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1. 发明申请

US20110042618A1 SYSTEMS AND METHODS FOR HANDLING AND/OR ISOLATING NANOTUBES AND OTHER NANOSTRUCTURES 审中-公开
标题翻译：用于处理和/或分离纳米管和其他纳米结构的系统和方法
公开(公告)号：US20110042618A1
公开(公告)日：2011-02-24
申请号：US12545787
申请日：2009-08-21
申请人： Michael S. Strano , Woo-Jae Kim , Paul W. Barone
发明人： Michael S. Strano , Woo-Jae Kim , Paul W. Barone
IPC分类号： D01F9/12 , C09K3/00 , C09K11/02
CPC分类号： B82Y30/00 , B82Y40/00 , C01B32/168 , C01B32/17 , C01B32/174
摘要： Systems and methods related to handling and/or isolating nanotubes and other nanostructures are generally described. In some embodiments, a polymer can be exposed to a collection of agglomerated nanostructures to produce individuated nanostructures. The polymer can comprise one or more pendant groups capable of participating in a pi-pi interaction with at least a portion of the agglomerated nanostructures to produce individuated nanostructures. Individuated nanostructures can be isolated from nanostructures that remain agglomerated. In some cases, individuated nanostructures can be freeze dried to provide, for example, a plurality of nanostructures in solid form. The systems and methods described herein may be so effective in maintaining separation between individuated nanostructures that pluralities of dried nanostructures can be re-suspended in a fluid after they are dried, in some cases with relatively low forces applied during re-suspension.
摘要翻译：通常描述与处理和/或分离纳米管和其它纳米结构有关的系统和方法。在一些实施方案中，聚合物可以暴露于聚集的纳米结构的集合以产生个体化的纳米结构。聚合物可以包含一个或多个能够参与与聚集的纳米结构的至少一部分的pi-pi相互作用以产生个体化纳米结构的侧基。分离的纳米结构可以从保持凝聚的纳米结构中分离出来。在一些情况下，个体化的纳米结构可以被冷冻干燥以提供例如固体形式的多个纳米结构。本文所述的系统和方法可以在保持单个纳米结构之间的分离方面如此有效，使得多个干燥的纳米结构在干燥后可以重新悬浮在流体中，在一些情况下在再悬浮期间施加相对较低的力。

2. 发明授权

US08377700B2 Systems and methods using photoluminescent nanostructure based hydrogels 有权
标题翻译：使用基于光致发光纳米结构的水凝胶的系统和方法
公开(公告)号：US08377700B2
公开(公告)日：2013-02-19
申请号：US12659193
申请日：2010-02-26
申请人： Michael S. Strano , Paul W. Barone , Jin-Ho Ahn , Ardemis Anoush Boghossian , Rene Ortiz-Garcia , Hyeonseok Yoon , Jingqing Zhang
发明人： Michael S. Strano , Paul W. Barone , Jin-Ho Ahn , Ardemis Anoush Boghossian , Rene Ortiz-Garcia , Hyeonseok Yoon , Jingqing Zhang
IPC分类号： G01N21/76 , G01N21/00
CPC分类号： G01N33/582 , B82Y15/00 , G01N33/588 , Y10T436/143333 , Y10T436/144444
摘要： Systems and methods related to compositions including hydrogels and photoluminescent nanostructures are described. The compositions can undergo a change in a physical, chemical, dielectric, or other property upon exposure to an altering stimulus. Changes in one or more properties of the hydrogel may impart a change in the photoluminescence of the nanostructures embedded in the hydrogel.
摘要翻译：描述与包括水凝胶和光致发光纳米结构的组合相关的系统和方法。当暴露于改变刺激物时，组合物可以经历物理，化学，电介质或其它性质的变化。水凝胶的一个或多个性质的变化可能使嵌入在水凝胶中的纳米结构的光致发光变化。

3. 发明申请

US20120178640A1 Nanotube Array for Optical Detection of Protein-Protein Interactions 审中-公开
标题翻译：用于光学检测蛋白质 - 蛋白质相互作用的纳米管阵列
公开(公告)号：US20120178640A1
公开(公告)日：2012-07-12
申请号：US13222706
申请日：2011-08-31
申请人： Michael S. Strano , Jin-Ho Ahn , Jong-Ho Kim , Paul W. Barone , Nigel F. Reuel
发明人： Michael S. Strano , Jin-Ho Ahn , Jong-Ho Kim , Paul W. Barone , Nigel F. Reuel
IPC分类号： C40B30/04 , C40B40/10 , C40B40/12 , C40B80/00 , C40B40/00 , C40B40/06 , B82Y15/00
CPC分类号： G01N33/54373 , B82Y5/00 , B82Y15/00 , G01N33/54353
摘要： A composition can include a nanostructure, and a linker associated with the nanostructure, wherein the linker is configured to interact with a capture protein. The nanostructure can include a single-walled carbon nanotube. A plurality of the compositions can be configured in an array.
摘要翻译：组合物可以包括纳米结构和与纳米结构相关联的接头，其中所述连接体配置成与捕获蛋白相互作用。纳米结构可以包括单壁碳纳米管。多个组合物可以被配置成阵列。

