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1. 发明授权

US08765910B2 Method for amidating polypeptides with basic amino acid C-terminals by means of specific endoproteases 有权
标题翻译：通过特异性内切蛋白酰胺化具有碱性氨基酸C-末端的多肽的方法
公开(公告)号：US08765910B2
公开(公告)日：2014-07-01
申请号：US12065643
申请日：2006-09-13
申请人： Sebastian Rissom , Paul Habermann , Christophe Salagnad , Frank Zocher , Laure Landric-Burtin
发明人： Sebastian Rissom , Paul Habermann , Christophe Salagnad , Frank Zocher , Laure Landric-Burtin
IPC分类号： C07K1/36 , C07K1/107 , C07K14/00 , A61K38/16 , C07K1/00
CPC分类号： C07K1/00 , A61K38/00 , A61K38/16 , C07K14/57563 , C07K14/605 , C12P21/02 , Y02A50/473 , Y02A50/481
摘要： The invention relates to a method for producing C-terminal amidated dibasic or polybasic peptides, consisting in reacting two peptides in the presence of trypsin biologically active enzymes and, if necessary, in purifying the thus obtainable compounds of formula (I) by means of protein chemistry.
摘要翻译：本发明涉及一种生产C-末端氨基化二元或多元肽的方法，其包括在胰蛋白酶生物活性酶存在下使两种肽反应，并且如果需要，通过蛋白质纯化由此得到的式（I）化合物化学。

2. 发明申请

US20140073563A1 FUSION PROTEINS FOR TREATING A METABOLIC SYNDROME 审中-公开
标题翻译：用于治疗代谢综合征的融合蛋白
公开(公告)号：US20140073563A1
公开(公告)日：2014-03-13
申请号：US14019735
申请日：2013-09-06
申请人： Oliver BOSCHEINEN , Matthias DREYER , Paul HABERMANN , Hans-Ludwig SCHAEFER , Mark SOMMERFELD , Thomas LANGER
发明人： Oliver BOSCHEINEN , Matthias DREYER , Paul HABERMANN , Hans-Ludwig SCHAEFER , Mark SOMMERFELD , Thomas LANGER
IPC分类号： C07K14/50 , C07K14/605
CPC分类号： C07K14/605 , A61K38/1825 , A61K38/26 , A61K47/60 , A61K2300/00 , C07K14/50 , C07K14/575 , C07K14/57563 , C07K2319/00 , C07K2319/21 , C07K2319/30 , C07K2319/31 , C07K2319/50 , C07K2319/90
摘要： The invention is directed to a fusion protein comprising at least one FGF-21 (fibroblast growth factor-21) compound and at least one GLP-1R (glucagon-like peptide-1 receptor) agonist as well as to pharmaceutical compositions, medical uses and methods of treatment involving the fusion protein, particularly in the field of diabetes, dyslipidemia, obesity and/or adipositas.
摘要翻译：本发明涉及包含至少一种FGF-21（成纤维细胞生长因子-21）化合物和至少一种GLP-1R（胰高血糖素样肽-1受体）激动剂以及药物组合物，医学用途和涉及融合蛋白的治疗方法，特别是在糖尿病，血脂异常，肥胖和/或脂肪酸领域。

3. 发明申请

US20090192073A1 METHOD FOR PRODUCING INSULIN ANALOGS HAVING A DIBASIC B CHAIN TERMINUS 有权
标题翻译：用于生产具有二维B链终止子的胰岛素类似物的方法
公开(公告)号：US20090192073A1
公开(公告)日：2009-07-30
申请号：US12349854
申请日：2009-01-07
申请人： Paul HABERMANN , Frank ZOCHER
发明人： Paul HABERMANN , Frank ZOCHER
IPC分类号： A61K38/28 , C12P21/06 , C07K14/62
CPC分类号： C07K14/62 , C07K2319/035 , C07K2319/75 , Y02P20/55
摘要： The invention relates to a method for producing a type of insulin by genetically engineering a precursor thereof and converting said precursor to the respective insulin in an enzyme-catalyzed ligation reaction with lysine amide or arginine amide, or by lysine or arginine which is modified by protective groups, and optionally subsequent hydrolysis.
摘要翻译：本发明涉及一种用于通过遗传工程化其前体并在与赖氨酰胺或精氨酸酰胺的酶催化的连接反应中将所述前体转化为相应的胰岛素，或通过被保护性修饰的赖氨酸或精氨酸来生产一种胰岛素的方法基团和任选的随后的水解。

