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1. 发明授权

US09510088B2 Intrauterine device 有权
标题翻译：宫内节育器
公开(公告)号：US09510088B2
公开(公告)日：2016-11-29
申请号：US13949621
申请日：2013-07-24
申请人： Michael G. Tal , Patrick N. Gutelius , Mark J. DeBisschop , Oleg Shikman , Pasquale Patrizio
发明人： Michael G. Tal , Patrick N. Gutelius , Mark J. DeBisschop , Oleg Shikman , Pasquale Patrizio
IPC分类号： H04R1/32 , H04R5/02 , A61F6/14 , B60R11/02 , H04R1/02 , H04R1/24
CPC分类号： H04R1/323 , A61F6/142 , A61F6/18 , A61F6/20 , B60R11/0217 , H04R1/026 , H04R1/24 , H04R5/02 , H04R2499/13
摘要： An intrauterine device for applying pressure to the walls of the uterine cavity includes a resilient body having an elongated member which includes a first end and a second end which are resiliently biased away from each other. The first end of the elongated member includes a first leg having a first end and a second end. The second end of the elongated member includes a second leg having a first end and a second end. A connection member is positioned between the first end of the first leg and the first end of the second leg. A first plug member is secured at the second end of the first leg and a second plug member is secured at the first end of the second leg. The first and second plug members are shaped and dimensioned for bearing against the walls of the uterine cavity as the elongated member spreads outwardly with the first end and the second end moving apart. A method for preventing conception within the uterine cavity is also disclosed.
摘要翻译：用于向子宫腔的壁施加压力的子宫内装置包括具有细长构件的弹性体，该细长构件包括彼此弹性偏压的第一端和第二端。细长构件的第一端包括具有第一端和第二端的第一腿。细长构件的第二端包括具有第一端和第二端的第二腿。连接构件位于第一腿的第一端和第二腿的第一端之间。第一插头构件固定在第一腿的第二端，并且第二插头构件固定在第二腿的第一端。当第一端部和第二端部移开时，第一和第二插塞构件的形状和尺寸被设计成用于承载在子宫腔的壁上，因为细长构件向外扩展。还公开了一种防止子宫腔内受孕的方法。

2. 发明授权

US09180039B2 Intrauterine device 有权
标题翻译：宫内节育器
公开(公告)号：US09180039B2
公开(公告)日：2015-11-10
申请号：US13294091
申请日：2011-11-10
申请人： Michael G. Tal , Patrick N. Gutelius , Mark J. DeBisschop , Oleg Shikhman , Pasquale Patrizio , Bob H. Katz
发明人： Michael G. Tal , Patrick N. Gutelius , Mark J. DeBisschop , Oleg Shikhman , Pasquale Patrizio , Bob H. Katz
IPC分类号： A61F6/14 , A61F6/18 , A61F6/20
CPC分类号： A61F6/144 , A61F6/142 , A61F6/18 , A61F6/20
摘要： An intrauterine device for applying force to a wall of a uterus to promote contraception without blocking the fallopian tubes may include an elongate member formed of a resilient material and having a default expanded configuration and a spring portion disposed approximately at a midpoint between two ends of the elongate member. The IUD may also include two tissue contact members, one tissue contact member disposed at one of the two ends of the elongate member and the other tissue contact member disposed at the other end. The tissue contact members may generate a laterally directed force against the wall of the uterus when the intrauterine device assumes its default expanded configuration.
摘要翻译：用于将力施加到子宫壁以促进避孕而不阻塞输卵管的子宫内装置可以包括由弹性材料形成并具有默认膨胀构型的细长构件和大致位于第二端的两端之间的中点处的弹簧部分细长构件。 IUD还可以包括两个组织接触构件，一个组织接触构件设置在细长构件的两个端部之一，另一个组织接触构件设置在另一端。当子宫内装置采取其默认扩展配置时，组织接触构件可以产生横向定向的力抵靠子宫壁。

3. 发明申请

US20100120624A1 ASSESSMENT OF OOCYTE COMPETENCE 失效
标题翻译：评估海洋生物能力
公开(公告)号：US20100120624A1
公开(公告)日：2010-05-13
申请号：US12312275
申请日：2007-11-02
申请人： Dagan Wells , Pasquale Patrizio
发明人： Dagan Wells , Pasquale Patrizio
IPC分类号： C40B30/00 , C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/158
摘要： Methods are provided for evaluating an oocyte for fertilization and implantation. For example, methods are provided for determining whether an oocyte expresses, or does not express, one or more of a group of markers identified as differently expressed between chromosomally normal and chromosomally abnormal oocytes. Also provided, for example, are methods for determining whether a cumulus cell expresses, or does not express, one or more of a group of markers identified as differently expressed between cumulus cells associated with chromosomally normal oocytes and cumulus cells associated with chromosomally abnormal oocytes. Methods are provided for the detection of marker expression of differentially expressed genes at the RNA level, as well as at the protein level.
摘要翻译：提供了用于评估受精和植入的卵母细胞的方法。例如，提供了用于确定卵母细胞是否表达或不表达鉴定为在染色体正常和染色体异常卵母细胞之间不同表达的一组标记物的方法。还提供了例如用于确定卵丘细胞是否表达或不表达鉴定为与染色体正常卵母细胞相关的卵丘细胞和与染色体异常卵母细胞相关的卵丘细胞之间不同表达的一组标记物的方法。提供了用于在RNA水平以及蛋白质水平检测差异表达基因的标记物表达的方法。