4. 发明授权

US09980668B2 Photoluminescent nanostructure-based sensors 有权
公开(公告)号：US09980668B2
公开(公告)日：2018-05-29
申请号：US13562403
申请日：2012-07-31
申请人： Michael S. Strano , Paul W. Barone , Jin-Ho Ahn , Kyungsuk Yum , Thomas P. McNicholas
发明人： Michael S. Strano , Paul W. Barone , Jin-Ho Ahn , Kyungsuk Yum , Thomas P. McNicholas
IPC分类号： A61B5/1455 , A61B5/1459 , A61B5/145 , G01N33/542 , G01N33/543 , G01N33/58 , G01N33/66
CPC分类号： A61B5/1459 , A61B5/14532 , G01N33/542 , G01N33/54373 , G01N33/582 , G01N33/587 , G01N33/66
摘要： A composition for sensing an analyte can include a photoluminescent nanostructure complexed to a sensing polymer, where the sensing polymer includes an organic polymer non-covalently bound to the photoluminescent nanostructure and an analyte-binding protein covalently bound to the organic polymer, and where the analyte-binding protein is capable of selectively binding the analyte, and the analyte-binding protein undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte, can include a complex, where the complex includes a photoluminescent nanostructure in an aqueous surfactant dispersion and a boronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte.

5. 发明申请

US20130035567A1 PHOTOLUMINESCENT NANOSTRUCTURE-BASED SENSORS 有权
标题翻译：基于光电子纳米结构的传感器
公开(公告)号：US20130035567A1
公开(公告)日：2013-02-07
申请号：US13562403
申请日：2012-07-31
申请人： Michael S. Strano , Paul W. Barone , Jin-Ho Ahn , Kyungsuk Yum , Thomas P. McNicholas
发明人： Michael S. Strano , Paul W. Barone , Jin-Ho Ahn , Kyungsuk Yum , Thomas P. McNicholas
IPC分类号： A61B5/1459 , B82Y15/00
CPC分类号： A61B5/1459 , A61B5/14532 , G01N33/542 , G01N33/54373 , G01N33/582 , G01N33/587 , G01N33/66
摘要： A composition for sensing an analyte can include a photoluminescent nanostructure complexed to a sensing polymer, where the sensing polymer includes an organic polymer non-covalently bound to the photoluminescent nanostructure and an analyte-binding protein covalently bound to the organic polymer, and where the analyte-binding protein is capable of selectively binding the analyte, and the analyte-binding protein undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte, can include a complex, where the complex includes a photoluminescent nanostructure in an aqueous surfactant dispersion and a boronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte.
摘要翻译：用于感测分析物的组合物可以包括与感测聚合物复合的光致发光纳米结构，其中感测聚合物包括非共价结合到光致发光纳米结构的有机聚合物和与有机聚合物共价结合的分析物结合蛋白，并且其中分析物结合蛋白能够选择性地结合分析物，并且当结合分析物时，分析物结合蛋白经历基本的构象变化。单独地，用于感测分析物的组合物可以包括配合物，其中复合物包含水性表面活性剂分散体中的光致发光纳米结构和能够与分析物选择性反应的硼酸。组合物可用于感测分析物的装置和方法。

6. 发明申请

US20100279421A1 Systems and methods using photoluminescent nanostructure based hydrogels 有权
标题翻译：使用基于光致发光纳米结构的水凝胶的系统和方法
公开(公告)号：US20100279421A1
公开(公告)日：2010-11-04
申请号：US12659193
申请日：2010-02-26
申请人： Michael S. Strano , Paul W. Barone
发明人： Michael S. Strano , Paul W. Barone
IPC分类号： G01N21/76
CPC分类号： G01N33/582 , B82Y15/00 , G01N33/588 , Y10T436/143333 , Y10T436/144444
摘要： Systems and methods related to compositions including hydrogels and photoluminescent nanostructures are described. The compositions can undergo a change in a physical, chemical, dielectric, or other property upon exposure to an altering stimulus. Changes in one or more properties of the hydrogel may impart a change in the photoluminescence of the nanostructures embedded in the hydrogel.
摘要翻译：描述与包括水凝胶和光致发光纳米结构的组合相关的系统和方法。当暴露于改变刺激物时，组合物可以经历物理，化学，电介质或其它性质的变化。水凝胶的一个或多个性质的变化可能使嵌入在水凝胶中的纳米结构的光致发光变化。

7. 发明授权

US10215752B2 Nanotube array for optical detection of protein-protein interactions 有权
公开(公告)号：US10215752B2
公开(公告)日：2019-02-26
申请号：US13222706
申请日：2011-08-31
申请人： Michael S. Strano , Jin-Ho Ahn , Jong-Ho Kim , Paul W. Barone , Nigel F. Reuel
发明人： Michael S. Strano , Jin-Ho Ahn , Jong-Ho Kim , Paul W. Barone , Nigel F. Reuel
IPC分类号： C40B40/10 , C40B40/12 , G01N33/543 , B82Y5/00 , B82Y15/00
摘要： A composition can include a nanostructure, and a linker associated with the nanostructure, wherein the linker is configured to interact with a capture protein. The nanostructure can include a single-walled carbon nanotube. A plurality of the compositions can be configured in an array.

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