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1. 发明申请

US20120044342A1 DIGITAL MICROSCOPE 审中-公开
标题翻译：数字显微镜
公开(公告)号：US20120044342A1
公开(公告)日：2012-02-23
申请号：US13212955
申请日：2011-08-18
申请人： PAUL HING , CHRISTIAN ROMER , SVEN HENSLER
发明人： PAUL HING , CHRISTIAN ROMER , SVEN HENSLER
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/361 , G02B21/365
摘要： A method including sensing an image without magnification of a portion of a tissue sample on a substrate with a sensor; displaying the sensed image on a display at a sensor to display pixel ratio greater than one to one; and performing at least one of the following: refreshing the sensed image at a predetermined rate, storing the sensed image, modifying the sensor to display pixel ratio, and sensing a magnified view of an area of the portion of the tissue sample. An apparatus comprising a digital microscope comprising: at least one image sensor; a stage configured to support at least one microscope slide; a first optic configured to project an image with a magnification of one or less; a second optic disposed between the at least one sensor and the stage, the second optic configured to project an image with a magnification greater than one; and a light source; and a computer coupled to the digital microscope and operable to direct an image capture by the at least one image sensor of a portion of a microslide on the stage projected through the first optic or the second optic
摘要翻译：一种方法，包括用传感器在基底上感测图像而不放大组织样本的一部分; 在传感器的显示器上显示感测图像以显示大于1比1的像素比; 并且执行以下中的至少一个：以预定速率刷新感测到的图像，存储感测图像，修改传感器以显示像素比，以及感测组织样本的该部分区域的放大视图。一种包括数字显微镜的装置，包括：至少一个图像传感器; 配置成支撑至少一个显微镜载玻片的台架; 第一光学器件，被配置为投影具有一个或更小的放大率的图像; 设置在所述至少一个传感器和所述台之间的第二光学器件，所述第二光学器件被配置为以大于1的倍率投影图像; 和光源; 以及耦合到所述数字显微镜并且可操作以将所述至少一个图像传感器的图像捕获引导到通过所述第一光学器件或所述第二光学器件投影的所述平台上的微滑块的一部分的图像的计算机

2. 发明申请

US20120038979A1 AUTOFOCUS METHOD AND AUTOFOCUS DEVICE 有权
标题翻译：自动方法和自动装置
公开(公告)号：US20120038979A1
公开(公告)日：2012-02-16
申请号：US13255827
申请日：2010-03-11
申请人： Paul Hing , Sven Hensler
发明人： Paul Hing , Sven Hensler
IPC分类号： G02B21/00
CPC分类号： G02B21/365 , G02B7/09 , G02B21/08 , G02B21/18 , G02B21/247
摘要： The invention is based on an autofocus method in which light from a light source (12) is focused at a measurement light focus (52) in a sample (6) and is reflected from there and the reflected light is guided through an optical system (22) in two light paths (48, 50) onto at least two detector elements (72, 74). In order to achieve fast and accurate automatic focusing on the sample, it is proposed that the measurement light focus (52) is moved in layers of the sample (6) which reflect light to different extents, and the detector elements (72, 74) are arranged in such a way that, in this case, profiles of a radiation property registered by the detector elements (72, 74) are different and a focus position is set in a manner dependent on the profiles.
摘要翻译：本发明基于自动聚焦方法，其中来自光源（12）的光聚焦在样品（6）中的测量光聚焦（52）处并从其中反射并且反射光被引导通过光学系统（ 22）在至少两个检测器元件（72,74）上的两个光路（48,50）中。为了实现对样品的快速和准确的自动聚焦，提出了将测量光聚焦（52）移动到反射光的样品（6）的不同程度的层中，并且检测器元件（72,74）以这样的方式布置，在这种情况下，由检测器元件（72,74）登记的辐射特性的轮廓不同，并且以取决于轮廓的方式设置对焦位置。

3. 发明授权

US09310598B2 Autofocus method and autofocus device 有权
标题翻译：自动对焦方式和自动对焦装置
公开(公告)号：US09310598B2
公开(公告)日：2016-04-12
申请号：US13255827
申请日：2010-03-11
申请人： Paul Hing , Sven Hensler
发明人： Paul Hing , Sven Hensler
IPC分类号： G02B21/00 , G02B21/24
CPC分类号： G02B21/365 , G02B7/09 , G02B21/08 , G02B21/18 , G02B21/247
摘要： The invention is based on an autofocus method in which light from a light source (12) is focused at a measurement light focus (52) in a sample (6) and is reflected from there and the reflected light is guided through an optical system (22) in two light paths (48, 50) onto at least two detector elements (72, 74). In order to achieve fast and accurate automatic focusing on the sample, it is proposed that the measurement light focus (52) is moved in layers of the sample (6) which reflect light to different extents, and the detector elements (72, 74) are arranged in such a way that, in this case, profiles of a radiation property registered by the detector elements (72, 74) are different and a focus position is set in a manner dependent on the profiles.
摘要翻译：本发明基于自动聚焦方法，其中来自光源（12）的光聚焦在样品（6）中的测量光聚焦（52）处并从其中反射并且反射光被引导通过光学系统（ 22）在至少两个检测器元件（72,74）上的两个光路（48,50）中。为了实现对样品的快速和准确的自动聚焦，提出了将测量光聚焦（52）移动到反射光的样品（6）的不同程度的层中，并且检测器元件（72,74）以这样的方式布置，在这种情况下，由检测器元件（72,74）登记的辐射特性的轮廓不同，并且以取决于轮廓的方式设置对焦位置。

