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1. 发明授权

US09476063B2 Diblock copolymers and polynucleotide complexes thereof for delivery into cells 有权
标题翻译：二嵌段共聚物和其多核苷酸复合物用于递送到细胞中
公开(公告)号：US09476063B2
公开(公告)日：2016-10-25
申请号：US12992517
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Danielle Benoit , Craig L. Duvall , Paul H. Johnson , Anna S. Gall
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Danielle Benoit , Craig L. Duvall , Paul H. Johnson , Anna S. Gall
IPC分类号： C08F293/00 , C12N5/071 , C12N15/87 , C12N15/11
CPC分类号： C08F293/005 , A61K31/713 , A61K47/32 , A61K47/58 , C07K2319/10 , C08F293/00 , C12N15/111 , C12N15/113 , C12N15/87 , C12N2310/14 , C12N2310/315 , C12N2310/351 , C12N2320/32
摘要： Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.
摘要翻译：本文描述的是共聚物，以及制备和利用这些共聚物的方法。这样的共聚物具有至少两个嵌段：在生理pH下具有至少一个亲水性单元的第一嵌段和具有疏水基团的第二嵌段。该第二嵌段还具有至少一个具有在约生理pH下为阴离子基团的单元。所述共聚物破坏细胞膜，包括细胞外膜，细胞内膜，囊泡，细胞器，内体，脂质体或红细胞。优选地，在某些情况下，共聚物破坏膜并进入细胞内环境。在具体实例中，共聚物是内体分解的。

2. 发明授权

US09339558B2 Micellic assemblies 有权
标题翻译：胶束装配
公开(公告)号：US09339558B2
公开(公告)日：2016-05-17
申请号：US12992525
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
IPC分类号： A61K9/16 , A61K9/50 , C12N5/00 , C12N5/02 , C08F293/00 , C08F295/00 , C08F297/00 , A61K48/00 , A61K9/107 , C08F290/06 , C12N15/11 , C12N15/87
CPC分类号： A61K31/713 , A61K9/1075 , A61K47/549 , A61K47/58 , A61K47/60 , A61K47/6907 , A61K48/0041 , C08F290/062 , C08F293/005 , C12N15/111 , C12N15/87 , C12N2320/32 , Y02A50/463
摘要： Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
摘要翻译：本文提供了包含多种共聚物的胶束组合物。在某些情况下，本文提供的胶束组件是pH敏感颗粒。

3. 发明授权

US08822213B2 Bispecific intracellular delivery vehicles 有权
标题翻译：双特异性细胞内递送载体
公开(公告)号：US08822213B2
公开(公告)日：2014-09-02
申请号：US13127968
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Robert W. Overell , Paul H. Johnson
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Robert W. Overell , Paul H. Johnson
IPC分类号： C12N5/00 , C12N5/07 , A61K47/48 , C07K16/46 , C07K16/32 , C07K16/28 , C07K16/18
CPC分类号： A61K47/48715 , A61K47/48176 , A61K47/48246 , A61K47/48384 , A61K47/48507 , A61K47/48561 , A61K47/48569 , A61K47/48646 , A61K47/48676 , A61K47/58 , A61K47/64 , A61K47/6803 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6871 , A61K47/6879 , A61K47/6889 , C07K16/18 , C07K16/28 , C07K16/2881 , C07K16/32 , C07K16/40 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2319/10
摘要： A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
摘要翻译：用于将试剂递送至细胞的组合物，其包含双特异性亲和试剂和pH响应性膜去稳定化聚合物。双特异性亲和试剂可以包括与第二亲和试剂共价连接的第一亲和试剂，其中第一亲和试剂与细胞表面上的分子结合，第二亲和试剂结合细胞内靶。

4. 发明授权

US08426214B2 System and method for magnetically concentrating and detecting biomarkers 失效
标题翻译：用于磁集中和检测生物标志物的系统和方法
公开(公告)号：US08426214B2
公开(公告)日：2013-04-23
申请号：US12815217
申请日：2010-06-14
申请人： Patrick S. Stayton , Michael Nash , Jriuan Lai
发明人： Patrick S. Stayton , Michael Nash , Jriuan Lai
IPC分类号： C12M1/00 , G01N31/00 , G01N31/22 , G01N9/00
CPC分类号： G01N33/558 , Y10T436/14 , Y10T436/142222 , Y10T436/143333
摘要： System and method for capturing, concentrating, and detecting a diagnostic target in a liquid, comprising applying a magnetic field to a mixture comprising a co-aggregate in the liquid to provide a collected co-aggregate in the liquid, wherein the co-aggregate comprises a magnetic particle having a stimuli-responsive polymer attached thereto and a non-magnetic particle having a stimuli-responsive polymer and a diagnostic target attached thereto.
摘要翻译：用于捕获，浓缩和检测液体中的诊断靶的系统和方法，包括对包含所述液体中的共聚集料的混合物施加磁场以在所述液体中提供收集的共聚集料，其中所述共聚集体包含附着有刺激响应性聚合物的磁性颗粒和具有刺激响应性聚合物的非磁性颗粒和附着于其上的诊断目标。

