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1. 发明申请

US20080050793A1 Method of drying biological material 有权
标题翻译：生物材料干燥方法
公开(公告)号：US20080050793A1
公开(公告)日：2008-02-28
申请号：US11701096
申请日：2007-02-01
申请人： Timothy Durance , Parastoo Yaghmaee , Shafique Ahmad , Guopeng Zhang
发明人： Timothy Durance , Parastoo Yaghmaee , Shafique Ahmad , Guopeng Zhang
IPC分类号： C12N13/00
CPC分类号： C08J9/28 , C08J2201/0484 , C08J2201/0504 , C08J2301/00 , F26B5/048 , F26B5/06
摘要： A method for producing foams containing biological materials is described. A solid or semi-solid paste is formed by combining biologically active material with a protecting agent in an aqueous solvent. The paste formed is allowed to set, and may optionally then be apportioned into the desired shape. The paste may be frozen to allow formation of ice crystals to act as porogens. Subsequently, the paste is exposed to travelling wave radiant energy under vacuum (t-REV) for drying. This causes the solvent to boil off, leaving dried material containing the biologically active material, the protecting agent, and a relatively low water content. Biologically active materials which can be used include cells, microbial cultures, live attenuated microbes, probiotics, yeasts, enzymes, vaccines, proteins, and any heat-sensitive biological material. By directing energy via a travelling wave through a sample, good control of temperature and process conditions can be achieved. The method provides an alternative to the conventional methods of particulate leaching or freeze drying.
摘要翻译：描述了生产含有生物材料的泡沫体的方法。通过在水性溶剂中将生物活性物质与保护剂组合而形成固体或半固体糊状物。允许形成的糊料固化，然后可任选地分配成所需的形状。可以将糊状物冷冻以允许形成冰晶以充当致孔剂。随后，将该糊剂暴露于真空下的行波辐射能（t-REV）以进行干燥。这导致溶剂沸腾，留下含有生物活性物质的干燥物质，保护剂和相对较低的含水量。可以使用的生物活性材料包括细胞，微生物培养物，活减毒微生物，益生菌，酵母，酶，疫苗，蛋白质和任何热敏生物材料。通过将能量经由行波引导通过样品，可以实现温度和工艺条件的良好控制。该方法提供了常规的微粒浸出或冷冻干燥方法的替代方案。

2. 发明授权

US09316437B2 Microwave vacuum-drying of organic materials 有权
标题翻译：微波真空干燥有机材料
公开(公告)号：US09316437B2
公开(公告)日：2016-04-19
申请号：US13521410
申请日：2010-10-25
申请人： Jun Fu , Timothy D. Durance , Parastoo Yaghmaee
发明人： Jun Fu , Timothy D. Durance , Parastoo Yaghmaee
IPC分类号： F26B3/347 , F26B5/04 , F26B17/04 , A23L3/01 , A23L3/54 , A23B4/03 , A23B7/02 , A23N12/08
CPC分类号： F26B5/048 , A23B4/031 , A23B7/02 , A23L3/01 , A23L3/54 , A23L5/34 , A23N12/08 , A23V2002/00 , F26B3/347 , F26B5/041 , F26B17/04
摘要： An apparatus 20 for microwave vacuum-drying organic materials such as foods and bioactives has a plurality of microwave generators 50 actuated so as to cause interference between their respective microwave streams and evenly distribute the microwave energy across the vacuum chamber 34. The microwave-transparent window 36 in the chamber is arranged so the organic material to be dried is moved across it on a conveyor belt 60 and the microwave energy passing into the chamber 34 immediately encounters the organic materials, thus attenuating the energy and reducing arcing.
摘要翻译：用于微波真空干燥有机材料如食品和生物活性物质的装置20具有致动多个微波发生器50，以便引起它们各自的微波流之间的干扰，并将微波能均匀分布在真空室34内。微波透明窗 36被布置成使得待干燥的有机材料在传送带60上移动穿过它，并且进入室34的微波能量立即遇到有机材料，从而衰减能量并减少电弧。

