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1. 发明授权

US08889711B2 Pyrazolopyridine derivatives as anticancer agent 有权
标题翻译：吡唑并吡啶衍生物作为抗癌剂
公开(公告)号：US08889711B2
公开(公告)日：2014-11-18
申请号：US13500757
申请日：2010-10-13
申请人： Karim Bedjeguelal , Rémi Rabot , El Bachir Kaloun , Patrice Mayer , Arnaud Marchand , Nicolas Rahier , Philippe Schambel , Hugues Bienayme
发明人： Karim Bedjeguelal , Rémi Rabot , El Bachir Kaloun , Patrice Mayer , Arnaud Marchand , Nicolas Rahier , Philippe Schambel , Hugues Bienayme
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , A61K31/44
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention concerns compounds of following general formula (I): (Formula I) and their pharmaceutically acceptable salts, their method of preparation and their uses, notably as anticancer agent.
摘要翻译：本发明涉及以下通式（I）：（式I）及其药学上可接受的盐，其制备方法及其用途，特别是抗癌剂的化合物。

2. 发明申请

US20120245170A1 PYRAZOLOPYRIDINE DERIVATIVES AS ANTICANCER AGENT 有权
标题翻译：吡唑并吡啶衍生物作为抗原剂
公开(公告)号：US20120245170A1
公开(公告)日：2012-09-27
申请号：US13500757
申请日：2010-10-13
申请人： Karim Bedjeguelal , Rémi Rabot , El Bachir Kaloun , Patrice Mayer , Arnaud Marchand , Nicolas Rahier , Philippe Schambel , Hugues Bienayme
发明人： Karim Bedjeguelal , Rémi Rabot , El Bachir Kaloun , Patrice Mayer , Arnaud Marchand , Nicolas Rahier , Philippe Schambel , Hugues Bienayme
IPC分类号： A61K31/437 , A61K31/5377 , A61P35/00 , A61K31/444 , A61K31/4545 , C07D487/04 , C07D471/04 , A61K31/496
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention concerns compounds of following general formula (I): (Formula I) and their pharmaceutically acceptable salts, their method of preparation and their uses, notably as anticancer agent.
摘要翻译：本发明涉及以下通式（I）：（式I）及其药学上可接受的盐，其制备方法及其用途，特别是抗癌剂的化合物。

3. 发明授权

US06610725B1 Fluorinated imidazoline benzodioxane, preparation and therapeutic uses thereof 有权
标题翻译：氟化咪唑啉苯并二氧杂环己烷，其制备和治疗用途
公开(公告)号：US06610725B1
公开(公告)日：2003-08-26
申请号：US10019614
申请日：2002-05-07
申请人： Thierry Imbert , Patrice Mayer , Marc Marien , Peters Pauwels
发明人： Thierry Imbert , Patrice Mayer , Marc Marien , Peters Pauwels
IPC分类号： C07D40504
CPC分类号： C07D405/04
摘要： The present invention relates to novel fluorinated benzodioxane imidazoline derivatives, to their preparation and to their therapeutic applications. The invention is directed more particularly toward the compounds corresponding to the structure of general formula 1: in which: R represents a linear, branched or cyclized alkyl or alkenyl group containing 1 to 7 carbon atoms, or a benzyl group, and the fluorine atom can occupy position 5, 6, 7 or 8, in their racemic form and their dextrorotatory and levorotatory pure enantiomeric forms, and also the addition salts thereof.
摘要翻译：本发明涉及新的氟化苯并二恶烷咪唑啉衍生物及其制备方法及其治疗应用。本发明更具体地涉及对应于通式1结构的化合物：其中：R表示直链，支链或环烷基或含有1至7个碳原子的烯基或苄基，并且氟原子可以占据其外消旋形式的第5,6,7或8位，以及它们的右旋和左旋纯对映体形式，以及它们的加成盐。

4. 发明授权

US5880296A Method for preparing an optically pure benzofuran carboxylic acid and use thereof for preparing efaroxan 失效
标题翻译：光学纯苯并呋喃羧酸的制备方法及其用于制备埃法鲁辛的方法
公开(公告)号：US5880296A
公开(公告)日：1999-03-09
申请号：US952133
申请日：1997-11-10
申请人： Thierry Imbert , Patrice Mayer
发明人： Thierry Imbert , Patrice Mayer
IPC分类号： C07D307/85 , C07D405/04
CPC分类号： C07D405/04 , C07D307/85
摘要： A method for preparing an optically pure 2-ethyl-2,3-dihydrobenzofurancarboxylic acid of formula II wherein R is a hydrogen atom, halogen, lower alkyl, lower alkoxy or hydroxy is described. ##STR1## The method comprises separating the racemic mixture by selective crystallization with the suitable optically pure enantiomer of 2-phenylglycinol, in a suitable solvent, whereafter the optically pure, crystallized acid of formula II is isolated and recovered. The invention also provides the optically pure 2-ethyl-2,3-dihydro-benzofurancarboxylic acid derivative thus obtained and the use thereof for the preparation of an optically pure derivative of efaroxan.
摘要翻译： PCT No.PCT / FR96 / 00697 Sec。 371日期：1997年11月10日 102（e）1997年11月10日日期PCT提交1996年5月9日PCT公布。公开号WO96 / 35682 日期：1996年11月14日描述了制备其中R为氢原子，卤素，低级烷基，低级烷氧基或羟基的光学纯的式II的2-乙基-2,3-二氢苯并呋喃羧酸的方法。该方法包括通过在合适的溶剂中用合适的光学纯对映异构体2-苯基甘氨醇分离外消旋混合物，然后分离并回收式Ⅱ的光学纯的结晶酸。本发明还提供由此获得的光学纯的2-乙基-2,3-二氢 - 苯并呋喃羧酸衍生物及其用于制备依法鲁昔的光学纯的衍生物。

