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1. 发明申请

WO1995013084A1 CATHEPSIN D IS AN AMYLOIDOGENIC PROTEASE IN ALZHEIMER'S DISEASE 审中-公开
标题翻译： CATHEPSIN D是阿尔茨海默病中的氨基酸分泌蛋白
公开(公告)号：WO1995013084A1
公开(公告)日：1995-05-18
申请号：PCT/US1994007043
申请日：1994-06-21
申请人： MILES INC. , TAMBURINI, Paul, Perry , BENZ, Günter, Hans, Heinz, Herbert , HÄBICH, Dieter , DREYER, Robert, Norman , KOENIG, Gerhard
发明人： MILES INC.
IPC分类号： A61K37/64
CPC分类号： C12N9/6478 , A61K38/00 , C07K14/4711 , C07K14/8142 , C07K16/18 , G01N33/6896 , G01N2333/4709 , G01N2333/8142 , G01N2333/96472
摘要： Deposition of the neurotoxic beta-amyloid peptide is a pathologic process that takes place in the brains of Alzheimer's disease patients. Disclosed are methods for treating a patient with a therapeutic compound that functions by blocking the formation of beta-amyloid from the amyloid precursor protein (APP). We have identified the aspartic protease cathepsin D as a protease responsible for amyloidogenic processing of APP. Non-toxic compounds are disclosed that block both the in vitro activity of human cathepsin D, and the release of beta-amyloid by human cells. Such aspartic protease inhibitors thus have utility as therapeutics for Alzheimer's disease by blocking the pathologic accumulation of beta-amyloid.
摘要翻译：神经毒性β-淀粉样蛋白肽的沉积是在阿尔茨海默病患者的大脑中发生的病理过程。公开了用于通过阻断淀粉样蛋白前体蛋白（APP）形成β-淀粉样蛋白而起作用的治疗化合物治疗患者的方法。我们已经鉴定出天冬氨酸蛋白酶组织蛋白酶D作为负责APP淀粉样生长加工的蛋白酶。公开了阻止人组织蛋白酶D的体外活性和人细胞释放β-淀粉样蛋白的无毒化合物。因此，这种天冬氨酸蛋白酶抑制剂因此通过阻断β-淀粉样蛋白的病理性积累而用作阿尔茨海默病的治疗剂。

2. 发明申请

WO1994013319A1 CATHEPSIN D IS AN AMYLOIDOGENIC PROTEASE IN ALZHEIMER'S DISEASE 审中-公开
标题翻译： CATHEPSIN D是阿尔茨海默病中的氨基酸分泌蛋白
公开(公告)号：WO1994013319A1
公开(公告)日：1994-06-23
申请号：PCT/US1993010889
申请日：1993-11-12
申请人： MILES INC. , TAMBURINI, Paul, Perry , BENZ, Günter, Hans, Heinz, Herbert , HÄBICH, Dieter , DREYER, Robert, Norman
发明人： MILES INC.
IPC分类号： A61K37/64
CPC分类号： C12N9/6478 , A61K38/55 , C07K14/4711 , C12Q1/37 , G01N33/6896 , G01N2333/4709 , G01N2333/8142 , G01N2333/96472 , G01N2800/2821
摘要： Disclosed are methods for regulating formation of beta-amyloid protein with inhibitors of proteases specific for the Precursor to the Alzheimer's Disease beta-amyloid protein, such as inhibitors of aspartic protease, cathepsin D, and a chymotryptic-like serine protease; a method for detecting in vitro protease activity for molecules which possess specificity necessary for the degradation of the Amyloid Precursor Protein; assays for identifying inhibitors of proteases specific for the Amyloid Precursor Protein; and identified inhibitors and their use as therapeutics for the treatment of Alzheimer's Disease.
摘要翻译：公开了调节β-淀粉样蛋白形成的方法，其具有对阿尔茨海默氏病前体β-淀粉样蛋白前体特异性蛋白酶的抑制剂，例如天冬氨酸蛋白酶，组织蛋白酶D和糜蛋白酶样丝氨酸蛋白酶的抑制剂; 用于检测具有淀粉样蛋白前体蛋白降解所必需的特异性的分子的体外蛋白酶活性的方法; 用于鉴定淀粉样前体蛋白特异性蛋白酶抑制剂的测定法; 并鉴定了抑制剂及其作为治疗阿尔茨海默病的治疗剂的用途。