3. 发明授权

US08718113B2 Apparatus and method for dehydrating biological materials 有权
标题翻译：用于脱水生物材料的设备和方法
公开(公告)号：US08718113B2
公开(公告)日：2014-05-06
申请号：US12677974
申请日：2008-09-12
申请人： Timothy D. Durance , Jun Fu , Parastoo Yaghmaee , Robert L. Pike , Vu Truong , Binh Pham
发明人： Timothy D. Durance , Jun Fu , Parastoo Yaghmaee , Robert L. Pike , Vu Truong , Binh Pham
IPC分类号： C03B5/02
CPC分类号： A61K39/0275 , A61K2039/545 , F26B3/347 , F26B5/048 , F26B21/006 , F26B25/003 , Y02A50/482
摘要： An apparatus for dehydrating a liquid sample of biological material has a microwave waveguide that is open to the atmosphere. It has a microwave generator, means for introducing a container of the material into the waveguide, means for evacuating the container, means for rotating the container and means for removing the container from the waveguide. It can include means for moving the container through the waveguide and for sealing it. In a dehydration method, a container of the liquid sample is put into the open waveguide, evacuated, rotated at high speed and microwaved. The container of dehydrated material is then removed from the waveguide. The apparatus and method are particularly suitable for dehydrating vaccines.
摘要翻译：用于使生物材料的液体样品脱水的装置具有对大气开放的微波波导。它具有微波发生器，用于将材料的容器引入波导的装置，用于抽出容器的装置，用于旋转容器的装置和用于从波导移除容器的装置。它可以包括用于移动容器通过波导并用于密封它的装置。在脱水方法中，将液体样品的容器放入开口波导中，抽真空，高速旋转并进行微波处理。然后将脱水材料的容器从波导管中取出。该装置和方法特别适用于脱水疫苗。

4. 发明申请

US20120291305A1 MICROWAVE VACUUM-DRYING OF ORGANIC MATERIALS 有权
标题翻译：微波真空干燥有机材料
公开(公告)号：US20120291305A1
公开(公告)日：2012-11-22
申请号：US13521410
申请日：2010-10-25
申请人： Jun Fu , Timothy D. Durance , Parastoo Yaghmaee
发明人： Jun Fu , Timothy D. Durance , Parastoo Yaghmaee
IPC分类号： F26B3/347
CPC分类号： F26B5/048 , A23B4/031 , A23B7/02 , A23L3/01 , A23L3/54 , A23L5/34 , A23N12/08 , A23V2002/00 , F26B3/347 , F26B5/041 , F26B17/04
摘要： An apparatus 20 for microwave vacuum-drying organic materials such as foods and bioactives has a plurality of microwave generators 50 actuated so as to cause interference between their respective microwave streams and evenly distribute the microwave energy across the vacuum chamber 34. The microwave-transparent window 36 in the chamber is arranged so the organic material to be dried is moved across it on a conveyor belt 60 and the microwave energy passing into the chamber 34 immediately encounters the organic materials, thus attenuating the energy and reducing arcing.
摘要翻译：用于微波真空干燥有机材料如食品和生物活性物质的装置20具有致动多个微波发生器50，以便引起它们各自的微波流之间的干扰，并将微波能均匀分布在真空室34内。微波透明窗 36被布置成使得待干燥的有机材料在传送带60上移动穿过它，并且进入室34的微波能量立即遇到有机材料，从而衰减能量并减少电弧。

5. 发明申请

US20110209354A1 APPARATUS AND METHOD FOR DEHYDRATING BIOLOGICAL MATERIALS WITH FREEZING AND MICROWAVING 有权
标题翻译：用冷冻和微波去除生物材料的装置和方法
公开(公告)号：US20110209354A1
公开(公告)日：2011-09-01
申请号：US13063718
申请日：2009-09-11
申请人： Timothy D. Durance , Jun Fu , Parastoo Yaghmaee , Robert L. Pike
发明人： Timothy D. Durance , Jun Fu , Parastoo Yaghmaee , Robert L. Pike
IPC分类号： F26B3/34
CPC分类号： C12N13/00 , A23L3/54 , C12M47/14 , C12N1/04 , C12N9/96 , F26B5/06 , F26B25/001
摘要： An apparatus and method for dehydrating biological materials, such as vaccines and microorganism cultures, in which the materials are dehydrated in an evacuated container which is in a microwave waveguide that is open to the atmosphere. The apparatus comprises means for freezing the container of biological material, a microwave generator, a waveguide, means for introducing the container into the waveguide, means for applying a vacuum to the container and means for removing the dehydrated material from the waveguide. In the method of the invention, the container of biological material is put in a microwave waveguide open to the atmosphere, a vacuum is applied to the container, the material is frozen and is radiated to dehydrate it. The dehydrated material is then removed from the waveguide.
摘要翻译：用于将生物材料如疫苗和微生物培养物脱水的装置和方法，其中材料在位于对大气开放的微波波导中的抽真空容器中脱水。该装置包括用于冷冻生物材料的容器的装置，微波发生器，波导管，用于将容器引入波导的装置，用于向容器施加真空的装置以及用于从波导去除脱水材料的装置。在本发明的方法中，将生物材料的容器放入通向大气的微波导管中，向容器施加真空，将其冷冻并辐射使其脱水。然后从波导中除去脱水材料。

