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1. 发明申请

US20120258039A1 TREATMENT OF TUMORS USING SPECIFIC ANTI-L1 ANTIBODY 有权
标题翻译：使用特异抗原抗体治疗肿瘤
公开(公告)号：US20120258039A1
公开(公告)日：2012-10-11
申请号：US13367178
申请日：2012-02-06
申请人： Daniela Gast , Peter Altevogt , Gerhard Moldenhauer , Frank Brietling , Achim Krüger , Silke Wolterink , Sandra Lüttgau , Ulrich Mõbius , Yi Li
发明人： Daniela Gast , Peter Altevogt , Gerhard Moldenhauer , Frank Brietling , Achim Krüger , Silke Wolterink , Sandra Lüttgau , Ulrich Mõbius , Yi Li
IPC分类号： A61K39/395 , A61M37/00 , A61N5/10 , A61K51/10 , A61P35/00
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/02 , A61N5/0613 , A61N5/10 , A61N2005/0661 , A61N2005/1087 , A61N2005/1089 , C07K2317/24 , C07K2317/41 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/57492
摘要： The present invention relates to the anti-L1 monoclonal antibody 9.3 as well as to related antibodies or binding molecules and well as to the uses thereof, especially in tumor treatment.
摘要翻译：本发明涉及抗L1单克隆抗体9.3以及相关抗体或结合分子，以及其用途，特别是在肿瘤治疗中。

2. 发明授权

US08003599B2 Inhibitors of L1 and ADAM10 for the treatment of carcinomas 有权
标题翻译： L1和ADAM10抑制剂用于治疗癌症
公开(公告)号：US08003599B2
公开(公告)日：2011-08-23
申请号：US11573269
申请日：2005-07-27
申请人： Peter Altevogt , Daniela Kelm , Mina Fogel
发明人： Peter Altevogt , Daniela Kelm , Mina Fogel
IPC分类号： A61K38/00 , C12N15/11
CPC分类号： C12N9/6489 , C07K14/70503
摘要： Described is a pharmaceutical composition comprising a compound(s) interfering with the biological activity of L1 and/or ADAM10 or their expression. Also described is the use of said compound(s) for the prevention/treatment of carcinomas like ovarian and endometrial carcinoma. Finally, the diagnosis of highly malignant forms of carcinomas which is based on the determination of the activity/expression of L1 and/or ADAM10 is described.
摘要翻译：描述了包含干扰L1和/或ADAM10的生物学活性或其表达的化合物的药物组合物。还描述了所述化合物用于预防/治疗诸如卵巢和子宫内膜癌的癌症的用途。最后，描述了基于L1和/或ADAM10的活性/表达的确定的高度恶性形式的癌症的诊断。

3. 发明授权

US07756863B2 System and method of enhancing decoding performance of text indexes 失效
标题翻译：提高文本索引解码性能的系统和方法
公开(公告)号：US07756863B2
公开(公告)日：2010-07-13
申请号：US11112612
申请日：2005-04-21
申请人： Peter Altevogt , Silvio Wiedrich
发明人： Peter Altevogt , Silvio Wiedrich
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30864 , G06F17/30622
摘要： A method of enhancing the decoding performance of text indexes of an indexed collection of text documents is disclosed. The posting list includes a plurality of list entries being of variable size depending on the value stored in each posting list entry. The inventive method is base on a statistical analysis of the posting list entries of the plurality of list entries. Prior to decoding, the method selects a decoding routine being appropriate to decode the most frequent type of posting list entries or of a plurality of various posting list entries. After selecting a particular decoding routine and executing the decoding routine for decoding of the entire posting list, a failure check is performed. In the exceptional case that a failure has occurred, a second alternative decoding procedure is selected and executed.
摘要翻译：公开了一种增强索引的文本文档集合的文本索引的解码性能的方法。发布列表包括根据存储在每个发布列表条目中的值而具有可变大小的多个列表条目。本发明的方法基于对多个列表条目的发布列表条目的统计分析。在解码之前，该方法选择适合于解码最频繁类型的发布列表条目或多个各种发布列表条目的解码程序。在选择特定解码例程并执行用于解码整个发布列表的解码程序之后，执行故障检查。在发生故障的特殊情况下，选择并执行第二替代解码过程。

4. 发明申请

US20080138331A1 DIAGNOSTIC AND THERAPEUTIC METHODS BASED ON THE L1 ADHESION MOLECULE FOR OVARIAN AND ENDOMETRIAL TUMORS 有权
标题翻译：诊断和治疗方法基于L1粘连分子的OVARIAN和子宫内膜肿瘤
公开(公告)号：US20080138331A1
公开(公告)日：2008-06-12
申请号：US11865989
申请日：2007-10-02
申请人： Peter Altevogt , Mina Fogel
发明人： Peter Altevogt , Mina Fogel
IPC分类号： A61K39/395 , A61P37/00
CPC分类号： G01N33/57449 , G01N33/57442 , G01N2333/70503 , G01N2333/70596
摘要： A method is described for the diagnosis of an ovarian or endometrial tumor or for a prognosis, characterized in that the L1 level is determined in a patient sample, preferably via an anti L1 antibody, the presence of L1 being an indication of the presence of an ovarian or endometrial tumor or a predisposition for such a tumor. Furthermore, methods for treating of ovarian or endometrial tumors are provided.
摘要翻译：描述了用于诊断卵巢或子宫内膜肿瘤或预后的方法，其特征在于L1水平优选通过抗L1抗体在患者样品中测定，L1的存在是存在卵巢或子宫内膜肿瘤或这种肿瘤的倾向。此外，提供了治疗卵巢或子宫内膜肿瘤的方法。

