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1. 发明授权

US4329343A Pyrrole amides and therapeutic use thereof 失效
标题翻译：吡咯酰胺及其治疗用途
公开(公告)号：US4329343A
公开(公告)日：1982-05-11
申请号：US228053
申请日：1981-01-26
申请人： Claude Bernhart , Jean P. Gagnol , Patrick Gautier
发明人： Claude Bernhart , Jean P. Gagnol , Patrick Gautier
IPC分类号： C07D207/32 , C07D207/327 , C07D487/04 , A61K31/535 , A61K31/40 , C07D413/06
CPC分类号： C07D207/327 , C07D487/04 , Y10S514/821 , Y10S514/822
摘要： The present invention relates to new derivatives of pyrrole of formula: ##STR1## in which: R.sub.1 represents an atom of hydrogen, a lower alkyl group, a phenyl radical or a pyridyl-2 radical,R.sub.2 represents an atom of hydrogen or a lower alkyl radicalR.sub.3 and R.sub.4 represent a lower alkyl or cycloalkyl radical or the radical ##STR2## is a heterocyclic amine radical, and n is equal to 2 or 3;The invention concerns drugs having an antiarrhythmic activity and an activity as blood platelet anti-aggregant, containing said derivatives.
摘要翻译：本发明涉及式（I）的吡咯的新衍生物，其中：R1表示氢原子，低级烷基，苯基或吡啶基-2基团，R2表示氢原子或低级烷基R3和R4代表低级烷基或环烷基，或者基团“IMAGE”是杂环胺基，n等于2或3; 本发明涉及含有所述衍生物的具有抗心律不齐活性和作为血小板抗聚集剂的活性的药物。

2. 发明授权

US08505582B2 Hydraulic valve 失效
标题翻译：液压阀
公开(公告)号：US08505582B2
公开(公告)日：2013-08-13
申请号：US13066990
申请日：2011-04-28
申请人： Patrick Gautier , Marc Hohmann , Wolf-Dietmar Schulze , Andre Selke , Markus Todt
发明人： Patrick Gautier , Marc Hohmann , Wolf-Dietmar Schulze , Andre Selke , Markus Todt
IPC分类号： F16K11/07
CPC分类号： F01L1/3442 , F01L2001/34426 , F01L2001/34433 , Y10T137/86702
摘要： A hydraulic valve for oscillating-motor camshaft adjuster is provided. The valve has a bush and a hollow piston with a piston bottom. The piston is axially movable within the bush by means of an actuator against the force of a screw-type pressure spring. The actuator is applied to the piston bottom. A sleeve secured in the bush is disposed inside the hollow piston and can be displaced relative to the piston. The wall of this sleeve has at least one through-opening, which leads to at least one opening of the hollow piston, which opening can guide a supply pressure (P) applied inside the sleeve alternatively to two sets of pressure chambers of the oscillating-motor camshaft adjuster. The sleeve has a sleeve bottom that seals off the inside space of hollow piston.
摘要翻译：提供了一种用于摆动马达凸轮轴调节器的液压阀。阀具有衬套和具有活塞底部的中空活塞。活塞可以通过抵抗螺杆式压力弹簧的力的致动器在衬套内轴向移动。致动器被施加到活塞底部。固定在衬套中的套筒设置在中空活塞的内部并且可相对于活塞移位。该套筒的壁具有至少一个通孔，其通向中空活塞的至少一个开口，该开口可将套筒内施加的供应压力（P）引导至两组振荡 - 电机凸轮轴调节器。套筒具有密封中空活塞的内部空间的套筒底部。