3. 发明授权

US09344883B2 System and method for wide area wireless connectivity to the internet 有权
公开(公告)号：US09344883B2
公开(公告)日：2016-05-17
申请号：US13072306
申请日：2011-03-25
申请人： Paul Perry , Sean Byrnes , Valeriy Elbert , Chivas Nambiar , Conor Hunt , Thanos Kosmidis , Vineet Gupta
发明人： Paul Perry , Sean Byrnes , Valeriy Elbert , Chivas Nambiar , Conor Hunt , Thanos Kosmidis , Vineet Gupta
IPC分类号： H04L29/06 , H04W12/06
CPC分类号： H04W12/06
摘要： A system and method for managing access to a Wi-Fi system include redirecting an access request, comprising a user credential, from a wireless user device to an authentication server, obtaining, from a first database, a list of a plurality of authentication databases from which users may be authenticated, the list including a protocol required for communication with each of the authentication databases, transmitting a request to each of the listed authentication databases using the identified protocol, and permitting the user access to the Internet through the Wi-Fi system if the user is authenticated by at least one of the listed authentication databases.

4. 发明申请

US20120042963A1 IN-WALL WATER SERVICE HOUSING 审中-公开
标题翻译：室内水服务房
公开(公告)号：US20120042963A1
公开(公告)日：2012-02-23
申请号：US12859838
申请日：2010-08-20
申请人： Brian D. Sanzone , Mahesh Cheerla , Joseph Schutte , Joseph M. Lehman , Jeffrey Robert Burger , Paul Perry Kolada , Nathan Daniel Durflinger
发明人： Brian D. Sanzone , Mahesh Cheerla , Joseph Schutte , Joseph M. Lehman , Jeffrey Robert Burger , Paul Perry Kolada , Nathan Daniel Durflinger
IPC分类号： F16K43/00
CPC分类号： F16K27/12 , D06F39/08 , E03C1/021 , Y10T137/598
摘要： A retrofit or new installation kit or apparatus has a junction box, a supply pipe that attaches to a quick-connect fitting inside the junction box that attaches to a valve within the junction box. The valve within the junction box has a stub-out that connects to the quick-connect fitting.
摘要翻译：改装或新的安装套件或设备具有接线盒，供应管连接到接线盒内的快速连接配件，该接线盒连接到接线盒内的阀。接线盒内的阀门有一个连接到快速接头的插座。

5. 发明申请

US20090235172A1 METHOD, APPARATUS, AND COMPUTER PROGRAM FOR PROVIDING WEB SERVICE TESTING 有权
标题翻译：用于提供WEB服务测试的方法，设备和计算机程序
公开(公告)号：US20090235172A1
公开(公告)日：2009-09-17
申请号：US12048504
申请日：2008-03-14
申请人： Amish Gandhi , Valeriy Elbert , Paul Perry , Gregory Wang
发明人： Amish Gandhi , Valeriy Elbert , Paul Perry , Gregory Wang
IPC分类号： G06F3/00 , G06F19/00
CPC分类号： G06F11/3696 , G06F11/3688 , H04L41/22 , H04L43/50
摘要： A method, apparatus, and a computer program product for providing web service testing are provided. The apparatus may include a processor that is configured to provide a user interface for a testing tool accessible in a distributed network architecture. The processor may also be configured to receive selections of an application(s) to be tested that is accessible in a distributed network architecture, a function(s) that is associated with the selected application and a method(s) that is associated with the selected function(s). Additionally, the processor may be configured to receive selections of a test case(s) that is associated with the selected method(s). Moreover, the processor may be configured to automatically conduct the selected test case(s).
摘要翻译：提供了一种用于提供Web服务测试的方法，装置和计算机程序产品。该设备可以包括处理器，其被配置为提供用于在分布式网络架构中可访问的测试工具的用户界面。处理器还可以被配置为接收在分布式网络架构中可访问的待测试应用的选择，与所选择的应用相关联的功能以及与所选择的应用相关联的方法所选功能。另外，处理器可以被配置为接收与所选择的方法相关联的测试用例的选择。此外，处理器可以被配置为自动地执行所选择的测试用例。

7. 发明申请

US20060000508A1 Passive pressure activation valve 失效
公开(公告)号：US20060000508A1
公开(公告)日：2006-01-05
申请号：US11094789
申请日：2005-03-31
申请人： Gilles Delaire , Kirk Ivens , Paul Perry , Andre Veinotte
发明人： Gilles Delaire , Kirk Ivens , Paul Perry , Andre Veinotte
IPC分类号： F16K13/10
CPC分类号： F02M25/0854 , F16K13/10 , F16K17/196 , Y10T137/4553 , Y10T137/4568 , Y10T137/4666 , Y10T137/8326 , Y10T137/8342
摘要： A valve apparatus includes a housing, which defines an interior chamber, a baffle disposed in the interior chamber, and a volume of liquid. The housing includes first, second and third portions. The first portion includes first and second ports that communicate with the interior chamber. The second portion is spaced from the first portion along a longitudinal axis. And the third portion extends along the longitudinal axis between the first and second portions. The baffle at least partially defines a helical fluid flow path between the first and second ports, and the volume of the liquid is disposed in the second portion of the housing.