5. 发明授权

US07324988B2 Method of generating a distributed text index for parallel query processing 有权
标题翻译：生成用于并行查询处理的分布式文本索引的方法
公开(公告)号：US07324988B2
公开(公告)日：2008-01-29
申请号：US10805402
申请日：2004-03-19
申请人： Peter Altevogt , Raiko Nitzsche
发明人： Peter Altevogt , Raiko Nitzsche
IPC分类号： G06F17/30
CPC分类号： G06F17/30619 , G06F17/3069 , Y10S707/99933
摘要： The present invention relates to a method of generating a distributed text index for parallel query processing by a number of nodes. A set of node indices is generated for text indexing a set of documents, each node text index covering a subset of the documents. For each node text index, a local frequency measure for each term of the node text index is calculated on the basis of a frequency of documents containing the term in the subset of the documents of the node. A global frequency measure for each term is calculated on the basis of a frequency of documents containing the term in the set of documents. A quality measure for each node text index is calculated on the basis of the local frequency measures of the terms of the node and the global frequency measure of the terms of the node.
摘要翻译：本发明涉及一种生成用于多个节点的并行查询处理的分布式文本索引的方法。生成一组节点索引，用于文本索引一组文档，每个节点文本索引覆盖文档的一个子集。对于每个节点文本索引，基于节点文档子集中包含术语的文档的频率来计算节点文本索引的每个术语的本地频率测量。每个术语的全球频率测量是根据包含该组文件中的术语的文档的频率计算的。基于节点的本地频率测量和节点项的全局频率测量，计算每个节点文本索引的质量度量。

6. 发明授权

US08580258B2 Treatment of tumors using specific anti-L1 antibody 有权
标题翻译：使用特异性抗L1抗体治疗肿瘤
公开(公告)号：US08580258B2
公开(公告)日：2013-11-12
申请号：US13367178
申请日：2012-02-06
申请人： Daniela Kelm , Peter Altevogt , Gerhard Moldenhauer , Frank Brietling , Achim Krueger , Silke Wolterink , Sandra Luettgau , Ulrich Moebius , Yi Li , Susanne Sebens , Heiner Schaefer
发明人： Daniela Kelm , Peter Altevogt , Gerhard Moldenhauer , Frank Brietling , Achim Krueger , Silke Wolterink , Sandra Luettgau , Ulrich Moebius , Yi Li , Susanne Sebens , Heiner Schaefer
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/02 , A61N5/0613 , A61N5/10 , A61N2005/0661 , A61N2005/1087 , A61N2005/1089 , C07K2317/24 , C07K2317/41 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/57492
摘要： The present invention relates to the anti-L1 monoclonal antibody 9.3 as well as to related antibodies or binding molecules and well as to the uses thereof, especially in tumor treatment.
摘要翻译：本发明涉及抗L1单克隆抗体9.3以及相关抗体或结合分子，以及其用途，特别是在肿瘤治疗中。

7. 发明申请

US20100217761A1 System and Method of Enhancing Decoding Performance of Text Indexes 失效
标题翻译：提高文本索引解码性能的系统和方法
公开(公告)号：US20100217761A1
公开(公告)日：2010-08-26
申请号：US12775546
申请日：2010-05-07
申请人： Peter Altevogt , Silvio Wiedrich
发明人： Peter Altevogt , Silvio Wiedrich
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30622
摘要： The present invention provides a system for enhancing the decoding performance of text indexes of an indexed collection of text documents. The posting list includes a plurality of list entries being of variable size depending on the value stored in each posting list entry. The inventive system is based on a statistical analysis of the posting list entries of the plurality of list entries. Prior to decoding, the system can select a decoding procedure being appropriate to decode the most frequent type of posting list entries or of a plurality of various posting list entries. After selecting a particular decoding procedure and executing the decoding procedure for decoding of the entire posting list, a failure check is performed. In the exceptional case that a failure has occurred, a second alternative decoding procedure is selected and executed.
摘要翻译：本发明提供了一种用于增强索引的文本文档集合的文本索引的解码性能的系统。发布列表包括根据存储在每个发布列表条目中的值而具有可变大小的多个列表条目。本发明的系统基于对多个列表条目的发布列表条目的统计分析。在解码之前，系统可以选择适合于解码最频繁类型的发布列表条目或多个各种发布列表条目的解码过程。在选择特定解码过程并执行用于解码整个发布列表的解码过程之后，执行故障检查。在发生故障的特殊情况下，选择并执行第二替代解码过程。