3. 发明申请

US20110266479A1 Hydraulic valve 失效
标题翻译：液压阀
公开(公告)号：US20110266479A1
公开(公告)日：2011-11-03
申请号：US13066990
申请日：2011-04-28
申请人： Patrick Gautier , Marc Hohmann , Wolf-Dietmar Schulze , Andre Selke , Markus Todt
发明人： Patrick Gautier , Marc Hohmann , Wolf-Dietmar Schulze , Andre Selke , Markus Todt
IPC分类号： F16K21/00
CPC分类号： F01L1/3442 , F01L2001/34426 , F01L2001/34433 , Y10T137/86702
摘要： The invention relates to a hydraulic valve for oscillating-motor camshaft adjuster The valve has a bush and a hollow piston with a piston bottom. The piston is axially movable within the bush by means of an actuator against the force of a screw-type pressure spring. The actuator is applied to the piston bottom. A sleeve secured in the bush is disposed inside the hollow piston and can be displaced relative to the piston. The wall of this sleeve has at least one through-opening, which leads to at least one opening of the hollow piston, which opening can guide a supply pressure (P) applied inside the sleeve alternatively to two sets of pressure chambers of the oscillating-motor camshaft adjuster. The sleeve has a sleeve bottom that seals off the inside space of hollow piston.
摘要翻译：本发明涉及一种用于振动电动机凸轮轴调节器的液压阀。该阀具有衬套和具有活塞底部的中空活塞。活塞可以通过抵抗螺杆式压力弹簧的力的致动器在衬套内轴向移动。致动器被施加到活塞底部。固定在衬套中的套筒设置在中空活塞的内部并且可相对于活塞移位。该套筒的壁具有至少一个通孔，其通向中空活塞的至少一个开口，该开口可将套筒内施加的供应压力（P）引导至两组振荡 - 电机凸轮轴调节器。套筒具有密封中空活塞的内部空间的套筒底部。

4. 发明授权

US07799799B2 Indolizine derivatives, method for preparing same, and therapeutic compositions comprising same 有权
标题翻译：中氮茚衍生物，其制备方法和包含其的治疗组合物
公开(公告)号：US07799799B2
公开(公告)日：2010-09-21
申请号：US12116996
申请日：2008-05-08
申请人： Patrick Gautier , David Marchionni , Alain Roccon , Bernard Tonnerre , Jean Wagnon
发明人： Patrick Gautier , David Marchionni , Alain Roccon , Bernard Tonnerre , Jean Wagnon
IPC分类号： A61K31/437
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds of formula (I): described as novel indolizine derivatives and to a method for their preparation along with pharmaceutical compositions thereof whose substituents are as described in the specification.
摘要翻译：本发明涉及式（I）化合物：描述为新的中氮茚衍生物及其制备方法及其取代基如说明书中所述的药物组合物。

5. 发明授权

US5185345A 4-amidino pyrano (3,2-c) pyridine derivatives, and pharmaceutical compositions containing them 失效
标题翻译： 4-脒基吡喃并（3,2-c）吡啶衍生物，以及含有它们的药物组合物
公开(公告)号：US5185345A
公开(公告)日：1993-02-09
申请号：US850994
申请日：1992-03-12
申请人： Georges Garcia , Patrick Gautier , Dino Nisato , Richard Roux
发明人： Georges Garcia , Patrick Gautier , Dino Nisato , Richard Roux
IPC分类号： C07D405/04 , C07D491/04 , C07D491/052
CPC分类号： C07D405/04 , C07D491/04
摘要： The present invention deals with 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them. Said derivatives have antihypertensive and antiarythmic activities. They respond to formula ##STR1## in which: A+B.dbd.--CH.dbd.CH--CH.dbd.N-- ou --CH.dbd.CR.sub.4 --CR.sub.5 .dbd.CH--; X.dbd.N,N.fwdarw.O, C--Z;R.sub.1 .dbd.H, CN, NO.sub.2, C.sub.1 -C.sub.4, alkyl, OH, C.sub.1 -C.sub.4 alkoxy, CF.sub.3 CO--, CH.sub.3 --SO.sub.2 --, .rho.--SO.sub.2 --;R.sub.2 .dbd.H;R.sub.3 .dbd.OH ou OCOCH.sub.3 ou R.sub.2 +R.sub.3 .dbd.double bond.
摘要翻译：本发明涉及4-脒基色满和4-脒基吡喃（3,2-c）吡啶衍生物，其制备方法和含有它们的药物组合物。所述衍生物具有抗高血压和抗血栓活性。它们响应式（I）其中：A + B = -CH = CH-CH = N-O -CH = CR4-CR5 = CH-; X = N，N-> O，C-Z; R1 = H，CN，NO2，C1-C4，烷基，OH，C1-C4烷氧基，CF3CO-，CH3-SO2-， R2 = H; R3 = OH o OCOCH3 ou R2 + R3 =双键。