6. 发明授权

US08877469B2 Method of drying biological material 有权
标题翻译：生物材料干燥方法
公开(公告)号：US08877469B2
公开(公告)日：2014-11-04
申请号：US11701096
申请日：2007-02-01
申请人： Timothy D. Durance , Parastoo Yaghmaee , Shafique Ahmad , Guopeng Zhang
发明人： Timothy D. Durance , Parastoo Yaghmaee , Shafique Ahmad , Guopeng Zhang
IPC分类号： C12N13/00 , F26B5/04 , C08J9/28 , F26B5/06
CPC分类号： C08J9/28 , C08J2201/0484 , C08J2201/0504 , C08J2301/00 , F26B5/048 , F26B5/06
摘要： A method for producing foams containing biological materials is described. A solid or semi-solid paste is formed by combining biologically active material with a protecting agent in an aqueous solvent. The paste formed is allowed to set, and may optionally then be apportioned into the desired shape. The paste may be frozen to allow formation of ice crystals to act as porogens. Subsequently, the paste is exposed to travelling wave radiant energy under vacuum (t-REV) for drying. This causes the solvent to boil off, leaving dried material containing the biologically active material, the protecting agent, and a relatively low water content. Biologically active materials which can be used include cells, microbial cultures, live attenuated microbes, probiotics, yeasts, enzymes, vaccines, proteins, and any heat-sensitive biological material. By directing energy via a travelling wave through a sample, good control of temperature and process conditions can be achieved. The method provides an alternative to the conventional methods of particulate leaching or freeze drying.
摘要翻译：描述了生产含有生物材料的泡沫体的方法。通过在水性溶剂中将生物活性物质与保护剂组合而形成固体或半固体糊状物。允许形成的糊料固化，然后可任选地分配成所需的形状。可以将糊状物冷冻以允许形成冰晶以充当致孔剂。随后，将该糊剂暴露于真空下的行波辐射能（t-REV）以进行干燥。这导致溶剂沸腾，留下含有生物活性物质的干燥物质，保护剂和相对较低的含水量。可以使用的生物活性材料包括细胞，微生物培养物，活减毒微生物，益生菌，酵母，酶，疫苗，蛋白质和任何热敏生物材料。通过将能量经由行波引导通过样品，可以实现温度和工艺条件的良好控制。该方法提供了常规的微粒浸出或冷冻干燥方法的替代方案。

7. 发明申请

US20110027868A1 APPARATUS AND METHOD FOR DEHYDRATING BIOLOGICAL MATERIALS 有权
标题翻译：脱水生物材料的装置和方法
公开(公告)号：US20110027868A1
公开(公告)日：2011-02-03
申请号：US12677974
申请日：2008-09-12
申请人： Timothy D. Durance , Jun Fu , Parastoo Yaghmaee , Robert L. Pike , Vu Truong , Binh Pham
发明人： Timothy D. Durance , Jun Fu , Parastoo Yaghmaee , Robert L. Pike , Vu Truong , Binh Pham
IPC分类号： C12N1/04 , C12M1/42
CPC分类号： A61K39/0275 , A61K2039/545 , F26B3/347 , F26B5/048 , F26B21/006 , F26B25/003 , Y02A50/482
摘要： An apparatus for dehydrating a liquid sample of biological material has a microwave waveguide that is open to the atmosphere. It has a microwave generator, means for introducing a container of the material into the waveguide, means for evacuating the container, means for rotating the container and means for removing the container from the waveguide. It can include means for moving the container through the waveguide and for sealing it. In a dehydration method, a container of the liquid sample is put into the open waveguide, evacuated, rotated at high speed and microwaved. The container of dehydrated material is then removed from the waveguide. The apparatus and method are particularly suitable for dehydrating vaccines.
摘要翻译：用于使生物材料的液体样品脱水的装置具有对大气开放的微波波导。它具有微波发生器，用于将材料的容器引入波导的装置，用于抽出容器的装置，用于旋转容器的装置和用于从波导移除容器的装置。它可以包括用于移动容器通过波导并用于密封它的装置。在脱水方法中，将液体样品的容器放入开口波导中，抽真空，高速旋转并进行微波处理。然后将脱水材料的容器从波导管中取出。该装置和方法特别适用于脱水疫苗。