5. 发明申请

US20130017167A1 HYDROPHOBIC BLOCK CONJUGATED THERAPEUTIC AGENTS 审中-公开
标题翻译：疏水性块联合治疗药剂
公开(公告)号：US20130017167A1
公开(公告)日：2013-01-17
申请号：US13509557
申请日：2010-11-12
申请人： Sean D. Monahan , Paul H. Johnson , Charbel Diab , Priyadarsi De , Patrick S. Stayton , Allan S. Hoffman
发明人： Sean D. Monahan , Paul H. Johnson , Charbel Diab , Priyadarsi De , Patrick S. Stayton , Allan S. Hoffman
IPC分类号： C08F220/34 , C12N5/07 , A61K31/795
CPC分类号： A61K47/6907 , A61K47/58
摘要： Provided herein are polymers having a therapeutic agent covalently coupled to a hydrophobic block thereof, as well as micelles and therapeutic compositions thereof.
摘要翻译：本文提供了具有与其疏水性嵌段共价偶联的治疗剂以及胶束和其治疗组合物的聚合物。

6. 发明申请

US20110281354A1 BISPECIFIC INTRACELLULAR DELIVERY VEHICLES 有权
标题翻译：双重细胞内输送车辆
公开(公告)号：US20110281354A1
公开(公告)日：2011-11-17
申请号：US13127968
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Robert W. Overell , Paul H. Johnson
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Robert W. Overell , Paul H. Johnson
IPC分类号： C12N5/071 , C08F126/06
CPC分类号： A61K47/48715 , A61K47/48176 , A61K47/48246 , A61K47/48384 , A61K47/48507 , A61K47/48561 , A61K47/48569 , A61K47/48646 , A61K47/48676 , A61K47/58 , A61K47/64 , A61K47/6803 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6871 , A61K47/6879 , A61K47/6889 , C07K16/18 , C07K16/28 , C07K16/2881 , C07K16/32 , C07K16/40 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2319/10
摘要： A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
摘要翻译：用于将试剂递送至细胞的组合物，其包含双特异性亲和试剂和pH响应性膜去稳定化聚合物。双特异性亲和试剂可以包括与第二亲和试剂共价连接的第一亲和试剂，其中第一亲和试剂与细胞表面上的分子结合，第二亲和试剂结合细胞内靶。

7. 发明授权

US06492492B1 Circularly permuted biotin binding proteins 失效
标题翻译：循环置换的生物素结合蛋白
公开(公告)号：US06492492B1
公开(公告)日：2002-12-10
申请号：US09285867
申请日：1999-04-02
申请人： Patrick S. Stayton
发明人： Patrick S. Stayton
IPC分类号： C07K1400
CPC分类号： C07K14/36 , C07K2299/00 , C07K2319/00 , C07K2319/22 , C12N15/62 , Y10S530/825
摘要： Circularly permuted proteins are described wherein the natural termini of the polypeptide are joined and the resulting circular protein is opened at another point to create new C- and N- termini. The resulting protein exhibits some altered characteristic such as reduced substrate binding, for example. Fusion proteins can be made from the circularly permuted protein by attaching the second polypeptide to these newly created termini. These fusion proteins will have altered properties from a fusion protein made by attaching the second polypeptide to the natural termini. For example, the second peptide or protein can be attached at a position where it is more accessible to its substrate or intended target. In the preferred embodiment, the base circularly permuted biotin binding protein. In one embodiment, a flexible polypeptide loop important for the binding of biotin was opened by creation of the circularly permuted protein. The original termini (residues 13 and 139 of SEQ ID NO:1) were joined by a linker. The biotin association constant was reduced approximately six orders of magnitude below that of wild type streptavidin to 107 M−1. Fusion proteins of the circularly permuted streptavidin can be made with secondary peptides/proteins such as IgG binding protein A or single-chain antibodies.
摘要翻译：描述了循环置换的蛋白质，其中多肽的天然末端连接并且得到的环状蛋白质在另一个位置打开以产生新的C-和N-末端。所得到的蛋白质例如显示出一些改变的特征，例如降低的底物结合。融合蛋白可以通过将第二多肽连接到这些新产生的末端从循环置换的蛋白质制备。这些融合蛋白将具有通过将第二多肽连接到天然末端而制备的融合蛋白质的改变的性质。例如，第二个肽或蛋白质可以连接到其底物或预期靶标更容易接近的位置。在优选的实施方案中，碱基环状置换的生物素结合蛋白。在一个实施方案中，通过产生循环置换的蛋白质来打开对生物素结合重要的柔性多肽环。原始末端（SEQ ID NO：1的残基13和139）通过接头连接。生物素缔合常数比野生型链霉抗生物素蛋白降低约六个数量级至107 M-1。可以用二级肽/蛋白质例如IgG结合蛋白A或单链抗体制备环状置换的链霉抗生物素蛋白的融合蛋白。