6. 发明申请

US20080287485A1 NOVEL INDOLIZINE DERIVATIVES, METHOD FOR PREPARING SAME, AND THERAPEUTIC COMPOSITIONS COMPRISING SAME 有权
标题翻译：新型吲哚啉衍生物，其制备方法和包含其的治疗组合物
公开(公告)号：US20080287485A1
公开(公告)日：2008-11-20
申请号：US12116996
申请日：2008-05-08
申请人： Patrick GAUTIER , David Marchionni , Alain Roccon , Bernard Tonnerre , Jean Wagnon
发明人： Patrick GAUTIER , David Marchionni , Alain Roccon , Bernard Tonnerre , Jean Wagnon
IPC分类号： A61K31/437 , C07D471/04 , A61P9/00
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds of formula (I): described as novel indolizine derivatives and to a method for their preparation along with pharmaceutical compositions thereof whose substituents are as described in the specification.
摘要翻译：本发明涉及式（I）化合物：描述为新的中氮茚衍生物及其制备方法及其取代基如说明书中所述的药物组合物。

7. 发明授权

US06946483B2 Aminoalkenylbenzoyl-benzofuran or benzothiophene, method for preparing same and compositions containing same 有权
标题翻译：氨基烯基苯甲酰基 - 苯并呋喃或苯并噻吩，其制备方法和含有它们的组合物
公开(公告)号：US06946483B2
公开(公告)日：2005-09-20
申请号：US10362291
申请日：2001-08-23
申请人： Jean-Louis Assens , Claude Bernhart , Frédérique Cabanel-Haudricourt , Victor Dos Santos , Patrick Gautier , Dino Nisato
发明人： Jean-Louis Assens , Claude Bernhart , Frédérique Cabanel-Haudricourt , Victor Dos Santos , Patrick Gautier , Dino Nisato
IPC分类号： C07D333/56 , A61K31/343 , A61K31/381 , A61K31/41 , A61K31/443 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P35/00 , C07D307/80 , C07D401/10 , C07D405/04 , C07D409/06
CPC分类号： C07D409/06 , C07D307/80
摘要： The invention relates to novel (aminoalkenyl-benzoyl) benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicaments, in particular in the treatment of pathological syndromes of the cardiovascular system.
摘要翻译：本发明涉及以下通式的新的（氨基烯基 - 苯甲酰基）苯并呋喃或苯并噻吩衍生物：这些化合物可用作药物，特别是用于治疗心血管系统的病理综合征。

8. 发明授权

US5391751A 2,2-dimethylchromene derivatives, process for their preparation and pharmaceutical compositions in which they are present 失效
标题翻译： 2,2-二甲基色烯衍生物，其制备方法及其存在的药物组合物
公开(公告)号：US5391751A
公开(公告)日：1995-02-21
申请号：US746974
申请日：1991-08-19
申请人： Georges Garcia , Alain Di Malta , Patrick Gautier
发明人： Georges Garcia , Alain Di Malta , Patrick Gautier
IPC分类号： A61K31/435 , A61K31/44 , A61K31/66 , A61K31/675 , A61P9/06 , A61P9/12 , C07D405/04 , C07F9/6558
CPC分类号： C07D405/04 , A61K31/44 , A61K31/675 , C07F9/65586
摘要： The present invention relates to 2,2-dimethylchromene derivatives of the formula: ##STR1## in which Z represents a halogen atom or a cyano, nitro, acetyl, phosphono or dialkoxyphosohoryl group, the alkoxy group containing 1 to 3 carbon atoms, and the pharmaceutically acceptable salts of the phosphono group.These compounds show an antihypertensive and antiarrythmic activity.The present invention also relates to a process for the preparation of said compounds and to the pharmaceutical compositions in which the are present.
摘要翻译：本发明涉及下式的2,2-二甲基色烯衍生物：其中Z表示卤素原子或氰基，硝基，乙酰基，膦酰基或二烷氧基苯硫基，含有1至3个碳原子的烷氧基和膦酰基的药学上可接受的盐。这些化合物显示抗高血压和抗焦虑的活性。本发明还涉及制备所述化合物的方法和其中存在的药物组合物。