8. 发明授权

US07670601B2 Diagnostic and therapeutic methods based on the L1 adhesion molecule for ovarian and endometrial tumors 有权
标题翻译：基于L1粘附分子的卵巢和子宫内膜肿瘤的诊断和治疗方法
公开(公告)号：US07670601B2
公开(公告)日：2010-03-02
申请号：US11865989
申请日：2007-10-02
申请人： Peter Altevogt , Mina Fogel
发明人： Peter Altevogt , Mina Fogel
IPC分类号： A61K39/395
CPC分类号： G01N33/57449 , G01N33/57442 , G01N2333/70503 , G01N2333/70596
摘要： A method is described for the diagnosis of an ovarian or endometrial tumor or for a prognosis, characterized in that the L1 level is determined in a patient sample, preferably via an anti L1 antibody, the presence of L1 being an indication of the presence of an ovarian or endometrial tumor or a predisposition for such a tumor. Furthermore, methods for treating of ovarian or endometrial tumors are provided.
摘要翻译：描述了一种用于诊断卵巢或子宫内膜肿瘤或预后的方法，其特征在于在患者样品中优选通过抗L1抗体测定L1水平，L1的存在是存在卵巢或子宫内膜肿瘤或这种肿瘤的倾向。此外，提供了治疗卵巢或子宫内膜肿瘤的方法。

9. 发明授权

US07618785B2 Diagnostic and therapeutic methods based on the L1 adhesion molecule for ovarian and endometrial tumors 有权
标题翻译：基于L1粘附分子的卵巢和子宫内膜肿瘤的诊断和治疗方法
公开(公告)号：US07618785B2
公开(公告)日：2009-11-17
申请号：US10332876
申请日：2001-07-10
申请人： Peter Altevogt , Mina Fogel
发明人： Peter Altevogt , Mina Fogel
IPC分类号： C12Q1/70 , G01N33/53
CPC分类号： G01N33/57449 , G01N33/57442 , G01N2333/70503 , G01N2333/70596
摘要： A method is described for the diagnosis of an ovarian or endometrial tumor or for a prognosis, characterized in that the L1 level is determined in a patient sample, preferably via an anti L1 antibody, the presence of L1 being an indication of the presence of an ovarian or endometrial tumor or a predisposition for such a tumor. Furthermore, methods for treating of ovarian or endometrial tumors are provided.
摘要翻译：描述了用于诊断卵巢或子宫内膜肿瘤或预后的方法，其特征在于L1水平优选通过抗L1抗体在患者样品中测定，L1的存在是存在卵巢或子宫内膜肿瘤或这种肿瘤的倾向。此外，提供了治疗卵巢或子宫内膜肿瘤的方法。

10. 发明申请

US20080098254A1 Method for Autonomous Dynamic Voltage and Frequency Scaling of Microprocessors 有权
标题翻译：微处理器的自动动态电压和频率调节方法
公开(公告)号：US20080098254A1
公开(公告)日：2008-04-24
申请号：US11838331
申请日：2007-08-14
申请人： Peter Altevogt , Hans Boettiger , Wesley M. Felter , Charles R. Lefurgy , Lutz Stiege , Malcolm S. Ware
发明人： Peter Altevogt , Hans Boettiger , Wesley M. Felter , Charles R. Lefurgy , Lutz Stiege , Malcolm S. Ware
IPC分类号： G06F1/08
CPC分类号： G06F1/3203 , G06F1/324 , G06F1/3296 , Y02D10/126 , Y02D10/172
摘要： A method for autonomous dynamic voltage (v) and frequency (f) scaling (DVFS) of a microprocessor, wherein autonomous detection of phases of high microprocessor workload and prediction of their duration is performed (PID). The microprocessor frequency (f) will be temporarily increased (LUT) to an appropriate safe value (even beyond its nominal frequency) consistent with technological and ambient constraints in order to improve performance when the computer system comprising the microprocessor benefits most, while during phases of low microprocessor workload its frequency (f) and voltage (v) will be decreased to save energy. This technique exploits hidden performance capabilities and improves the total performance of a computer system without compromising operational stability. No additional hardware such as service processors is needed for contemporary computer systems supporting performance counters and DFVS already. The invention allows significantly increasing the total computer system performance with only minimal impact on power (PMAX, PACTUAL) consumption.
摘要翻译：一种用于微处理器的自主动态电压（v）和频率（f）缩放（DVFS）的方法，其中执行高微处理器工作负载的相位的自主检测及其持续时间的预测（PID）。微处理器频率（f）将临时增加（LUT）到与技术和环境约束一致的适当的安全值（甚至超过其标称频率），以便当包括微处理器的计算机系统受益最大时，提高性能，同时在低微处理器工作负载，其频率（f）和电压（v）将降低以节省能源。该技术利用隐藏的性能功能，并提高计算机系统的总体性能，而不会影响操作稳定性。不需要支持性能计数器和DFVS的现代计算机系统等附加硬件，如服务处理器。本发明允许显着地增加总计算机系统的性能，而对功率（P MAX），功耗（P <

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