4. 发明申请

US20120097172A1 INTRAUTERINE DEVICE 有权
标题翻译： INTRAUTERINE设备
公开(公告)号：US20120097172A1
公开(公告)日：2012-04-26
申请号：US13294091
申请日：2011-11-10
申请人： Michael G. Tal , Patrick N. Gutelius , Mark J. DeBisschop , Oleg Shikhman , Pasquale Patrizio , Bob H. Katz
发明人： Michael G. Tal , Patrick N. Gutelius , Mark J. DeBisschop , Oleg Shikhman , Pasquale Patrizio , Bob H. Katz
IPC分类号： A61F6/18 , A61F6/14
CPC分类号： A61F6/144 , A61F6/142 , A61F6/18 , A61F6/20
摘要： An intrauterine device for applying force to a wall of a uterus to promote contraception without blocking the fallopian tubes may include an elongate member formed of a resilient material and having a default expanded configuration and a spring portion disposed approximately at a midpoint between two ends of the elongate member. The IUD may also include two tissue contact members, one tissue contact member disposed at one of the two ends of the elongate member and the other tissue contact member disposed at the other end. The tissue contact members may generate a laterally directed force against the wall of the uterus when the intrauterine device assumes its default expanded configuration.
摘要翻译：用于将力施加到子宫壁以促进避孕而不阻塞输卵管的子宫内装置可以包括由弹性材料形成并具有默认膨胀构型的细长构件和大致位于第二端的两端之间的中点处的弹簧部分细长构件。 IUD还可以包括两个组织接触构件，一个组织接触构件设置在细长构件的两个端部之一，另一个组织接触构件设置在另一端。当子宫内装置采取其默认扩展配置时，组织接触构件可以产生横向定向的力抵靠子宫壁。

5. 发明授权

US08026065B2 Assessment of oocyte competence 失效
标题翻译：卵母细胞能力评估
公开(公告)号：US08026065B2
公开(公告)日：2011-09-27
申请号：US12312275
申请日：2007-11-02
申请人： Dagan Wells , Pasquale Patrizio
发明人： Dagan Wells , Pasquale Patrizio
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/158
摘要： Methods are provided for evaluating an oocyte for fertilization and implantation. For example, methods are provided for determining whether an oocyte expresses, or does not express, one or more of a group of markers identified as differently expressed between chromosomally normal and chromosomally abnormal oocytes. Also provided, for example, are methods for determining whether a cumulus cell expresses, or does not express, one or more of a group of markers identified as differently expressed between cumulus cells associated with chromosomally normal oocytes and cumulus cells associated with chromosomally abnormal oocytes. Methods are provided for the detection of marker expression of differentially expressed genes at the RNA level, as well as at the protein level.
摘要翻译：提供了用于评估受精和植入的卵母细胞的方法。例如，提供了用于确定卵母细胞是否表达或不表达鉴定为在染色体正常和染色体异常卵母细胞之间不同表达的一组标记物的方法。还提供了例如用于确定卵丘细胞是否表达或不表达鉴定为与染色体正常卵母细胞相关的卵丘细胞和与染色体异常卵母细胞相关的卵丘细胞之间不同表达的一组标记物的方法。提供了用于在RNA水平以及蛋白质水平检测差异表达基因的标记物表达的方法。