8. 发明授权

US09006193B2 Polymeric carrier 有权
标题翻译：聚合载体
公开(公告)号：US09006193B2
公开(公告)日：2015-04-14
申请号：US12992536
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E. E. Paschal , Charbel Diab , Priyadarsi De
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Craig L. Duvall , Danielle Benoit , Robert W. Overell , Paul H. Johnson , Anna S. Gall , Mary G. Prieve , Amber E. E. Paschal , Charbel Diab , Priyadarsi De
IPC分类号： A61K47/48 , A01N43/04 , A61K48/00 , A61K47/30 , C12Q1/68 , C12N15/00 , C08F120/18 , C12N15/87 , A61K9/107 , C08F293/00
CPC分类号： A61K47/488 , A61K9/1075 , A61K47/549 , A61K47/58 , A61K47/60 , A61K47/6907 , C08F293/005 , C12N15/113 , C12N15/87 , C12N2310/11 , C12N2310/14
摘要： Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.
摘要翻译：本文提供适合于将多核苷酸（例如寡核苷酸）和/或其它治疗剂递送至活细胞的聚合物载体。

9. 发明申请

US20110143434A1 DIBLOCK COPOLYMERS AND POLYNUCLEOTIDE COMPLEXES THEREOF FOR DELIVERY INTO CELLS 有权
标题翻译：二嵌段共聚物和多核苷酸复合物，用于递送至细胞
公开(公告)号：US20110143434A1
公开(公告)日：2011-06-16
申请号：US12992517
申请日：2009-05-13
申请人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Danielle Benoit , Craig L. Duvall , Paul H. Johnson , Anna S. Gall
发明人： Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Danielle Benoit , Craig L. Duvall , Paul H. Johnson , Anna S. Gall
IPC分类号： C12N5/071 , C08F293/00
CPC分类号： C08F293/005 , A61K31/713 , A61K47/32 , A61K47/58 , C07K2319/10 , C08F293/00 , C12N15/111 , C12N15/113 , C12N15/87 , C12N2310/14 , C12N2310/315 , C12N2310/351 , C12N2320/32
摘要： Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.
摘要翻译：本文描述的是共聚物，以及制备和利用这些共聚物的方法。这样的共聚物具有至少两个嵌段：在生理pH下具有至少一个亲水性单元的第一嵌段和具有疏水基团的第二嵌段。该第二嵌段还具有至少一个具有在约生理pH下为阴离子基团的单元。所述共聚物破坏细胞膜，包括细胞外膜，细胞内膜，囊泡，细胞器，内体，脂质体或红细胞。优选地，在某些情况下，共聚物破坏膜并进入细胞内环境。在具体实例中，共聚物是内体分解的。

10. 发明申请

US20110142951A1 MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于细胞内递送治疗药物的细胞
公开(公告)号：US20110142951A1
公开(公告)日：2011-06-16
申请号：US12992541
申请日：2009-05-13
申请人： Paul H. Johnson , Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Robert W. Overell , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
发明人： Paul H. Johnson , Patrick S. Stayton , Allan S. Hoffman , Anthony J. Convertine , Robert W. Overell , Anna S. Gall , Mary G. Prieve , Amber E.E. Paschal , Charbel Diab , Priyadarsi De
IPC分类号： A61K9/14 , A61K31/7088 , C12N5/02
CPC分类号： A61K9/1075 , A61K9/0019 , A61K31/7105 , A61K47/551 , A61K47/58 , A61K47/60 , A61K47/6907 , A61K48/0041 , C08F293/005 , C08F2438/03 , C12N15/111 , C12N2320/32
摘要： Composition comprising a polymeric micelle and an associated polynucleotide.
摘要翻译：包含聚合胶束和相关多核苷酸的组合物。

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