4. 发明申请

US20110017902A1 METHOD AND APPARATUS FOR AUTOFOCUS 有权
标题翻译：自动对焦的方法和装置
公开(公告)号：US20110017902A1
公开(公告)日：2011-01-27
申请号：US12509595
申请日：2009-07-27
申请人： Paul Hing , Sven Hensler
发明人： Paul Hing , Sven Hensler
IPC分类号： G02B27/40
CPC分类号： G02B27/40 , G02B21/241
摘要： An autofocus apparatus and a method achieve a higher level of speed and robustness, and are particularly suited for fluorescence microscopy of biological samples, automated microscopy and scanning microscopy. A high speed is achieved via a light pattern in the sample, detected spatially resolved by a detector generating at least two signals corresponding to a reflex pattern of the light pattern. The two signals are subtracted generating a positioning signal and the focus of the objective in the sample is adjusted depending on the positioning signal.
摘要翻译：自动对焦装置和方法实现更高的速度和鲁棒性，并且特别适用于生物样品的荧光显微镜，自动显微镜和扫描显微镜。通过样品中的光图案实现高速度，通过检测器进行空间解析，产生对应于光图案的反射图案的至少两个信号。减去两个信号产生定位信号，并根据定位信号调整样品中的物镜的焦点。

5. 发明申请

US20070057159A1 Apparatus and method for photo-electric measurement 失效
标题翻译：光电测量装置及方法
公开(公告)号：US20070057159A1
公开(公告)日：2007-03-15
申请号：US10559140
申请日：2003-06-02
申请人： Paul Hing
发明人： Paul Hing
IPC分类号： H01J40/14
CPC分类号： G01J3/2803 , G01N21/31
摘要： The invention relates to an apparatus and a method for photo-electric measurement. The apparatus comprises a single or a plurality of photo-electric conversion devices, preferably array sensor(s) such as CCD, CMOS, CID and the like, an optical system which is modularly expandable in one axis or a plurality of axes in order to acquire electromagnetic radiation from a line or area of any desired size on an object, with any desired resolution, wherein the said optical system preferably separates the said electromagnetic radiation modularly into a plurality of smaller segments, and projects electromagnetic radiation corresponding to the said smaller segments onto said single or a plurality of individual photo-electric conversion devices and sensor electronics related to said photo-electric conversion device(s) which enable the operating mode and functionality of said photo-electric conversion device(s) to be defined and changed in real-time, whereby functions such as the readout sequence of pixels and unlimited flexibility of pixel binning in two dimensions are fully programmable, and said photo-electric conversion device(s) may operate and/or be controlled independently and/or simultaneously.
摘要翻译：本发明涉及光电测量的装置和方法。该装置包括单个或多个光电转换装置，优选地诸如CCD，CMOS，CID等的阵列传感器，可以在一个轴或多个轴上模块地展开的光学系统，以便以任何期望的分辨率从物体上的任何所需尺寸的线或区域获取电磁辐射，其中所述光学系统优选地将所述电磁辐射模块化地分离成多个较小的部分，并且投射对应于所述较小部分的电磁辐射在与所述光电转换装置相关的所述单个或多个单独的光电转换装置和传感器电子装置上，使得所述光电转换装置的操作模式和功能能够被定义和改变实时的，像素的读出顺序和二维像素分档的无限灵活性等功能完全是专业的并且所述光电转换装置可以独立地和/或同时地操作和/或控制。

6. 发明申请

US20100302631A1 MICROSCOPE 审中-公开
标题翻译：显微镜
公开(公告)号：US20100302631A1
公开(公告)日：2010-12-02
申请号：US12855988
申请日：2010-08-13
申请人： Paul HING , Martin VOGEL , Stefan BICKERT
发明人： Paul HING , Martin VOGEL , Stefan BICKERT
IPC分类号： G02B21/06
CPC分类号： G02B21/0076 , G01N21/6458 , G02B21/06
摘要： The invention is based on a microscope, in particular a fluorescence analysis microscope, comprising an illumination carrier and illumination units arranged thereon for a reflected-light illumination of a sample region. In order to be able to illuminate a sample region uniformly in a simple manner by means of a compact device, it is proposed that at least three illumination units for the simultaneous reflected-light illumination of the sample region from different directions are arranged on the illumination carrier.
摘要翻译：本发明基于显微镜，特别是荧光分析显微镜，其包括照射载体和布置在其上用于样品区域的反射光照明的照射单元。为了能够通过紧凑的装置以简单的方式均匀地照射样品区域，提出了用于将来自不同方向的样品区域的同时反射光照射的至少三个照明单元布置在照明载体