6. 发明授权

US08662081B2 Intrauterine device 有权
标题翻译：宫内节育器
公开(公告)号：US08662081B2
公开(公告)日：2014-03-04
申请号：US12856876
申请日：2010-08-16
申请人： Michael G. Tal , Patrick N. Gutelius , Mark J. DeBisschop , Oleg Shikhman , Pasquale Patrizio
发明人： Michael G. Tal , Patrick N. Gutelius , Mark J. DeBisschop , Oleg Shikhman , Pasquale Patrizio
IPC分类号： A61F6/06
CPC分类号： H04R1/323 , A61F6/142 , A61F6/18 , A61F6/20 , B60R11/0217 , H04R1/026 , H04R1/24 , H04R5/02 , H04R2499/13
摘要： An intrauterine device for applying pressure to the walls of the uterine cavity includes a resilient body having an elongated member which includes a first end and a second end which are resiliently biased away from each other. The first end of the elongated member includes a first leg having a first end and a second end. The second end of the elongated member includes a second leg having a first end and a second end. A connection member is positioned between the first end of the first leg and the first end of the second leg. A first plug member is secured at the second end of the first leg and a second plug member is secured at the first end of the second leg. The first and second plug members are shaped and dimensioned for bearing against the walls of the uterine cavity as the elongated member spreads outwardly with the first end and the second end moving apart. A method for preventing conception within the uterine cavity is also disclosed.
摘要翻译：用于向子宫腔的壁施加压力的子宫内装置包括具有细长构件的弹性体，该细长构件包括彼此弹性偏压的第一端和第二端。细长构件的第一端包括具有第一端和第二端的第一腿。细长构件的第二端包括具有第一端和第二端的第二腿。连接构件位于第一腿的第一端和第二腿的第一端之间。第一插头构件固定在第一腿的第二端，并且第二插头构件固定在第二腿的第一端。当第一端部和第二端部移开时，第一和第二插塞构件的形状和尺寸被设计成用于支撑抵靠子宫腔的壁。还公开了一种防止子宫腔内受孕的方法。

7. 发明申请

US20100300452A1 INTRAUTERINE DEVICE 有权
标题翻译： INTRAUTERINE设备
公开(公告)号：US20100300452A1
公开(公告)日：2010-12-02
申请号：US12856876
申请日：2010-08-16
申请人： Michael G. Tal , Patrick N. Gutelius , Mark J. DeBisschop , Oleg Shikhman , Pasquale Patrizio
发明人： Michael G. Tal , Patrick N. Gutelius , Mark J. DeBisschop , Oleg Shikhman , Pasquale Patrizio
IPC分类号： A61F6/14
CPC分类号： H04R1/323 , A61F6/142 , A61F6/18 , A61F6/20 , B60R11/0217 , H04R1/026 , H04R1/24 , H04R5/02 , H04R2499/13
摘要： An intrauterine device for applying pressure to the walls of the uterine cavity includes a resilient body having an elongated member which includes a first end and a second end which are resiliently biased away from each other. The first end of the elongated member includes a first leg having a first end and a second end. The second end of the elongated member includes a second leg having a first end and a second end. A connection member is positioned between the first end of the first leg and the first end of the second leg. A first plug member is secured at the second end of the first leg and a second plug member is secured at the first end of the second leg. The first and second plug members are shaped and dimensioned for bearing against the walls of the uterine cavity as the elongated member spreads outwardly with the first end and the second end moving apart. A method for preventing conception within the uterine cavity is also disclosed.
摘要翻译：用于向子宫腔的壁施加压力的子宫内装置包括具有细长构件的弹性体，该细长构件包括彼此弹性偏压的第一端和第二端。细长构件的第一端包括具有第一端和第二端的第一腿。细长构件的第二端包括具有第一端和第二端的第二腿。连接构件位于第一腿的第一端和第二腿的第一端之间。第一插头构件固定在第一腿的第二端，并且第二插头构件固定在第二腿的第一端。当第一端部和第二端部移开时，第一和第二插塞构件的形状和尺寸被设计成用于承载在子宫腔的壁上，因为细长构件向外扩展。还公开了一种防止子宫腔内受孕的方法。

8. 发明申请

US20130137590A1 Assessment of Oocyte Competence 审中-公开
标题翻译：评估卵母细胞能力
公开(公告)号：US20130137590A1
公开(公告)日：2013-05-30
申请号：US13243085
申请日：2011-09-23
申请人： Dagan Wells , Pasquale Patrizio
发明人： Dagan Wells , Pasquale Patrizio
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/158
摘要： Methods are provided for evaluating an oocyte for fertilization and implantation. For example, methods are provided for determining whether an oocyte expresses, or does not express, one or more of a group of markers identified as differently expressed between chromosomally normal and chromosomally abnormal oocytes. Also provided, for example, are methods for determining whether a cumulus cell expresses, or does not express, one or more of a group of markers identified as differently expressed between cumulus cells associated with chromosomally normal oocytes and cumulus cells associated with chromosomally abnormal oocytes. Methods are provided for the detection of marker expression of differentially expressed genes at the RNA level, as well as at the protein level.
摘要翻译：提供了用于评估受精和植入的卵母细胞的方法。例如，提供了用于确定卵母细胞是否表达或不表达鉴定为在染色体正常和染色体异常卵母细胞之间不同表达的一组标记物的方法。还提供了例如用于确定卵丘细胞是否表达或不表达鉴定为与染色体正常卵母细胞相关的卵丘细胞和与染色体异常卵母细胞相关的卵丘细胞之间不同表达的一组标记物的方法。提供了用于在RNA水平以及蛋白质水平检测差异表达基因的标记物表达的方法。

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