9. 发明授权

US5225415A 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them 失效
标题翻译： 4-脒基色满和4-脒基吡喃（3,2-c）吡啶衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5225415A
公开(公告)日：1993-07-06
申请号：US850993
申请日：1992-03-12
申请人： Georges Garcia , Patrick Gautier , Dino Nisato , Richard Roux
发明人： Georges Garcia , Patrick Gautier , Dino Nisato , Richard Roux
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/443 , A61K31/505 , A61P9/06 , A61P9/12 , C07D213/74 , C07D405/04 , C07D491/04 , C07D491/052 , C07D493/04
CPC分类号： C07D405/04 , C07D491/04
摘要： The present invention deals with 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them. Said derivatives have antihypertensive and antiarythmic activities. They respond to formula ##STR1## in which: A+B=--CH.dbd.CH--CH.dbd.N-- ou --CH.dbd.CR.sub.4 --CR.sub.5 .dbd.CH--;X=N, N.fwdarw.O, C-Z;R.sub.1 =H, CN, NO.sub.2, C.sub.1 -C.sub.4 alkyl, OH, C.sub.1 -C.sub.4 alcoxy, CF.sub.3 CO--, CH.sub.3 --SO.sub.2 --,.rho.--SO.sub.2 --;R.sub.2 =H;R.sub.3 =OH ou OCOCH.sub.3ou R.sub.2 +R.sub.3 =double bond.
摘要翻译：本发明涉及4-脒基色满和4-脒基吡喃（3,2-c）吡啶衍生物，其制备方法和含有它们的药物组合物。所述衍生物具有抗高血压和抗血栓活性。它们响应式（I）其中：A + B = -CH = CH-CH = N-O -CH = CR4-CR5 = CH-; X = N，N-> O，C-Z; R1 = H，CN，NO2，C1-C4烷基，OH，C1-C4烷氧基，CF3CO-，CH3-SO2-， R2 = H; R3 = OH o OCOCH3 ou R2 + R3 =双键。

10. 发明授权

US4542134A Derivatives of .gamma.-butyrolactone with an anti-arrythmic activity and compositions 失效
标题翻译：具有抗arrythmic活性和组成的γ-丁内酯的衍生物
公开(公告)号：US4542134A
公开(公告)日：1985-09-17
申请号：US543898
申请日：1983-10-20
申请人： Claude Bernhart , Werner Cautreels , Patrick Gautier
发明人： Claude Bernhart , Werner Cautreels , Patrick Gautier
IPC分类号： A61K31/341 , A61K31/443 , A61P9/06 , C07D213/57 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/14 , A61K31/44 , A61K31/535
CPC分类号： C07D405/04 , C07D213/57 , C07D405/12 , C07D413/14
摘要： The present invention relates to the products of general formula: ##STR1## in which: R represents a straight or branched alkyl group having from 2 to 5 atoms of carbon, or the group ##STR2## represents a morpholino or piperidino group possibly substituted by 1 or 2 methyl groups;n=2 or 3;R.sub.1 and R.sub.2 considered independently each represent hydrogen or a lower alkyl group (1 to 4 carbon atoms) or R.sub.1 and R.sub.2 taken together represent a (CH.sub.2).sub.m group where m=4 or 5, R.sub.3 being equal to H or R.sub.1 is H and R.sub.2 and R.sub.3 considered together represent (CH.sub.2).sub.p where p is 3 or 4the butyrolactone cycle substitutes the pyridyl group in 2', 3' or 4' position,the salts, isomers and mixtures of isomers of said products; and to a process for preparing said products and to the myocardium-protecting drugs containing same.
摘要翻译：本发明涉及以下通式的产物：其中：R表示具有2至5个碳原子的直链或支链烷基，或者“IMAGE”组可表示吗啉代或哌啶子基被1或2个甲基取代; n = 2或3; 独立地考虑的R 1和R 2各自表示氢或低级烷基（1至4个碳原子），或者R 1和R 2一起表示（CH 2）m基团，其中m = 4或5，R 3等于H或R 1为H， R2和R3一起代表（CH2）p，其中p是3或4，丁内酯循环代替2'，3'或4'位的吡啶基，所述产物的盐，异构体和异构体的混合物; 以及制备所述产品的方法和含有其的心肌保护药物的方法。

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