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    • 3. 发明专利
    • An improved process for refining mineral oils and/or their distillates
    • GB273351A
    • 1927-06-27
    • GB207526
    • 1926-01-25
    • JULIAN PAUL FRASER
    • C10G21/00
    • 273,351. Burmah Oil Co., Ltd., (Fraser J. P.). Jan. 25, 1926. Drawings to Specification. Mineral oils, purifying. - Aromatic and unsaturated hydrocarbons are absorbed from mineral oils by shaking the oils with phenol containing a small quantity of water. (1) The mineral oil is agitated with an equal (or more or less) volume of phenol, containing 5 to 15 per cent but preferably not more than 10 per cent of water, at a temperature above the setting point of the phenol, is then allowed to rest at a temperature below the miscibility point, and the layers are separated. (2) Water (pure or phenolic) preferably in proportion of 10 to 20 per cent is added to the separated phenol layer with gentle agitation, and the liquid allowed to rest, when an oily layer containing the aromatic &c. hydrocarbons floats off the top, and is separated. (3) the remaining phenol layer is agitated at a temperature above 70‹ C. (but preferably between 90 and 100 degrees centigrade) with pure or phenolic water in such a proportion that by dissolving the phenol under treatment quantitatively it will form a solution of 15 to 20 per cent phenol content; the liquid is allowed to settle at the same temperature, and the top oily layer separated. (4) The top oily layer in stage (3) is washed with a large excess of water (pure or phenolic) at above 90‹ C., the water separated, and then used in stage (2) and/or stage (3). (5) The lower layer in stage 3 consisting of a solution of phenol in water is cooled to a temperature below approximately 40‹ C., and the emulsion thereby formed broken by centrifugal means or filtration; the phenol layer is separated from the aqueous layer. (6) The phenolic water obtained in stage (5) is used for the purpose of stage (4). (7) The phenol obtained in stage (5) is concentrated by heating the same to a temperature of 110-120‹ C. and is used for treating a fresh batch of mineral oil as described in stage (1).
    • 7. 发明申请
    • FISHING TRAVEL TOOL
    • 钓鱼旅行工具
    • US20130306506A1
    • 2013-11-21
    • US13472465
    • 2012-05-15
    • Andre Paul Fraser
    • Andre Paul Fraser
    • B65D85/00
    • A01K97/08
    • A tool protects fishing equipment, such as fishing rods and reels, from damage, whether the equipment is in storage or transit. The tool provides the angler with the security that their equipment will be safe. The tool includes a hollow, tubular storage chamber having one open end for inserting an end of a fishing rod therein. The storage chamber may include a buoyant material at a closed end thereof. A flexible strap extends from the open end of the storage chamber to run along the length of the fishing rod. An adjustable loop at the end of the flexible strap is adapted to loop around the reel end of the rod and can be held in place by the reel. One or more straps can be disposed along the flexible strap to secure the flexible strap to the rod. One or more rods may be carried by the tool.
    • 一种工具可以保护钓鱼设备(如钓鱼竿和卷轴)免受损坏,无论设备是否存放或运输。 该工具为钓鱼者提供了他们的设备安全的安全。 工具包括一个中空的管状储存室,其具有用于将钓鱼竿的一端插入其中的一个开口端。 存储室可以在其封闭端包括浮力材料。 柔性带从储存室的开口端延伸,沿着钓鱼杆的长度延伸。 在柔性带的端部处的可调环路适于围绕杆的卷轴端环绕,并且可以通过卷轴保持就位。 可以沿着柔性带布置一个或多个带子,以将柔性带固定到杆上。 一个或多个杆可以由工具承载。
    • 8. 发明申请
    • System and Method for Generating, Funding, and Distributing Multiple Jackpots
    • 用于生成,资助和分配多个积分的系统和方法
    • US20120098201A1
    • 2012-04-26
    • US12911147
    • 2010-10-25
    • Ian MATTHEWSPaul FRASERDamon BARNARD
    • Ian MATTHEWSPaul FRASERDamon BARNARD
    • A63F1/00
    • G07F17/3258G07F17/32
    • A method and system of generating, funding, and distributing multiple jackpots in a game such as poker, specifically such as Texas Hold 'Em. The jackpots may be separate, independent bad beat jackpots that pay out at different intervals due to having independent triggering conditions that have different odds of occurring. Preferably, the triggering condition for each jackpot may be a losing player's hand strength. The specific values for the triggering conditions may be chosen by random, may be generally evenly distributed over the number of jackpots, may be determined by an algorithm, e.g., one that relies on the odds of each hand occurring, or by another method. The jackpots may be funded from rakes collected from substantially every hand that is played—subject to certain prerequisites being established—such that each jackpot may be considered progressive in that it grows over time.
    • 一种在诸如扑克之类的游戏中产生,资助和分发多个累积奖金的方法和系统,特别是像Texas Hold'Em。 由于具有不同发生机率的独立触发条件,累积奖金可能是分开的,独立的不良搏斗奖金,以不同的间隔支付。 优选地,每个累积奖金的触发条件可能是失败的玩家的手力。 触发条件的具体值可以通过随机选择,可以通常均匀地分布在累积头数上,可以通过算法来确定,例如依赖于每只手发生的几率的算法,或者通过另一种方法来确定。 累积奖金可能来自大部分每只手收集的耙子,这些耙子必须经过确定的某些先决条件,这样每个累积奖金可能被认为是随着时间的推移逐渐增加。
    • 10. 发明申请
    • Proteins related to schizophrenia and uses thereof
    • 与精神分裂症相关的蛋白质及其用途
    • US20080064638A1
    • 2008-03-13
    • US11893494
    • 2007-08-15
    • Peter St. George-HyslopPaul Fraser
    • Peter St. George-HyslopPaul Fraser
    • A61K38/00A61P43/00C12Q1/68G01N33/00G01N33/53
    • C12Q1/6883A01K2217/05A61K38/00C07K14/705C12Q2600/156G01N33/6893G01N33/6896G01N2500/00G01N2800/28G01N2800/30G01N2800/302
    • Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodevelopmental and neuropsychiatric disorders. In a specific embodiment, mutations in PAMP are diagnostic for schizophrenia. The invention further relates to screening, particularly using high-throughput screens and transgenic animal models, for compounds that modulate the activity of PAMP and presenilins. Such compounds, or gene therapy with PAMP, can be used in treating neurodevelopmental and neuropsychiatric disorders, particularly schizophrenia. In addition, the invention provides PAMP mutants, nucleic acids encoding for PAMP mutants, and transgenic animals expressing PAMP mutants, which in a preferred aspect result in biochemical, morphological, or neuropsychological changes similar to those associated with schizophrenia.
    • 提供了早老素联合膜蛋白(PAMP)和编码该蛋白的核酸。 PAMP和PAMP核酸提供诊断和治疗工具,用于评估和治疗或预防神经发育和神经精神障碍。 在具体实施方案中,PAMP中的突变是精神分裂症的诊断。 本发明进一步涉及对调节PAMP和早老素活性的化合物筛选,特别是使用高通量筛选和转基因动物模型。 这些化合物或用PAMP进行的基因治疗可用于治疗神经发育和神经精神障碍,特别是精神分裂症。 此外,本发明提供PAMP突变体,编码PAMP突变体的核酸和表达PAMP突变体的转基因动物,其在优选的方面导致类似于与精神分裂症相关的生化,形态或神经心理学变化。