8. 发明授权

US10178873B2 Apparatus and method for microwave vacuum-drying of organic materials 有权
公开(公告)号：US10178873B2
公开(公告)日：2019-01-15
申请号：US12682989
申请日：2008-10-15
申请人： Timothy D. Durance , Jun Fu , Parastoo Yaghmaee
发明人： Timothy D. Durance , Jun Fu , Parastoo Yaghmaee
IPC分类号： F26B3/347 , F26B13/30 , F26B5/04 , A23L3/01 , A23B7/01 , A23B7/02 , A23B7/148 , A23L3/3418 , A23L3/54 , F26B15/14 , F26B17/30
摘要： An apparatus and method for microwave vacuum-drying of organic materials, such as food products. The apparatus has a microwave vacuum chamber 20, a loading module 36 to load containers 38 of the organic material into the vacuum chamber, a rotatable cylindrical cage 64 in the vacuum chamber for rotating the containers, a piston 114 for moving the rotating containers through the vacuum chamber, and means for unloading the containers of dehydrated material from the vacuum chamber. The apparatus may include an equilibration chamber 150 for cooling the dehydrated material under reduced pressure, and a transfer module 42 to transfer the containers from the vacuum chamber to the equilibration chamber. The apparatus has a microwave transparent window 54 for transmission of radiation into the vacuum chamber, and a gas jet 58, 60, 62 for blowing a stream of gas, such as air or nitrogen, into the vacuum chamber adjacent to the window.

9. 发明授权

US10023857B2 Apparatus and method for dehydrating biological materials with freezing and microwaving 有权
公开(公告)号：US10023857B2
公开(公告)日：2018-07-17
申请号：US13063718
申请日：2009-09-11
申请人： Timothy D. Durance , Jun Fu , Parastoo Yaghmaee , Robert L. Pike
发明人： Timothy D. Durance , Jun Fu , Parastoo Yaghmaee , Robert L. Pike
IPC分类号： F26B5/06 , F26B3/34 , C12N13/00 , A23L3/54 , C12M1/00 , C12N1/04 , C12N9/96 , F26B25/00
摘要： An apparatus and method for dehydrating biological materials, such as vaccines and microorganism cultures, in which the materials are dehydrated in an evacuated container which is in a microwave waveguide that is open to the atmosphere. The apparatus comprises means for freezing the container of biological material, a microwave generator, a waveguide, means for introducing the container into the waveguide, means for applying a vacuum to the container and means for removing the dehydrated material from the waveguide. In the method of the invention, the container of biological material is put in a microwave waveguide open to the atmosphere, a vacuum is applied to the container, the material is frozen and is radiated to dehydrate it. The dehydrated material is then removed from the waveguide.

10. 发明授权

US09273901B2 Microwave vacuum-drying of organic materials 有权
标题翻译：微波真空干燥有机材料
公开(公告)号：US09273901B2
公开(公告)日：2016-03-01
申请号：US14123671
申请日：2012-07-12
申请人： Jun Fu , Timothy D. Durance , Parastoo Yaghmaee
发明人： Jun Fu , Timothy D. Durance , Parastoo Yaghmaee
IPC分类号： F26B3/347 , A61K39/00 , F26B25/00 , C12M1/00 , A23L3/54 , C12N13/00 , A61K35/741 , C12N9/00
CPC分类号： F26B3/347 , A23L3/54 , A61K35/741 , A61K39/00 , C12M47/14 , C12N9/00 , C12N13/00 , F26B25/001 , F26B25/008
摘要： An apparatus (20) for dehydrating organic material in batches has a processing unit (22) having a microwave-vacuum chamber (34), an input module (28) and an output module (30), with a conveyor (54) for moving the material through the chamber on a microwave-transparent window. A material reservoir (68) is arranged to receive the material exiting the output module. A conveyor (78) external to the vacuum chamber conveys material that exits the reservoir to the input module. The vacuum chamber (34), reservoir (68) and external conveyor (78) are in fluid communication to operate at a common, reduced pressure. The organic material passes through the vacuum chamber multiple times to equilibrate and dry to the desired degree.
摘要翻译：批量脱水有机材料的装置（20）具有具有微波真空室（34），输入模块（28）和输出模块（30）的处理单元（22），其中输送机（54）用于移动材料通过室内的微波透明窗口。材料储存器（68）布置成接收离开输出模块的材料。在真空室外部的输送机（78）将离开储存器的材料输送到输入模块。真空室（34），储存器（68）和外部输送器（78）流体连通以在共同的减压下操作。有机材料多次通过真空室以平衡并干燥至所需程度。

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