7. 外观设计

USD545031S1 Athletic training shoe 有权
标题翻译：运动训练鞋
公开(公告)号：USD545031S1
公开(公告)日：2007-06-26
申请号：US29226679
申请日：2005-04-01
申请人： Paul Hing Fai Tse
设计人： Paul Hing Fai Tse

8. 发明申请

US20060039583A1 Method for recording a charcteristic of at least one object 审中-公开
标题翻译：记录至少一个对象的特征的方法
公开(公告)号：US20060039583A1
公开(公告)日：2006-02-23
申请号：US10534887
申请日：2003-11-12
申请人： Stefan Bickert , Ulrich Gunther , Paul Hing , Jurgen Wieser
发明人： Stefan Bickert , Ulrich Gunther , Paul Hing , Jurgen Wieser
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/73 , G06T2207/30041
摘要： The invention relates to a method for recording a characteristic of at least one object (28, 56, 68). According to the invention, a) a luminous radiation that is influenced by the object (28, 56, 68) is fed to an image sensor (6), b) at least two different partial images (32, 34, 36, 48, 78, 90, 94, T1, T2) consisting of pixels (26) are read out in succession from the image sensor (A11, A12, A13, A21) and values assigned to the pixels (26) are fed to an evaluation unit (10), c) the respective characteristic (B11, B12, B13, B21) of the object is determined from the values that are assigned to a partial image (32, 34, 36, 48, 78, 90, 94, T1, T2), d) the partial images (32, 34, 36, 48, 78, 90, 94, T1, T2) are combined to form a total image (38), which is output for further processing.
摘要翻译：本发明涉及一种用于记录至少一个物体（28,56,68）的特征的方法。根据本发明，a）受物体（28,56,68）影响的发光辐射被馈送到图像传感器（6），b）至少两个不同的部分图像（32,34,36,48，由像素（26）构成的像素（78），90,94，T 1，T 2（2）由图像传感器（A 11＆lt; 11＆gt; 分配给像素（26）的值被馈送到评估单元（10），其中，，c）物体的相应特征（B 11，B 12，B 13，B 21）由分配给部分图像（32,34,36,48,78,90,94，T 1，T 2）的值确定，d）组合部分图像（32,34,36,48,78,90,94，T 1，T 2）以形成总图像（38），其中输出进一步处理。

9. 发明授权

US10139613B2 Digital microscope and method of sensing an image of a tissue sample 有权
公开(公告)号：US10139613B2
公开(公告)日：2018-11-27
申请号：US13212955
申请日：2011-08-18
申请人： Paul Hing , Christian Romer , Sven Hensler
发明人： Paul Hing , Christian Romer , Sven Hensler
IPC分类号： H04N7/18 , H04N9/47 , G02B21/36
摘要： A method including sensing an image without magnification of a portion of a tissue sample; displaying the sensed image on a display; and performing at least one of the following: refreshing a sensed image at a predetermined rate, storing the sensed image, modifying the sensor to display pixel ratio, and sensing a magnified view of an area of the portion of the tissue sample. A digital microscope comprising: at least one image sensor; a first optic configured to project an image with a magnification of one or less; a second optic disposed between the at least one sensor and the stage, the second optic configured to project an image with a magnification greater than one; and a computer operable to direct an image capture by the at least one image sensor of a portion of a microslide on the stage projected through the first optic or the second optic.

10. 发明授权

US08304704B2 Method and apparatus for autofocus using a light source pattern and means for masking the light source pattern 有权
标题翻译：使用光源图案的自动对焦的方法和装置以及用于掩蔽光源图案的装置
公开(公告)号：US08304704B2
公开(公告)日：2012-11-06
申请号：US12509595
申请日：2009-07-27
申请人： Paul Hing , Sven Hensler
发明人： Paul Hing , Sven Hensler
IPC分类号： G02B27/40 , G02B21/00
CPC分类号： G02B27/40 , G02B21/241
摘要： An autofocus apparatus and a method achieve a higher level of speed and robustness, and are particularly suited for fluorescence microscopy of biological samples, automated microscopy and scanning microscopy. A high speed is achieved via a light pattern in the sample, detected spatially resolved by a detector generating at least two signals corresponding to a reflex pattern of the light pattern. The two signals are subtracted generating a positioning signal and the focus of the objective in the sample is adjusted depending on the positioning signal.
摘要翻译：自动对焦装置和方法实现更高的速度和鲁棒性，并且特别适用于生物样品的荧光显微镜，自动显微镜和扫描显微镜。通过样品中的光图案实现高速度，通过检测器进行空间解析，产生对应于光图案的反射图案的至少两个信号。减去两个信号产生定位信号，并根据定位信号调整样品中的物镜的焦点。

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