4. 发明授权

US06686177B1 Insulin analogs with enhanced zinc binding 有权
标题翻译：胰岛素类似物具有增强的锌结合
公开(公告)号：US06686177B1
公开(公告)日：2004-02-03
申请号：US09701968
申请日：2001-05-14
申请人： Johann Ertl , Paul Habermann , Karl Geisen , Gerhard Seipke , Axel Wollmer
发明人： Johann Ertl , Paul Habermann , Karl Geisen , Gerhard Seipke , Axel Wollmer
IPC分类号： A61K3828
CPC分类号： C07K14/62 , A61K38/00 , Y10S514/866
摘要： The invention relates to insulin analogs exhibiting enhanced zinc binding capacity and to stable zinc complexes thereof having a retarded activity in comparison with human insulin. The invention further relates to a method for the production of said insulin analogs and to their use, particularly in pharmaceutical preparations for therapy of type I and type II diabetes mellitus.
摘要翻译：本发明涉及具有增强的锌结合能力的胰岛素类似物和与人胰岛素相比具有延迟活性的稳定的锌络合物。本发明还涉及生产所述胰岛素类似物的方法及其用途，特别是用于治疗I型和II型糖尿病的药物制剂。

5. 发明授权

US5322926A Isohirudins 失效
标题翻译：异水蛭素
公开(公告)号：US5322926A
公开(公告)日：1994-06-21
申请号：US35498
申请日：1993-03-22
申请人： Dominique Tripier , Peter Crause , Paul Habermann , Martin Kramer , Joachim Engels , Matthias Scharf
发明人： Dominique Tripier , Peter Crause , Paul Habermann , Martin Kramer , Joachim Engels , Matthias Scharf
IPC分类号： A61K38/55 , A61K38/00 , A61P7/02 , C07K1/02 , C07K1/113 , C07K1/14 , C07K1/20 , C07K1/22 , C07K14/81 , C07K14/815 , A61K37/00 , A61K37/02 , C07K5/00 , C07K7/00
CPC分类号： C07K14/815 , A61K38/00
摘要： Thrombin inhibitors from the hirudin family which differ from the previously known hirudins by mutation in the protein chain, and a process for their preparation are described. The novel hirudins are distinguished by a high specific activity, high stability and good pharmacokinetics.
摘要翻译：描述了水蛭素家族中不同于先前已知的水蛭素蛋白质链中突变的凝血酶抑制剂及其制备方法。水蛭素具有高比活性，高稳定性和良好的药动学特征。

6. 发明授权

US5180668A Hirudin derivative 失效
标题翻译：水蛭素衍生物
公开(公告)号：US5180668A
公开(公告)日：1993-01-19
申请号：US295422
申请日：1989-01-10
申请人： Peter Crause , Paul Habermann , Dominique Tripier
发明人： Peter Crause , Paul Habermann , Dominique Tripier
IPC分类号： C12P21/02 , A61K38/00 , A61K38/55 , A61P7/02 , C07H21/04 , C07K1/20 , C07K14/00 , C07K14/815 , C12N15/09 , C12R1/865
CPC分类号： C07K14/815 , A61K38/00 , Y10S530/855
摘要： A hirudin derivative which has the N-terminal amino acid sequence Leu-Thr-Tyr-Thr-Asp shows high biological activity. Moreover, this hirudin derivative can be obtained very efficiently by genetic engineering preparation in yeasts.
摘要翻译：具有N-末端氨基酸序列Leu-Thr-Tyr-Thr-Asp的水蛭素衍生物显示出高生物活性。此外，通过在酵母中的遗传工程制备，可以非常有效地获得该水蛭素衍生物。

