a marker for colorectal cancer 审中-公开
标题翻译：使用蛋白质PSA3作为结肠直肠癌的标志物
公开(公告)号：US20070218510A1
公开(公告)日：2007-09-20
申请号：US11348865
申请日：2006-02-07
申请人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
发明人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/95
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein proteasome subunit alpha 3 (PSA3) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring PSA3 in said sample. Measurement of PSA3 can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质蛋白酶体亚单位α3（PSA3）在结肠直肠癌诊断中的应用。本发明涉及通过测量所述样品中的PSA3从来自个体的液体样品诊断结肠直肠癌的方法。 PSA3的测定可以例如用于结肠直肠癌的早期检测或诊断。

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