8. 发明授权

US06913036B2 Bi-directional flow seal for a fuel vapor pressure management apparatus 失效
标题翻译：用于燃料蒸汽压力管理装置的双向流动密封
公开(公告)号：US06913036B2
公开(公告)日：2005-07-05
申请号：US10171470
申请日：2002-06-14
申请人： Andre Veinotte , Paul Perry
发明人： Andre Veinotte , Paul Perry
IPC分类号： F02M25/08 , F16K17/196
CPC分类号： F02M25/0854 , F02M25/0809 , F02M25/0836 , Y10T137/0324 , Y10T137/0396 , Y10T137/778 , Y10T137/7851 , Y10T137/792 , Y10T137/8326
摘要： A device for a fuel vapor pressure management apparatus of a fuel system supplying fuel to an internal combustion engine. The fuel vapor pressure management apparatus performs leak detection on a headspace of the fuel system, performs excess negative pressure relief of the headspace, and performs excess positive pressure relief of the headspace. The device includes a seal that is deformable between a substantially symmetrically deformed configuration, a generally asymmetrically deformed configuration, and an undeformed configuration. The seal is adapted to cooperatively engage a poppet such that a first arrangement that includes the seal in the substantially symmetrically deformed configuration and the poppet engaging the seal, a second arrangement that includes the seal in the generally asymmetrically deformed configuration and the poppet engaging the seal, and a third arrangement that includes the seal in an undeformed configuration and the poppet being disengaged from the seal. The first arrangement is associated with the performing leak detection, the second arrangement is associated with the performing excess negative pressure relief; and the third arrangement is associated with the performing excess positive pressure relief.
摘要翻译：一种用于向内燃机供应燃料的燃料系统的燃料蒸气压力管理装置。燃料蒸气压管理装置对燃料系统的顶部空间进行泄漏检测，对顶部空间进行过剩的负压释放，并对顶部空间进行过度的正压力释放。该装置包括可在基本上对称变形的构型，大致不对称变形构型和未变形构型之间变形的密封件。密封件适于协作地接合提升阀，使得包括基本上对称变形的构造中的密封件和接合密封件的提升阀的第一布置，包括大致不对称变形构造中的密封件的第二布置以及接合密封件的提升阀以及包括处于未变形构造的密封件并且提升阀与密封件脱离接合的第三布置。第一布置与执行泄漏检测相关联，第二布置与执行过量的负压释放相关联; 并且第三布置与执行过量的正压力释放有关。

9. 发明授权

US1909628A Ironing machine 失效
公开(公告)号：US1909628A
公开(公告)日：1933-05-16
申请号：US60894332
申请日：1932-05-03
申请人： PAUL PERRY
发明人： PAUL PERRY
IPC分类号： D06F65/06
CPC分类号： D06F65/06

10. 发明授权

US07028722B2 Rationality testing for a fuel vapor pressure management apparatus 有权
标题翻译：燃油蒸汽压力管理装置的合理性测试
公开(公告)号：US07028722B2
公开(公告)日：2006-04-18
申请号：US10667903
申请日：2003-09-23
申请人： Paul Perry , Andre Veinotte
发明人： Paul Perry , Andre Veinotte
IPC分类号： B65B1/04
CPC分类号： F02M25/0809 , F02M25/0836
摘要： A method of rationalizing the functioning of a fuel vapor pressure management system. The fuel vapor pressure management system is in fluid communication with a headspace of a fuel system, and the fuel system supplies fuel to an internal combustion engine of a vehicle. The method includes providing a fuel vapor pressure management apparatus detecting an absence of leaks with respect to the headspace, counting a number of leak detection tests performed by the fuel vapor pressure management apparatus, counting a number of occurrences of the fuel vapor pressure management apparatus detecting an absence of a leak, and evaluating the number of occurrences within a selected number of tests.
摘要翻译：一种使燃料蒸汽压力管理系统功能合理化的方法。燃料蒸汽压力管理系统与燃料系统的顶部空间流体连通，并且燃料系统向车辆的内燃机供应燃料。该方法包括提供燃料蒸汽压力管理装置，其检测相对于顶部空间的泄漏的不存在，计算由燃料蒸气压力管理装置进行的泄漏检测试验的次数，计算燃料蒸气压力管理装置检测的次数没有泄漏，并且在所选数量的测试中评估出现的次数。

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