5. 发明申请

US20140031362A1 TRI - AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT 有权
标题翻译：三异丁基吡唑并[3,4-B]吡啶化合物作为抗肿瘤药
公开(公告)号：US20140031362A1
公开(公告)日：2014-01-30
申请号：US14111098
申请日：2012-04-12
申请人： Rémi Rabot , Karim Bedjeguelal , El Bachir Kaloun , Philippe Schmitt , Nicolas Rahier , Patrice Mayer , Emmanuel Fournier
发明人： Rémi Rabot , Karim Bedjeguelal , El Bachir Kaloun , Philippe Schmitt , Nicolas Rahier , Patrice Mayer , Emmanuel Fournier
IPC分类号： C07D471/04 , A61K31/4745 , A61K31/4375 , A61K31/496 , C07D491/147 , A61K31/437 , C07D471/14 , A61K45/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/4745 , A61K31/496 , A61K45/06 , C07D471/14 , C07D491/147 , C07D493/14
摘要： The present invention relates to compounds of following general formula (I): and to the pharmaceutically acceptable salts of same, the tautomers of same, the stereoisomers or mixture of stereoisomers in any proportions of same, such as a mixture of enantiomers, notably a racemic mixture, as well as to methods for preparing same and uses of same, notably as an antineoplastic agent.
摘要翻译：本发明涉及以下通式（I）的化合物：及其药学上可接受的盐，其互变异构体，立体异构体或立体异构体的混合物在任何比例相同的情况下，例如对映异构体的混合物，特别是外消旋混合物，以及其制备方法和其用途，特别是作为抗肿瘤剂。

6. 发明授权

US09085575B2 Tri- and tetracyclic pyrazolo[3,4-B]pyridine compounds as antineoplastic agent 有权
标题翻译：三环和四环吡唑并[3,4-B]吡啶化合物作为抗肿瘤剂
公开(公告)号：US09085575B2
公开(公告)日：2015-07-21
申请号：US14111098
申请日：2012-04-12
申请人： Rémi Rabot , Karim Bedjeguelal , El Bachir Kaloun , Philippe Schmitt , Nicolas Rahier , Patrice Mayer , Emmanuel Fournier
发明人： Rémi Rabot , Karim Bedjeguelal , El Bachir Kaloun , Philippe Schmitt , Nicolas Rahier , Patrice Mayer , Emmanuel Fournier
IPC分类号： C07D471/00 , C07D471/04 , C07D471/14 , C07D493/14 , A61K31/437 , A61K31/4375 , A61K31/4745 , A61K31/496 , A61K45/06 , C07D491/147
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/4745 , A61K31/496 , A61K45/06 , C07D471/14 , C07D491/147 , C07D493/14
摘要： The present invention relates to compounds of following general formula (I): and to the pharmaceutically acceptable salts of same, the tautomers of same, the stereoisomers or mixture of stereoisomers in any proportions of same, such as a mixture of enantiomers, notably a racemic mixture, as well as to methods for preparing same and uses of same, notably as an antineoplastic agent.
摘要翻译：本发明涉及以下通式（I）的化合物：及其药学上可接受的盐，其互变异构体，立体异构体或立体异构体的混合物在任何比例相同的情况下，例如对映异构体的混合物，特别是外消旋混合物，以及其制备方法和其用途，特别是作为抗肿瘤剂。

7. 发明授权

US06967948B2 Out-of-band signalling apparatus and method for an optical cross connect 有权
标题翻译：用于光交叉连接的带外信令装置和方法
公开(公告)号：US06967948B2
公开(公告)日：2005-11-22
申请号：US10284652
申请日：2002-10-31
申请人： Giovanni Iacovino , Patrice Mayer , Yannick Dansereau-Daoust
发明人： Giovanni Iacovino , Patrice Mayer , Yannick Dansereau-Daoust
IPC分类号： H04J3/08 , H04Q11/00
CPC分类号： H04J3/085 , H04Q2011/0039 , H04Q2011/0052 , H04Q2011/0088
摘要： A signaling architecture for a cross connect switch utilizes out-of-band communications channels to transmit status information from line modules to the switch module. The out-of-band communication channels are separate from the in-band payload data connections routinely used to connect line modules to the switch module. A framer is used to extract payload data for transmission on the in-band payload data connections. The framer also extracts status information that may be encoded before sending to the switch module via the out-of-band communications channels. The switch module logically pairs STS-1s into working/protect pairs and utilizes the STS-1 granular status information to decide which of the pair is a better copy which is output as the working copy after the cross-connect switch fabric is configured according to user demands. A redundant switch module may also be used for equipment protection.
摘要翻译：用于交叉连接交换机的信令架构利用带外通信信道将状态信息从线路模块传送到交换机模块。带外通信信道与常规用于将线路模块连接到交换机模块的带内有效载荷数据连接是分开的。成帧器用于提取有效载荷数据以在带内有效载荷数据连接中传输。成帧器还提取在通过带外通信信道发送到交换机模块之前可能被编码的状态信息。交换机模块将STS-1逻辑对应到工作/保护对，并利用STS-1粒度状态信息来确定在交叉连接交换结构根据以下情况配置交换连接交换结构后，哪一对是作为工作副本输出的更好的副本用户需求冗余开关模块也可用于设备保护。

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