7. 发明授权

US5093322A Tick-derived amblyommin and method of antithrombin therapy 失效
标题翻译： TICK-DERIVED AMBLYOMMIN AND METHOD OF ANTIROMBIN THERAPY
公开(公告)号：US5093322A
公开(公告)日：1992-03-03
申请号：US360573
申请日：1989-06-02
申请人： Werner Bonin , Paul Habermann , Dominique Tripier , Elisabet Wohner
发明人： Werner Bonin , Paul Habermann , Dominique Tripier , Elisabet Wohner
IPC分类号： A61K38/55 , A61K35/56 , A61K38/00 , A61P7/02 , C07K1/14 , C07K1/16 , C07K14/00 , C07K14/435 , C07K14/44 , C07K14/81
CPC分类号： C07K14/43527 , A61K35/646 , C07K14/811 , A61K38/00 , Y10S530/855
摘要： The invention relates to a new active substance--amblyommin--for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequencesIle-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-,Lys-Ile-Leu-Phe-X-Gln-Gly- andAla-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile-in which each radical X can be identical or different and each represents a naturally occurring amino acid.
摘要翻译：本发明涉及用于抗凝治疗的新型活性物质 - 抗凝血酶活性物质，以及将其与硬蜱分离的方法。具有凝血酶抑制作用的分离蛋白质的分子量为20000〜30000道尔顿，等电点为5.05〜5.65，部分氨基酸序列Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly- Glu-Leu-Glu-Asn-X-Phe-Glu-，Lys-Ile-Leu-Phe-X-Gln-Gly-和Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser- Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile-，其中每个基团X可以相同或不同，并且各自表示天然存在的氨基酸。

8. 发明授权

US08603970B2 Insulin derivatives having an extremely delayed time-action profile 有权
公开(公告)号：US08603970B2
公开(公告)日：2013-12-10
申请号：US12820727
申请日：2010-06-22
申请人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
发明人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
IPC分类号： A61K38/28 , A61K38/26
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.

9. 发明申请

US20100311112A1 METHOD FOR AMIDATING POLYPEPTIDES WITH BASIC AMINO ACID C-TERMINALS BY MEANS OF SPECIFIC ENDOPROTEASES 有权
标题翻译：通过特异性内源性方法将氨基酸与基本氨基酸C-末端相结合的方法
公开(公告)号：US20100311112A1
公开(公告)日：2010-12-09
申请号：US12065643
申请日：2006-09-13
申请人： Sebastian Rissom , Paul Habermann , Christophe Salagnad , Frank Zocher , Laure Landric-Burtin
发明人： Sebastian Rissom , Paul Habermann , Christophe Salagnad , Frank Zocher , Laure Landric-Burtin
IPC分类号： C12P21/02 , C07K14/00
CPC分类号： C07K1/00 , A61K38/00 , A61K38/16 , C07K14/57563 , C07K14/605 , C12P21/02 , Y02A50/473 , Y02A50/481
摘要： The invention relates to a method for producing C-terminal amidated dibasic or polybasic peptides, consisting in reacting two peptides in the presence of trypsin biologically active enzymes and, if necessary, in purifying the thus obtainable compounds of formula (I) by means of protein chemistry.
摘要翻译：本发明涉及一种生产C-末端氨基化二元或多元肽的方法，其包括在胰蛋白酶生物活性酶存在下使两种肽反应，并且如果需要，通过蛋白质纯化由此得到的式（I）化合物化学。

10. 发明授权

US07202059B2 Fusion proteins capable of being secreted into a fermentation medium 有权
标题翻译：能够分泌到发酵培养基中的融合蛋白
公开(公告)号：US07202059B2
公开(公告)日：2007-04-10
申请号：US10076634
申请日：2002-02-19
申请人： Paul Habermann , Johann Ertl
发明人： Paul Habermann , Johann Ertl
IPC分类号： C12P21/04 , C07H21/04
CPC分类号： C12N15/625 , C07K14/62 , C07K14/815 , C07K2319/035 , C07K2319/75 , C12N15/74
摘要： Fusion protein including a fusion part and a protein of interest, the combination of the two proteins leading to the fusion protein being secreted into a supernatant of a bacterial host with the protein of interest being present in its correct three-dimensional structure. Nucleic acid including a sequence coding for a fusion protein, the sequence including: —F—Asm—Rn—Y—, where F is a nucleic acid sequence coding for an amino acid sequence which allows secretion of a protein encoded by Y into a fermentation medium, As is a chemical bond or a nucleic acid sequence comprising a codon, m is an integer from 0–10, R is a chemical bond or an arginine codon, n is 0 or 1, and Y is a nucleic acid sequence coding for a protein of interest. Processes therefor.
摘要翻译：融合蛋白包括融合部分和感兴趣的蛋白质，导致融合蛋白的两种蛋白质的组合分泌到细菌宿主的上清液中，其中感兴趣的蛋白质以其正确的三维结构存在。包含编码融合蛋白的序列的核酸，所述序列包括：-F-As m -R n -Y-，其中F是编码允许由Y编码的蛋白质分泌到发酵培养基中的氨基酸序列As是化学键或包含密码子的核酸序列，m是0-10的整数，R是化学键或精氨酸密码子，n为0或1，Y为编码感兴趣的蛋白质的核酸序列。流程。

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